SISTM

Statistics in systems biology and translationnal medicine

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Sandrine Darmigny

Rodolphe Thiebaut

Pr. Rodolphe Thiebaut
MD, PhD, SISTM Director

Rodolphe Thiebaut is a medical doctor, with specialization in Public Health. He holds a PhD in Biostatistics from Bordeaux University.

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Objectives

The team is devoted to the development of statistical methods for the integrative analysis of data in medicine and biology. Thanks to the technological improvements, clinical and biological research is generating massive amounts of data. Of importance are the « omics » data such as genomics (gene expression) and proteomics but also other types of data, for which modern technologies have strongly increased the amount of information (e.g. medical imaging, cell counts).
This SISTM team is labelled by both Inserm and Inria.

The applications are carried out in collaboration with the Vaccine Research Institute (VRI), other teams from the center as well as the Methodological Support Unit for Clinical and Epidemiological Research (USMR) of the Bordeaux University Hospital.

The two main objectives of the SISTM team are:

  • To accelerate the development of vaccines by analyzing all the information available in early clinical trials and optimizing new trials.
  • To develop new data science approaches to analyze and model high dimensional data in small sample size studies.

Research area

The team is organized around three axes sharing a common objective. It is embarked in a double challenge of developing methods to deal with high dimensional data with low sample size and a main application for accelerating vaccine development.

Hence in Axis 1, the relevant information is extracted from big data. This information is used to estimate mechanistic model parameters in Axis 2. Mechanistic models can then be used for simulating the optimal vaccine strategies to be evaluated in the next clinical trials.

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2022 Key publications

Agniel D, Hejblum BP, Thiebaut R, Parast L. Doubly robust evaluation of high-dimensional surrogate markers. Biostatistics. 2022 Jul 6. https://doi.org/10.1093/biostatistics/kxac020

Alexandre M, Marlin R, Prague M, Coleon S, Kahlaoui N, Cardinaud S, Naninck T, Delache B, Surenaud M, Galhaut M, Dereuddre-Bosquet N, Cavarelli M, Maisonnasse P, Centlivre M, Lacabaratz C, Wiedemann A, Zurawski S, Zurawski G, Schwartz O, Sanders RW, Le Grand R, Levy Y, Thiebaut R. Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection. Elife. 2022 Jul 8;11. https://doi.org/10.7554/eLife.75427

Anywaine Z, Barry H, Anzala O, Mutua G, Sirima SB, Eholie S, Kibuuka H, Betard C, Richert L, Lacabaratz C, McElrath MJ, De Rosa SC, Cohen KW, Shukarev G, Katwere M, Robinson C, Gaddah A, Heerwegh D, Bockstal V, Luhn K, Leyssen M, Thiebaut R, Douoguih M, group EBLS. Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in children and adolescents in Africa: A randomised, placebo-controlled, multicentre Phase II clinical trial. PLoS Med. 2022 Jan 11;19(1):e1003865. https://doi.org/10.1371/journal.pmed.1003865

Avalos-Fernandez M, Alin T, Métayer C, Thiébaut R, Enaud R, Delhaes L. The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis. Respir Res. 2022 Aug 23;23(1):214. https://doi.org/10.1186/s12931-022-02132-4

Clairon Q, Samson A. Optimal control for parameter estimation in partially observed hypoelliptic stochastic differential equations. Computation Stat. 2022 Nov;37(5):2471-91. https://doi.org/10.1007/s00180-022-01212-9

Ferté T, Jouhet V, Griffier R, Hejblum BP, Thiébaut R, Faure I, Revel P, Tentillier E, Dindart J-M, Gruson D, Joannes-Boyau O, Malvy J-MD, Pistone T, Neau D, Nguyen D, Lafon M-E, Molimard M, Schaeverbeke T, Grenier N, Salles N, Rouanet F. The benefit of augmenting open data with clinical data-warehouse EHR for forecasting SARS-CoV-2 hospitalizations in Bordeaux area, France. JAMIA Open. 2022 Dec;5(4):ooac086. https://doi.org/10.1093/jamiaopen/ooac086

Prague M, Lavielle M. SAMBA: A novel method for fast automatic model building in nonlinear mixed-effects models. CPT Pharmacometrics Syst Pharmacol. 2022 Feb 1;11(2):161-72. https://doi.org/10.1002/psp4.12742

Richert L, Lelievre J-D, Lacabaratz C, Hardel L, Hocini H, Wiedemann A, Lucht F, Poizot-Martin I, Bauduin C, Diallo A, Rieux V, Rouch E, Surenaud M, Lefebvre C, Foucat E, Tisserand P, Guillaumat L, Durand M, Hejblum B, Launay O, Thiebaut R, Levy Y. T Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial. J Immunol. 2022 Jun 15;208(12):2663-74. https://doi.org/10.4049/jimmunol.2101076

Team PS, Kieh M, Richert L, Beavogui AH, Grund B, Leigh B, D’Ortenzio E, Doumbia S, Lhomme E, Sow S, Vatrinet R, Roy C, Kennedy SB, Faye S, Lees S, Millimouno NP, Camara AM, Samai M, Deen GF, Doumbia M, Esperou H, Pierson J, Watson-Jones D, Diallo A, Wentworth D, McLean C, Simon J, Wiedemann A, Dighero-Kemp B, Hensley L, Lane HC, Levy Y, Piot P, Greenwood B, Chene G, Neaton J, Yazdanpanah Y. Randomized Trial of Vaccines for Zaire Ebola Virus Disease. N Engl J Med. 2022 Dec 29;387(26):2411-24. https://doi.org/10.1056/NEJMoa2200072

Collin A, Hejblum BP, Vignals C, Lehot L, Thiebaut R, Moireau P, Prague M. Using a population-based Kalman estimator to model the COVID-19 epidemic in France: estimating associations between disease transmission and non-pharmaceutical interventions. Int J Biostat. 2023 Jan 6. https://doi.org/10.1515/ijb-2022-0087

View all of the team’s publications in Oskar

Last News

Posted on : 20 Jun 2023

The BPH SISTM team is accredited by both Inria & Inserm

Team
The SISTM team – © Inria / Photo F. Stucin The BPH SISTM team is accredited by both Inria & Inserm The two main objectives of the SISTM team (Statistics in Systems biology and Translationnal Medicine), led by Pr Rodolphe Thiébaut, are: i) to accelerate the development of vaccines by analyzing all the information available […]
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Posted on : 02 Jan 2023

More than 3 M€ for our project UB 2030 CAP Digital Health labellized by the call AMI CMA "Skills and future professions" of the 2030 France national plan

Awards
This new project coordinated by Rodolphe Thiébaut leader of the BPH’s SISTM team, is part of the 70 awarded of the second call for expression of interest AMI CMA 2022. The ambition is to offer innovative training schemes in the field of digital health. The project UB 2030 CAP Digital Health  brings together a large […]
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