EPIdemiology of Cancer and EnviroNmental Exposures

Pr. Isabelle BALDI, MD, PhD, EPICENE Director
Dr. Alain MONNEREAU, MD, PhD, EPICENE Deputy Director


Centre de recherche INSERM U1219
Université de Bordeaux – ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex

Tél : 05 57 57 95 31

Tél : 05 57 57 12 34

Fax : 05 57 57 47 33


Sabrina Constant

Christel Dantas

Isabelle Baldy

Pr. Isabelle Baldi
MD, PhD, EPICENE Director

Isabelle Baldi is the head of the EPICENE team of the BPH INSERM center (INSERM U1219).

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Dr. Fleur Delva
MD, PhD, EPICENE Deputy director

Fleur Delva  is a medical doctor specialized in public health and hospital practitioner at the Bordeaux University Hospital and co-director of the INSERM EPICENE “Cancer environment” team.



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EPICENE’s research is focused on cancers and their environmental and occupational determinants. Our projects address methodological challenges in a multidisciplinary approach with the aim of expanding knowledge on cancer survival and its determinants, developing new approaches to estimate life-long environmental exposures (Exposome concept), understanding the role of environment and work in the occurrence of some cancers.

Research areas

Theme 1: Cancer survival: improving knowledge, detecting frail individuals, identifying surrogate endpoints.

Even though survival rates have improved for the main cancers in the past decades, they remain highly variable depending on the cancer site and a large range of parameters. We develop efforts to better understand the factors associated with better survival for cancer patients. Thanks to our involvement in population-based cancer registries, we generate new data on cancer survival and its determinants (treatments, comorbidities, care practices, palliative care) for several cancer types (chronic myeloid leukemia, breast cancer, lymphoma through the REALYSA cohort study …).

We pay particular attention to the frail people, for whom efforts of detection and prevention are strongly needed, including elderly people whose number will rapidly increase in the next decades.
We develop new tools to be used in detection programs and we investigate cancer literacy in elderly cancer patients.

Our efforts also focus on strategies for improving cancer screening strategies (organized mass screening and others). We also develop new biostatistical approaches to assess treatment efficacy and patients survival in randomized controlled trials but also in real life settings.

Theme 2: Methods in environmental and occupational exposures: the exposome concept

Our research aims to improve the knowledge of levels and determinants of exposures to some major contaminants with field measurements in order to identify the main determinants of exposure (usable in retrospective questionnaires and in large population cohorts).

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2021 Key Publications

Baldi I, Carles C, Blanc-Lapierre A, Fabbro-Peray P, Druet-Cabanac M, Boutet-Robinet E, Soulat JM, Bouvier G, Lebailly P, Group P. A French crop-exposure matrix for use in epidemiological studies on pesticides: PESTIMAT. J Expo Sci Environ Epidemiol. 2017 Jan;27(1):56-63. https://doi.org/10.1038/jes.2015.72

Carles C, Bouvier G, Esquirol Y, Piel C, Migault L, Pouchieu C, Fabbro-Peray P, Lebailly P, Baldi I. Residential proximity to agricultural land and risk of brain tumor in the general population. Environ Res. 2017 Nov;159:321-30. https://doi.org/10.1016/j.envres.2017.08.025

Piel C, Pouchieu C, Tual S, Migault L, Lemarchand C, Carles C, Boulanger M, Gruber A, Rondeau V, Marcotullio E, Lebailly P, Baldi I, group A. Central nervous system tumors and agricultural exposures in the prospective cohort AGRICAN. Int J Cancer. 2017 Nov 01;141(9):1771-82. https://doi.org/10.1002/ijc.30879

Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Niksic M, Bonaventure A, Valkov M, Johnson CJ, Esteve J, Ogunbiyi OJ, Azevedo ESG, Chen WQ, Eser S, Engholm G, Stiller CA, Monnereau A, Woods RR, Visser O, Lim GH, Aitken J, Weir HK, Coleman MP. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018 Mar 17;391(10125):1023-75. https://doi.org/10.1016/s0140-6736(17)33326-3

Bellera C, Proust-Lima C, Joseph L, Richaud P, Taylor J, Sandler H, Hanley J, Mathoulin-Pelissier S. A two-stage model in a Bayesian framework to estimate a survival endpoint in the presence of confounding by indication. Stat Methods Med Res. 2018 Apr;27(4):1271-81. https://doi.org/10.1177/0962280216660127
Galvin A, Helmer C, Coureau G, Amadeo B, Joly P, Sabathe C, Monnereau A, Baldi I, Rainfray M, Soubeyran P, Delva F, Mathoulin-Pelissier S. Determinants of cancer treatment and mortality in older cancer patients using a multi-state model: Results from a population-based study (the INCAPAC study). Cancer Epidemiol. 2018 Aug;55:39-44. https://doi.org/10.1016/j.canep.2018.04.013

Piel C, Pouchieu C, Migault L, Beziat B, Boulanger M, Bureau M, Carles C, Gruber A, Lecluse Y, Rondeau V, Schwall X, Tual S, Lebailly P, Baldi I, group A. Increased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN. Int J Epidemiol. 2019 Nov 23;48(2):512-26. https://doi.org/10.1093/ije/dyy246

Amadeo B, Penel N, Coindre JM, Ray-Coquard I, Ligier K, Delafosse P, Bouvier AM, Plouvier S, Gallet J, Lacourt A, Coureau G, Monnereau A, Mathoulin-Pelissier S, Desandes E. Incidence and time trends of sarcoma (2000-2013): results from the French network of cancer registries (FRANCIM). BMC Cancer. 2020 Mar 6;20(1):190. https://doi.org/10.1186/s12885-020-6683-0

Frasca M, Sabathe C, Delaloge S, Galvin A, Patsouris A, Levy C, Mouret-Reynier MA, Desmoulins I, Vanlemmens L, Bachelot T, Goncalves A, Perotin V, Uwer L, Frenel JS, Ferrero JM, Bouleuc C, Eymard JC, Dieras V, Leheurteur M, Petit T, Dalenc F, Jaffre A, Chevrot M, Courtinard C, Mathoulin-Pelissier S. Palliative care delivery according to age in 12,000 women with metastatic breast cancer: Analysis in the multicentre ESME-MBC cohort 2008-2016. Eur J Cancer. 2020 Sep;137:240-9. https://doi.org/10.1016/j.ejca.2020.07.007

Ghesquières H, Rossi C, Cherblanc F, Le Guyader-Peyrou S, Bijou F, Sujobert P, Fabbro-Peray P, Bernier A, Belot A, Chartier L, Fornecker LM, Baldi I, Bouabdallah K, Laurent C, Oberic L, Morineau N, Le Gouill S, Morschhauser F, Haioun C, Damaj G, Guidez S, Labouré G, Fitoussi O, Lebras L, Gressin R, Salles G, Ysebaert L, Monnereau A. A French multicentric prospective prognostic cohort with epidemiological, clinical, biological and treatment information to improve knowledge on lymphoma patients: study protocol of the “REal world dAta in LYmphoma and survival in adults” (REALYSA) cohort. BMC Public Health. 2021 Mar 2;21(1):432. https://doi.org/10.1186/s12889-021-10433-4

Monnereau A; EUROCARE-5 Working Group. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000-2007: Results of EUROCARE-5 population-based study. Eur J Cancer 2015: 51(15) : 2254–2268

View all of the team’s publications in Oskar

Last News

Posted on : 22 Aug 2022

Les chercheurs de l’équipe EPICENE du BPH interviendront au prochain séminaire Vins & environnement du 15 novembre prochain sur la question de la santé en lien avec les utilisations de pesticides en vigne

Ce 6ème séminaire Vins & environnement organisé par l’ISVV Institut des Sciences de la Vigne et du Vin de l’Université de Bordeaux, en partenariat avec INNO’VIN le cluster de la filière vitivinicole en Nouvelle-Aquitaine portera sur « Viticulture, pesticides et santé : Que récolte la recherche ? » Contact : Isabelle.baldi@u-bordeaux.fr Mathilde Bureau@u-bordeaux.fr Le séminaire […]
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Doctorante en ergonomie


Maître de conférences


Hygiéniste du travail et de l'environnement






Attachée de recherche clinique




Chargée de projets scientifiques Pesticides & Santé

Canal RaffinMireille



Pharmacien Épidémiologiste


MCU-PH en santé travail Equipe EPICENE




Médecin épidémiologiste MCU-PH


PhD Student



Chercheur Inserm

de GraafLucie





DialloKaramoko Alpha




Hygieniste industriel ; animateur de réseaux


Hygieniste industriel



Attachée de Recherche Clinique


Professeur des universités en ergonomie



Epidémiologiste - cheffe de projet




Jestin GuyonNolwenn



Chargée de recherche INSERM

Le Guyader-PeyrouSandra






Doctorante en épidémiologie


Praticien hospitalier des Centres de Lutte Contre le Cancer






Post Doctorante


Attachée de Recherche Clinique

Raherison Chantal



Souchet RenaudEmma