ELEANOR
Molecular epidemiology of vascular and brain disorders
Details
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Objectives
The purpose of our research is to identify groups of individuals who are at high risk of developing three common and tightly linked neurological and vascular conditions, dementia, stroke and venous thrombosis, to discover novel etiological factors and therapeutic targets, and to propose more personalized preventive strategies through improved risk stratification.
Research areas
Our research program relies on major components:
- Large-scale epidemiological and clinical cohorts coupled with biosamples;
- The deployment of cutting-edge high-throughput technologies for deep molecular phenotyping;
- The application of advanced statistical methodologies;
- A group of experts in molecular-clinical epidemiology;
- A widespread network of collaborators that enables us to contribute to the functional characterization of the identified biomarkers.
2023 Key Publications
Baudry J, Rebouillat P, Samieri C, Berlivet J, Kesse-Guyot E. Dietary pesticide exposure and non-communicable diseases and mortality: a systematic review of prospective studies among adults. Environ Health. 2023;22(1):76. https://doi.org/10.1186/s12940-023-01020-8
Duering M, Biessels GJ, Brodtmann A, Chen C, Cordonnier C, de Leeuw F-E, Debette S, Frayne R, Jouvent E, Rost NS, Ter Telgte A, Al-Shahi Salman R, Backes WH, Bae H-J, Brown R, Chabriat H, De Luca A, deCarli C, Dewenter A, Doubal FN, Ewers M, Field TS, Ganesh A, Greenberg S, Helmer KG, Hilal S, Jochems ACC, Jokinen H, Kuijf H, Lam BYK, Lebenberg J, MacIntosh BJ, Maillard P, Mok VCT, Pantoni L, Rudilosso S, Satizabal CL, Schirmer MD, Schmidt R, Smith C, Staals J, Thrippleton MJ, van Veluw SJ, Vemuri P, Wang Y, Werring D, Zedde M, Akinyemi RO, Del Brutto OH, Markus HS, Zhu Y-C, Smith EE, Dichgans M, Wardlaw JM. Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurol. 2023;22(7):602-18. https://doi.org/10.1016/s1474-4422(23)00131-x
Duperron M-G, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Tregouet D-A, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bulow R, Carrera C, Chen C, Cheng C-Y, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Munoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdes Hernandez MC, Vernooij MW, Volker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu Y-C, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023;29(4):950-62. https://doi.org/10.1038/s41591-023-02268-w
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong M-G, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmstrom M, Magnusson M, Silveira A, Uhlen M, Renne T, Martinez-Perez A, Emmerich J, Deleuze J-F, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange P-E, Butler LM, Tregouet D-A, Odeberg J. Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. Nat Commun. 2023;14(1):7752. https://doi.org/10.1038/s41467-023-43764-4
Le Grand Q, Ecker Ferreira L, Metso TM, Schilling S, Tatlisumak T, Grond-Ginsbach C, Engelter ST, Lyrer P, Majersik JJ, Worrall BB, Southerland AM, Markus HS, Lathrop M, Thijs V, Leys D, Amouyel P, Dallongeville J, Dichgans M, Pezzini A, Bersano A, Sargurupremraj M, Debette S. Genetic Insights on the Relation of Vascular Risk Factors and Cervical Artery Dissection. J Am Coll Cardiol. 2023;82(14):1411-23. https://doi.org/10.1016/j.jacc.2023.07.021
Munsch G, Proust C, Labrouche-Colomer S, Aissi D, Boland A, Morange P-E, Roche A, de Chaisemartin L, Harroche A, Olaso R, Deleuze J-F, James C, Emmerich J, Smadja DM, Jacqmin-Gadda H, Tregouet D-A. Genome-wide association study of a semicontinuous trait: illustration of the impact of the modeling strategy through the study of Neutrophil Extracellular Traps levels. NAR Genom Bioinform. 2023;5(2):lqad062. https://doi.org/10.1093/nargab/lqad062
Ong KL, Marklund M, Huang L, Rye K-A, Hui N, Pan X-F, Rebholz CM, Kim H, Steffen LM, van Westing AC, Geleijnse JM, Hoogeveen EK, Chen Y-Y, Chien K-L, Fretts AM, Lemaitre RN, Imamura F, Forouhi NG, Wareham NJ, Birukov A, Jager S, Kuxhaus O, Schulze MB, de Mello VD, Tuomilehto J, Uusitupa M, Lindstrom J, Tintle N, Harris WS, Yamasaki K, Hirakawa Y, Ninomiya T, Tanaka T, Ferrucci L, Bandinelli S, Virtanen JK, Voutilainen A, Jayasena T, Thalamuthu A, Poljak A, Bustamante S, Sachdev PS, Senn MKn, Rich SS, Tsai MY, Wood AC, Laakso M, Lankinen M, Yang X, Sun L, Li H, Lin X, Nowak C, Arnlov J, Riserus U, Lind L, Le Goff M, Samieri C, Helmer C, Qian F, Micha R, Tin A, Kottgen A, de Boer IH, Siscovick DS, Mozaffarian D, Wu JH. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ. 2023;380:e072909. https://doi.org/10.1136/bmj-2022-072909
Soukarieh O, Tillet E, Proust C, Dupont C, Jaspard-Vinassa B, Soubrier F, Goyenvalle A, Eyries M, Tregouet D-A. uAUG creating variants in the 5’UTR of ENG causing Hereditary Hemorrhagic Telangiectasia. NPJ Genom Med. 2023;8(1):32. https://doi.org/10.1038/s41525-023-00378-5
Tor-Roca A, Sanchez-Pla A, Korosi A, Pallas M, Lucassen PJ, Castellano-Escuder P, Aigner L, Gonzalez-Dominguez R, Manach C, Carmona F, Vegas E, Helmer C, Feart C, Lefevre-Arbogast S, Neuffer J, Lee H, Thuret S, Andres-Lacueva C, Samieri C, Urpi-Sarda M. A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study. Mol Nutr Food Res. 2023:e2300271. https://doi.org/10.1002/mnfr.202300271
Yang Y, Knol MJ, Wang R, Mishra A, Liu D, Luciano M, Teumer A, Armstrong N, Bis JC, Jhun MA, Li S, Adams HHH, Aziz NA, Bastin ME, Bourgey M, Brody JA, Frenzel S, Gottesman RF, Hosten N, Hou L, Kardia SLR, Lohner V, Marquis P, Maniega SM, Satizabal CL, Sorond FA, Valdes Hernandez MC, van Duijn CM, Vernooij MW, Wittfeld K, Yang Q, Zhao W, Boerwinkle E, Levy D, Deary IJ, Jiang J, Mather KA, Mosley TH, Psaty BM, Sachdev PS, Smith JA, Sotoodehnia N, DeCarli CS, Breteler MMB, Arfan Ikram M, Grabe HJ, Wardlaw J, Longstreth WT, Launer LJ, Seshadri S, Debette S, Fornage M. Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. Brain. 2023;146(2):492-506. https://doi.org/10.1093/brain/awac290
Last News
VBHI CONFERENCE ‘Triangulation of the role of type I interferons in sporadic disease using modern epidemiology’
Non classé
Official launch of the VBHI (Vascular Brain Health Institute) university hospital institute
Centre Broca Nouvelle-Aquitaine - Campus Carreire
Events
4th edition of the InScience festival (May 27 to June 9, 2024)
& Portrait of Cecilia Samieri
Focus
Young Researcher Award for Ilana Caro at the 10th European Stroke Organisation (SEO) Conference
AwardsPublication of the results of a genomic study of cervical artery dissection in the Journal of the American College of Cardiology by ELEANOR team & CADISP consortium
NewsA genomic study by ELEANOR team & CADISP consortium among the Top picks of the Journal of the American College of Cardiology
PressAlzheimer's disease: Is research at a major turning point in the treatment of the disease?
Press
Publication in Nature Medicine:
Large genomic study on perivascular space burden unravels early mechanisms of cerebral small vessel disease
Press
Une vaste étude génomique internationale sur les accidents vasculaires cérébraux (AVC) ouvre de nouvelles perspectives en termes d’innovation thérapeutique et de prédiction de risque.
PressMembers
BordesConstance
PhD student in epidemiologyCaroIlana
PhD studentD'AOUSTTimothy
DoctorantDebetteStephanie
BPH Director - Team co-director - ProfessorDelgadoCoralie
Project ManagerDuperronMarie-Gabrielle
MD, PhD studentGendreBlandine
PhD, Research engineerGERMAINMarine
Ingénieure de Recherche en analyse de données biologiquesLachaize GaboreauMorgane
Clinical Project ManagerLefèvre-ArbogastSophie
Postdoctoral Research Fellow in EpidemiologyLegrandAudrey
Assistante de gestion administrativeMEGUERDITCHIANCaroline
Bioinformatics EngineerMishraAniket
Tenured Researcher in Statistical GeneticsMoeyaertChloe
MorvanAlexandre
MunschGaelle
PhD studentNeufferJeanne
PhD studentProustcarole
Assistant IngénieurSabaYasaman
PhD StudentSamieriCécilia
SoukariehOmar
SoumaréAïcha
EpidemiologistThomas CrusellsJudith
International Project ManagerTrégouëtDavid-Alexandre
ELEANOR Team DirectorTsuchidaAmi
Neuroimaging Analysis Researcher