Molecular epidemiology of vascular and brain disorders


Centre de recherche INSERM U1219
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex

Tél : 05 57 57 16 59

David-Alexandre Tregouet

Dr. David-Alexandre Trégouët
PhD, ELEANOR director

Holder of a PhD in Public Health (1999), with strong emphasis on genetic epidemiology, his research career started with the development of statistical methods to analyze family data as well as genetic polymorphisms in the context of candidate association studies.

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Stéphanie Debette

Pr. Stéphanie Debette
MD, PhD, ELEANOR Deputy Director

Stéphanie Debette, MD PhD, is Professor of Epidemiology/Public Health at the university of Bordeaux and practicing Neurologist at Bordeaux University Hospital.

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The purpose of our research is to identify groups of individuals who are at high risk of developing three common and tightly linked neurological and vascular conditions, dementia, stroke and venous thrombosis, to discover novel etiological factors and therapeutic targets, and to propose more personalized preventive strategies through improved risk stratification.

Research areas

Our research program relies on major components:

  • Large-scale epidemiological and clinical cohorts coupled with biosamples;
  • The deployment of cutting-edge high-throughput technologies for deep molecular phenotyping;
  • The application of advanced statistical methodologies;
  • A group of experts in molecular-clinical epidemiology;
  • A widespread network of collaborators that enables us to contribute to the functional characterization of the identified biomarkers.

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2023 Key Publications

Baudry J, Rebouillat P, Samieri C, Berlivet J, Kesse-Guyot E. Dietary pesticide exposure and non-communicable diseases and mortality: a systematic review of prospective studies among adults. Environ Health. 2023;22(1):76. https://doi.org/10.1186/s12940-023-01020-8

Duering M, Biessels GJ, Brodtmann A, Chen C, Cordonnier C, de Leeuw F-E, Debette S, Frayne R, Jouvent E, Rost NS, Ter Telgte A, Al-Shahi Salman R, Backes WH, Bae H-J, Brown R, Chabriat H, De Luca A, deCarli C, Dewenter A, Doubal FN, Ewers M, Field TS, Ganesh A, Greenberg S, Helmer KG, Hilal S, Jochems ACC, Jokinen H, Kuijf H, Lam BYK, Lebenberg J, MacIntosh BJ, Maillard P, Mok VCT, Pantoni L, Rudilosso S, Satizabal CL, Schirmer MD, Schmidt R, Smith C, Staals J, Thrippleton MJ, van Veluw SJ, Vemuri P, Wang Y, Werring D, Zedde M, Akinyemi RO, Del Brutto OH, Markus HS, Zhu Y-C, Smith EE, Dichgans M, Wardlaw JM. Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurol. 2023;22(7):602-18. https://doi.org/10.1016/s1474-4422(23)00131-x

Duperron M-G, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Tregouet D-A, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bulow R, Carrera C, Chen C, Cheng C-Y, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Munoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdes Hernandez MC, Vernooij MW, Volker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu Y-C, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023;29(4):950-62. https://doi.org/10.1038/s41591-023-02268-w

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong M-G, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmstrom M, Magnusson M, Silveira A, Uhlen M, Renne T, Martinez-Perez A, Emmerich J, Deleuze J-F, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange P-E, Butler LM, Tregouet D-A, Odeberg J. Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. Nat Commun. 2023;14(1):7752. https://doi.org/10.1038/s41467-023-43764-4

Le Grand Q, Ecker Ferreira L, Metso TM, Schilling S, Tatlisumak T, Grond-Ginsbach C, Engelter ST, Lyrer P, Majersik JJ, Worrall BB, Southerland AM, Markus HS, Lathrop M, Thijs V, Leys D, Amouyel P, Dallongeville J, Dichgans M, Pezzini A, Bersano A, Sargurupremraj M, Debette S. Genetic Insights on the Relation of Vascular Risk Factors and Cervical Artery Dissection. J Am Coll Cardiol. 2023;82(14):1411-23. https://doi.org/10.1016/j.jacc.2023.07.021

Munsch G, Proust C, Labrouche-Colomer S, Aissi D, Boland A, Morange P-E, Roche A, de Chaisemartin L, Harroche A, Olaso R, Deleuze J-F, James C, Emmerich J, Smadja DM, Jacqmin-Gadda H, Tregouet D-A. Genome-wide association study of a semicontinuous trait: illustration of the impact of the modeling strategy through the study of Neutrophil Extracellular Traps levels. NAR Genom Bioinform. 2023;5(2):lqad062. https://doi.org/10.1093/nargab/lqad062

Ong KL, Marklund M, Huang L, Rye K-A, Hui N, Pan X-F, Rebholz CM, Kim H, Steffen LM, van Westing AC, Geleijnse JM, Hoogeveen EK, Chen Y-Y, Chien K-L, Fretts AM, Lemaitre RN, Imamura F, Forouhi NG, Wareham NJ, Birukov A, Jager S, Kuxhaus O, Schulze MB, de Mello VD, Tuomilehto J, Uusitupa M, Lindstrom J, Tintle N, Harris WS, Yamasaki K, Hirakawa Y, Ninomiya T, Tanaka T, Ferrucci L, Bandinelli S, Virtanen JK, Voutilainen A, Jayasena T, Thalamuthu A, Poljak A, Bustamante S, Sachdev PS, Senn MKn, Rich SS, Tsai MY, Wood AC, Laakso M, Lankinen M, Yang X, Sun L, Li H, Lin X, Nowak C, Arnlov J, Riserus U, Lind L, Le Goff M, Samieri C, Helmer C, Qian F, Micha R, Tin A, Kottgen A, de Boer IH, Siscovick DS, Mozaffarian D, Wu JH. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ. 2023;380:e072909. https://doi.org/10.1136/bmj-2022-072909

Soukarieh O, Tillet E, Proust C, Dupont C, Jaspard-Vinassa B, Soubrier F, Goyenvalle A, Eyries M, Tregouet D-A. uAUG creating variants in the 5’UTR of ENG causing Hereditary Hemorrhagic Telangiectasia. NPJ Genom Med. 2023;8(1):32. https://doi.org/10.1038/s41525-023-00378-5

Tor-Roca A, Sanchez-Pla A, Korosi A, Pallas M, Lucassen PJ, Castellano-Escuder P, Aigner L, Gonzalez-Dominguez R, Manach C, Carmona F, Vegas E, Helmer C, Feart C, Lefevre-Arbogast S, Neuffer J, Lee H, Thuret S, Andres-Lacueva C, Samieri C, Urpi-Sarda M. A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study. Mol Nutr Food Res. 2023:e2300271. https://doi.org/10.1002/mnfr.202300271

Yang Y, Knol MJ, Wang R, Mishra A, Liu D, Luciano M, Teumer A, Armstrong N, Bis JC, Jhun MA, Li S, Adams HHH, Aziz NA, Bastin ME, Bourgey M, Brody JA, Frenzel S, Gottesman RF, Hosten N, Hou L, Kardia SLR, Lohner V, Marquis P, Maniega SM, Satizabal CL, Sorond FA, Valdes Hernandez MC, van Duijn CM, Vernooij MW, Wittfeld K, Yang Q, Zhao W, Boerwinkle E, Levy D, Deary IJ, Jiang J, Mather KA, Mosley TH, Psaty BM, Sachdev PS, Smith JA, Sotoodehnia N, DeCarli CS, Breteler MMB, Arfan Ikram M, Grabe HJ, Wardlaw J, Longstreth WT, Launer LJ, Seshadri S, Debette S, Fornage M. Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. Brain. 2023;146(2):492-506. https://doi.org/10.1093/brain/awac290

View all of the team’s publications in Oskar

Last News

Posted on : 28 May 2024

Young Researcher Award for Ilana Caro at the 10th European Stroke Organisation (SEO) Conference

Young Researcher Award for Ilana Caroat the 10th European Stroke Organisation (SEO) Conference Ilana Caro, PhD student in the ELEANOR team, was awarded the Young Researcher Prize at the 10th European Stroke Organisation (SEO) Conference held in Basel from May 15-17, 2024. The study Ilana Caro is working on focuses on small cerebral vessel disease […]
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Posted on : 12 Oct 2023

Publication of the results of a genomic study of cervical artery dissection in the Journal of the American College of Cardiology by ELEANOR team & CADISP consortium

Publication of the results of a genomic study of cervical artery dissection in the Journal of the American College of Cardiology by ELEANOR team & CADISP consortium Cervical artery dissection is a major cause of ischemic stroke in young adults. It involves bleeding into the wall of the carotid or vertebral arteries, which “tears” the […]
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Posted on : 12 Oct 2023

A genomic study by ELEANOR team & CADISP consortium among the Top picks of the Journal of the American College of Cardiology

A genomic study by ELEANOR team & CADISP consortiumamong the Top picks of the Journal of the American College of Cardiology Cervical artery dissection is a major cause of ischemic stroke in young adults. It involves bleeding into the wall of the carotid or vertebral arteries, which “tears” the artery (hence the term dissection) longitudinally […]
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Posted on : 21 Sep 2023

Alzheimer's disease: Is research at a major turning point in the treatment of the disease?

Alzheimer’s disease:Is research at a major turning point in the treatment of the disease A l’occasion de la journée mondiale sur la maladie d’Alzheimer, retour sur la nouvelle campagne de mobilisation de la Fondation pour la Recherche Médicale (FRM) dans laquelle est à mise à l’honneur le projet de recherche de Cécilia SAMIERI de l’équipe […]
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Posted on : 19 Apr 2023

Publication in Nature Medicine:
Large genomic study on perivascular space burden unravels early mechanisms of cerebral small vessel disease

The results of a large genomic study on perivascular spaces, coordinated by researchers from the ELEANORE team and the Institute of Clinical Neurodegenerative Diseases at the University Hospital of Bordeaux, have been published in the journal Nature Medicine. The study reveals mechanisms involved early in the disease of small cerebral arteries.   Cerebral small vessel […]
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Posted on : 04 Oct 2022

Une vaste étude génomique internationale sur les accidents vasculaires cérébraux (AVC) ouvre de nouvelles perspectives en termes d’innovation thérapeutique et de prédiction de risque.

Alors que l’AVC est la deuxième cause de décès dans le monde, la plus grande étude génomique jamais réalisée sur les AVC vient de révéler des informations majeures publiées dans Nature le 28 septembre. Portant sur plus de 200 000 patients victimes d’AVC et plus de 2 millions d’individus témoins d’origines géographiques très diverses, ces […]
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