Molecular epidemiology of vascular and brain disorders

Dr. David-Alexandre TREGOUET, ELEANOR Director
Pr. Stéphanie DEBETTE, ELEANOR Deputy Director


Centre de recherche INSERM U1219
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex

Tél : 05 57 57 16 59

David-Alexandre Tregouet

Dr. David-Alexandre Trégouët
PhD, ELEANOR director

Holder of a PhD in Public Health (1999), with strong emphasis on genetic epidemiology, his research career started with the development of statistical methods to analyze family data as well as genetic polymorphisms in the context of candidate association studies.

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Stéphanie Debette

Pr. Stéphanie Debette
MD, PhD, BPH Director, ELEANOR Deputy Director

Stéphanie Debette, MD PhD, is Professor of Epidemiology/Public Health at the university of Bordeaux and practicing Neurologist at Bordeaux University Hospital.

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The purpose of our research is to identify groups of individuals who are at high risk of developing three common and tightly linked neurological and vascular conditions, dementia, stroke and venous thrombosis, to discover novel etiological factors and therapeutic targets, and to propose more personalized preventive strategies through improved risk stratification.

Research areas

Our research program relies on major components:

  • Large-scale epidemiological and clinical cohorts coupled with biosamples;
  • The deployment of cutting-edge high-throughput technologies for deep molecular phenotyping;
  • The application of advanced statistical methodologies;
  • A group of experts in molecular-clinical epidemiology;
  • A widespread network of collaborators that enables us to contribute to the functional characterization of the identified biomarkers.

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2022 Key Publications

Bordes C, Sargurupremraj M, Mishra A, Debette S. Genetics of common cerebral small vessel disease. Nat Rev Neurol. 2022 Feb;18(2):84-101. https://doi.org/10.1038/s41582-021-00592-8

de la Morena-Barrio ME, Suchon P, Jacobsen EM, Iversen N, Minano A, de la Morena-Barrio B, Bravo-Perez C, Padilla J, Cifuentes R, Asenjo S, Deleuze JF, Tregouet DA, Lozano ML, Vicente V, Sandset PM, Morange PE, Corral J. Two SERPINC1 variants affecting N-glycosylation of Asn224 cause severe thrombophilia not detected by functional assays. Blood. 2022 Jul 14;140(2):140-51. https://doi.org/10.1182/blood.2021014708

Le Grand Q, Satizabal CL, Sargurupremraj M, Mishra A, Soumare A, Laurent A, Crivello F, Tsuchida A, Shin J, Macalli M, Singh B, Beiser AS, DeCarli C, Fletcher E, Paus T, Lathrop M, Adams HHH, Bis JC, Seshadri S, Tzourio C, Mazoyer B, Debette S. Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Jun;7(6):616-28. https://doi.org/10.1016/j.bpsc.2021.10.011

Mishra A, Duplaa C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhao NR, […], Soumare A, Smith JA, Knopman DS, Morris Z, Zhu Y, Rotter JI, Dufouil C, Valdes Hernandez M, Munoz Maniega S, Lathrop M, Boerwinkle E, Schmidt R, Ihara M, Mazoyer B, Yang Q, Joutel A, Tournier-Lasserve E, Launer LJ, Deary IJ, Mosley TH, Amouyel P, DeCarli CS, Psaty BM, Tzourio C, […], Debette S. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain. 2022 Jun 30;145(6):1992-2007. https://doi.org/10.1093/brain/awab432

Mishra A, Malik R, Hachiya T, Jurgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw Y-C, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae H-J, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Carcel-Marquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, […], Tregouet D-A, […], Debette S. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Sep 30:1-15. https://doi.org/10.1038/s41586-022-05165-3

Neuffer J, Gourru M, Thomas A, Lefevre-Arbogast S, Foubert-Samier A, Helmer C, Delcourt C, Feart C, Samieri C. A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community. J Alzheimers Dis. 2022 Nov 18;85(1):331-42. https://doi.org/10.3233/JAD-215011

Samieri C, Yassine HN, Melo van Lent D, Lefevre-Arbogast S, van de Rest O, Bowman GL, Scarmeas N. Personalized nutrition for dementia prevention. Alzheimers Dement. 2022 Jul;18(7):1424-37. https://doi.org/10.1002/alz.12486

Thibord F, Klarin D, Brody JA, Chen M-H, Levin MG, Chasman DI, Goode EL, Hveem K, Teder-Laving M, Martinez-Perez A, Aissi D, Daian-Bacq D, Ito K, Natarajan P, Lutsey PL, Nadkarni GN, de Vries PS, Cuellar-Partida G, Wolford BN, Pattee JW, Kooperberg C, Braekkan SK, Li-Gao R, Saut N, Sept C, Germain M, […], Tregouet D-A, Damrauer SM, Johnson AD, Smith NL. Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors. Circulation. 2022 Sep 26:101161. https://doi.org/10.1161/CIRCULATIONAHA.122.059675

Thomas A, Lefèvre-Arbogast S, Féart C, Foubert-Samier A, Helmer C, Catheline G, Samieri C. Association of a MIND Diet with Brain Structure and Dementia in a French Population. J Prev Alzheimers Dis. 2022 Aug 9;9(4):655-64. https://doi.org/10.14283/jpad.2022.67

Yassine HN, Samieri C, Livingston G, Glass K, Wagner M, Tangney C, Plassman BL, Ikram MA, Voigt RM, Gu Y, O’Bryant S, Minihane AM, Craft S, Fink HA, Judd S, Andrieu S, Bowman GL, Richard E, Albensi B, Meyers E, Khosravian S, Solis M, Carrillo M, Snyder H, Grodstein F, Scarmeas N, Schneider LS. Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. Lancet Healthy Longev. 2022 Jul;3(7):e501-e12. https://doi.org/10.1016/s2666-7568(22)00120-9

View all of the team’s publications in Oskar

Last News

Posted on : 12 Oct 2023

Publication of the results of a genomic study of cervical artery dissection in the Journal of the American College of Cardiology by ELEANOR team & CADISP consortium

Publication of the results of a genomic study of cervical artery dissection in the Journal of the American College of Cardiology by ELEANOR team & CADISP consortium Cervical artery dissection is a major cause of ischemic stroke in young adults. It involves bleeding into the wall of the carotid or vertebral arteries, which “tears” the […]
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Posted on : 21 Sep 2023

Alzheimer's disease: Is research at a major turning point in the treatment of the disease?

Alzheimer’s disease:Is research at a major turning point in the treatment of the disease A l’occasion de la journée mondiale sur la maladie d’Alzheimer, retour sur la nouvelle campagne de mobilisation de la Fondation pour la Recherche Médicale (FRM) dans laquelle est à mise à l’honneur le projet de recherche de Cécilia SAMIERI de l’équipe […]
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Posted on : 19 Apr 2023

Publication in Nature Medicine:
Large genomic study on perivascular space burden unravels early mechanisms of cerebral small vessel disease

The results of a large genomic study on perivascular spaces, coordinated by researchers from the ELEANORE team and the Institute of Clinical Neurodegenerative Diseases at the University Hospital of Bordeaux, have been published in the journal Nature Medicine. The study reveals mechanisms involved early in the disease of small cerebral arteries.   Cerebral small vessel […]
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Posted on : 04 Oct 2022

Une vaste étude génomique internationale sur les accidents vasculaires cérébraux (AVC) ouvre de nouvelles perspectives en termes d’innovation thérapeutique et de prédiction de risque.

Alors que l’AVC est la deuxième cause de décès dans le monde, la plus grande étude génomique jamais réalisée sur les AVC vient de révéler des informations majeures publiées dans Nature le 28 septembre. Portant sur plus de 200 000 patients victimes d’AVC et plus de 2 millions d’individus témoins d’origines géographiques très diverses, ces […]
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