LEHA

Lifelong Exposures Health & Aging

Dr. Cécile DELCOURT, PhD, Research Director at Inserm, LEHA Director

Details

Centre de recherche INSERM U1219
Université de Bordeaux, ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex

Tél : 05 57 57 95 38

Tél : 05 57 57 15 96

Fax : 05 57 57 14 86

Contact

Sylvie Mivielle

Cécile Delcourt

Dr Cécile Delcourt
PhD, LEHA Director

Cécile Delcourt, has a PhD in statistics and public health and is senior researcher at Inserm U1219-Bordeaux Population Health Research Center, where she leads the LEHA (Lifelong Exposures, Health and Aging) research group.

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Objectives

The objective of team LEHA is to study age-related diseases, in particular those of the brain (dementia, Alzheimer’s disease) and of the eye (age-related macular degeneration, glaucoma), using a lifelong approach and focusing on shared mechanisms and exposures, in order to define strategies for the prevention of age-related functional loss and the promotion of healthy aging.

Research area

We study populations of different ages (elderly, middle-aged, young) in prospective designs allowing for the study of slow long-term processes, using early biomarkers (in particular eye and brain imaging) allowing for the early detection of health related effects of exposures.

As age-related diseases share common mechanisms and consequences and interact with each other, aging is considered as a global state promoting the occurrence of diseases. Models of aging are mainly neurological diseases (cognitive decline and dementia/ Alzheimer’s) and eye diseases (mainly age-related macular degeneration (AMD) and glaucoma), but also extend to other health endpoints, such as diabetes, kidney disease or physical performance.

Our research is based on population-based cohorts that we have been conducting in elderly populations for more than 30 years: the PAQUID cohort (n=3777, followed since 1988) and the 3C Study (n=9294 including 2104 in Bordeaux, followed since 1999), and its ancillary ophthalmological study in Bordeaux Alienor (n=963, followed since 2006).

We also participate in population-based cohort studies (i-Share, 20,000 students, PI C. Tzourio), Constances (220,000 adults aged 18-69 years, followed since 2012, PI M. Zins, Inserm U1018, Villejuif) and B cube (planned 2000 aged 55-80 years in Bordeaux, PI C Samieri), in particular by generating cutting edge ophthalmological phenotypic information and several ranges of biomarkers. Finally, we collaborate with European and American cohorts, individually or within collaborative projects.

Overall, these studies collect information on many aspects of aging (functions, chronic and degenerative diseases, disability) and their determinants (clinical factors, nutrition, environmental exposures, genetics), which allow a very comprehensive study of the epidemiology of health and aging in older adults, but also offer a scope for a broader lifelong approach, thanks to the epidemiological and clinical studies conducted in younger individuals.

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Main publications

Acar N, Merle BMJ, Ajana S, He Z, Gregoire S, Hejblum BP, Martine L, Buaud B, Bron AM, Creuzot-Garcher CP, Korobelnik JF, Berdeaux O, Jacqmin-Gadda H, Bretillon L, Delcourt C, Biomarkers of Lipid S, metabolism in Retinal ageing Study G. Predicting the retinal content in omega-3 fatty acids for age-related macular-degeneration. Clin Transl Med. 2021 Jul;11(7):e404. https://doi.org/10.1002/ctm2.404

Ajana S, Cougnard-Gregoire A, Colijn JM, Merle BMJ, Verzijden T, de Jong P, Hofman A, Vingerling JR, Hejblum BP, Korobelnik JF, Meester-Smoor MA, Ueffing M, Jacqmin-Gadda H, Klaver CCW, Delcourt C, Consortium E-R. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning. Ophthalmology. 2021 Apr;128(4):587-897. https://doi.org/10.1016/j.ophtha.2020.08.031

Andre P, Pais de Barros JP, Mj Merle B, Samieri C, Helmer C, Delcourt C, Feart C. Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults. Am J Clin Nutr. 2021 Sep 1;114(3):1080-91. https://doi.org/10.1093/ajcn/nqab126

Linard M, Baillet M, Letenneur L, Garrigue I, Catheline G, Dartigues JF, Peres K, Helmer C. Herpes simplex virus, early neuroimaging markers and incidence of Alzheimer’s disease. Transl Psychiatry. 2021 Jul 31;11(1):414. https://doi.org/10.1038/s41398-021-01532-2

Merle BMJ, Cougnard-Gregoire A, Korobelnik JF, Schalch W, Etheve S, Rougier MB, Feart C, Samieri C, Delyfer MN, Delcourt C. Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study. Nutrients. 2021 Jun 15;13(6). https://doi.org/10.3390/nu13062047
Morillon C, Le Goff M, Gattoussi S, Korobelnik JF, Rougier MB, Schweitzer C, Delcourt C, Delyfer MN. Incidence, Progression, and Risk Factors of Epiretinal Membranes in the Elderly. Retina. 2021 Mar 1;41(3):495-504. https://doi.org/10.1097/iae.0000000000002871

Chuy V, Gentreau M, Artero S, Berticat C, Rigalleau V, Peres K, Helmer C, Samieri C, Feart C. Simple Carbohydrate Intake and Higher Risk for Physical Frailty Over 15 Years in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):10-8. https://doi.org/10.1093/gerona/glab243

Prezelin-Reydit M, Madden I, Macher M-A, Salomon R, Sellier-Leclerc A-L, Roussey G, Lahoche A, Garaix F, Decramer S, Ulinski T, Fila M, Dunand O, Merieau E, Pongas M, Zaloszyc A, Baudouin V, Berard E, Couchoud C, Leffondre K, Harambat J. Preemptive Kidney Transplantation Is Associated With Transplantation Outcomes in Children: Results From the French Kidney Replacement Therapy Registry. Transplantation. 2022 Feb 1;106(2):401-11. https://doi.org/10.1097/tp.0000000000003757

View all of the team’s publications in Oskar

Last News

Posted on : 22 Aug 2022

New Macu-Life Project: Evaluation of the relationship between our lifestyles and the development of AMD

News
Macu-Life : Exposome du mode de vie et risque de dégénérescence maculaire liée à l’âge dans la cohorte E3N Le projet « Macu-Life » ambitionne de contribuer à l’évaluation des relations entre nos modes de vie et le développement de la dégénérescence maculaire liée à l’âge (DMLA) dans un objectif de mise en œuvre de […]
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Posted on : 22 Aug 2022

February 3, 2023:
"Doing with" seminar - What effect on my posture as a public health researcher?

Events
Les doctorants du Réseau doctoral en santé publique animé par l’École des Hautes Études en Santé Publique (EHESP) ont le plaisir de vous inviter à leur séminaire interdisciplinaire intitulé : “Faire avec”, quel effet sur ma posture de chercheur en santé publique ? Date de l’événement : Vendredi 3 février 2023 de 9h à 17h Contacts : Irwin […]
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Posted on : 22 Aug 2022

PhD and startuper: Interview with Soufiane Ajana former PhD student in the BPH LEHA team

Focus
Creator and promoter of the startup Retinet, incubated during his thesis at the BPH and winner of the Microsoft For Startups Founders Hub – 2022 Edition competition; the opportunity for Soufiane to review his career and the transition to the BPH Interview with Soufiane Ajana
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Posted on : 22 Aug 2022

Soufiane Ajana from our LEHA team has been selected by Microsoft to join a development programme

Awards
  We are proud of the RetiNet startup, a spin-off of the Bordeaux Population Health Research Center laboratory, which has been selected by Microsoft to join the Microsoft for Startups Founders Hub program! This award represents a unique opportunity for this deeptech startup to gain access to personalized mentoring and valuable resources (up to $150,000 […]
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Posted on : 22 Aug 2022

Prix ISEE Laure Gayraud Doctorante

Awards
The BPH and LEHA team congratulate Laure Gayraud, PhD student in epidemiology, for the ISEE International Society for Environmental Epidemiology – Prize for the “Best Student Abstract and Young Researcher” last september in Athens. This prize rewards for the presentation at the 34th Annual Congress of her work on the associations between air pollution exposure […]
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Posted on : 22 Aug 2022

Classification des aliments selon leur degré de transformation: NOVA n’est pas aussi robuste qu’il n’y parait !

Press
European Journal of Clinical Nutrition (2022), article Open Access Bien que le système de classification NOVA en fonction de critères liés à la transformation des aliments soit largement utilisé, sa robustesse et ses fonctionnalités restent peu explorées. Cette étude, menée par une équipe de chercheurs dont Catherine Féart de l’équipe LEHA du BPH a déterminé […]
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Posted on : 22 Aug 2022

Exposition solaire professionnelle et santé de la peau et des yeux : le projet EXPOLUX

News
Le 2 décembre dernier, notre équipe LEHA a lancé le projet EXPOLUX, avec le soutien de la Fondation Bordeaux Université. Bravo aux responsables scientifiques Audrey COUGNARD-GREGOIRE et Cécile DELCOURT. La peau et les yeux sont les principaux organes cibles d’une exposition aigue et prolongée aux rayonnement ultraviolets (UV) solaires. Les affections majeures voire irréversibles touchant […]
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