LEHA
Lifelong Exposures Health & Aging
Details
Université de Bordeaux, ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex
Objectives
The objective of team LEHA is to study age-related diseases, in particular those of the brain (dementia, Alzheimer’s disease) and of the eye (age-related macular degeneration, glaucoma), using a lifelong approach and focusing on shared mechanisms and exposures, in order to define strategies for the prevention of age-related functional loss and the promotion of healthy aging.
Research area
We study populations of different ages (elderly, middle-aged, young) in prospective designs allowing for the study of slow long-term processes, using early biomarkers (in particular eye and brain imaging) allowing for the early detection of health related effects of exposures.
As age-related diseases share common mechanisms and consequences and interact with each other, aging is considered as a global state promoting the occurrence of diseases. Models of aging are mainly neurological diseases (cognitive decline and dementia/ Alzheimer’s) and eye diseases (mainly age-related macular degeneration (AMD) and glaucoma), but also extend to other health endpoints, such as diabetes, kidney disease or physical performance.
Our research is based on population-based cohorts that we have been conducting in elderly populations for more than 30 years: the PAQUID cohort (n=3777, followed since 1988) and the 3C Study (n=9294 including 2104 in Bordeaux, followed since 1999), and its ancillary ophthalmological study in Bordeaux Alienor (n=963, followed since 2006).
We also participate in population-based cohort studies (i-Share, 20,000 students, PI C. Tzourio), Constances (220,000 adults aged 18-69 years, followed since 2012, PI M. Zins, Inserm U1018, Villejuif) and B cube (planned 2000 aged 55-80 years in Bordeaux, PI C Samieri), in particular by generating cutting edge ophthalmological phenotypic information and several ranges of biomarkers. Finally, we collaborate with European and American cohorts, individually or within collaborative projects.
Overall, these studies collect information on many aspects of aging (functions, chronic and degenerative diseases, disability) and their determinants (clinical factors, nutrition, environmental exposures, genetics), which allow a very comprehensive study of the epidemiology of health and aging in older adults, but also offer a scope for a broader lifelong approach, thanks to the epidemiological and clinical studies conducted in younger individuals.
2023 Key Publications
Bardinet J, Pouchieu C, Chuy V, Helmer C, Etheve S, Gaudout D, Samieri C, Berr C, Delcourt C, Cougnard-Gregoire A, Feart C. Plasma carotenoids and risk of depressive symptomatology in a population-based cohort of older adults. J Affect Disord. 2023;339:615-23.
Cougnard-Gregoire A, Merle BMJ, Aslam T, Seddon JM, Aknin I, Klaver CCW, Garhofer G, Layana AG, Minnella AM, Silva R, Delcourt C. Blue Light Exposure: Ocular Hazards and Prevention-A Narrative Review. Ophthalmol Ther. 2023;12(2):755-88.
Dulau I, Recur B, Helmer C, Delcourt C, Beurton-Aimar M, Ieee, editors. Connected-Components-based Post-processing for Retinal Vessels Deep-Learning Segmentation. IEEE 13th International Conference on Pattern Recognition Systems (ICPRS); 2023 Jul 04-07; Guayaquil, ECUADOR2023.
Gayraud L, Mortamais M, Schweitzer C, de Hoogh K, Cougnard-Gregoire A, Korobelnik J-F, Delyfer M-N, Rougier M-B, Leffondre K, Helmer C, Vienneau D, Berr C, Delcourt C. Association of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective Alienor study. Environ Res. 2023;232:116364.
Jacquemot A-F, Prat R, Gazan R, Dubois C, Darmon N, Feart C, Verger EO. Development and validation of an occurrence-based healthy dietary diversity (ORCHID) score easy to operationalise in dietary prevention interventions in older adults: a French study. Br J Nutr. 2023:1-11.
Le Gall L, Harambat J, Combe C, Philipps V, Proust-Lima C, Dussartre M, Drueke T, Choukroun G, Fouque D, Frimat L, Jacquelinet C, Laville M, Liabeuf S, Pecoits-Filho R, Massy ZA, Stengel B, Alencar de Pinho N, Leffondre K, Prezelin-Reydit M, group C-Rs. Haemoglobin trajectories in chronic kidney disease and risk of major adverse cardiovascular events. Nephrol Dial Transplant. 2023.
Larsen PP, Feart C, Pais de Barros JP, Merle BMJ, Gayraud L, Delyfer MN, Korobelnik JF, Delcourt C. Association of Age-Related Macular Degeneration with a Blood Biomarker of Lipopolysaccharide, a Gut Bacterial Proinflammatory Toxin. Invest Ophthalmol Vis Sci. 2023;64(14):47.
Lima Reboucas SC, Crivello F, Tsuchida A, Tzourio C, Schweitzer C, Korobelnik J-F, Delcourt C, Helmer C. Association of retinal nerve layers thickness and brain imaging in healthy young subjects from the i-Share-Bordeaux study. Hum Brain Mapp. 2023;44(13):4722-37.
Linard M, Foubert-Samier A, Pacaud J, Helmer C. Could JC virus be involved in the onset of multiple system atrophy? A hypothesis. Parkinsonism Relat Disord. 2023;109:105358.
Prezelin-Reydit M, Combe C, Fouque D, Frimat L, Jacquelinet C, Laville M, Massy ZA, Lange C, Ayav C, Pecoits-Filho R, Liabeuf S, Stengel B, Harambat J, Leffondre K, group C-Rs. Longitudinal uric acid has nonlinear association with kidney failure and mortality in chronic kidney disease. Sci Rep. 2023;13(1):3952.
Reboucas SCL, Cougnard-Gregoire A, Arnould L, Delyfer M-N, Schweitzer C, Korobelnik J-F, Foubert-Samier A, Cheung CY, Wong TY, Delcourt C, Helmer C. Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort. Alzheimers Dement (Amst). 2023;15(4):e12480.
Last News
Video presentation of the Macu-Life project
FocusLaunch of the ANR BIOMAC project on blood biomarkers for age-related macular degeneration
EventsPress Release: Air pollution and retinal neurodegeneration in residents of Bordeaux
PressNew Macu-Life Project: Evaluation of the relationship between our lifestyles and the development of AMD
News
February 3, 2023:
"Doing with" seminar - What effect on my posture as a public health researcher?
Events
PhD and startuper: Interview with Soufiane Ajana former PhD student in the BPH LEHA team
FocusSoufiane Ajana from our LEHA team has been selected by Microsoft to join a development programme
AwardsPrix ISEE Laure Gayraud Doctorante
AwardsClassification des aliments selon leur degré de transformation: NOVA n’est pas aussi robuste qu’il n’y parait !
PressExposition solaire professionnelle et santé de la peau et des yeux : le projet EXPOLUX
NewsMembers
AmariBouchra
PhD student in EpidemiologyBardinetJeanne
PhD student in EpidemiologyBonnefousLouis
Postdoctoral researcherChuyVirginie
Junior Assistant Professor, PhD in EpidemiologyCougnard-GrégoireAudrey
Ingénieur de Recherche, PhDDelcourtCécile
Directrice de Recherche Inserm - Directrice de l'équipeDelyferMarie-Noëlle
Professeur des Universités - Praticien HospitalierFaureLéa
Doctorante en ÉpidémiologieFeartCatherine
Chargée de recherche INSERMGattoussiSarra
GayraudLaure
PhD Student in EpidemiologyGontierBrigitte
OrthoptisteHarambatJérôme
MD PhDHelmerCatherine
Directrice de Recherche InsermHucteauEmilie
Ingénieure d'études - StatisticienneJacquemotAnne-Fleur
Doctorante en santé publiqueKayembe MulumbaBlondy
PhD Candidate in EpidemiologyKOROBELNIKJean-Francois
Professeur des Universités Praticien HospitalierLamireauThierry
LarsenPetra
MD, FEBOLe GallLisa
PhD student EpidemiologyLe GoffMelanie
Ingénieur d'études - StatisticienneLinardMorgane
Post-doc, MD PhDMerleBenedicte
Tenured Researcher (Chargée de Recherche INSERM - CRCN)MivielleSylvie
Assistante de Gestion Administrative et FinancièrePietrowskiMarie-Anne
PhD Student in EpidemiologyPrezelin-ReyditMathilde
Néphrologue --MD PhD studentReboucas-RondeauSara
PhD Student in EpidemiologySCHWEITZERCEDRIC
MD FEBO