ACTIVE

Aging, chronic diseases, technology, disability, and environment.

Details

Centre de recherche INSERM U1219
Université de Bordeaux – ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex

Tél : 05 57 57 15 96

Tél : 05 57 57 15 98

Contact

Marie-Hélène Sage

Pr. Hélène Amieva
PhD, ACTIVE Director

Hélène Amieva has a PhD in Neurosciences. After one year of post-doctoral fellowship at the Psychology Department of Aberdeen University (UK), she has been working in the CNRS as a permanent researcher for 9 years. She is currently Professor of Psychogerontology in Bordeaux University.

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Informations Publications

Objectives

Most of the researches conducted within the ACTIVE team aim at studying:

intrinsic capacities of individuals and environmental factors contributing to develop / maintain/ reduce functional capacity in the context of acute/chronic disease, disability, and/or old age; and
innovative strategies based on the optimization of such factors. The team is composed of epidemiologists, psychologists, cognitive scientists, geriatricians, physical therapists, neurologists and a psychiatrist.

Research area

The first research axis is coordinated by Karine Pérès.
It investigates to what extent intrinsic capacity and environments contribute to develop / maintain / reduce functional ability. Functional trajectories associated with aging process are studied through a continuum distinguishing robustness, pre-frailty, frailty, and activity limitation.
We examine their determinants through a multidimensional approach considering intrinsic capacities (cognition, depression, sensory impairments, personality traits…) and environmental factors (family support, social network, (un)adapted home, professional assistance, digital technologies) that may influence the sequence and speed of functional deterioration.
The heterogeneity of these trajectories is explored in several prospective population-based and clinical studies (PAQUID, AMI, 3C, CONSTANCES, COGLOC…).
More recently, taking advantage of the ongoing cohort studies, the PA-COVID survey, set up very shortly after the first COVID-19 lockdown in France, aims at providing valuable knowledge on older adults’ social and psychological experiences of the COVID-19 crisis and its impact on cognitive, mental and functional health.

The second research axis coordinated by Hélène Sauzéon focuses on innovative strategies based on the optimization of individuals’ intrinsic capacity and/or environments.
As an example of strategies based on optimized environments, the French Alzheimer village is an experimental accommodation facility for older adults with Alzheimer’s disease built like a traditional village.
The team is currently conducting an ambitious multidimensional research program evaluating whether this innovative model is relevant compared to traditional nursing homes (see below). Other researches involve interventions relying on digital technologies.
They generally address two main health issues: rehabilitation access and patient agentivity (i.e., active role of the patient).

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Research area

A research project is being conducted on patients with vascular aphasia to evaluate the benefits of tele-rehabilitation compared to a conventional face-to-face rehabilitation. Another research stresses the role of self-determination in cognitive rehabilitation by leveraging recent technological advances. The program includes a large panel of individuals of various ages and with various disability conditions. The goal is to study the impact of the technology properties of adaptability (self-configuration of objectives/ contents of the intervention by the care recipient) and/or adaptivity (self-configuration of intervention by machine learning algorithms) on rehabilitation results.

2024 Key publications

Boucaud-Maitre D, Letenneur L, Dartigues JF, Amieva H, Tabue-Teguo M. Letter to the Editor: The French Model of Senior Housing to Tackle Housing Inequalities. J Frailty Aging. 2024;13(1):73. https://doi.org/10.14283/jfa.2024.7

Boucaud-Maitre D, Villeneuve R, Rambhojan C, Simo-Tabue N, Thibault N, Rinaldo L, Dartigues J-F, Drame M, Amieva H, Tabue-Teguo M. Clinical Characteristics of Older Adults Living in Foster Families in the French West Indies: Baseline Screening of the KArukera Study of Aging in Foster Families (KASAF) Cohort. Innov Aging. 2024;8(7):igae063. https://doi.org/10.1093/geroni/igae063

Caillot-Ranjeva S, Bergua V, Meillon C, Amieva H. Impact of Cohabitation during Confinement on Older Adults’ Negative Affect: What Specificity of Life as a Couple? J Frailty Aging. 2024;13(1):64-70. https://doi.org/10.14283/jfa.2023.25

Dorey J-M, Pongan E, Padovan C, Chaillet A, Herrmann M, Krolak-Salmon P, Rouch I. Prodromal or mild Alzheimer’s disease: Influence of neuropsychiatric symptoms and premordid personality on caregivers’ burden. Int J Geriatr Psychiatry. 2024;39(6):e6114. https://doi.org/10.1002/gps.6114

Gbessemehlan A, Cambois E, Brouard N, Letenneur L, Amieva H, Peres K. Differences between subjective and disability health expectancies across ages in older adults. Sci Rep. 2024;14(1):14731. https://doi.org/10.1038/s41598-024-65416-3

Goncalves S, Mandigout S, Le Bourvellec M, Duclos NC. Comparison of motion sensor and heart rate monitor for assessment of physical activity intensity in stroke outpatient rehabilitation sessions: an observational study. J Rehabil Med. 2024;56:jrm40559. https://doi.org/10.2340/jrm.v56.40559

Hernandez-Ruiz V, Roubaud-Baudron C, Von Campe H, Retuerto N, Megraud F, Helmer C, Amieva H, Peres K. Association between Helicobacter pylori infection and incident risk of dementia: The AMI cohort. J Am Geriatr Soc. 2024;72(4):1191-8. https://doi.org/10.1111/jgs.18748

Husky MM, Pic O, Callahan S, Navarro-Mateu F. Twelve-month suicidal ideation, incidence and persistence among college students pre-pandemic and during the pandemic: A longitudinal study. Psychiatry Res. 2024;331:115669. https://doi.org/10.1016/j.psychres.2023.115669

Ruiz-Manriquez CA, Avila-Funes JA, Branas F, Crabtree-Ramirez B, Amieva H, Hernandez-Ruiz V. Association between a lower T-CD4+ /CD8+ lymphocyte ratio and cognitive impairment in older persons with HIV. Eur Geriatr Med. 2024. https://doi.org/10.1007/s41999-024-01079-7

Saulnier T, Fabbri M, Le Goff M, Helmer C, Pavy-Le Traon A, Meissner WG, Rascol O, Proust-Lima C*, Foubert-Samier A*. Patient-perceived progression in multiple system atrophy: natural history of quality of life. J Neurol Neurosurg Psychiatry. 2024;95(9):804-11. https://doi.org/10.1136/jnnp-2023-332733

* equal contribution

View all of the team’s publications in Oskar

Last News

Posted on : 18 Oct 2024

Seminars

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Posted on : 20 Apr 2022

Les têtes au football

Press

Une équipe de recherche française publie une série de données inédites sur une pratique pas si anodine pour la santé des joueurs. Le Docteur Hélène Cassoudesalle et le Professeur Patrick Dehail, deux médecins hospitalo-universitaires au CHU et à l’université de Bordeaux et membres de l’équipe Inserm ACTIVE du centre de recherche Bordeaux Population Health […]

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