Aging, chronic diseases, technology, disability, and environment.


Centre de recherche INSERM U1219
Université de Bordeaux – ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex

Tél : 05 57 57 15 96

Tél : 05 57 57 15 98


Marie-Hélène Sage

Hélène Amieva

Pr. Hélène Amieva
PhD, ACTIVE Director

Hélène Amieva has a PhD in Neurosciences. After one year of post-doctoral fellowship at the Psychology Department of Aberdeen University (UK), she has been working in the CNRS as a permanent researcher for 9 years. She is currently Professor of Psychogerontology in Bordeaux University.

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Most of the researches conducted within the ACTIVE team aim at studying:

  • intrinsic capacities of individuals and environmental factors contributing to develop / maintain/ reduce functional capacity in the context of acute/chronic disease, disability, and/or old age; and
  • innovative strategies based on the optimization of such factors. The team is composed of epidemiologists, psychologists, cognitive scientists, geriatricians, physical therapists, neurologists and a psychiatrist.

Research area

The first research axis is coordinated by Karine Pérès.
It investigates to what extent intrinsic capacity and environments contribute to develop / maintain / reduce functional ability. Functional trajectories associated with aging process are studied through a continuum distinguishing robustness, pre-frailty, frailty, and activity limitation.
We examine their determinants through a multidimensional approach considering intrinsic capacities (cognition, depression, sensory impairments, personality traits…) and environmental factors (family support, social network, (un)adapted home, professional assistance, digital technologies) that may influence the sequence and speed of functional deterioration.
The heterogeneity of these trajectories is explored in several prospective population-based and clinical studies (PAQUID, AMI, 3C, CONSTANCES, COGLOC…).
More recently, taking advantage of the ongoing cohort studies, the PA-COVID survey, set up very shortly after the first COVID-19 lockdown in France, aims at providing valuable knowledge on older adults’ social and psychological experiences of the COVID-19 crisis and its impact on cognitive, mental and functional health.

The second research axis coordinated by Hélène Sauzéon focuses on innovative strategies based on the optimization of individuals’ intrinsic capacity and/or environments.
As an example of strategies based on optimized environments, the French Alzheimer village is an experimental accommodation facility for older adults with Alzheimer’s disease built like a traditional village.
The team is currently conducting an ambitious multidimensional research program evaluating whether this innovative model is relevant compared to traditional nursing homes (see below). Other researches involve interventions relying on digital technologies.
They generally address two main health issues: rehabilitation access and patient agentivity (i.e., active role of the patient).

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Key publications 2023

Bergua V, Blanchard C, Amieva H. Depression in Older Adults: Do Current DSM Diagnostic Criteria Really Fit? Clin Gerontol. 2023:1-38.

Boucaud-Maitre D, Letenneur L, Drame M, Taube-Teguo N, Dartigues J-F, Amieva H, Tabue-Teguo M. Comparison of mortality and hospitalizations of older adults living in residential care facilities versus nursing homes or the community. A systematic review. Plos One. 2023;18(5):e0286527.

Dartigues JF, Avila-Funes JA, Letenneur L, Meillon C, Helmer C, Amieva H, Peres K. Ten Years after the National Alzheimer’s Plan: Dementia Remains a Hidden Syndrome in France. J Prev Alzheimers Dis. 2023;10(3):600-6.

Goncalves S, Le Bourvellec M, Mandigout S, Duclos NC. Impact of Active Physiotherapy on Physical Activity Level in Stroke Survivors: A Systematic Review and Meta-Analysis. Stroke. 2023;54(12):3097-106.

Husky MM, Leon C, du Roscoat E, Vasiliadis H-M. Prevalence of past-year major depressive episode among young adults between 2005 and 2021: Results from four national representative surveys in France. J Affect Disord. 2023;342:192-200.

Krier D, de Boer B, Hiligsmann M, Wittwer J, Amieva H. Evaluation of Dementia-Friendly Initiatives, Small-Scale Homelike Residential Care, and Dementia Village Models: A Scoping Review. J Am Med Dir Assoc. 2023;24(7):1020-7 e1.

Mazure CM, Husky MM, Pietrzak RH. Stress as a Risk Factor for Mental Disorders in a Gendered Environment. JAMA Psychiatry. 2023;80(11):1087-8.

Molina-Donoso M, Parrao T, Meillon C, Thumala D, Lillo P, Villagra R, Ibanez A, Cerda M, Zitko P, Amieva H, Slachevsky A. Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked? J Clin Exp Neuropsychol. 2023;45(3):313-20.

Proust-Lima C, Saulnier T, Philipps V, Traon AP-L, Peran P, Rascol O, Meissner WG, Foubert-Samier A. Describing complex disease progression using joint latent class models for multivariate longitudinal markers and clinical endpoints. Stat Med. 2023;42(22):3996-4014.

Rouch I, Strippoli M-PF, Dorey J-M, Ranjbar S, Laurent B, von Gunten A, Preisig M. Psychiatric disorders, personality traits, and childhood traumatic events predicting incidence and persistence of chronic pain: results from the CoLaus|PsyCoLaus study. Pain. 2023;164(9):2084-92.

View all of the team’s publications in Oskar

Last News

Posted on : 11 Jun 2024

laureate of the 2024 selection of the Institut Universitaire de France (IUF)

Hélène AMIEVA lauréate de la sélection 2024 de l’Institut universitaire de France IUF The BPH is proud to announce that Hélène AMIEVA, researcher and director of the ACTIVE team, is a laureate of the 2024 selection of the Institut Universitaire de France (IUF) in the category of fundamental chair, starting from October 1, 2024, for […]
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Posted on : 18 Dec 2023

ACTIVE Ph.D students in the spotlights

ACTIVE Ph.D students in the spotlights Thesis defenses in 2023: Marion PECH defended her PhD thesis in Psychology on March 17 (title: Detection of risky situations in daily life among frail elderly people using artificial intelligence methods: testing of a device in the general population) supervised by Helene Amieva & Jenny Benois-Pineau. Sophie ARHEIX-PARRAS defended […]
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Posted on : 25 Oct 2023

General Assembly of the ACTIVE team

General Assembly of the ACTIVE team The ACTIVE team held its General Assembly on October 23 and 24. On the program, discussion about achievements and prospects, and above all, the opportunity for the whole team to be together in a stimulating and friendly atmosphere.
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Posted on : 05 Oct 2023

The ACTIVE team celebrates the Village Landais Alzheimer Henri Emmanuelli annual festival

The ACTIVE team celebrates the Village Landais AlzheimerHenri Emmanuelli annual festival Since its opening in 2020, the ACTIVE team is conducting an evaluation of the Village Landais Henri Emmanuelli (Alzheimer Village), an innovative and experimental dementia friendly-facility, unique in France. The study involves a prospective follow up of the villagers, family caregivers and healthcare professionals […]
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Posted on : 10 Sep 2023

Linking the European Alzheimer Villages: The ACTIVE team meets the Italian Alzheimer Village

Linking the European Alzheimer Villages:The ACTIVE team meets the Italian Alzheimer Village Since its opening in 2020, the ACTIVE team is conducting an evaluation of the Village Landais Henri Emmanuelli (Alzheimer Village), an innovative and experimental dementia friendly-facility, unique in France. The study involves a prospective follow up of the villagers, family caregivers and healthcare […]
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Posted on : 10 Apr 2023

Invitation of Prof Sylvie Nadeau, physiotherapist at the Readaptation School of Montreal University

Invitation of Prof Sylvie Nadeau,physiotherapist at the Readaptation School of Montreal University Prof Sylvie Nadeau is full professor in physiotherapy teaching at the Readaptation School of Montreal University, and researcher at the Centre de Recherche Interdisciplinaire en Réadaptation (CRIR) and at the Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM). Prof Sylvie […]
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Posted on : 20 Apr 2022

Les têtes au football

Une équipe de recherche française publie une série de données inédites sur une pratique pas si anodine pour la santé des joueurs.   Le Docteur Hélène Cassoudesalle et le Professeur Patrick Dehail, deux médecins hospitalo-universitaires au CHU et à l’université de Bordeaux et membres de l’équipe Inserm ACTIVE du centre de recherche Bordeaux Population Health […]
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Doctorant en sciences cognitives et intelligence artificielle


Full Professor in Psychogerontology, Team leader

Arheix ParrasSophie

PhD Student - ATER




Maitre de conférences en Psychogérontologie



Doctorante en Psychologie de la Santé


MCU-PH en Médecine Physique et de Réadaptation


de SezeMathieu




Doctorante en Sciences Cognitives


Maître de conférences


Maitre de conférences en Sciences Cognitives


Psychologue clinicienne



Post-doctorant en épidémiologie




Assistante de recherche


Doctorant en Psychologie de la Santé

Hernandez RuizVirgilio

PhD candidate / Geriatrician


PhD student


PhD student in Clinical Psychology and Psychopathology


Maître de conférences en psychologie de la santé


Doctoral student


Adjointe Administratif



Chargé de Recherche INSERM


Maitre de conférences en Sciences Cognitives

Molina DonosoMatias

PhD Candidate




Maître de conférences


Post Doctorante en épidémiologie / oncogériatrie


Chargée de recherche




Ingénieur d'études Inserm - Psychologue Msc


Professeur de Psychologie de la santé




Médecin PH en santé publique

SAGEMarie Hélène

Assistante Administrative


Psychologue neuropsychologue, Doctorante en épidémiologie


Doctorante en Sciences Cognitives





Doctorante en Psychogérontologie


Doctorante en Epidémiologie


MCF associé -Chercheur associé

Tabue TeguoMaturin



Gestionnaire administrative et financière