
AHeaD
Assessing Health in a Digitalizing Real-World Setting Pharmacoepi & beyond
Pr. Antoine Pariente, MD, PhD, AHEAD Director
Dr. Gayo DIALLO, PhD, AHEAD Deputy Director

Details
Université de Bordeaux – ISPED case 11
146 rue Léo-Saignat
33076 BORDEAUX cedex
Objectives
We are interested in better understanding healthcare real-world setting and better assessing medicines in this observational environment.
In particular, we aim to investigate trajectories of care and their determinants, with a specific interest into emergency care use from one side, and trajectories of care for patients with chronic diseases relating to cardiovascular health or mental health from the other.
Research areas
In the past five years, we belonged to three different teams (“Pharmacoepidemiology – Pharmacoepi”; “Injuries – IETO”; “Informatics in Health – ERIAS”). The collaborations we developed ultimately concentrated most of our teams research efforts, typically around the secondary use of electronic databases for the study of health and medicines in a real-world setting,
Anticipating the research challenges that will emerge from the multiplication, diversification, and complexification of digital health data, we decided to join forces into the AHeaD team project.
This will combine our originating teams expertise in electronic health records databases (HERs), hospital datawarehouses, ontologies, data visualization, knowledge representation, and machine learning and natural language processing for health research, thus constituting a tremendous research opportunity.
Indeed, if the questions and needs for health assessment in real-world settings will remain, how to answer these questions will likely change dramatically. In the coming years, the use of electronic health databases, that developed tremendously over the past 30 years, will need to be complemented using information from other sources that will help strengthen and substantiate the real-world evidence provided. Building bridges between applied health research, already widely using EHRs, and informatics consequently appears as a requirement when envisioning the future development of health-assessment in real-world settings.
2021 Key Publications
Altman MC, Rinchai D, Baldwin N, Toufiq M, Whalen E, Garand M, Syed Ahamed Kabeer B, Alfaki M, Presnell SR, Khaenam P, Ayllon-Benitez A, Mougin F, Thebault P, Chiche L, Jourde-Chiche N, Phillips JT, Klintmalm G, O’Garra A, Berry M, Bloom C, Wilkinson RJ, Graham CM, Lipman M, Lertmemongkolchai G, Bedognetti D, Thiebaut R, Kheradmand F, Mejias A, Ramilo O, Palucka K, Pascual V, Banchereau J, Chaussabel D. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data. Nat Commun. 2021 Jul 19;12(1):4385. https://doi.org/10.1038/s41467-021-24584-w
Gil-Jardiné C, Chenais G, Pradeau C, Tentillier E, Revel P, Combes X, Galinski M, Tellier E, Lagarde E. Trends in reasons for emergency calls during the COVID-19 crisis in the department of Gironde, France using artificial neural network for natural language classification. Scand J Trauma Resusc Emerg Med. 2021 Mar 31;29(1):55. https://doi.org/10.1186/s13049-021-00862-w
Klann JG, Weber GM, Estiri H, Moal B, Avillach P, Hong C, Castro V, Maulhardt T, Tan ALM, Geva A, Beaulieu-Jones BK, Malovini A, South AM, Visweswaran S, Omenn GS, Ngiam KY, Mandl KD, Boeker M, Olson KL, Mowery DL, Morris M, Follett RW, Hanauer DA, Bellazzi R, Moore JH, Loh NW, Bell DS, Wagholikar KB, Chiovato L, Tibollo V, Rieg S, Li A, Jouhet V, Schriver E, Samayamuthu MJ, Xia Z, Hutch M, Luo Y, Consortium for Clinical Characterization of C-bEHR, Kohane IS, Brat GA, Murphy SN. Validation of an Internationally Derived Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data. J Am Med Inform Assoc. 2021 Feb 10;28(7):1411-20. https://doi.org/10.1093/jamia/ocab018
Letinier L, Jouganous J, Benkebil M, Bel-Letoile A, Goehrs C, Singier A, Rouby F, Lacroix C, Miremont G, Micallef J, Salvo F, Pariente A. Artificial intelligence for unstructured healthcare data: application to coding of patient reporting of adverse drug reactions. Clin Pharmacol Ther. 2021 Apr 18;110(2):392-400. https://doi.org/10.1002/cpt.2266
Osman I, Ben Yahia S, Diallo G. Ontology Integration: Approaches and Challenging Issues. Inform Fusion. 2021 Jul;71:38-63. https://doi.org/10.1016/j.inffus.2021.01.007
Ramiz L, Contrand B, Rojas Castro MY, Dupuy M, Lu L, Sztal-Kutas C, Lagarde E. A longitudinal study of mental health before and during COVID-19 lockdown in the French population. Global Health. 2021 Mar 22;17(1):29. https://doi.org/10.1186/s12992-021-00682-8
Chouchana L, Blet A, Al-Khalaf M, Kafil TS, Nair G, Robblee J, Drici M-D, Valnet-Rabier M-B, Micallef J, Salvo F, Treluyer J-M, Liu PP. Features of Inflammatory Heart Reactions Following mRNA COVID-19 Vaccination at a Global Level. Clin Pharmacol Ther. 2022 Mar;111(3):605-13. https://doi.org/10.1002/cpt.2499
Gil-Jardine C, Chenais G, Pradeau C, Tentillier E, Revel P, Combes X, Galinski M, Tellier E, Lagarde E. Surveillance of COVID-19 using a keyword search for symptoms in reports from emergency medical communication centers in Gironde, France: a 15 year retrospective cross-sectional study. Intern Emerg Med. 2022 Mar;17(2):603-8. https://doi.org/10.1007/s11739-021-02818-5
Linard M, Bezin J, Hucteau E, Joly P, Garrigue I, Dartigues J-F, Pariente A, Helmer C. Antiherpetic drugs: a potential way to prevent Alzheimer’s disease? Alzheimers Res Ther. 2022 Jan 7;14(1):3. https://doi.org/10.1186/s13195-021-00950-0
Tournier M, Pambrun E, Maumus-Robert S, Pariente A, Verdoux H. The risk of dementia in patients using psychotropic drugs: Antidepressants, mood stabilizers or antipsychotics. Acta Psychiatr Scand. 2022 Jan;145(1):56-66. https://doi.org/10.1111/acps.13380
Last News

Members
Al JobooriSamantha
AlloucheryMarion
AmourouxFrancoise
AUGERMuriel
AwukluKokou-Yvon
AzziRabia
Chercheur postdoctoralBaumevieilleMarie
MCU-HDRBénard-LaribièreAnne
PharmD - MSc, Drugs-SafeRBezinJulien
Maitre de Conférence des Universités - Praticien HospitalierBouchetStephane
BoudinMarina
PhD studentBouyerBenjamin
Researcher - Coordinator of the orthopedic pharmacoepidemiology axisCatoirePierre
ChenaisGabrielle
PhD graduate studentCombesXavier
ContrandBenjamin
Statisticien / Data ManagerCossinSebastien
Assistant Hospitalier UniversitaireCOSTEMarie-Odile
AssistanteDaoud PineauFrederic
DaveluyAmélie
de Germaysibylle
DegondeEmmanuel
DialloGayo
HDR- Professeur en Informatique - Directeur adjoint AHeaDDiopPapa Yatma
DranceMartin
dugaAlemayehu
DumartinCatherine
MCU-PH, PharmD PhDEvrardGregoire
GalinskiMichel
GigouVéronique
GoncalvesRuben
GriffierRomain
Médecin de Santé Publique, spécialisé en Informatique MédicaleGriotMarine
GuyonJoris
HucteauEmilie
Ingénieure d'études - StatisticienneJarne MunozAna
Ingénieur de rechercheJouhetVianney
LagardeEmmanuel
Directeur équipe IETOLerouge BailhacheMarion
LetinierLouis
MATHIEUClément
Postdoctoral researcherMattaRoula
Mbwe MpohMaurice
MiremontGhada
MolimardMathieu
PU PH Chef du Service de PharmacologieMouginFleur
NaprousAlexandre
NoizePernelle
PharmD, PhDOuedraogoIsmaila
DoctorantPambrunElodie
StatisticienneParienteAntoine
Directeur - Equipe AHeaD, Inserm U1219 BPHPellayHermine
Post Doctorante en épidémiologie / oncogériatriePerinoJustine
PerrierJulia
Doctorante en pharmaco-épidémiologiePradeauCatherine
QuilesC
RevelPhilippe
RoguesAnne-Marie
Professor MD, PhD, HDRRussonDylan
SaezTheo
SalmiRachid
MD, PhDSalvoFrancesco
Senior Researcher - Hospitali PractitionerSILVA Maria Laura
Maître de ConférencesSingierAllison
PhD StudentTellierÉric
MD, PhDThiao-LayelBruno
Doctorant en informatique et santéThiessardFrantz
Tortes St JammesJuiale
TouchaisHélène
TournierM