Sophie Lefevre-Arbogast

Postdoctoral Research Fellow in Epidemiology, Bordeaux Population Health Research Center, team ELEANOR, INSERM U1219, Univ Bordeaux

RESEARCH EXPERIENCE

Bordeaux Population Health Research Center (team ELEANOR), INSERM U1219, Univ Bordeaux, France & Research Institute for Environmental and Occupational Health (team 9), INSERM U1085, EHESP, Univ Rennes
- Since Apr 2022 : Postdoctoral Research Fellow
François Baclesse Cancer Center, ANTICIPE INSERM U1086, Caen, France
- Nov 2020 – Mar 2022 : Biostatistian
Rush University Medical Center, Rush Institute for Healthy Aging, Chicago, United States
- Mar 2020 – Oct 2020 : Postdoctoral Research Fellow
Bordeaux Population Health Research Center (team LEHA), INSERM U1219, Univ Bordeaux, France
- Nov 2019 – Feb 2020 : Postdoctoral Research Fellow
- Oct 2016 – Oct 2019 : PhD Fellow (Supervision: C. Samieri)
- Feb 2016 – Sept 2016 : MSc Training Course

Oct 2019 : Public Health – Epidemiology, PhD, University of Bordeaux, Bordeaux, France
Sept 2016 : Agri-Food Sciences, MSc (French Engineering Degree), Agrocampus Ouest, Rennes, France
Sept 2016 : Applied Statistics, MSc, University of Rennes 2 – Agrocampus Ouest, Rennes, Franc

My research in molecular epidemiology focuses on environmental exposures (e.g. diet and pollutants) and brain aging, with main interests in:

Lifestyle (mainly nutritionnal) risk and protective factors for cognitive decline and dementia
Statistical modeling of complex environmental exposures such as multi-nutrient patterns and multi-pollutants networks
Exploring the blood exposome (food metabolomics, chemical exposomics…) to identify biomarkers of exposure and biological responses related to brain aging
Integrating omics technologies to decipher the biological mechanisms linking environmental exposures to brain health and aging
Inter-individual variability in biological responses to dietary exposures, including genetic and microbiota influences

Samieri C*, Sonawane A*, Lefèvre-Arbogast S, …Grodstein F, Glass K. Using network science tools to identify novel diet patterns in prodromal dementia: The Three-City Study. Neurology, 2020;94(19):e2014-e2025. doi: 10.1212/WNL.0000000000009399.
Lefèvre-Arbogast S, Wagner M, Proust-Lima C, Samieri C. Nutrition and metabolic profiles in the natural history of dementia: recent insights from systems biology and life-course epidemiology. Current Nutrition Reports, 2019;8(3):256-269. doi: 10.1007/s13668-019-00285-1.
Low-Yanwen D*, Lefèvre-Arbogast S*, …Samieri C**, Manach C**. Diet-related metabolites associated with cognitive decline revealed by untargeted metabolomics in a prospective cohort. Mol Nutr Food Res, 2019;63(18):e1900177. doi: 10.1002/mnfr.201900177.
Lefèvre-Arbogast S, Gaudout D, Bensalem J, …Delcourt C, Samieri C. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology, 2018;90(22):1979-88. doi:10.1212/WNL.0000000000005607.
Amadieu C, Lefèvre-Arbogast S, Delcourt C, …Feart C, Samieri C. Nutrient biomarker patterns and long-term risk of dementia in older adults. Alzheimers Dement, 2017;13(10):1125-32. doi:10.1016/j.jalz.2017.01.025.
Lefèvre-Arbogast S, Féart C, Dartigues J-F, …Letenneur L, Samieri C. Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons. Nutrients, 2016;8(12):761. doi:10.3390/nu8120761.