Research director


Carole Dufouil, is research director at Inserm Center UMR1219, and co-director of the VINTAGE team (Vascular and Neurological diseases: INTegrative and GEnetic epidemiology).
She is also adjunct director for international partnerships of Bordeaux School of Public Health (ISPED). She has published over 142 articles in international journals (H-index 53) and is a member of the editorial board of Alzheimer’s and Dementia: translational research & clinical interventions. Her research focuses on the determinants of neurological diseases, particularly Alzheimer’s disease.
She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on determinants of brain health and has created the international MELODEM initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.
Dr. Dufouil is co-PI of the 3C-Dijon study and co-PI of the MEMENTO study, a national clinical cohort, which was set up in the context of the Alzheimer Plan 2008-2013 and aims at improving our understanding of the natural course of Alzheimer’s disease.


(From 142 papers; H-index: 44; 6164 citations)

  1. Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of Dementia over Three Decades in the Framingham Heart Study. N Engl J Med. 2016;374(6):523-32.
  2. Dufouil C, Beiser A, McClure LA, A. Wolf PA et al. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation (in press)
  3. Weuve J, Proust-Lima C, Power MC, Gross AL, Hofer SM, Thiébaut R, Chêne G, Glymour MM, Dufouil C for the MELODEM Initiative. Guidelines for reporting methodological challenges and evaluating potential bias in dementia research. MELODEM Initiative. Alzheimers Dement 2015;11(9):1098-109.
  4. Vivot A, Glymour MM, Tzourio C, Amouyel P, Chêne G, Dufouil C. Association of Alzheimer’s related genotypes with cognitive decline in multiple domains: results from the Three-City Dijon study. Mol Psychiatry 2015;20(10):1173-8.
  5. Dufouil C, Richert L, Thiébaut R, Bruyand M, Amieva H, Dauchy FA, Dartigues JF, Neau D, Morlat P, Dehail P, Dabis F, Bonnet F, Chêne G; ANRS CO3 Aquitaine Study Group. Diabetes and cognitive decline in a French cohort of patients infected with HIV-1. Neurology 2015; 85(12):1065-73.
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