Main degrees

  • 1996: MSc Public Health, Biostatistics concentration, Paris-Sud University
  • 1999: PhD Biostatistics, Paris-Sud University
  • 2014: HDR Public Health, University of Bordeaux

Main appointements

  • 1999-2003: Post-doc, McGill University, Dep. of Epidemiology and Biostatistics
  • 2003-2008: Assistant Professor, University of Montreal, Dep.of Social and Preventive Medicine
  • 2008-2020: Associate Professor (MCF Section CNU 26), University of Bordeaux, ISPED
  • 2020-: Professor (PR Section CNU 26), University of Bordeaux, ISPED


  • Graduate Program Director, MSc Public Health, Epidemiology concentration, since 2014
  • Teaching about 150 hours in class each year, MSc Public Health, main topics:
    • Linear and logistic regression
    • Survival analysis
    • Design and analysis of case-control studies

 Research interests

  • Statistical methods for the analysis of epidemiological data, in particular cohort and case-control data
  • Survival analysis, longitudinal analysis
  • Statistical modeling of protracted environmental and occupational exposures in etiologic cancer research
  • Statistical modeling of longitudinal biological markers and chronic kidney disease progression

Selected papers

  • Underlined names: students and research assistants under my supervision.
  • For full list of publications: please see my CV on ISPED website or Google Scholar (links below).


  • Leffondré K, Lellouch J, Com-Nougué C, Moreau T. Optimality of non-parametric tests for association between survival time and continuous covariate. Communications in Statistics – Theory and Methods, 2001; 30(5):913-29.
  • Leffondré K, Abrahamowicz M, Siemiatycki J, Rachet B. Modeling smoking history: A comparison of different approaches. American Journal of Epidemiology, 2002; 156(9):813-23.
  • Leffondré K, Abrahamowicz M, Siemiatycki Evaluation of Cox’s model and logistic regression for matched case-control data with time-dependent covariates: A simulation study. Statistics in Medicine, 2003; 22(24):3781-94.
  • Leffondré K, Abrahamowicz M, Regeasse A, Hawker GA, Badley EM, McCusker J, Belzile E. Statistical measures were proposed for identifying longitudinal patterns of change in quantitative health indicators. Journal of Clinical Epidemiology, 2004; 57(10):1049-62.
  • Leffondré K, Abrahamowicz M, Siemiatycki J, Xiao Y. Modeling smoking history using a comprehensive smoking index: Application to lung cancer. Statistics in Medicine, 2006; 25(24):4132-46.
  • Leffondré K, Wynant W, Cao Z, Abrahamowicz M, Heinze G, Siemiatycki J. A weighted Cox model for modelling time-dependent exposures in the analysis of case-control studies. Statistics in Medicine, 2010; 29(7-8):839-850.


  • Gauvin H, Lacourt A, Leffondré K. On the proportional hazards model for case-control analyses of environmental and occupational exposures. BMC Medical Research Methodology, 2013; 13:18.
  • Leffondré K, Touraine C, Helmer C, Joly P. Interval-censored time-to-event and competing risk with death: is the illness-death model more accurate than the Cox model? International Journal of Epidemiology, 2013; 42(4):1177-1186.
  • Boucquemont J, Heinze G, Jager KJ, Oberbauer R, Leffondré K. Regression methods for investigating risk factors of chronic kidney disease outcomes: the state of the art. BMC Nephrology, 2014; 15(1):45.
  • Leffondré K, Jager KJ, Boucquemont J, Stel VS, Heinze G. Representation of exposures in regression analysis and interpretation of regression coefficients: basic concepts and pitfalls. Nephrology Dialysis Transplantation, 2014; 29(10):1806-1814.
  • Boucquemont J, Metzger M, Combe C, Stengel B, Leffondré K for the NephroTest Study Group. Should we use standard survival models or the illness-death model for interval-censored data to investigate risk factors of chronic kidney disease progression? PLoS ONE 2014; 9(12):e114839.
  • Leffondré K, Boucquemont J, Tripepi G, Stel VS, Heinze G, Dunkler D. Analysis of risk factors associated with renal function trajectory over time: A comparison of different statistical approaches. Nephrology Dialysis Transplantation 2015; 30(8):1237-1243.


  • Boucquemont J, Loubère L, Metzger M, Combe C, Stengel B, Leffondré K, and the NephroTest Study Group. Identifying subgroups of renal function trajectories. Nephrology Dialysis Transplantation.2017; 32(suppl 2): ii185-ii193.
  • Kaboré R, Haller MC, Harambat J, Heinze G, Leffondré K. Risk prediction models for graft failure in kidney transplantation: A systematic review. Nephrology Dialysis Transplantation 2017; 32(suppl 2):ii68-ii76.
  • Kaboré R, Couchoud C, Macher MA, Salomon R, Ranchin B, Lahoche A, Roussey-Kesler G, Garaix F, Decramer S, Piètrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K (co-last author), Harambat J. Age dependent risk of graft failure in young kidney transplant recipients. Transplantation 2017; 101(6):1327-1335.
  • Lacourt A, Lévêque E (co-first author), Guichard E, Gilg Soit Ilg A, Sylvestre MP, Leffondré K. Dose-time response association between occupational asbestos exposure and pleural mesothelioma. Occupational and Environmental Medicine 2017; 74(9):691-697.
  • Lévêque E, Lacourt A, Luce D, Sylvestre MP, Guénel P, Stücker I, Leffondré K. Time-dependent effect of intensity of smoking and of occupational exposure to asbestos on the risk of lung cancer: results from the ICARE case–control study. Occupational and Environmental Medicine 2018; 75(8):586-592.
  • Prezelin-Reydit M, Combe C, Harambat J, Jacquelinet C, Merville P, Couzi L, Leffondré K for the CRISTAL investigators. Prolonged dialysis duration is associated with graft failure and mortality after kidney transplantation: results from the French transplant database. Nephrology Dialysis Transplantation 2019; 34(3):538-545.
  • Driollet B, Bayer F, Chatelet V, Macher MA, Salomon R, Ranchin B, Roussey G, Lahoche A, Garaix F, Decramer S, Mérieau E, Fila M, Zaloszyc A, Deschênes G, Valeri L, Launay L, Couchoud C, Leffondré K (co last-author), Harambat J. Social deprivation is associated with kidney transplantation outcome in children. Kidney International 2019; 96(3):769-776.
  • Lévêque E, Lacourt A, Phillipps V, Luce D, Guénel P, Stücker I, Proust-Lima C, Leffondré K. A new trajectory approach for investigating the association between an environmental or occupational exposure over lifetime and the risk of chronic disease: Application to smoking, asbestos, and lung cancer. PLoS ONE 2020; 15(8):e0236736.


  • Kaboré R, Ferrer L, Couchoud C, Hogan J, Cochat P, Dehoux L, Roussey-Kesler G, Novo R, Garaix F, Brochard K, Fila M, Parmentier C, Fournier MC, Macher MA, Harambat J, Leffondré K. Dynamic prediction models for graft failure in pediatric kidney transplantation. Nephrology Dialysis Transplantation 2021; 36(5):927-935.
  • Prezelin-Reydit M, Madden L, Macher MA, Salomon R, Sellier-Leclerc AL, Roussey G, Lahoche A, Garaix f, Decramer S, Ulinski T, Fila M, Dunand O, Merieau E, Pongas M, Zaloszyc A, Bérard Z, Couchoud C, Leffondré K (co-last author), Harambat J. Preemptive kidney transplantation is associated with transplantation outcomes in children: results from the French kidney replacement therapy registry. Transplantation 2021.
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