Associate Professor (Maître de Conférences)

Education (main degrees)

  • 1994: BSc equivalent in Statistics and Econometrics, Vannes Institute of Technology and Rennes 1 University

  • 1996: MSc in Public Health (Biostatistics stream), Paris-Sud University.

  • 1999: PhD in Biostatistics, Paris-Sud University // Inserm U1018 (Biostatistics team).

  • 2014: Habilitation (HDR, French degree of accreditation to supervise PhD students), University of Bordeaux.

Appointments (main affiliations)

  • 1999-2003: Post-doc, McGill University (Dep. of Epidemiology and Biostatistics) // Research Centre of the MUHC (Division of Clinical Epidemiology).

  • 2003-2008: Assistant Professor, University of Montreal (Dep.of Social and Preventive Medicine) // Research Centre of the CHUM (Risks to Health Axis).

  • 2008-present: Associate Professor (« Maître de conférences »), University of Bordeaux (Bordeaux School of Public Health, ISPED) // Inserm UMR 1219 (Biostatistics team).

Current awards and recognitions

  • 2013-2017: Scientific excellence award (« PES »), Bordeaux Segalen University (with external reviewers from mathematics sections).

  • 2015: Promotion to the rank of « Maître de conférences hors classe », French National Board of Universities (CNU), section 26 (Applied mathematics and applications of mathematics).

  • 2015: Qualification to apply for a full Professor position (“Qualification aux fonctions de professeur des universités”), CNU section 26.

  • 2017-2021: Award for doctoral research supervision (« PEDR »), CNU section 26

Service within University of Bordeaux

  • Co-chair, MSc in Public Health, Epidemiology Stream, Bordeaux School of Public Health (ISPED), since 2014.
  • Co-chair, International Relations Committee, Bordeaux School of Public Health (ISPED), since 2015.
  • Member, Training Program Committee, Bordeaux School of Public Health (ISPED), since 2014.
  • Member, Board of Governors, Bordeaux School of Public Health (ISPED), since 2014.
  • Member, Steering Committee, Bordeaux Clinical Investigation Center-Clinical Epidemiology (CIC 1401-EC), since 2015.


  • Teaching about 150 hours in class per year since 2008 in the ISPED MSc programme in Public Health.
  • Main current courses:
    • Linear and logistic regression (≈ 50h/year) in Master 1 Public Health and Master 2 Epidemiology
    • Survival analysis (≈ 45h/year) in Master 2 Epidemiology and Master 2 International Health
    • Design and analysis of case-control studies (≈ 15h/year) in Master 2 Epidemiology

 Research interests

  • Statistical methods for the analysis of epidemiological data, in particular cohort and case-control data
  • Survival analysis, competing risks, multi-state models, interval censoring
  • Statistical modeling of environmental and occupational exposures in etiologic cancer research
  • Statistical modeling of chronic kidney disease progression

Methodological papers in peer-reviewed journals

  1. Leffondré K, Lellouch J, Com-Nougué C, Moreau T. Optimality of non-parametric tests for association between survival time and continuous covariate. Communications in Statistics – Theory and Methods, 2001; 30(5):913-29.
  2. Leffondré K, Abrahamowicz M, Siemiatycki J, Rachet B. Modeling smoking history: A comparison of different approaches. American Journal of Epidemiology, 2002; 156(9):813-23.
  3. Leffondré K, Abrahamowicz M, Siemiatycki J. Evaluation of Cox’s model and logistic regression for matched case-control data with time-dependent covariates: A simulation study. Statistics in Medicine, 2003; 22(24):3781-94.
  4. Abrahamowicz M, du Berger R, Krewski D, Burnett R, Bartlett G, Tamblyn, R, Leffondré K. Bias due to aggregation of covariates in the Cox regression model. American Journal of Epidemiology, 2004; 160(7):696-706.
  5. Leffondré K, Abrahamowicz M, Regeasse A, Hawker GA, Badley EM, McCusker J, Belzile E. Statistical measures were proposed for identifying longitudinal patterns of change in quantitative health indicators. Journal of Clinical Epidemiology, 2004; 57(10):1049-62.
  6. Mahmud M, Abrahamowicz M, Leffondré K, Chaubey YP. Selecting the optimal transformation of a continuous covariate in Cox’s regression: Implications for hypothesis testing. Communications in Statistics – Simulation and Computation, 2006; 35(1):27-45.
  7. Leffondré K, Abrahamowicz M, Siemiatycki J, Xiao Y. Modeling smoking history using a comprehensive smoking index : Application to lung cancer. Statistics in Medicine, 2006; 25(24):4132-46.
  8. Benedetti A, Abrahamowicz M, Leffondré K, Goldberg MS, Tamblyn R. Using generalized additive models to detect and estimate threshold associations. The International Journal of Biostatistics, 2009; 5(1):article 26.
  9. Leffondré K, Wynant W, Cao Z, Abrahamowicz M, Heinze G, Siemiatycki J. A weighted Cox model for modelling time-dependent exposures in the analysis of case-control studies. Statistics in Medicine, 2010; 29(7-8):839-850.
  10. Gauvin H, Lacourt A, Leffondré K. On the proportional hazards model for case-control analyses of environmental and occupational exposures. BMC Medical Research Methodology, 2013; 13:18.
  11. Leffondré K, Touraine C, Helmer C, Joly P. Interval-censored time-to-event and competing risk with death: is the illness-death model more accurate than the Cox model? International Journal of Epidemiology, 2013; 42(4):1177-1186.
  12. Noordzij M, Leffondré K, van Stralen K, Zoccali C, Dekker FW, Jager KJ. When do we need competing risks models for survival analysis in nephrology? Nephrology Dialysis Transplantation, 2013; 28(11):2670-2677.
  13. Boucquemont J, Heinze G, Jager KJ, Oberbauer R, Leffondré K. Regression methods for investigating risk factors of chronic kidney disease outcomes: the state of the art. BMC Nephrology, 2014; 15(1):45.
  14. Wolbers M, Koller MT, Stel VS, Schaer B, Jager KJ, Leffondré K, Heinze G. Competing risks analyses: objectives and approaches. European Heart Journal, 2014; 35(42):2936-2941.
  15. Leffondré K, Jager KJ, Boucquemont J, Stel VS, Heinze G. Representation of exposures in regression analysis and interpretation of regression coefficients: basic concepts and pitfalls. Nephrology Dialysis Transplantation, 2014; 29(10):1806-1814.
  16. Dunkler D, Plischke M, Leffondré K, Heinze G. Augmented backward elimination: A pragmatic and purposeful way to develop statistical models. PLoS ONE 2014; 9(11):e113677.
  17. Boucquemont J, Metzger M, Combe C, Stengel B, Leffondre K for the NephroTest Study Group. Should we use standard survival models or the illness-death model for interval-censored data to investigate risk factors of chronic kidney disease progression? PLoS ONE 2014; 9(12):e114839.
  18. Kohl M, Plischke M, Leffondré K, Heinze G. PSHREG: A SAS macro for proportional and nonproportional subdistribution hazards regression. Computer Methods and Programs in Biomedicine 2015; 118(2):218-233.
  19. Leffondré K, Boucquemont J, Tripepi G, Stel VS, Heinze G, Dunkler D. Analysis of risk factors associated with renal function trajectory over time: A comparison of different statistical approaches. Nephrology Dialysis Transplantation 2015; 30(8):1237-1243.
  20. Heinze G, Wallisch C, Kainz A, Hronsky M, Leffondré K, Oberbauer R, Mayer G. Chances and challenges of using routine data collections for renal health care research. Nephrology Dialysis Transplantation 2015; 30(suppl 4): iv68-iv75.
  21. Karp I, Sylvestre MP, Abrahamowicz M, Leffondré K, Siemiatycki J. Bridging the etiologic and prognostic outlooks in individualized assessment of absolute risk of an illness: application to lung cancer. European Journal of Epidemiology 2016; 31(11):1091-1099.
  22. Kaboré R, Haller MC, Harambat J, Heinze G, Leffondré K. Risk prediction models for graft failure in kidney transplantation: A systematic review. Nephrology Dialysis Transplantation 2017; 32(suppl 2):ii68-ii76.
  23. Boucquemont J, Loubère L, Metzger M, Combe C, Stengel B, Leffondré K, and the NephroTest Study Group. Identifying subgroups of renal function trajectories. Nephrology Dialysis Transplantation.2017; 32(suppl 2): ii185-ii193.
  24. Gillaizeau F, Sénage T; Le Borgne F, Le Tourneau T, Roussel JC, Leffondre K, Porcher R, Giraudeau B, Dantan E, Foucher Y. Inverse Probability Weighting to control confounding in an illness-death model for interval-censored data. Statistics in Medicine 2017; doi:10.1002/sim.755

Substantive papers in peer-reviewed journals

  1. MacDougall LA, Gyorkos TW, Leffondré K, Abrahamowicz M, Tessier D, Ward BJ, MacLean JD. Increasing referral of at-risk travellers to travel health clinics: Evaluation of a health promotion intervention targeted to travel agents. Journal of Travel Medicine, 2001; 8(5):232-42.
  2. Abrahamowicz M, Schopflocher T, Leffondré K, du Berger R, Krewski D. Flexible modeling of the exposure-response relationship between long-term exposure to average levels of particulate air pollution and mortality in the American Cancer Society study. Journal of Toxicology and Environmental Health Part A, 2003; 66(16-19):1625-54
  3. Sewitch MJ, Leffondré K, Dobkin PL. Clustering patients according to health perceptions: Relationships to psychosocial characteristics and medication nonadherence. Journal of Psychosomatic Research, 2004; 56(3):323-32.
  4. Rachet B, Siemiatycki J, Abrahamowicz M, Leffondré K. A flexible modelling approach estimated the respective effects of different elements of smoking behaviour on lung cancer risk. Journal of Clinical Epidemiology, 2004; 57(10):1076-85.
  5. Vassiliou MC, Feldman LS, Andrew CG, Bergman S, Leffondré K, Stanbridge D, Fried GM. A global assessment tool for evaluation of intraoperative laparoscopic skills. American Journal of Surgery, 2005; 190(1):107-13.
  6. Fortes C, Mastroeni S, Leffondré K, Sampogna F, Melchi CF, Mazzoti E, Pasquini P, Abeni D, for the IDI Multipurpose Psoriasis Research on Vital Experiences (IMPROVE) Study Group. Relationship between smoking and the clinical severity of psoriasis. Archives of Dermatology, 2005; 141(12):1580-4.
  7. Vassiliou MC, Ghitulescu GA, Feldman LS, Stanbridge D, Leffondré K, Sigman HH, Fried GM. The MISTELS program to measure technical skill in laparoscopic surgery: Evidence for reliability. Surgical Endoscopy and Other Interventional Techniques, 2006; 20(5):744-7.
  8. Ehrmann Feldman D, Bernatsky S, Haggerty J, Leffondré K, Tousignant P, Roy Y, Xiao Y, Zummer M, Abrahamowicz M. Delay in consultation with specialists for persons with suspected new-onset rheumatoid arthritis: a population-based study. Arthritis and Rheumatism (Arthritis Care and Research), 2007; 57(8):1419-25.
  9. Ehrmann Feldman D, Bernatsky S, Abrahamowicz M, Roy Y, Xiao Y, Haggerty J, Leffondré K, Tousignant P, Duffy CM. Consultation with arthritis specialists for children with suspected juvenile rheumatoid arthritis: a population-based study. Archives of Pediatrics & Adolescent Medicine, 2008; 162(6):538-43.
  10. Ehrmann Feldman D, Xiao Y, Bernatsky S, Haggerty J, Leffondré K, Tousignant P, Roy Y, Abrahamowicz M. Consultation with cardiologists for persons with new-onset chronic heart failure: a population-based study. The Canadian Journal of Cardiology, 2009; 25(12):690-694.
  11. Bettaieb J, Toumi A, Leffondré K, Ben Alaya N, Boukthir A, Chlif S, Hajem S, Ben Salah A. Relation température-mortalité pour la ville de Tunis: 2005-2007. Archives de l’Institut Pasteur de Tunis, 2010; 87(1-2) :75-83.
  12. Queinec R, Beitz C, Contrand B, Jougla E, Leffondré K, Lagarde E, Encrenaz G. Copycat effect after celebrity suicides: results from the French national death register. Psychological Medicine 2011; 41(3):668-71.
  13. Lacourt A, Leffondré K, Gramond C, Ducamp S, Rolland P, Gilg Soit Ilg A, Houot M, Imbernon E, Févotte J, Goldberg M, Brochard P. Estimation of the effects of temporal patterns of occupational asbestos exposure on the risk of pleural mesothelioma: results from a French pooled case-control study. European Respiratory Journal, 2012; 39(6):1304-12.
  14. Encrenaz G, Contrand B, Leffondré K, Queinec R, Aouba A, Jougla E, Miras A, Lagarde E. The impact of the 98 football world cup on suicide rates in France: results from the national death registry. Suicide and Life-Threatening Behavior, 2012; 42(2):129-35.
  15. Blanc-Lapierre A, Bouvier G, Gruber A, Leffondre K, Lebailly P, Fabrigoule C, Baldi I. Cognitive disorders and occupational exposure to organophosphates: Results from the PHYTONER study. American Journal of Epidemiology, 2013; 177 (10):1086-109.
  16. Jacqmin-Gadda H, Alperovitch A, Montlahuc C, Commenges D, Leffondré K, Dufouil C, Elbaz A, Tzourio C, Ménard J, Dartigues JF, Joly P. 20-year prevalence projections for dementia and impact of preventive policy about risk factors. European Journal of Epidemiology, 2013; 28(6):493-502.
  17. Papadopoulos A, Guida F, Leffondré K, Cénée S, Cyr D, Schmaus A, Radoï L, Paget-Bailly S, Carton M, Menvielle G, Woronoff AS, Tretarre B, Luce D, Stücker I. Heavy smoking and lung cancer: are women at higher risk? Result of the ICARE study. British Journal of Cancer, 2014; 110(5):1385-1391.
  18. Coureau G, Bouvier G, Lebailly P, Fabro-Peray P, Gruber A, Leffondré K, Guillamo JS, Loiseau H, Mathoulin-Pélissier S, Salamon R, Baldi I. Mobile phone use and brain tumors in the CERENAT study. Occupational and Environmental Medicine 2014; 71(7):514-522.
  19. Vida S, Richardson L, Cardis E, Krewski D, McBride M, Parent ME, Abrahamowicz M, Leffondré K, Siemiatycki J. Brain tumors and cigarette smoking: analysis of the INTERPHONE Canada case-control study. Environmental Health 2014; 13(1):55.
  20. Bruyand M, Le Marec F, Lavole A, Leffondré K, Spano JP, Le Moing V, Tattevin P, March L, Cadranel J, Bonnet F, Guiguet M. Protease inhibitors exposure is not related to lung cancer risk in HIV smoker patients: a nested case-control study. AIDS 2015; 29(9):1105-1109.
  21. Pimouguet C, Le-Goff M, Rizzuto D, Berr C, Leffondré K, Pérès K, Dartigue JF, Helmer C. Effect of early recourse to specialist in dementia on institutionalization and functional decline: findings from a population-based study. Journal of Alzheimer’s Disease 2015; 49(3):819-828.
  22. Kaboré R, Couchoud C, Macher MA, Salomon R, Ranchin B, Lahoche A, Roussey-Kesler G, Garaix F, Decramer S, Piètrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K (co-last author), Harambat J. Age dependent risk of graft failure in young kidney transplant recipients. Transplantation 2017; 101(6):1327-1335.
  23. Lacourt A, Lévêque E, Guichard E, Gilg Soit Ilg A, Sylvestre MP, Leffondré K. Dose-time response association between occupational asbestos exposure and pleural mesothelioma. Occupational and Environmental Medicine 2017; 74(9):691-697.
  24. Frasca M, Soubeyran P, Bellera C, Rainfray M, Leffondré K, Mathoulin-Pellissier S. Alterations in Comprehensive Geriatric Assessment decreases survival of elderly patients with cancer. In Press in European Journal of Cancer.
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