GHiGS – Global Health in the Global South

Olivier MARCY, MD, PhD, GhiGS director
Renaud BECQUET, PhD, Research Director at Inserm, GhiGS deputy director

Objectives

The objectives of the GHiGS team are:
– to produce data on diseases affecting the global south, their epidemiology, risk factors and consequences;
– to use these findings to design and to evaluate innovative interventions at individual and population level, which are effective, but also equitable and sustainable, and contribute to the advancement of global health.

Per the definition of Koplan et al. (The Lancet 2009;373(9679):1993-5), global health is an area for study, research, and practice that places a priority on improving health and achieving equity in health for all people worldwide. Global health emphasizes transnational health issues, determinants, and solutions; involves many disciplines within and beyond the health sciences and promotes interdisciplinary collaboration; and is a synthesis of population-based prevention with individual-level clinical care.

Per the definition of the World Bank, the global south is made up of Africa, Latin America and the Caribbean, Pacific Islands, and the developing countries in Asia, including the Middle East.

Research areas

Scientific orientations of the research team
The GHiGS team aims to contribute to improving health at individual and population level in countries from the Global South and to contribute to reducing health inequities between countries, as well as within countries.
Low- and middle-income countries, and in particular in Sub-Saharan Africa, are going through major changes including epidemiologic, sociodemographic, economic, agronomic, technological, and climatic transitions. At the same time, they are carrying the triple burden of: (i) infectious diseases, including HIV, tuberculosis, malaria, hepatitis and a number of other emerging infectious disease threats (including hemorrhagic fevers and other epidemics); (ii) growingly prevalent non-communicable diseases (NCDs; diabetes, cancers, hypertension, obesity), and (iii) unprecedented outdoor pollutions and environmental threats. The GHiGS team aims to respond to these major transitions and new challenges through integrated, multi-level and inter-disciplinary research approaches in the context of the Global South.
Among the key highlights of the past five years, the GHiGS team contributed to a major revision in the international HIV treatment guidelines issued by the World Health Organization and was among the rare research teams worldwide having conducted a treatment trial to reduce mortality during the Ebola virus disease epidemic in West Africa.

In the coming years, the GHiGS team will strengthen and expand two key research themes, i.e. infectious diseases and mother and child health issues, to address new challenges in the field of diagnosis, care, and treatment and beyond. NCD research, previously addressed by the team in relation with infectious diseases (HPV and HBV related cancers, cardiovascular and metabolic HIV-comorbidities), will become a standalone research theme. Major challenges in implementing evidence-based interventions will be addressed within a cross-sectional and structural research axis on “Models of care, implementation and health systems”. Finally, beyond individual and health systems levels, the GHiGS team will explore the impact on health (NCDs, emerging epidemics,..) of global forces and environmental changes (climate change, bacterial ecosystem, resistance to antimicrobials, pollution…), as part of the “People in their environment” axis.
Research in the GHiGS team will be built on equal partnership and co-construction with scientific partners, clinicians, policy-makers from Global South countries. Through its expanded research program and strengthened and expanded collaborations and partnerships, the ambition of the GHiGS team is to contribute to the achievement of the Sustainable Development Goal #3 on Health and Well-Being.

Structuration of the research team
The GHiGS activities will be organized around 3 research themes (infectious diseases; maternal and child health; non-communicable diseases) which correspond to major global health challenges; and 3 cross-sectional axes (Prevention, diagnosis and treatment; models of care, implementation, and health systems; people in their environment) that will structure research efforts, collaborations, and development of methods and scientific engineering capacities.

 



Main publications

  1. Accrombessi M, Fievet N, Yovo E, Cottrell G, Agbota G, Massougbodji A, Cot M, Briand V. Prevalence and associated risk factors of malaria in the first trimester of pregnancy: a pre-conceptional cohort study in Benin. J Infect Dis. 2018 (in press).
  2. Iwuji C, Orne-Gliemann J, Larmarange J, et al. Universal Test and Treat and the HIV epidemic in rural South Africa; a community cluster randomized trial. Lancet HIV. 2018 Mar;5(3):e116-e125.
  3. Jaquet A, Tchounga B, Tanon A, Bagny A, Ekouevi DK, Traore HA, Sasco AJ, Maiga M, Dabis F. Etiology of hepatocellular carcinoma in West Africa, a case-control study. Int J Cancer. 2018 Mar 23. [ahead of print].
  4. Marcy O, Tejiokem M, Msellati P, Truong HK, Do CV, Tran ND, (…)  Blanche S, for the ANRS 12229 PAANTHER 01 Study Group. Mortality and its determinants in ART-naive HIV-infected children with a suspicion of tuberculosis, an observational cohort study. Lancet HIV. 2018;5(2):e87-e95.
  5. Arikawa S, Rollins N, Jourdain G, et al. Contribution of maternal ART and breastfeeding to 24-month survival in HIV-exposed uninfected children: an individual pooled analysis of African and Asian studies. Clin Infect Dis. doi: 10.1093/cid/cix1102
  6. Oyeledun B, Phillips A, Oronsaye F, Alo O, Shaffer N, Osibo B, (…)  Becquet R. The effect of a continuous quality improvement intervention on retention-in-care at 6 months postpartum of pregnant women and mothers in an HIV antiretroviral programme in Northern Nigeria: results of a cluster randomized controlled study. J Acquir Immune Defic Syndr. 2017;75 Suppl 2:S156-S164.
  7. Foster G, Orne-Gliemann J, Font H, et al. The impact of facility-based mother support groups on retention in care and PMTCT outcomes in rural Zimbabwe: the EPAZ cluster-randomised controlled trial. J Acquir Immune Defic Syndr. 2017; 75(Suppl 2): S207-15.
  8. Badje A, Moh R, Gabillard D, Guéhi C, Kabran M, Ntakpé JB, (…) Eholie SP, Anglaret X. Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial. Lancet Glob Health. 2017;5(11):e1080‑9
  9. Sissoko D, Duraffour S, Kerber R, Kolie JS, Beavogui AH, Camara AM, (…) Malvy D, Carroll M, Anglaret X, Gunther S. Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study. Lancet Glob Health. 2017;5(1):e80‑
  10. Marcy O, Ung V, Goyet S, et al. Performance of Xpert MTB/RIF and Alternative Specimen Collection Methods for the Diagnosis of Tuberculosis in HIV-Infected Children. Clin Infect Dis. 2016; 62(9): 1161-8.
  11. Orne-Gliemann J, Zuma T, Chikovore J, et al. Community perceptions of repeat HIV-testing: experiences of the ANRS 12249 Treatment as Prevention trial in rural South Africa. AIDS Care. 2016; 28 Suppl 3: 14-23.
  12. Sissoko D, Laouenan C, Folkesson E, M’Lebing A-B, Beavogui A-H, (…) Anglaret X, Malvy D. Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea. PLoS Med. 2016;13(3):e1001967
  13. Ouattara EN, Robine M, Eholie SP, et al. Laboratory Monitoring of Antiretroviral Therapy for HIV Infection: Cost-Effectiveness and Budget Impact of Current and Novel Strategies. Clin Infect Dis 2016; 62(11): 1454-62.
  14. Danel C, Moh R, Gabillard D, Badje A, Le Carrou J, Ouassa T, (…) Eholié SP, Anglaret X. A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa. N Engl J Med. 2015; 373(9): 808-22.
  15. Jaquet A, Odutola M, Ekouevi DK, Tanon A, Oga E, Akakpo J, (…) Dabis F; IeDEA West Africa Collaboration. Cancer and HIV infection in referral hospitals from four West African countries. Cancer Epidemiol. 2015 Dec;39(6):1060-5.
  16. Rollins NC, Becquet R, Orne-Gliemann J, et al. Defining and analyzing retention-in-care among pregnant and breastfeeding HIV-infected women: unpacking the data to interpret and improve PMTCT outcomes. J Acquir Immune Defic Syndr. 2014; 67 Suppl 2: S150-6.

Details

Centre de recherche INSERM U1219
Université de Bordeaux – ISPED Case 11
146 rue Léo-Saignat
33076 BORDEAUX cedex

Tel : +33 (0)5 57 57 15 80
Tel : +33 (0)5 57 57 92 40
Tel : +33 (0)5 57 57 95 69

  • Director:
    MD, MPH, Clinical epidemiologist

    UNIVERSITY EDUCATION

    2015 – now PhD candidate – Epidemiology, University of Bordeaux, France
    2011-2012 Master of Public Health – Clinical Epidemiology, ISPED, University of Bordeaux, France
    2000-2001 Master’s degree 1: Diploma in sanitary and social sciences, specialized in public health, Paris XI University, France
    1987-1999 Doctor of Medicine, specializing in general medicine, Pitié-Salpêtrière Faculty of Medicine, Paris, France

  • Co-director:
    Chargé de Recherche INSERM
    Responsable pédagogique du Master Santé Internationale

    Parcours

    2014       

    “Habilitation à diriger des recherches” in Public Health and Epidemiology 

    Institute of Public Health & Epidemiology, Bordeaux University , Bordeaux, France

    2002 – 2005           

    PhD in Public Health and Epidemiology

    Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

    Fellow of the French Ministry of Education, Research and Technology

    2001 – 2002

    Master of Public Health, Biostatistics and Epidemiology 

    Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

    2000 – 2001

    Post-graduate diploma in Public Health 

    Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

  • Contacts: Elodie Vernoux – Gwenaëlle Clouet – Elodie Rabourdin


Informations

Members


  • Mathias Altmann
    RIPOST project Coordinator

    Education

    2009 – 2011     Master of Science in Applied Epidemiology at Charité University, Berlin, Germany

    2009 – 2011     European Programme for Intervention Epidemiology Training (EPIET), ECDC, Stockholm, Sweden

    2007       Doctor Thesis in Pharmacy, option clinical biology at Marseille University, France

    2005 – 2006     Master International Public Health at ISPED, University Bordeaux, France

    2002 – 2007      Diploma in specialized study (D.E.S.): Microbiology, Parasitology, Immunology, Biochemistry and Hematology

    1997 – 2002          University Education in Pharmacy at Faculty of Pharmaceutical and Biological Sciences, Paris V, University René Descartes

     

  • Xavier Anglaret
  • Anani Badje
  • Emmanuelle Baillet
    Chargée de Communication – TB-Speed
  • Eric Balestre
    Statistician/data manager

    In the team IDLIC as biostatistician and data manager since 2004. I worked mainly for research on HIV infection within international multi-cohort collaborations as the Antiretroviral treatment in low income countries collaboration (ART-LINC) and the International Epidemiologic Databases to Evaluate AIDS in West Africa (IeDEA West Africa).

    I also worked for the randomized intervention trial Prenahtest (ANRS 12127, Prenatal HIV testing) and for the randomized trial TasP (ANRS 12249, treatment as prevention) in South Africa.

    Currently, I work for the project TB-Speed as data manager. The TB-Speed project will carry out research activities aiming at reducing childhood mortality from TB by evaluating innovative and cost-effective TB diagnostic approaches for resource-limited settings. Implemented over a period of four years in seven countries of Africa and Asia (Cambodia, Cameroon, Côte d’Ivoire, Mozambique, Sierra Leone, Uganda, and Zambia), the project will contribute to screening of a total of approximately 77,000 children.

    Main education:
    2009-2010: Master degree in Biostatistics, ISPED
    1997-1999: Master degree in Public Health and Epidemiology, ISPED

  • Renaud Becquet
    Chargé de Recherche INSERM
    Responsable pédagogique du Master Santé Internationale

    Parcours

    2014       

    “Habilitation à diriger des recherches” in Public Health and Epidemiology 

    Institute of Public Health & Epidemiology, Bordeaux University , Bordeaux, France

    2002 – 2005           

    PhD in Public Health and Epidemiology

    Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

    Fellow of the French Ministry of Education, Research and Technology

    2001 – 2002

    Master of Public Health, Biostatistics and Epidemiology 

    Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

    2000 – 2001

    Post-graduate diploma in Public Health 

    Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

  • Aurelie Beuscart
  • Valérie Briand
    M.D., PhD, HDR
    Chargée de Recherche (IRD)

    UNIVERSITY EDUCATION

    1993-2003       Doctor of Medicine, specialization in Public Health – University of Paris-XIII, France

    2003                 Master in Public Health and Epidemiology – University of Paris-XI, School of Public Health, France

    2008                 PhD in Epidemiology – University of Paris-VI, School of Public Health, France

    2009-2010      Post-doc position – University of Montreal, CHU Sainte-Justine Research Center, Canada

    2017                  HDR – University of Paris-V, School of Public Health, France

  • Gwenaelle Clouet
  • Christine Danel
  • Bruno Debono
  • Alexandre Duvignaud
    Chercheur doctorant / PhD candidate

    Médecin infectiologue / Infectious Diseases and Tropical Medicine physician

    Master Santé Publique, Epidémiologie, ISPED

  • Delphine Gabillard

    Statisticien

    (Equipe Mereva)

  • Valérie Journot
    Ingénieur de recherche

    Parcours

    J’ai obtenu le titre d’ingénieur agronome (ENSAIA, Nancy) en 1987, et celui de docteur-ingénieur en sciences agronomiques (INA-PG, Paris) en 1991. C’est là que je me suis spécialisée en statistiques. Je suis rapidement rentrée à l’INSERM et j’ai intégré en 1995 l’équipe bordelaise de recherche clinique sur le VIH. En 2016, j’ai rejoint l’équipe travaillant sur les maladies infectieuses dans les pays du Sud.

  • Sophie Karcher
  • Nicolas Koskas
    Communication Manager
  • Jérôme Le Carrou
  • Karen Malateste
  • Denis Malvy
    MD
    PhD
    Professor of infectious diseases
    Permanent senior researcher
  • Olivier Marcy
    MD, MPH, Clinical epidemiologist

    UNIVERSITY EDUCATION

    2015 – now PhD candidate – Epidemiology, University of Bordeaux, France
    2011-2012 Master of Public Health – Clinical Epidemiology, ISPED, University of Bordeaux, France
    2000-2001 Master’s degree 1: Diploma in sanitary and social sciences, specialized in public health, Paris XI University, France
    1987-1999 Doctor of Medicine, specializing in general medicine, Pitié-Salpêtrière Faculty of Medicine, Paris, France

  • Bessekon Serge NIANGORAN
    Doctorant en Biostatistique au BPH, 3ème année – Biostatisticien au Programme PACCI / CERMIPA, CHU de Treichville (Abidjan, Côte d’Ivoire)

    Depuis Septembre 2019 : Inscrit en doctorat de Biostatistique à l’Université de Bordeaux, centre Bordeaux Population Health (BPH) 

    2016-2017 : Master 2 de Santé Publique spécialité «Biostatistiques», Institut de Santé Publique, d’Epidémiologie et de Développement (ISPED), Université de Bordeaux, Bordeaux, France.

    2014-2015 : Master 2 de Recherche «Expertise en Population et Développement», Université Paris V – Réné Descartes, Paris, France.

    2008-2010 : Master 2 Professionnel en Démographie, Institut de Formation et de Recherche Démographique (IFORD), Yaoundé – Cameroun.

    2006-2007 : Maîtrise de Mathématique et informatique, Université de Cocody, Abidjan, Côte d’Ivoire.

    2005-2006 : Licence de Mathématique et informatique, Université de Cocody, Abidjan, Côte d’Ivoire.

    2002–2003 : Diplôme de Technicien de la Statistique, Ecole Nationale Supérieure de Statistique et d’Economie Appliquée (ENSEA), Abidjan, Côte d’Ivoire.

    2001-2002 : Baccalauréat série C (Mathématique et Physique), Lycée Classique d’Abidjan, Côte d’Ivoire.

  • Joanna Orne-Gliemann
    Chercheuse en santé publique, Responsable pédagogique Master 2 Santé Internationale

    EDUCATION

    2005. PhD Sociology – Public Health. Institut de Santé Publique, d’Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen, Bordeaux

    2001. Masters in Public Health – Research. Institut Santé Développement, Université Paris 6 – Pierre et Marie Curie, Paris

    2001. Masters in Public Health – Professional. ISPED, Université Bordeaux Segalen, Bordeaux

    1999. MSc Geography, Université Paris 4 – Sorbonne, Paris

  • Eric Nindougou Ouattara
  • Thierry Pistone
    MD
    PhD
    Senior infectious diseases specialist
  • Melanie Plazy
    Maitre de conférence en Epidémiologie – Santé publique internationale

    Parcours

    • Formation académique

      • 2011-2014 : Doctorat de Santé Publique – EpidémiologieEcole doctorale Sociétés, Politique et Santé Publique, Université de Bordeaux, France
      • 2009-2011 : Master Recherche de Santé Publique – Epidémiologie, option Epidémiologie d’InterventionISPED, Université Bordeaux Segalen, France
      • 2006-2009: Licence de Biologie, option Mathématique et Informatique du VivantUniversité Claude Bernard, Lyon, France
    • Formation complémentaire

      • 2014 : Diplôme Universitaire “Santé, Précarité”
        ISPED, Université de Bordeaux, France
      • 2011 : Université des Jeunes Chercheurs sur le VIH/Sida
        SIDACTION

     

  • Angéline Serre
    Global Project Manager
  • Pierre Touret
    Equipe Mereva/Credim
  • Elodie Vernoux
  • Aurelia Vessiere
    PhD
    Clinical Researcher / Project Manager
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