The centre

Presentation

Established in 2008, the Bordeaux Population Health (BPH) research center is co-hosted by the University of Bordeaux and the French National Institute of health and medical research (INSERM)

The BPH brings together over 500 staff members with a common goal: to explore and address major public health challenges and priorities with a multidisciplinary perspective and robust methodological approaches. The BPH comprises 10 research teams, as well as a scientific coordination across teams covering (i) brain health across the lifecourse, (ii) data science (AI, omics, longitudinal data, real world data in pharmacoepidemiology and beyond), (iii) infectious diseases and preparedness, (iv) aging and resilience, and (v) environmental and social determinants of health, with research objects ranging from observational studies to interventions.
The tight collaboration of biostatisticians, data scientists, and computer scientists with epidemiologists and clinicians allows the rapid development and timely application of cutting-edge methods for analysis of epidemiological data. An important methodological focus since inception has been prediction modelling, leveraging high-dimensional biological information and machine learning algorithms. The BPH hosts several clinical trial platforms dedicated to clinical research in France and internationally.
Population neuroscience and global health are longstanding key components of the BPH with an extensive track record and numerous collaborations with clinicians at Bordeaux University Hospital and with middle- and low-income countries (international associated laboratory with Abidjan) respectively. In recent years there has been an increasing focus on developing precision population health approaches, leveraging large-scale molecular resources derived from cutting-edge biotechnologies, combined with deep phenotyping using AI approaches. Lately, the research spectrum was also expanded towards prevention and population health interventions, research on the impact and mitigation of social disparities on health across the life-course, and on strategies to improve health services. The centre is involved in public health surveillance, through the secondary use of large administrative databases (e.g. electronic health records, DRUGS-SAFEr center activities) and the coordination of disease registries (cancer, infectious, and cardio-neurovascular diseases).

Over the past decades, BPH researchers have created and followed up several large and deeply characterized cohort studies spanning across the age and clinical spectrum, both in a population-based and clinic-based setting (e.g. Three-City [N~10,000], Paquid [N~3,700], i-Share [N>20,000], MEMENTO [N=2,300], B3 [N~2,000], HIV Aquitaine [N>10,000], IeDEA [N>54,000], Agrican [N>180,000]…), with associated biobanks from which an increasingly wide variety of genomic and multi-omic biomarkers are derived. BPH researchers also have a leadership role in various world-class international consortia and clinical trials.
The center has a close relationship with the University of Bordeaux public health teaching and training structure, the ISPED (Institute of Public Health and Development) that attracts ~1000 students per year. It also hosts graduate schools in digital public health (including a joint master degree with McGill University) and in African transitions, as well as various international summer schools, reflecting its strong involvement in research-based teaching. The BPH is strongly committed to contributing to the United Nations’ Sustainable Development Goals and to improving population health both locally and globally, embracing a comprehensive precision and global health approach targeting major health challenges, with a special focus on brain, vascular and infectious diseases, aging, and cancer. Several initiatives illustrate this, beyond the actual research being conducted, ranging from a privileged partnership with the Ban Ki-moon Center for Global Citizens to the active contribution to bottom-up initiatives, such as ACE climate-environment-action.

 

Governance and organisation chart

The Research center is directed by Professor Stéphanie DEBETTE.
She is assisted by Isabelle BELY serving as Secretary General and coordinator of the BPH administrative staff, and by the BPH .

Governance

  • Steering Committee
  • The Steering Committee meets on a biweekly basis to address urgent questions and prepare material for the Board of Directors
  • It is composed of six members with complementary expertise, all are also members of the Board of Directors: Stéphanie Debette, BPH director Carole Dufouil, PHARes team director (international relations) Hélène Jacqmin-Gadda, BIOSTAT team director (scientific coordination across teams) Olivier Marcy, GHiGS team director (liaison with administrative staff, global outreach) Antoine Pariente, AHEAD team director and director of the public health department (link with department of public health, regulatory questions) David-Alexandre Trégouët, ELEANOR team director (strategy of IT infrastructures)

 

  • Board of Directors
  • The Board of Directors is comprised of the directors and deputy directors of the 10 BPH teams. It meets on a monthly basis and discusses and approves (through a vote whenever needed) strategic decisions regarding funding, recruitments, promotions, scientific directions, governance, IT infrastructure, communication with host institutions, etc.

 

  • Lab Council
  • The Lab Council is composed of team directors, administrative service leaders, and elected staff representatives. Its members discuss and approve (through voting whenever needed) practical and strategic aspects related to the BPH

 

  • General Assembly
  • The General Assembly (GA) gathers all staff members once a year to provide updates and discuss and approval of practical and scientific aspects related to the BPH. The GA of the BPH meets jointly with the GAs of the ISPED and the Department of Public Health (staff largely shared)

    assembleegenerale

 

  • Scientific Advisory Board
  • Currently being appointed.

 

  • Administrative support
  • Secretary General: Isabelle Bely, in charge of coordinating the administrative staff (human resources, grant management, communication, library)
  • Thierry Voyemant, director of the CREDIM IT infrastructure, a University of Bordeaux Platform embedded in the Department of Public Health

Organization

Research teams

The Center is composed of 10 complementary research teams gathering basic and clinician scientists, healthcare professionals, technicians and engineers, post-doctoral fellows, PhD and undergraduate students who work together towards a common goal. ….More about our teams ( lien sur teams)

 

 

 

Scientific coordination across research teams

To foster interaction across teams, strengthen collaboration in the center’s domains of excellence and enhance our competitiveness in competitive grant applications we have established a scientific coordination across teams organized around 5 themes, which also reflect our main areas of expertise: -brain health across the life course, -data science (AI, omics, real world data, longitudinal data), -infectious diseases and preparedness, -aging and resilience, -environmental and social determinants of health.

 

 

 

Research ecosystem

The BPH is located in a dedicated building in the heart of the Carreire biomedical campus of the University of Bordeaux, immediately next to Bordeaux University Hospital.

Many clinicians (neurologists, psychiatrists, infectious disease specialists, oncologists, emergency medicine specialists, etc.) participate actively in BPH research projects or even lead some of the research teams. Within Bordeaux University Hospital, BPH researchers also lead the medical information department, a unit for innovation in prevention, and the occupational health unit for research organizations. Researchers of the BPH are also in charge of the Centre for Clinical Investigations (Clinical Epidemiology), the EUCLID F-CRIN platform for international trials, the USMR for clinical research at the University Hospital, the CMG-EC for HIV, hepatitis, and vaccine research, MEREVA for clinical research in low income countries. The BPH also has longstanding links with the Institut Bergonié, the regional cancer institute integrating cancer patient care and research, with the « SIRIC » (integrated research site) label from the national cancer institute (INCa).

Département de recherche santé publique Université de Bordeaux logo_ISPED logo_INRIA logo_HONcode