HEALTHY – Epidemiology, development and prevention of mental health problems using a life span perspective

Pr. Cédirc GALERA, MD, PhD, HEALTHY Director
Pr. Christophe TZOURIO, MD, PhD, HEALTHY Deputy Director

Objectives

The research focus of our team is to understand and prevent mental health problems in youths
We aim to:

(1) Investigate the risk and protective factors of Mental, Neurological and Substance use (MNS) problems in young people using a lifespan perspective

(2) Test the efficacy of strategies to prevent Mental, Neurological and Substance use problems and build resilience to stressors in youths / parents

 

 

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Research areas

In the past five years the team has provided relevant evidences on the early contribution of the social environment and biological factors on youth mental health (cognition, externalizing behaviors, internalizing problems, ADHD and risk for suicide). Team members have studied the modulation of biological factors by the social environment in relation to externalizing problems and ADHD and the relative contributions of genes and environment on the developmental course of the ADHD phenotype and suicide risk, from the peri-conceptional period to adolescence. Team members have also found that cytokine patterns in the cord blood is associated with childhood anxiety/depression symptoms. Regarding interventions aiming at improving mental health, cognitive development and social outcomes, the team has shown the benefits of early non-parental care and evidenced the moderate efficacy of a multicomponent early intervention program on behavior, cognition and health, in an Irish sample. Team members have developped eHealth tools to be used for MNS in youths, particularly in students. These findings provide key elements to inform public policies and to tailor our experimental interventions. Research of team members takes advantages of various cohorts including birth cohorts (ex: ELFE and ELDEQ) and young adult cohorts (iShare and CONFINS).
Our future research works will rely on 3 axes:

Axis 1 Mental health epidemiology in the youths: understanding the risk and protective factors underlying MNS problems (Cédric Galera)
The HEALTHY team is particularly interested in quantifying (1) the putatively protective role that psychosocial services plays on the prevention of MNS problems; (2) the impact of MNS problems on individual functioning including educational and professional achievement; and (3) the contribution biological and social mechanisms underlying specific mental health disorders and problems like ADHD, depression, suicidality, pathological low levels of self-esteem, etc.

Axis 2 Exploring social and behavioral features of mental health in the youths (Ilaria Montagni, Christophe Tzourio)
This axis will aim at describing and analyzing health behaviors/lifestyle, health representations, and health literacy of young people, relying on sociological and communication approaches (Humanities and Social Sciences) and mixed-methods studies.

Axis 3 Designing, testing and evaluating interventions preventing MNS problems and promoting mental health in the youths (Cédric Galera, Ilaria Montagni, Christophe Tzourio)
We will conduct (1) specific interventions focusing on a defined mental health problem or disorder (selective and indicated interventions); and (2) general-population interventions targeting health behaviors, e.g., health literacy, healthy lifestyles, life-skills training, psycho-education (universal interventions).



2021 Key Publications

Arsandaux J, Montagni I, Macalli M, Texier N, Pouriel M, Germain R, Mebarki A, Kinouani S, Tournier M, Schuck S, Tzourio C. Mental health condition of college students compared to non-students during COVID-19 lockdown: the CONFINS study. BMJ Open. 2021 Aug 19;11(8):e053231. https://doi.org/10.1136/bmjopen-2021-053231

Galera C, Barbosa S, Collet O, Khalfallah O, Aouizerate B, Sutter-Dalley AL, Koehl M, Capuron L, Van der Waerden J, Melchior M, Cote S, Heude B, Glaichenhaus N, Davidovic L, Group EM-CCS. Cord Serum Cytokines at Birth and Children’s Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother-Child Cohort. Biol Psychiatry. 2021 Mar 15;89(6):541-9. https://doi.org/10.1016/j.biopsych.2020.10.009

Macalli M, Navarro M, Orri M, Tournier M, Thiebaut R, Cote SM, Tzourio C. A machine learning approach for predicting suicidal thoughts and behaviours among college students. Sci Rep. 2021 Jun 15;11(1):11363. https://doi.org/10.1038/s41598-021-90728-z

Macalli M, Orri M, Tzourio C, Cote SM. Contributions of childhood peer victimization and/or maltreatment to young adult anxiety, depression, and suicidality: a cross-sectional study. BMC Psychiatry. 2021 Jul 14;21(1):354. https://doi.org/10.1186/s12888-021-03354-4

Macalli M, Texier N, Schuck S, Cote SM, Tzourio C. A repeated cross-sectional analysis assessing mental health conditions of adults as per student status during key periods of the COVID-19 epidemic in France. Sci Rep. 2021 Nov 9;11(1):21455. https://doi.org/10.1038/s41598-021-00471-8

Monnier M, Moulin F, Thierry X, Vandentorren S, Cote S, Barbosa S, Falissard B, Plancoulaine S, Charles MA, Simeon T, Geay B, Marchand L, Ancel PY, Melchior M, Rouquette A, group Ss, Galera C. Children’s mental and behavioral health, schooling, and socioeconomic characteristics during school closure in France due to COVID-19: the SAPRIS project. Sci Rep. 2021 Nov 17;11(1):22373. https://doi.org/10.1038/s41598-021-01676-7

Montagni I, Roussel N, Thiébaut R, Tzourio C. Health Care Students’ Knowledge of and Attitudes, Beliefs, and Practices Toward the French COVID-19 App: Cross-sectional Questionnaire Study. J Med Internet Res. 2021 Mar 3;23(3):e26399. https://doi.org/10.2196/26399

Moulin F, El-Aarbaoui T, Bustamante JJH, Heron M, Mary-Krause M, Rouquette A, Galera C, Melchior M. Risk and protective factors related to children’s symptoms of emotional difficulties and hyperactivity/inattention during the COVID-19-related lockdown in France: results from a community sample. Eur Child Adolesc Psychiatry. 2021 Mar 9:1-12. https://doi.org/10.1007/s00787-021-01752-3

Queroue M, Pouymayou A, Pereira E, Tzourio C, Gonzalez-Caballero JL, Montagni I. An interactive video increasing French students’ mental health literacy: a mixed-methods randomized controlled pilot study. Health Promot Int. 2021 Dec 13. https://doi.org/10.1093/heapro/daab202

Galera C, Cortese S, Orri M, Collet O, van der Waerden J, Melchior M, Boivin M, Tremblay RE, Cote SM. Medical conditions and Attention-Deficit/Hyperactivity Disorder symptoms from early childhood to adolescence. Mol Psychiatry. 2022 Feb;27(2):976-84. https://doi.org/10.1038/s41380-021-01357-x


Details

Centre de recherche INSERM U1219
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 16 59  

  • Director : Cédric Galéra
  • Co-director  : Christophe Tzourio
  • Contacts  : Nathalie Wattrelos


Informations

News

Members


  • Julie Arsandaux
    Docteur en épidémiologie

    2016-2019     Doctorat de santé publique spécialité Epidémiologie – équipe HEALTHY – Santé et réussite des jeunes du Centre de Recherche Inserm-université de Bordeaux U1219 Bordeaux Population Health, université de Bordeaux

    2012-2013     Master Sciences, Technologies, Santé, Mention Santé Publique – Spécialité Epidémiologie – ISPED, Université Bordeaux Segalen

    2009-2011     Licence Sciences, Technologies, Santé, Mention Biologie santé, spécialité Biologie Cellulaire et Physiologie – Université Bordeaux Segalen

  • Laura Castel
    Biostatisticienne
  • Francois Jean
    Doctorant

    2006 – 2012 Premier et Deuxième cycle des études médicales Faculté Hyacinthe Vincent UFR2, Université Bordeaux 2 Victor Ségalen

    2012 – 2017 Internat de Psychiatrie à Bordeaux

    2014 – 2016 Master 2 Recherche Biologie Santé Environnement, spécialité Cognition Naturelle et Artificielle, à l’École Pratique des Hautes Etudes (EPHE) à Paris, Responsable : Pr Thierry Dupressoir

    2017 – 2019 Clinicat de Psychiatrie de l’enfant et de l’adolescent à Bordeaux

    2019 Praticien hospitalier contractuel au CH de Calais

    2019 – 2021 Responsable de la filière adolescents et jeunes adultes dans le pôle de Psychiatrie du CH de Calais :

    2020 – / Praticien hospitalier au CH de Calais

    2020 – / Doctorant en santé publique épidémiologie, sous la direction du Pr Cédric Galéra, Association entre le TDAH et les substances illicites, Bordeaux Population Health, U1219, Université de Bordeaux – INSERM, équipe HEALTHY (Health, well being and achievement in the young )

    2021 – / Chef de service de la filière adolescents et jeunes adultes dans le pôle de Psychiatrie du CH de Calais

  • Shérazade Kinouani
    MD, PhD

    Médecin généraliste, docteure en épidémiologie

  • Melissa Macalli
    Post-doctorante en Santé Publique, spécialité Epidémiologie

    Infirmière de formation, Mélissa a travaillé dans différentes structures de soins avant d’intégrer l’ONG Médecins sans frontières comme coordinatrice projet. Après une thèse en santé publique, épidémiologie en 2021, elle poursuit ses travaux en post-doctorat au sein de l’équipe Healthy. Ses recherches portent sur la santé mentale des étudiants à partir de données de cohorte (i-Share, CONFINS) et plus particulièrement sur les facteurs de risque de la dépression et des conduites suicidaires.  

  • Elena Milesi
    Responsable communication étude i-Share

    Parcours

    Après avoir été assistante de communication interne pour la Direction du Développement du Système d’Information d’Orange France Télécom, j’ai occupé le poste de chargée de communication projets européens de coopération transfrontalière à l’Université de Perpignan Via Domitia pendant près de 3 ans. J’ai intégré l’équipe i-Share en avril 2013. Ma mission principale : coordonner la communication de l’étude i-Share.

  • Ilaria Montagni
    Researcher-Lecturer BPH-ISPED

    Academic background

    I graduated in Communication Theories at the University of Florence, Italy. I received a European doctorate in Psychological and Psychiatric Sciences from the University of Verona (Italy) and the INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris, France. My research projects are in the area of communication, internet, and new technologies concerning mental health. I am particularly interested in young adults’ use of the web for mental health information and advice seeking, and on mental health polices for students. 

  • Marie Mougin
    Chef de projets opérationnels

    Diplômée en psychologie clinique santé à l’université de Bordeaux, j’ai travaillé pour l’équipe INSERM U897 sur des études-actions relatives à la prévention du suicide ainsi que pour le CEID (Comité d’Étude et d’Information sur la Drogue) sur un projet concernant la problématique des alcoolisations massives des jeunes bordelais. J’ai rejoint l’équipe en avril 2013 pour coordonner les étudiants relais de l’étude i-Share et gérer différents projets opérationnels.

  • Marie Navarro
    Postdoctoral Fellow

    My work focuses on the prediction of mental health problems (suicide, depression, anxiety…) among adolescents and young adults. My research utilizes machine learning approaches and national and international population-based cohorts (QLSCD, QLSKC, i-Share) to predict mental health problem.

    I have a bachelor degree in biology from the University of Pau and Pays de l’Adour (UPPA) and a master in biostatistics from the Bordeaux School of Public Health (ISPED), in France. I completed a PhD, in Public Health, Biostatistics in the Healthy Team of the Bordeaux Population Health research center, in France. I am currently a post-doctoral fellow and I work on the EpiCov project, which studied the impact of Covid-19 health crisis on adolescents’ mental health.

     

    • 2022 – : Postdoctoral fellow
      • “Covid-19 health crisis and social inequalities in mental health in children and adolescents in France: Research using data from the EPICOV project”
    • 2018 – 2022:  PhD, Public Health, Biostatistics
      • “Machine learning prediction of suicidal behaviors in adolescents and young adults “, under the supervision of Pr. Sylvana Côté and Dr. Massimiliano Orri
    • 2014-2017: Master Public Health – Biostatistics (magna cum laude), Bordeaux School of Public Health (ISPED), University of Bordeaux.
    • 2011-2017: Bachelor degree in Biology (cum laude), University of Pau and Pays de l’Adour (UPPA)
  • Massimiliano Orri
    Marie-Curie postdoctoral fellow

    My research aims to identify developmental risk factors for suicidal behaviours across the lifespan in population-based cohorts. It relies on different approaches, such as psychiatric epidemiology, developmental psychopathology, and behavioural genetics.

    I received my training in psychology at the University of Padova, Italy, where I completed a Bachelor’s degree in Psychology and Master degree in Clinical Psychology. I the persuaded my training in France, completing a PhD in Psychology and Cognitive Science at the University of Paris Descartes as well as a Master’ s degree in public health methodology and biostatistics at the University Paris Sud. I am currently a Marie-Curie postdoctoral fellow at the McGill Group for Suicide Studies and Research Unit on Children Psychosocial Maladjustment (McGill University, Canada) and Bordeaux Population Health Research Centre (Inserm, U1219, University of Bordeaux, France).

  • Garance Perret
    Ingénieure statisticienne
  • Reda Salamon
    Maître de conférences en sciences de l’éducation

    2021                Habilitation à diriger des recherches. Université de Bordeaux

    2014-présent   Maître de Conférences en Sciences de l’Education au Collège Santé, Centre de recherche INSERM U1219, Equipe : Santé et réussite des jeunes – HEALTHY, UMR 1219,  INSERM

     

    2013-2014      Chargé de TD à l’Université Bordeaux 4 (ESPE d’Aquitaine)

     

    2013                Obtention de la qualification aux fonctions de maître de conférences :

                            Psychologie, psychologie clinique, psychologie sociale (CNU section 16)

                            Sciences de l’éducation (CNU section 70)

     

    2008-2014    Professeur des écoles, (Ecole Jean Cocteau)

                            Chargé de TD à l’Université Bordeaux 2

                            Chercheur affilié au CNRS UMR 5231 (actuellement 5287)

     

    2008               Docteur en psychologie

                            Titre de la thèse : « La vie quotidienne des enfants en difficulté scolaire ». Soutenue le 27/06/2008, Mention très honorable

                             Laboratoire de psychologie Santé et Qualité de vie, Université de Bordeaux 2 / CNRS UMR 5231

     

    2003-2008       Doctorant en Psychologie 

    2003-2008      Professeur des écoles (à mi-temps), Ecole David Johnston

    2002                 Professeur des écoles, titulaire, Ecole de Saint Magne de Castillon          

    2001                 Professeur des écoles, stagiaire, I.U.F.M. de Bordeaux-Caudéran

    2000                 DEA de Sciences Cognitives (Mention AB), Université Bordeaux 2

  • Ashlyn Schwartz
    Doctoral Candidate

    I am a PhD candidate of Public Health Sciences at the University of Tennessee, Knoxville currently on a Fulbright Fellowship in Bordeaux, France. My research utilizes mixed-methodological approaches in addressing youth and perinatal health challenges related to substance use. Since 2017, I have continued my research on developmental outcomes related to childhood trauma and neonatal abstinence syndrome.

  • Christophe Tzourio
    Directeur

    Parcours

    Christophe Tzourio est neurologue et épidémiologiste. Il a été Interne des Hôpitaux de Paris et Chef de Clinique en neurologie à l’Hôpital Lariboisière. Il a rejoint l’INSERM en 1994 comme Chargé de Recherche et a été promu Directeur de Recherche en 2000. En 2005, il est devenu directeur d’une nouvelle unité de recherche INSERM U708, à l’hôpital de la Pitié-Salpêtrière à Paris. En 2001, il a été nommé professeur d’épidémiologie à l’Université de Bordeaux et praticien hospitalier au CHU de Bordeaux. En Septembre 2013, il est devenu directeur du Bordeaux Population Health (BPH), Inserm U1219, à l’Université de Bordeaux.

  • Nathalie Wattrelos
    Gestionnaire administrative et financière
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