HEALTHY

Epidemiology, development and prevention of mental health problems using a life span perspective

Details

Centre de recherche INSERM U1219
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex

Tél : 05 57 57 16 59

Cédric Galera

Pr. Cédric Galera
MD, PhD, HEALTHY Director

Cédric Galera is child psychiatrist and epidemiologist. He was resident in child psychiatry at the University of Bordeaux between 2000 and 2004.

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Dr. Melissa Macalli
PhD, HEALTHY Deputy Director

Melissa Macalli is an epidemiologist and research scientist in public health, focusing on suicidal behaviors among young adults and university students

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Objectives

The research focus of our team is to understand and prevent mental health problems in youths.
We aim to:

  • Investigate the risk and protective factors of Mental, Neurological and Substance use (MNS) problems in young people using a lifespan perspective
  • Test the efficacy of strategies to prevent Mental, Neurological and Substance use problems and build resilience to stressors in youths / parents

Research areas

In the past five years the team has provided relevant evidences on the early contribution of the social environment and biological factors on youth mental health (cognition, externalizing behaviors, internalizing problems, ADHD and risk for suicide).

Team members have studied the modulation of biological factors by the social environment in relation to externalizing problems and ADHD and the relative contributions of genes and environment on the developmental course of the ADHD phenotype and suicide risk, from the peri-conceptional period to adolescence. Team members have also found that cytokine patterns in the cord blood is associated with childhood anxiety/depression symptoms.

Regarding interventions aiming at improving mental health, cognitive development and social outcomes, the team has shown the benefits of early non-parental care and evidenced the moderate efficacy of a multicomponent early intervention program on behavior, cognition and health, in an Irish sample. Team members have developped eHealth tools to be used for MNS in youths, particularly in students. These findings provide key elements to inform public policies and to tailor our experimental interventions.

Research of team members takes advantages of various cohorts including birth cohorts (ex: ELFE and ELDEQ) and young adult cohorts (iShare and CONFINS).

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2025 Key Publications

Baggio T, Grecucci A, Crivello F, Joliot M, Tzourio C. Resting state connectivity patterns associated with trait anxiety in adolescence. Sci Rep. 2025;15(1):9711. https://doi.org/10.1038/s41598-025-94790-9

Bailhache M, El-Khoury F, Leproux O, Chazelas E, Gomajee R, Van Der Waerden J, Galera C, Charles MA, Melchior M. Psychological intimate partner violence, child witnessing of parental arguments, and emotional-behavioral outcomes in five-years old: The French ELFE cohort. Child Abuse Negl. 2025;160:107185. https://doi.org/10.1016/j.chiabu.2024.107185

Coelho J, Montagni I, Micoulaud-Franchi J-A, Taillard J, Philip P, Plancoulaine S, Tzourio C. The associations of screen time and physical activity with sleep health during the COVID-19 crisis. Sleep Epidemiol. 2025;5:100119. https://doi.org/10.1016/j.sleepe.2025.100119

Galera C, Navarro MC, Galesne C, Retuerto N, Bentivegna F, Flouri E. Neighborhood green space and psychological distress: a longitudinal study of socioeconomic disparities in mental health outcomes. Environ Int. 2025;204:109799. https://doi.org/10.1016/j.envint.2025.109799

Jean FAM, Montagni I, Schwartz AN, Navarro MC, Galesne C, Macalli M, Cherruaud L, Lerouge-Bailhache M, Cote SM, Tzourio C, Galera C. Illicit substance use and attention deficit hyperactivity disorder symptoms among French university students: a multiple correspondence analysis and a cluster analysis. Eur Arch Psychiatry Clin Neurosci. 2025. https://doi.org/10.1007/s00406-025-02092-y

Kinouani S, Da Cruz H, Simon M, Abraham M, Perret G, Langlois E, Tzourio C. The transition from cigarette smoking to the exclusive or partial use of e-cigarettes: A multi-stage mixed methods study among French university students. Addict Behav. 2025;161:108205. https://doi.org/10.1016/j.addbeh.2024.108205

Kinouani S, Roux F, Questel B, Abraham M, Tzourio C. Reasons for using electronic cigarettes among young adults aged 18 – 30: a systematic review. Excli J. 2025;24:204-37. https://doi.org/10.17179/excli2024-8085

Labrosse D, Vie C, Harb M, Montagni I. Escape Game to Promote Students’ Mental Health Outcomes in the Aftermaths of COVID-19 Pandemic: Protocol for a Mixed Methods Study Evaluating a Cocreated Intervention. JMIR Res Protoc. 2025;14:e64068. https://doi.org/10.2196/64068

Macalli M, Castel L, Jacqmin-Gadda H, Galesne C, Tournier M, Galera C, Pereira E, Tzourio C. Depressive symptoms and suicidal ideation among university students before and after the COVID-19 pandemic. J Affect Disord. 2025;369:149-54. https://doi.org/10.1016/j.jad.2024.09.093

Schwartz A, Galera C, Arsandaux J, Montagni I, Tzourio C. Adverse Childhood Experiences and Illegal Drug Use Among College Students: Findings from a French Sample. Int J Behav Med. 2025;32(2):258-66. https://doi.org/10.1007/s12529-023-10256-0

Last News

Posted on : 20 Jan 2026

PRESS RELEASE : ADHD symptoms may be associated with risky sexual behaviour among students

Press
The study on young people’s health carried out by our BPH HEALTHY team was the subject of a national press release by Inserm, which was widely reported in the media.   This large-scale study conducted by Cédric Galéra and his team among approximately 13,000 students in France examined the link between attention, impulsivity and sexuality. […]
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Posted on : 19 Jan 2026

A look back at Cédric Galéra's conference at the Collège de France

Focus
As part of the Collège de France’s annual public health chair, Cédric Galéra gave a talk at the seminar ‘Attention deficit disorder with or without hyperactivity: between neurodevelopment and neurodiversity’. This was an opportunity to discuss this disorder, which is at the heart of medical and societal issues               […]
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Posted on : 15 Jan 2026

Green spaces and mental health – a study conducted by Cédric Galera

Major publication
A team of European researchers and members of the BPH, led by Cédric Galera, studied the impact of the presence and accessibility of green spaces on mental health. This study provides findings that could inform public prevention policies, particularly those aimed at the most disadvantaged populations who are more exposed to these difficulties     […]
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Posted on : 08 Dec 2025

PUBLIC HEALTH SEMINAR : MELISSA MACALLI 16/01/2026

Evènement
The next public health seminar will focus on   Understanding, detecting and preventing suicidal behaviour among students         The speaker is Mélissa MACALLI, epidemiologist and Inserm research fellow in public health and epidemiology. She conducts research on mental health of young adults as part of the Healthy team (Epidemiology, development and prevention […]
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Posted on : 09 Oct 2024

Mélissa Macalli, a BPH young researcher awarded the L'Oréal-UNESCO 2024 Young Talent Prize

Awards & nominations
The L’Oréal Foundation and UNESCO have announced the winners of the prestigious 2024 L’Oréal-UNESCO For Women in Science France Young Talents prizes which rewards young scientific researchers every year. One of the 35 winners is Mélissa Macalli, currently post-doctoral researcher in the BPH’s HEALTHY team, who has already had a great career particulary in her […]
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Posted on : 04 Apr 2024

Study on the mental health of students, 4 years after the lockdown. Effects still struggling to subside
- Press Review

Press
Study on the Mental Health of Students,4 Years After the Lockdown.Effects Still Struggling to Subside Press Review Four years have now passed since the initial lockdowns in response to the Covid-19 pandemic. These policies have had a considerable impact across all layers of the population, with effects that are still struggling to diminish. The HEALTHY […]
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photo classe enfant et professeur
Posted on : 28 Mar 2024

Cocreation and evaluation of an intervention promoting teachers’ mental health literacy: the TEACH-MHE project

Nouveau projet
  Although rarely studied, children’s mental health is a major public health issue. Teachers play a key role in preventing and promoting students’ mental well-being, but often lack the necessary tools. The TEACH-MHE project aims to develop a scale for measuring mental health literacy and to create an online course for future teachers, to better […]
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Posted on : 18 Dec 2023

COMMUNIQUE DE PRESSE :
Une nouvelle étude éclaircit le lien entre les symptômes de TDAH pendant l’enfance et plusieurs comorbidités médicales non psychiatriques

Press
Le TDAH (ADHD en anglais) se manifeste par des niveaux élevés d’inattention et/ou d’agitation et d’impulsivité. © Adobe Stock Une nouvelle étude éclaircit le lien entre les symptômes de TDAHpendant l’enfance et plusieurs comorbidités médicales non psychiatriques Le trouble du déficit de l’attention avec ou sans hyperactivité (TDAH) touche de nombreux enfants et s’accompagne souvent […]
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