A study based on rich data from the CKD-REIN cohort identified five typical haemoglobin trajectory profiles in patients with moderate to severe chronic kidney disease. It emerged that two-thirds of the population studied belonged to a profile with a stable haemoglobin trajectory over time and one-third belonged to a profile with a declining haemoglobin trajectory. These profiles were associated with distinct risks of clinical events

 

 

 

 

 

 

 

 

 

Chronic kidney disease (CKD) is a disease characterised by progressive loss of kidney function. The disease is widespread throughout the world, and its epidemiological incidence is rising rapidly.

Anemia, defined in CKD, as in the general population, as a haemoglobin level below 12g/dl in women and 13g/dl in men, is a frequent metabolic complication of CKD. A large number of epidemiological studies have reported an association between anemia and an increase in morbidity and mortality, particularly cardiovascular, and a reduction in quality of life. Despite an abundance of literature on the subject, there is no description of haemoglobin trajectories over time in this population.

 

 

 

 

This work was made possible by data from the CKD-REIN cohort for ‘Chronic Kidney Disease- Renal Epidemiology and Information Network Cohort’, coordinated by the University of Paris-Saclay and promoted by Inserm, in collaboration with 13 academic partners, and funded by the Cohortes-Investissements d’Avenir Programme, the PHRC and a public-private partnership. This French multicentre cohort included and followed subjects with moderate to severe CKD for 5 years. A large amount of clinical and biological data was collected during follow-up, enabling repeated measurements of biomarkers such as haemoglobin to be studied.

The original study on the description of haemoglobin trajectories over time carried out by researchers from the LEHA and BIOSTAT teams at the BPH revealed 5 typical and distinct haemoglobin trajectory profiles in subjects with moderate to severe CKD.

 

 

 

 

 

 

 

 

 

 

It appeared that two-thirds of the population belonged to a profile with a stable trajectory over time and one-third to a profile with a declining trajectory.
The stable trajectory profile was associated with a low risk of cardiovascular events, kidney disease or mortality, while the declining trajectory profiles were associated with an increase in these risks.

This work highlights the importance of considering repeated haemoglobin measurements rather than a unique value.

 

 

 

 

 

 

https://doi.org/10.1093/ndt/gfad235