In the Southwest of the United States people more likely to die of stroke. African Americans living in the South have a greater risk than any other race/ethnic/geographic population. Diet, socioeconomic status, and the built environment are among the most commonly provided exposures contributing to these disparities. This talk will discuss what is currently known about the role of diet and socioeconomic status as a mediator of racial disparities in stroke risk in the United States. It will also discuss the design and outcomes from the REasons for Geographic and Racial Différences in Stroke (REGARDS) study.