ELEANOR – Molecular epidemiology of vascular and brain disorders

Dr. David-Alexandre TREGOUET, ELEANOR Director
Pr. Stéphanie DEBETTE, ELEANOR Deputy Director

Objectives

The purpose of our research is to identify groups of individuals who are at high risk of developing three common and tightly linked neurological and vascular conditions, dementia, stroke and venous thrombosis, to discover novel etiological factors and therapeutic targets, and to propose more personalized preventive strategies through improved risk stratification.

 

Research areas

Our research program relies on major components: (i) large-scale epidemiological and clinical cohorts coupled with biosamples; (ii) the deployment of cutting-edge high-throughput technologies for deep molecular phenotyping; (iii) the application of advanced statistical methodologies; (iv) a group of experts in molecular-clinical epidemiology and (v) a widespread network of collaborators that enables us to contribute to the functional characterization of the identified biomarkers.
Our project is focusing on three inter-related clinical outcomes, cognitive impairment / dementia, stroke, and thrombosis and is organized around 4 themes:

Molecular epidemiology of vascular brain aging, (PI: Stéphanie Debette)
Using collaborative genome-wide association study meta-analyses and next generation sequencing data we are studying the genetic underpinnings of stroke and MRI-markers of covert cerebral small vessel disease (SVD). We have a growing interest in cross-ancestry studies, as these are crucial to enhance genomic discovery and make results more representative. Through the ERC SEGWAY we are taking a lifespan approach to explore early determinants of brain aging and the impact of genes predisposing to stroke, dementia and SVD on brain microstructure in young adults (i-Share cohort). In the RHU SHIVA project (national investment for the future funding), following up on efforts that we initiated in the EU-JPND BRIDGET program, we are now expanding our explorations to other omics approaches (epigenomics, transcriptomics, proteomics and metabolomics), focusing in particular on deciphering the molecular underpinnings of covert SVD and its contribution to stroke and dementia. Finally, we are engaged in leveraging these molecular epidemiology studies to accelerate drug discovery and improve risk prediction/stratification for targeted prevention. Our group is also involved in European therapeutic guideline coordination.

Exposome of brain aging and dementia (PI: Cécilia Samieri)
The network and dynamics of environmental factors leading to age-related brain diseases has yet to be elucidated, in order to identify the most impactful targets for prevention. This exposome research axis leverages molecular epidemiology, brain imaging and advanced statistical approaches deployed to population-based cohorts with biobanks in order to investigate: (1) the exposome of brain health at key ages, and (2) the underlying pathways and life-course dynamics. The general aims are to: refine assessment of already-known exposures (eg, diet biomarkers); explore novel exposures (eg, chemical mixtures); investigate beyond individual exposures (eg, microbiome interactions); and eventually model the global exposome network, to improve etiological modeling of age-related brain diseases. We will capitalize on existing data (e.g. the 3C cohort) and target younger populations, building a new population-based cohort of 2000 participants aged 55-80 years from the community living in Bordeaux metropole, the B cube (Biobank and Brain Health in Bordeaux) study.

Precision Medicine for better prophylaxis & better knowledge in venous thrombosis (PI: David-Alexandre Trégouët)
After spending several years to identify common genetic factors for venous thrombosis (VT) in the general population, we are now embarking into a more integrative analysis of various molecular determinants (genes; epigenetic marks, proteins,…) on specific subgroups of individuals at higher risk of VT including women under oral contraceptives, patients with a previous history of VT and patients with viral infections.
In parallel, building on our recent successes, we will continue our genetic investigations of rare forms of unexplained inherited VT through the application of whole exome/genome sequencing in familial cases.

Integrative approach for vascular and brain disorders (all PIs)
The deep characterization and understanding of the biology of a complex disease requires to integrate results/data from others diseases as they very often share common risk factors and pathophysiological mechanisms. By capitalizing on the existence of complementary and synergistic expertise and bioresources brought by ELEANOR’s PIs in different but interrelated diseases, we are implementing an integrative research strategy to optimize the identification and the characterization of molecular determinants associated with some of the most common age-related diseases.



2021 Key Publications

Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdes Hernandez MC, van der Grond J, Wright MJ, Knol MJ, Dorr M, Thomson RJ, Bordes C, Le Grand Q, Duperron MG, Smith AV, Knopman DS, Schreiner PJ, Evans DA, Rotter JI, Beiser AS, Maniega SM, Beekman M, Trollor J, Stott DJ, Vernooij MW, Wittfeld K, Niessen WJ, Soumare A, Boerwinkle E, Sidney S, Turner ST, Davies G, Thalamuthu A, Volker U, van Buchem MA, Bryan RN, Dupuis J, Bastin ME, Ames D, Teumer A, Amouyel P, Kwok JB, Bulow R, Deary IJ, Schofield PR, Brodaty H, Jiang J, Tabara Y, Setoh K, Miyamoto S, Yoshida K, Nagata M, Kamatani Y, Matsuda F, Psaty BM, Bennett DA, De Jager PL, Mosley TH, Sachdev PS, Schmidt R, Warren HR, Evangelou E, Tregouet DA, International Network against Thrombosis C, International Headache Genomics C, Ikram MA, Wen W, DeCarli C, Srikanth VK, Jukema JW, Slagboom EP, Kardia SLR, Okada Y, Mazoyer B, Wardlaw JM, Nyquist PA, Mather KA, Grabe HJ, Schmidt H, Van Duijn CM, Gudnason V, Longstreth WT, Jr., Launer LJ, Lathrop M, Seshadri S, Tzourio C, Adams HH, Matthews PM, Fornage M, Debette S. Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun. 2020 Dec 8;11(1):6285. https://doi.org/10.1038/s41467-020-19111-2

Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook-Kanamori DO, Deleuze JF, Johnson A, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet DA, Morange PE. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. Blood. 2021 Apr 29;137(17):2394-402. https://doi.org/10.1182/blood.2020008997

Harris WS, Tintle NL, Imamura F, Qian F, Korat AVA, Marklund M, Djousse L, Bassett JK, Carmichael P-H, Chen Y-Y, Hirakawa Y, Kupers LK, Laguzzi F, Lankinen M, Murphy RA, Samieri C, Senn MK, Shi P, Virtanen JK, Brouwer IA, Chien K-L, Eiriksdottir G, Forouhi NG, Geleijnse JM, Giles GG, Gudnason V, Helmer C, Hodge A, Jackson R, Khaw K-T, Laakso M, Lai H, Laurin D, Leander K, Lindsay J, Micha R, Mursu J, Ninomiya T, Post W, Psaty BM, Riserus U, Robinson JG, Shadyab AH, Snetselaar L, Sala-Vila A, Sun Y, Steffen LM, Tsai MY, Wareham NJ, Wood AC, Wu JHY, Hu F, Sun Q, Siscovick DS, Lemaitre RN, Mozaffarian D. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nat Commun. 2021 Apr 22;12(1):2329. https://doi.org/10.1038/s41467-021-22370-2

Le Grand Q, Satizabal CL, Sargurupremraj M, Mishra A, Soumare A, Laurent A, Crivello F, Tsuchida A, Shin J, Macalli M, Singh B, Beiser AS, DeCarli C, Fletcher E, Paus T, Lathrop M, Adams HHH, Bis JC, Seshadri S, Tzourio C, Mazoyer B, Debette S. Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Oct 23. https://doi.org/10.1016/j.bpsc.2021.10.011

Lefevre-Arbogast S, Hejblum BP, Helmer C, Klose C, Manach C, Low DY, Urpi-Sarda M, Andres-Lacueva C, Gonzalez-Dominguez R, Aigner L, Altendorfer B, Lucassen PJ, Ruigrok SR, De Lucia C, Du Preez A, Proust-Lima C, Thuret S, Korosi A, Samieri C. Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study. EBioMedicine. 2021 Feb;64:103216. https://doi.org/10.1016/j.ebiom.2021.103216
Morange PE, Peiretti F, Gourhant L, Proust C, Soukarieh O, Pulcrano-Nicolas AS, Saripella GV, Stefanucci L, Lacroix R, Ibrahim-Kosta M, Lemarie CA, Frontini M, Alessi MC, Tregouet DA, Couturaud F. A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant. PLoS Genet. 2021 Jan 19;17(1):e1009284. https://doi.org/10.1371/journal.pgen.1009284

Razzaq M, Iglesias MJ, Ibrahim-Kosta M, Goumidi L, Soukarieh O, Proust C, Roux M, Suchon P, Boland A, Daiain D, Olaso R, Havervall S, Thalin C, Butler L, Deleuze JF, Odeberg J, Morange PE, Tregouet DA. An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism. Sci Rep. 2021 Jul 7;11(1):14015. https://doi.org/10.1038/s41598-021-93390-7

Samieri C, Yassine HN, Melo van Lent D, Lefevre-Arbogast S, van de Rest O, Bowman GL, Scarmeas N. Personalized nutrition for dementia prevention. Alzheimers Dement. 2021 Nov 10. https://doi.org/10.1002/alz.12486

Thomas A, Crivello F, Mazoyer B, Debette S, Tzourio C, Samieri C. Fish Intake and MRI Burden of Cerebrovascular Disease in Older Adults. Neurology. 2021 Nov 30;97(22):e2213-e22. https://doi.org/10.1212/WNL.0000000000012916

Bordes C, Sargurupremraj M, Mishra A, Debette S. Genetics of common cerebral small vessel disease. Nat Rev Neurol. 2022 Feb;18(2):84-101. https://doi.org/10.1038/s41582-021-00592-8

Mishra A, Duplaa C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhao NR, Li S, Bartz TM, Jian X, Zhao W, Hofer E, Wittfeld K, Harris SE, van der Auwera-Palitschka S, Luciano M, Bis JC, Adams HHH, Satizabal CL, Gottesman RF, Gampawar PG, Bulow R, Weiss S, Yu M, Bastin ME, Lopez OL, Vernooij MW, Beiser AS, Volker U, Kacprowski T, Soumare A, Smith JA, Knopman DS, Morris Z, Zhu Y, Rotter JI, Dufouil C, Valdes Hernandez M, Munoz Maniega S, Lathrop M, Boerwinkle E, Schmidt R, Ihara M, Mazoyer B, Yang Q, Joutel A, Tournier-Lasserve E, Launer LJ, Deary IJ, Mosley TH, Amouyel P, DeCarli CS, Psaty BM, Tzourio C, Kardia SLR, Grabe HJ, Teumer A, van Duijn CM, Schmidt H, Wardlaw JM, Ikram MA, Fornage M, Gudnason V, Seshadri S, Matthews PM, Longstreth WT, Couffinhal T, Debette S. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain. 2022 May 2. https://doi.org/10.1093/brain/awab432


Details

Centre de recherche INSERM U1219
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 16 59

  • Director :
  • Co-director  :
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Contact : Christophe Abrantes


Informations

Members


  • Christophe Abrantes
    Responsable Administratif et Financier
  • Marlène Barus
    Bioinformatics engineer
  • Constance Bordes
    PhD student in epidemiology

    Constance Bordes obtained a master’s degree in Public Health/Epidemiology from the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux (2019). Constance joined ELEANOR team during her master’s internship, where she explored the mechanisms of early MRI-markers of cerebral Small Vessel Disease. Between 2019 and 2021, Constance worked in Pr. Debette team as an epidemiologist. Her research interests are focus on exploring the very early mechanisms of structural brain changes leading to cognitive decline or dementia as well as the mechanisms underlying the association between Small Vessel Disease and cognitive decline/dementia. 

    She is currently a PhD student in epidemiology under the supervision of Pr. Debette with the purpose of exploring the lifetime impact of cerebral small vessel disease on cognitive decline and dementia, by using genomics as a tool.

     

  • Vincent Bouteloup
  • Ilana Caro
    PhD student in epidemiolgy

    Ilana Caro obtained a Master’s degree in Genetic, Genomic and System Biology (GGBS) in 2021 in Nantes. She has been awarded a PhD grant from the Digital Public Health graduate program, to work with Prof. Stéphanie Debette in the VINTAGE team on “Deciphering the molecular signature of covert cerebral small vessel disease (cSVD) with a focus on transcriptomic and proteomic biomarkers”.

  • Stephanie Debette
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Coralie Delgado
  • Marie-Gabrielle Duperron
    MD, PhD student

    Marie-Gabrielle is a Public Health resident in Bordeaux. She is following the MD-PhD program “Ecole de l’Inserm Liliane Bettencourt” (Paris), that allowed her early research training. She did her master 1 directed by Pr Bloch, working on the anatomy of dopamine receptors in rats (Unit “Mouvement – Adaptation – Cognition”, Bordeaux). She obtained a master 2 in Neurosciences (“Ecole pratique des hautes études”, Sorbonne, Paris) where she studied anatomical correlation of neuropsychological tests in a cohort of healthy elderly subjects (3C-cohort) with Voxel Based Morphometry, directed by G. Catheline.

    She is currently a master 2 student in Epidemiology at the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux. She is focusing on MRI markers of cerebral small vessel disease and their shared genetic variants, under the supervision of Stéphanie Debette.

  • Blandine Gendre
  • Morgane Lachaize Gaboreau
    Clinical Project Manager

    Education:

    2011-2012: Study coordinator degree (DIU FARC)

    2009 – 2011: MSc degree on Neurosciences et Neuropsychopharmacology 

    2006-2009: Bachelor degree on Biology

    Positions:

    Jul 2011 – Apr 2012: Clinical Research Technicien in Hepatogastroenterlogy department (Bordeaux Hospital)

    May 2012 – Mar 2017: Study Coordinator in Neurology department (Bordeaux Hospital) on parkinsonian syndromes, amyotrophic lateral sclerosis, neuromuscular disease

    Since Jan 2017: Project Manager in the ELEANOR team of the clinical and regulatory part of the Prof Stephanie Debette’s projects (SHIVA University-Hospital Research, PRESTIGE-AF…)

     

  • Quentin Le Grand
    PhD Student in Epidemiology
  • Sophie Lefevre-Arbogast
    Postdoctoral Research Fellow in Epidemiology, Bordeaux Population Health Research Center, team ELEANOR, INSERM U1219, Univ Bordeaux

    RESEARCH EXPERIENCE

     

    • Bordeaux Population Health Research Center (team ELEANOR),  INSERM U1219, Univ Bordeaux, France  & Research Institute for Environmental and Occupational Health (team 9), INSERM U1085, EHESP, Univ Rennes
      • Since Apr 2022 : Postdoctoral Research Fellow
    • François Baclesse Cancer Center, ANTICIPE INSERM U1086, Caen, France
      • Nov 2020 – Mar 2022 : Biostatistian
    • Rush University Medical Center, Rush Institute for Healthy Aging, Chicago, United States
      • Mar 2020 – Oct 2020 : Postdoctoral Research Fellow
    • Bordeaux Population Health Research Center (team LEHA),  INSERM U1219, Univ Bordeaux, France
      • Nov 2019 – Feb 2020 : Postdoctoral Research Fellow
      • Oct 2016 – Oct 2019 : PhD Fellow (Supervision: C. Samieri)
      • Feb 2016 – Sept 2016 : MSc Training Course

    EDUCATION

    • Oct 2019 : Public Health – Epidemiology, PhD, University of Bordeaux, Bordeaux, France
    • Sept 2016 : Agri-Food Sciences, MSc (French Engineering Degree), Agrocampus Ouest, Rennes, France
    • Sept 2016 : Applied Statistics, MSc, University of Rennes 2 – Agrocampus Ouest, Rennes, Franc

     

  • Caroline Meguerditchian
  • Aniket Mishra
    Tenured Researcher in Statistical Genetics
    Serial Number  Degree University Year
    1. Bachelor of Engineering in Biotechnology Shivaji University, Kolhapur, India 2004-08
    2. Master of Science in Analytical Genomics University of Birmingham, Birmingham, United Kingdom 2009-10 
    3. PhD in Statistical Genetics University of Queensland, Brisbane, Australia  2011-15 
  • Gaelle Munsch
  • Carole Proust
    Assistant Ingénieur

    Carole Proust is Engineer inserm since 2004. Carole is a biologist working with David-Alexandre Trégouët to characterize the role of rare DNA variants in thrombotic disorders using various experimental functional analyses. Carole was recruited at INSERM in 2004 to reorganize, perpetuate and establish new cardiovascular DNA biobanks (up to ~50 000 samples) as part of the previous INSERM U525/U937 department directed by Dr François Cambien in Paris. She was then in charge of several high-throughput genotyping and transcriptomics projects to search for new susceptibility genes for cardiovascular diseases. By 2014, as part of the Team Genomics of Cardiovascular Diseases headed by David Trégouët at INSERM U1166 in Paris, she gained experience in more experimental biology to functionally characterize the role of genetic variations on thrombotic processes. In 2018, she followed David Trégouët and move to Bordeaux, INSERM U1219 , to pursue their joint research program on venous thrombosis. On a daily basis, Carole is working in the INSERM U1034 lab directed by Thierry Couffinahl which offers the necessary environment to follow her experimental work.

  • Cecilia Samieri
    Chercheuse INSERM (Senior Researcher, INSERM (French National Institute for Health)

    Parcours

    EDUCATION/TRAINING

    INSTITUTION AND LOCATION DEGREE COMPLETION DATE FIELD OF STUDY
    Université de Bordeaux, Bordeaux, France HDR (Habilitation à diriger des recherches ; accreditation to direct research) 2018
    Epidemiology
    INSERM U897 and Université de Bordeaux, Bordeaux, France Junior Research Position (French Fondation Plan Alzheimer grant) 2012-2015 Epidemiology – Alzheimer’s disease
    Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

    Postdoctoral Research fellow

    2011-2012 Epidemiology
    Université de Bordeaux, Bordeaux, France Postdoctoral Research fellow 2010-2011 Epidemiology (applied Biostatistics and neuro-imaging)
    Université de Bordeaux, Bordeaux, France Ph.D (upper honours, Mention Très Honorable) 2007-2009 Epidemiology
    Université Paris XI, Paris, France M.Sc (upper honours, Mention Très Bien) 2005-2006 Methodology and Statistics in Biomedical Research
    Université Paris XII, Paris, France Doctorate 2004 Veterinary medicine

    Lycée Michel Montaigne, Bordeaux, France

    Baccalaureate diploma (upper honours, Mention Très Bien) 1997 Mathematics
  • Aïcha Soumaré
    Epidemiologist

    Aïcha Soumaré, earned a PhD in Public Health-Epidemiology with upper honors from the Paris-Sud 11 University in 2009, and is a recipient of the Halimi/Aguirre-Basualdo Ph.D award specialized in medicine*.

    Her research focuses on the environmental and genetic determinants of stroke, dementia, and MRI markers of brain aging.

    Prior to joining the Bordeaux team of Pr. Debette in 2015 as an epidemiologist, she worked in the same capacity at the Parisian INSERM unit U708-“neuroepidemiology” for five years. There, she contributed, among other things, to the identification of risk factors of dilated perivascular spaces in the general population, as well as to the first study and paper reporting the increased risk of dementia associated with this particular emerging MRI marker of cerebral small vessel disease (cSVD) in the context of a large population-based sample of elderly individuals. 

    Since then, her Bordeaux adventure has led to various other contributions to the scientific literature including –but not limited to– the investigation of the influence of environmental factors (e.g., orthostatic hypotension, lipids, blood biomarkers or individual protein levels) on dementia and MRI-cSVD markers, the exploration of causal pathways between cerebrovascular disease and dementia using genetic instruments/polygenic risk scores, or the assessment of the prevalence and severity of brain incidental findings on healthy young adults MRIs.

    Recently, she has developed an interest in the “the retina is a window to the brain” concept which proposes that the retinal microvasculature might be used as a proxy for its brain counterpart based on their similarities. Leveraging this concept could theoretically facilitate early detection of patients at high risk for cSVD and improve characterization of cSVD into subtypes based on retinal vascular characteristics. Hence, one of her objectives is to test this “retina-brain”model as reflected by some of her current orientations that involve for example (i) conducting a systematic review of the literature summarizing current data on the relation between brain MRI and retinal cSVD biomarkers, (ii) examining, as proof of concept, whether traditional fundus-based retinal microvascular geometric features are associated with common visible MRI-cSVD markers including a newly generated extreme cSVD phenotype, (iii) extending those investigations to novel high-resolution AO and OCT-A retinal microvascular biomarkers and cSVD biomarkers (common and emerging) quantified by cutting-edge methods developed by her group (RHU SHIVA), (iv) exploring associations of genetic (polygenic) risk scores of those cSVD biomarkers with incident dementia…

    Dr. Soumaré also collaborates with the Steering committee of the 3C study by handling the proposals of ancillary studies and data access to the cohort in the context of its coordinating center.

     

    * from the Chancellerie des Universités de Paris
  • Judith Thomas Crusells
    PhD
    International Project Manager

    Judith Thomas Crusells est titulaire d’un doctorat en neurosciences de l’université d’Helsinki (Finlande), d’un master en biotechnologie de l’université de Kuopio (Finlande) et d’un diplôme en commerce, marketing et relations publiques de l’université ouverte de Catalogne (Espagne). Sa carrière scientifique dans les domaines des facteurs de croissance neuronale et de la survie neuronale après une lésion a été développée dans des institutions internationales renommées telles que l’Institut de biotechnologie (Helsinki, Finlande), l’hôpital universitaire de la Sarre (Homburg, Allemagne), l’hôpital universitaire de Zurich et l’École polytechnique fédérale de Zurich (ETH, Zürich, Suisse).

    Judith a également été engagée comme consultante technique à l’Organisation mondiale de la santé (OMS, Genève, Suisse) dans les départements de la santé publique et environnementale, des vaccins et de la santé mentale, où elle était responsable de la coordination de projets et d’initiatives internationaux, de l’organisation de conférences internationales et de l’élaboration de documents techniques sur l’évaluation de la charge mondiale de morbidité.

    Depuis janvier 2016, Judith travaille en tant que chef de projet dans l’équipe ELEANOR en collaborant à la gestion de projets nationaux et internationaux dirigés par le Prof. Stéphanie Debette

     

     

  • David-Alexandre Trégouët
  • Violaine Verrecchia
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