Directeur de Recherche INSERM
PhD in Biostatistics


2008, HDR (Hability to conduct Research), France.

2001, Post-Doctorat at USC University, U.S.A.

2000, PhD in Biostatistics (University of Bordeaux), France.


The main goal of my research is to improve statistical methods for making inferences using medical data. As a statistician engaged in clinical and epidemiological research programs, my interests reflect both the medical and the statistical areas. In the domain of medicine, I have been focused for the last several years on Alzheimer, cancer recurrences, cancer survival, and environmental health.

Statistically, the major impetus of my work has been in survival analysis. I have been studying a collection of methods that enable us to take into account correlated data in survival analysis and competing risks, with a particular interest in random effects survival models or frailty models. My other major research interest is flexible joint models for handling both recurrent events, longitudianl biomarkers and a terminal event. These developments are associated with the development of dynamic prediction tools for predicting survival outcome. My recent interests are on the development of new statistical tools to validate surrogate endpoints in clinical trials, especially for meta-analyses datasets.

New methods, were largely developed in the field of correlated survival data and have been shown to be far superior to more traditional methods. Nevertheless, they are still not widely used by medical scientists. I hope to change that by making these methods easier to use and better understood. This is also why I invested time in developing the R package « FRAILTYPACK » ( for analyzing clustered or recurrent events, or more generally correlated survival data.

  • 2014, recruited as a director of research in Biostatistics at the INSERM institute
  • 2001, recruited as a researcher in Biostatistics at the INSERM Institute


[1] C. Piel, C. Pouchieu, S. Tual, L. Migault, C. Lemarchand, C. Carles, M. Boulanger, A. Gruber, V. Rondeau, E. Marcotullio, FRANCIM, P. Lebailly, and I Baldi. Central nervous system tumors and agricultural exposures in the prospective cohort agrican. International Journal of Cancer, 2017, in press.
[2] A. Mauguen, S. Michiels, and V. Rondeau. Joint model imputation to estimate the treatment eff ect on long-term survival using auxiliary events. Journal of Biopharmaceutical Statistics, In press, 2017.
[3] T. Emura, M. Nakatochi, S. Matsui, H. Michimae, and V. Rondeau. Personalized dynamic prediction of death according to tumour progression and high-dimensional genetic factors : meta-analysis with a joint model. Statistical Methods in Medical Research, In press, 2016.
[4] A. Krol, A. Mauguen, Y. Mazroui, A. Laurent, S. Michiels, and V. Rondeau. Tutorial in joint models and prediction : a statistical software for correlated longitudinal outcomes, recurrent events and a terminal outcome. Journal of Statistical Software, in press, 2016.
[5] V. Rondeau, E. Cornet, P. Moreau, and X. Troussard. Prediction of patients with
multiple myeloma eligible for second- or third-line treatment in france. Annals of
Hematology, 95(8) :1307{1313, 2016.
[6] S. Perrot, V. Rondeau, I. Chartier, R. Arnaud, J.Y. Milon, and D. Pouchain. Kine-
siophobia and treatment related-pain are key factors in the ecacy of musculoskeletal
pain management by physical therapy : A large national multicenter cohort study on
patients and their general physicians. European Journal of Pain, In press, 2016.
[7] Kyu Ha Lee, Virginie Rondeau, and Sebastien Haneuse. Accelerated failure time models for semi-competing risks data in the presence of complex censoring. Biometrics, pages n/a{n/a, 2017.
[8] L. Ferrer, V. Rondeau, J. Dignam, T. Pickles, H. Jacqmin-Gadda, and Proust-Lima
C. Joint modelling of longitudinal and multi-state processes : application to clinical
progressions in prostate cancer. Statistics in Medicine, 35(22) :3933{48, 2016.
[9] D. Seyoum, Y. Getachew, V. Rondeau, D. Yewhalaw, L. Duchateau, A. Rosas-Aguirre, and N. Speybroeck. Identi cation of di erent patterns of malaria disease due to plasmodium falciparum and plasmodium vivax in ethiopian children : a prospective cohort study. Malaria Journal, 15(208), 2016.
[10] A. Krol, L. Ferrer, JP. Pignon, C. Proust-Lima, M. Ducreux, O. Bouche, S. Michiels, and V. Rondeau. Joint model for left-censored longitudinal data, recurrent events and terminal event : Predictive abilities of tumor burden for cancer evolution with application to the cd 2000-05 trial. Biometrics, 72(3) :907{16, 2016.
[11] D. Commenges, H. Jacqmin-Gadda, A. Amadou, P. Joly, B. Liquet, C. Proust-Lima, V. Rondeau, and R. Thiebaut. Dynamical Biostatistical Models, volume 86. CRC Press, 2015.
[12] D. Commenges, H. Jacqmin-Gadda, A. Amadou, P. Joly, B. Liquet, C. Proust-Lima, V. Rondeau, and R. Thiebaut. Modeles biostatistiques pour l’epidemiologie. De Boeck, 2015.
[13] Y. Mazroui, A. Mauguen, S. Mathoulin-Pelissier, G. MacGrogan, V. Brouste, and
V. Rondeau. Time-varying coecients in a multivariate frailty model : Application
to breast cancer recurrences of several types and death. Lifetime data analysis, pages
1{25, 2015.
[14] T. Emura, M. Nakatochi, K. Murotani, and V. Rondeau. A joint frailty-copula model between tumour progression and death for meta-analysis. Statistical Methods in Medical Research, 2015.
[15] F. Rotolo, V. Rondeau, and C. Legrand. Incorporation of nested frailties into multistate models with an application to a multicenter lung cancer clinical trial. Statistics in  Medicine, 35(4) :609{621, 2015.
[16] C. Pradeau, V. Rondeau, E. Leveque, P. Guerniaud, E. Tentillier, M. Thicoipe, and
P. Brochard. Air pollution and activation of mobile medical team for out-of-hospital
cardiac arrest. American Journal of Emergency Medicine, 33 :367{372, 2015.
[17] B. Amadeo, C. Robert, V. Rondeau, M.A. Mounouchy, L. Cordeau, X. Birembaux,
E. Citadelle, J. Gotin, M. Gouranton, G. Marcin, L. David, and C Raherison. Impact
of close-proximity and background air pollution on lung function of elementary school-children in French West Indies : an observational study. BMC Public Health, 15(45), 2015.
[18] A. Mauguen, B. Rachet, S. Mathoulin-Pelissier, GM Lawrence, S. Siesling, G. MacGrogan, A. Laurent, and V. Rondeau. Validation of death prediction after breast cancer relapses using joint models. BMC Medical Research Methodology, 15(1) :27, 2015.
[19] V. Rondeau, A. Mauguen, A. Laurent, C. Berr, and C. Helmer. Dynamic prediction
models for clustered and interval-censored outcomes : Investigating the intra-couple
correlation in the risk of dementia. Statistical methods in medical research, 2015.
[20] I. Baldi, M.D. Lebailly, G. Bouvier, V. Rondeau, V. Kientz-Bouchart, and A. Garrigou. Levels and determinants of pesticide exposure in re-entry workers in vineyards : results of the PESTEXPO study. Environmental Research, 132 :360{369, 2014.
[21] A. Mauguen, S. Collette, JP. Pignon, and V. Rondeau. Reply to “Interpretation of
concordance measures for clustered data”. Statistics in Medicine, 33(4) :717{718, Fe-
bruary 2014.
[22] A Belot, V. Rondeau, L. Remontet, and R. Giorgi. A joint frailty model to estimate
the recurrence event process and the disease-speci c mortality process without needing
the cause of death. Statistics in Medicine, 33(18) :3147{3166, 2014.
[23] A. Doussau, P. Perez, M. Puntous, J. Calderon, M. Jeanne, C. Germain, B. Rozec,
V. Rondeau, G. Ch^ene, A. Ouattara, et al. Fresh-frozen plasma transfusion did not
reduce 30-day mortality in patients undergoing cardiopulmonary bypass cardiac sur-
gery with excessive bleeding : the plasmacard multicenter cohort study. Transfusion,
54(4) :1114{24, 2014.
[24] S. Desmonde, J. Bosco Essanin, A. Edmond Aka, E. Messou, M. Amorissani Folquet, V. Rondeau, A. Ciaranello, and V Leroy. Morbidity and healthcare resource utilisation in HIV-infected children following antiretroviral therapy (ART) initiation in C^ote d’Ivoire, 2004-2009. JAIDS, 65(7) :e95{e103, 2014.
[25] A. Mauguen, B. Rachet, S. Mathoulin-Pelissier, G. MacGrogan, and V. Rondeau. Dynamic prediction of risk of death using history of cancer recurrences in joint frailty models. Statistics in Medicine, 32(30) :5366{5380, 2013.
[26] A. Mauguen, S. Collette, J.P. Pignon, and V. Rondeau. Concordance measures in
shared frailty models : application to multicenter data in cancer prognosis. Statistics in
Medicine, 32(27) :4803{4820, 2013.
[27] Y. Mazroui, S. Mathoulin-Pelissier, G. MacGrogan, V. Brouste, and V. Rondeau. Multivariate frailty models for two types of recurrent events with a dependent terminal
event : Application to breast cancer data. Biometrical Journal, 55(6) :866{884, 2013.
[28] Y. Mazroui, S. Mathoulin-Pelissier, P. Soubeyran, and V. Rondeau. General joint frailty model for recurrent event data with a dependent terminal event : Application to follicular lymphoma data. Statistics in Medicine, 897(December 2010) :n/a{n/a, February 2012.
[29] I. Baldi, M.D. Lebailly, V. Rondeau, V. Bouchart, A. Blanc-Lapierre, G. Bouvier,
M. Canal-Ran, and A. Garrigou. Levels and determinants of pesticide exposure in
operators involved in treatment of vineyards : resultst of the PESTEXPO study. Journal of Exposure Science And Environmental Epidemiology, 22(6) :593{600, 2012.
[30] B. Liquet, J.F. Timsit, and V. Rondeau. Investigating hospital heterogeneity with a multi-state frailty model : application to nosocomial pneumonia disease in intensive care units. BMC medical research methodology, 12(1) :79, 2012.
[31] V. Rondeau, Y. Mazroui, and J.R. Gonzalez. frailtypack : An R package for the analysis of correlated survival data with frailty models using penalized likelihood estimation or parametrical estimation. Journal of Statistical Software, 47(4) :1{28, 2012.
[32] I. Baldi, Gruber A. Coureau, G., V. Rondeau, and H. Loiseau. Re :occupational and
residential exposure to electromagnetic elds and risk of brain tumours in adults : a
case-control study in gironde, france. International Journal of Cancer, 130(3) :744,
[33] A.M. Gallagher, G.W. Meijer, D.P. Richardson, V. Rondeau, M. Skarp, M. Stasse-
Wolthuis, G.C. Tweedie, R. Witkamp, et al. A standardised approach towards proving
the efficacy of foods and food constituents for health claims (proclaim) : providing
guidance. British Journal of Nutrition, 106(2) :S16{S28, 2011.
[34] I. Baldi, A. Gruber, V. Rondeau, P. Lebailly, P. Brochard, and C. Fabrigoule. Neuro-behavioral e ects of long-term exposure to pesticides : results from the 4-year follow-up of the PHYTONER study. Occupational and environmental medicine, 68(2) :108{15, February 2011.
[35] V. Rondeau, E. Scha ner, F. Corbiere, S. Mathoulin-Pelissier, and J.R. Gonzalez. Cure frailty models for survival data : an application to breast cancer recurrences. Statistical Methods in Medical Research, 897, June 2011.
[36] V. Rondeau, J.P. Pignon, and S. Michiels. A joint model for the dependence between clustered times to tumour progression and deaths : A meta-analysis of chemotherapy in head and neck cancer. Statistical methods in medical research, 897 :1{19, October 2011.
[37] J. Lepeule, H. Seegers, V. Rondeau, C. Robert, and J.M. Denoix. Risk factors for the presence and extent of Developmental Orthopaedic Disease in the limbs of young horses : insights from a count model. Preventive veterinary medicine, 22(5) :671{679, 2011.
[38] V. Rondeau, S. Mathoulin-Pelissier, L. Tanneau, A.J. Sasco, G. MacGrogan, and M. Debled. Separate and combined analysis of successive dependent outcomes after breast-conservation surgery : recurrence, metastases, second cancer and death. BMC Cancer, 2010.
[39] V. Rondeau. Statistical models for recurrent events and death : application to cancer events. Mathematical and Computer Modeling, 52 :949{955, 2010.
[40] G. Encrenaz, A. Benard, V. Rondeau, F. Bonnet, E. Lazzaro, D. Neau, M. Dupon,
F. Dabis, P. Mercie, G. Chene, and the ANRS CO3 Aquitaine Study Group (Groupe
d’Epidemiologie Clinique du Sida en Aquitaine). Determinants of smoking cessation
attempts among HIV-infected patients Results from a hospital-based prospective cohort. Current HIV Research, 1(8) :212{207, 2010.
[41] C. Feart, C. Samieri, V. Rondeau, H. Amieva, F. Portet, JF. Dartigues, N. Scarmeas, and P. Barberger-Gateau. Adherence to a mediterranean diet, cognitive decline, and risk of Dementia. Journal of the American Medical Association, 302(6) :638{648, 2009.
[42] B. Marin, R. Thiebaut, H.C. Bucher, V. Rondeau, D. Costagliola, M. Dorrucci, O. Hamouda, M. Prins, S. Walker, K. Porter, et al. Non-AIDS-de ning deaths and immuno-de ciency in the era of combination antiretroviral therapy. Aids, 23(13) :1743, 2009.
[43] V. Rondeau, H. Jacqmin-Gadda, D. Commenges, C. Helmer, and J.F. Dartigues. Aluminum and Silica in Drinking Water and the Risk of Alzheimer’s Disease or Cognitive Decline : Findings From 15-Year Follow-up of the PAQUID Cohort. American Journal of Epidemiology, 169(4) :489{496, 2009.
[44] V. Rondeau and J.F. Dartigues. Exposition a l’aluminium Quel est le risque pour la sante ? Le quotidien du medecin. Quotidien du medecin, 20 Juin, 2008.
[45] V. Rondeau. Encyclopedia of medical decision making : Recurrent events. Sage Publications, Inc, 2009.
[46] V. Rondeau, H. Allain, S. Bakchine, P. Bonet, F. Brudon, G. Chauplannaz, B. Dubois, T. Gallarda, J.P. Lepine, F. Pasquier, et al. General practice-based intervention for suspecting and detecting dementia in France. Dementia, 7(4) :433, 2008.
[47] V. Rondeau, S. Michiels, B. Liquet, and J.P. Pignon. Investigating trial and treatment heterogeneity in an individual patient data meta-analysis of survival data by means of the penalized maximum likelihood approach. Statistics in Medicine, 27(11) :1894{1910,2008.
[48] D. Krewski, R.A. Yokel, E. Nieboer, D. Borchelt, J. Cohen, J. Harry, S. Kacew, J. Lindsay, A.M. Mahfouz, and V. Rondeau. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. Journal of Toxicology and Environmental Health, Part B, 10 :1{269, 2007.
[49] V. Rondeau, S. Mathoulin-Pelissier, H. Jacqmin-Gadda, V. Brouste, and P. Soubeyran. Joint frailty models for recurring events and death using maximum penalized likelihood estimation : application on cancer events. Biostatistics, 8(4) :708{721, 2007.
[50] J. Lepeule, V. Rondeau, J.F. Dartigues, and L. Filleul. Survival Analysis to Estimate Association Between Short-term Mortality and Air Pollution. Environmental Health Perspectives, 114(2) :242{7, 2006.
[51] J. Lepeule, V. Rondeau, J.F. Dartigues, and L. Filleul. Cox Models : Lepeule et al.
Respond. Environmental Health Perspectives, 114(12) :A691, 2006.
[52] V. Rondeau, A. Iron, L. Letenneur, D. Commenges, F. Duchene, B. Arveiler, and J.F. Dartigues. Analysis of the e ect of aluminum in drinking water and transferrin C 2
allele on Alzheimer’s disease. European Journal of Neurology, 13(9) :1022{1025, 2006.
[53] V. Rondeau, L. Filleul, and P. Joly. Nested frailty models using maximum penalized likelihood estimation. Statistics in Medicine, 25(23) :4036{4052, 2006.
[54] D. Commenges and V. Rondeau. Relationship between derivatives of the observed
and full loglikelihoods and application to newton-raphson algorithm observed and full
loglikelihoods and application to newton-raphson algorithm. The International Journal of Biostatistics, 2(1) :1{26, 2006.
[55] I. Harrabi, V. Rondeau, J.F. Dartigues, J.F. Tessier, and L. Filleul. E ects of particulate air pollution on systolic blood pressure : a population-based approach. Environmental research, 101(1) :89{93, 2006.
[56] V. Rondeau, K. Berhane, and D.C. Thomas. A three-level model for binary time-series data : the e ects of air pollution on school absences in the Southern California Children’s Health Study. Statistics in Medicine, 24(7) :1103{1115, 2005.
[57] V. Rondeau and J.R. Gonzalez. frailtypack : A computer program for the analysis of correlated failure time data using penalized likelihood estimation. Computer Methods and Programs in Biomedicine, 80(2) :154{164, 2005.
[58] L. Filleul, V. Rondeau, S. Vandentorren, N. Le Moual, A. Cantagrel, I. Annesi-Maesano, D. Charpin, C. Declercq, F. Neukirch, C. Paris, et al. Twenty ve year mortality and air pollution : results from the French PAARC survey. British Medical Journal, 62(7) :453{460, 2005.
[59] G. Encrenaz, V. Rondeau, A. Messiah, and M. Auriacombe. Examining the in
uence of drop-outs in a follow-up of maintained opiate users. Drug and alcohol dependence, 79(3) :303{310, 2005.
[60] L. Filleul, V. Rondeau, A. Cantagrel, J.F. Dartigues, and J.F. Tessier. CME Do Subject Characteristics Modify the E ects of Particulate Air Pollution on Daily Mor-
tality Among the Elderly ? Journal of Occupational and Environmental Medicine,
46(11) :1115{1122, 2004.
[61] V. Rondeau, D. Commenges, and P. Joly. Maximum penalized likelihood estimation in a gamma-frailty model. Lifetime Data Analysis, 9(2) :139{153, 2003.
[62] V. Rondeau and D. Commenges. Modelisation de la fragilite en survie. Journal de la Societe Francaise de Statistique, 143(1-2) :103{119, 2002.
[63] V. Rondeau. A review of epidemiologic studies on aluminum and silica in relation
to Alzheimer’s disease and associated disorders. Reviews on Environmental Health,
17(2) :107{122, 2002.
[64] V. Rondeau, H. Jacqmin-Gadda, D. Commenges, and J.F. Dartigues. Re : aluminum in drinking water and cognitive decline in elderly subjects : the Paquid cohort. American Journal of Epidemiology, 154(3) :288{290, 2001.
[65] V. Rondeau and D. Commenges. The epidemiology of aluminium and Alzheimer’s disease.
[66] I. Bourdel-Marchasson and V. Rondeau. Nutritional intervention trials for preventing and treating pressure ulcer. Nutrition, 17(2) :155{156, 2001.
[67] I. Bourdel-Marchasson, M. Barateau, V. Rondeau, L. Dequae-Merchadou, N. Salles Montaudon, J.P. Emeriau, G. Manciet, and J.F. Dartigues. A multi-center trial of the eff ects of oral nutritional supplementation in critically ill older inpatients. Nutrition, 16(1) :1{5, 2000.
[68] V. Rondeau, D. Commenges, H. Jacqmin-Gadda, and J.F. Dartigues. Relation between aluminum concentrations in drinking water and Alzheimer’s disease : an 8-year follow-up study. American Journal of Epidemiology, 152(1) :59{66, 2000.
[69] D. Commenges and V. Rondeau. Standardized martingale residuals applied to grouped left truncated observations of dementia cases. Lifetime Data Analysis, 6(3) :229{235, 2000.
[70] V. Rondeau. Analyse par vraisemblance penalisee de donnees de survie
groupees : application a la relation entre aluminium et demence. (Thesis,
Bordeaux, France : Universite Victor Segalen Bordeaux2 ), 2000.
[71] V. Rondeau, D. Commenges, and I. Bourdel-Marchasson. Relation entre la composition d’aluminium et de silice dans l’eau de boisson et le risque de maladie d’Alzheimer. Revue Epidemiol Sante Publique, 47 :555{561, 1999.
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