Post-doctoral research fellow

Sabrina was initially trained as an Agrohealth engineer and joined the clinical research field in 2007, first as a clinical research associate and then as a study engineer. After a university diploma in statistical methods in epidemiology, she applied for a PhD in Public Health/Epidemiology at the Doctoral Network of the Ecole des Hautes Etudes en Santé Publique (EHESP). During her PhD she explored the association between lipid metabolism (apolipoprotein E ε genotype and plasma lipid levels) and MRI-markers of cerebrovascular disease (white matter hyperintensities, subclinical brain infarcts and microbleeds). Her post-doctoral work is a continuation of her PhD, focusing mainly on finding determinants and clinical implications of MRI-markers of cerebral small vessel disease. She is also involved in organizational missions within the unit (international meetings and workshops, Neurepiomics summer school, etc.).


– Sargurupremraj M, […], Schilling S, […], Fornage M*, Debette S*. Cerebral small vessel disease genomics: implications across the lifespan. Nature Communications, in press


– Debette S, Schilling S, Duperron M.-G., Larsson S, Markus H S. Clinical significance of MRI-markers of vascular brain injury: a systematic review and meta-analysis. JAMA Neurol, 2019;76:81-94     

-Guglielmi V, Visser J, Arnold M, Sarikaya H, van den Berg R, Nederkoorn PJ, Leys D, Calvet D, Kloss M, Pezzini A, Tatlisumak T, Schilling S, Debette S, Coutinho JM. Triple and quadruple cervical artery dissections: a systematic review of individual patient data. J Neurol. 2019 Jun;266(6):1383-1388


– Compter A,* Schilling S,* Vaineau C, Goeggel-Simonetti B, Metso T M, Southerland A, Pezzini A, Kloss M, Touzé E, Worrall B B, Thijs V, MD, Bejot Y, Reiner P, Grond-Ginsbach C, Bersano A, Brandt T, Caso V, Lyrer PA, Traenka C, Lichy C, Martin J J, Leys D, Sarikaya H, Baumgartner R W, Jung S, Fischer U, Engelter S T, Dallongeville J, Chabriat H, Tatlisumak T, Bousser MG, Arnold M, Debette S, for the CADISP-plus consortium. Determinants and outcome of multiple and early recurrent cervical artery dissections. Neurology. 2018 Aug 21;91(8):e769-e780

– Duperron MG, Tzourio C, Sargurupremraj M, Mazoyer B, Soumaré A, Schilling S, Amouyel P, Chauhan G, Zhu YC, Debette S. Burden of dilated perivascular spaces, an emerging marker of cerebral small vessel disease, is highly heritable. Stroke, 2018 Feb;49(2):282-287

– Chauhan G*, […], Schilling S, […], the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer’s Disease Genetics Consortium (ADGC), the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Ikram MA**, Fornage M**, J Launer LJ**, Seshadri S**, Longstreth WT Jr**, Debette S**, on behalf of the CHARGE Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology, 2019;92(5):e486-e503


Schilling S, Tzourio C, Soumaré A, Kaffashian S, Dartigues J.-F, Ancelin M.-L, Samieri C, Dufouil C, Debette S. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study. PLOS Medicine, 2017;14:e1002265


– Debette S*, Compter A*, Labeyrie MA, Uyttenboogaart M, Metso TM, Majersik JJ, Goeggel-Simonetti B, Engelter ST, Pezzini A, Bijlenga P, Southerland AM, Naggara O, Béjot Y, Cole JW, Ducros A, Giacalone G, Schilling S, Reiner P, Sarikaya H, Welleweerd JC, Kappelle LJ, de Borst GJ, Bonati LH, Jung S, Thijs V, Martin JJ, Brandt T, Grond-Ginsbach C, Kloss M, Mizutani T, Minematsu K, Meschia JF, Pereira VM, Bersano A, Touzé E, Lyrer PA, Leys D, Chabriat H, Markus HS, Worrall BB, Chabrier S, Baumgartner R, Stapf C, Tatlisumak T, Arnold M, Bousser MG. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Lancet Neurol. 2015;14:640-654

– Hofer E, Cavalieri M, Bis JC, DeCarli C,  Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BFJ, Wolf C,  Yang Q, Adams HHH, Amouyel P, Beiser A, Buckley BM, Callisaya M, Chauhan G, de Craen AJM, Dufouil C,  van Duijn CM, Ford I, Freudenberger P, Gottesman RF, Gudnason V, Heiss G, Hofman A, Lumley T, Martinez O, Mazoyer B, Moran C, Niessen WJ, Phan T, Psaty BM, Satizabal C, Sattar N, Schilling S, Shibata DK, Slagboom PE, Smith A, Stott DJ, Taylor KD, Thomson R, Töglhofer AM, Tzourio C, van Buchem M, Wang J, Westendorp RGJ, Windham BG, Vernooij MW, Zijdenbos A, Beare R,  Debette S, Ikram MA, Jukema JW, Launer LJ, Longstreth WT Jr, Mosley TH, Seshadri S, Schmidt H, Schmidt R.   White matter lesion progression: A genome-wide search for genetic influences. Stroke, 2015;46:3048-57


– Debette S, Wolf C, Lambert JC, Crivello F, Soumaré A, Zhu YC, Schilling S, Dufouil C, Mazoyer B, Amouyel P, Tzourio C*, Elbaz A*. Abdominal obesity and lower gray matter volume: a Mendelian randomization study. Neurobiology of Aging, 2014;35:378-86

Schilling S, Tzourio C, Dufouil C, Zhu YC, Berr C, Alpérovitch A, Crivello F, Mazoyer B, and Debette S. Plasma lipids and cerebral small vessel disease. Neurology, 2014;83:1844-1852

– Debette S*, Goeggel Simonetti B*, Schilling S, Martin JJ, Kloss M, Sarikaya H, Hausser I, Engelter ST, Metso TM, Pezzini A, Thijs VN, Touzé E, Costa P, Sessa M, Paolucci S, Samson Y, Béjot Y, Altintas A, Metso A, Herve D, Lichy C, Jung S, Fischer U, Lamy C, Grau AJ, Chabriat H, Caso V, Lyrer P, Stapf C, Tatlisumak T, Brandt T, Tournier-Lasserve E, Germain DP, Frank M, Baumgartner RW, Grond-Ginsbach C, Bousser MG, Leys D, Dallongeville J, Bersano A, and Arnold M. Familial occurrence and heritable disorders of connective tissue in cervical artery dissection. Neurology, 2014;83:2023-2031


– Brisset M, Boutouyrie P, Pico F, Zhu YC, Zureik M, Schilling S, Dufouil C, Mazoyer B, Laurent S, Tzourio C, Debette S. Large Vessel Correlates of Cerebral Small Vessel Disease. Neurology, 2013;80:662-669

Schilling S, Seshadri S, Sachdev PS, DeStefano A, Mather K, Beiser A, Wen W, Hogh P, Raz N, DeCarli C, Zhu YC, Romero R, Lunetta KL, Farrer L, Dufouil C, Kuller LH, Mazoyer B, Tzourio C, Debette S. ApoE genotype and MRI-markers of cerebrovascular disease: A systematic review and meta-analysis. Neurology, 2013;82:292-300

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