Chercheuse INSERM (Senior Researcher, INSERM (French National Institute for Health)



Université de Bordeaux, Bordeaux, France HDR (Habilitation à diriger des recherches ; accreditation to direct research) 2018
INSERM U897 and Université de Bordeaux, Bordeaux, France Junior Research Position (French Fondation Plan Alzheimer grant) 2012-2015 Epidemiology – Alzheimer’s disease
Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

Postdoctoral Research fellow

2011-2012 Epidemiology
Université de Bordeaux, Bordeaux, France Postdoctoral Research fellow 2010-2011 Epidemiology (applied Biostatistics and neuro-imaging)
Université de Bordeaux, Bordeaux, France Ph.D (upper honours, Mention Très Honorable) 2007-2009 Epidemiology
Université Paris XI, Paris, France M.Sc (upper honours, Mention Très Bien) 2005-2006 Methodology and Statistics in Biomedical Research
Université Paris XII, Paris, France Doctorate 2004 Veterinary medicine

Lycée Michel Montaigne, Bordeaux, France

Baccalaureate diploma (upper honours, Mention Très Bien) 1997 Mathematics



My research mainly focuses on the epidemiology of aging, with the aim of understanding how environmental factors, in particular diet, influences the etiology of brain diseases and conditions in aging such as dementia and cognitive decline. I have been working on several large cohorts, including the French Three-City study and Harvard cohorts (Nurses’ Health Study and Women’s Health Study), and developed a multidisciplinary epidemiological expertise across nutrition, neurosciences, applied biostatistics and brain imaging. I have evidenced protective associations between fish and marine omega-3 fatty acids, olive oil, overall healthy diets and exposure to multiple nutrients, and a lower risk of various age-related brain diseases. Since environmental factors have a pleiotropic role in health, a broader perspective of my research has focused on the impact of a healthier diet in midlife (eg., a Mediterranean diet) for healthy aging.

There is increasing evidence that a number of age-related diseases are determined by exposures over the entire life-course. For example, cumulative environmental exposures throughout life may modulate the burden of lesions and resilience capacities of the aging brain, which are the two core neuro-pathophysiological components of Alzheimer’s dementia. Hence, it has become more and more evident that future brain aging research should move on early prevention. In this context, my research objectives are two-fold. First, I aim at identifying in prospective cohort studies the time window and the mechanisms linking environmental risk factors to brain health, by using (i) dynamic methodological approaches to investigate risk factor trajectories, and (ii) innovative markers of exposures (eg, metabolomics), outcomes (eg, brain imaging markers) and mechanisms (eg, neurogenesis) across both young and older populations. Secondly, I work on the identification of relevant targets (population, intervention) for early prevention. This includes exploration of gene-by-nutrient interactions in cognitive decline and dementia and investigation of potential novel preventive agents/combination through both candidate and untargeted, agnostic approaches applied to various omics data.


Positions and employment

2012-15 Junior Research Position, INSERM U897 and Université de Bordeaux, France.

2015-      Permanent senior researcher, INSERM (French National Institute for Health).


2010-12  Pilot Award from the LECMA (European League Against Alzheimer’s Disease, France); Thesis prize from the SFEL (French Society for the Study of Lipids, France).

2011-12  Fulbright Research Scholar Award; Medical research award from the Philippe Foundation (USA & France); travel award from the International Conference on Alzheimer Disease (France).

2012-15  Junior Researcher Position grant from the French Fondation Plan Alzheimer; 1st prize for best free communication at the 2012 Aquitaine Conferences on Neurosciences, Université de Bordeaux (France); travel award, Alzheimer Association International Conference (Canada).

2016      Alzheimer’s Association Research Grant.

2017-20 Prime d’encadrement doctoral et de recherche (PEDR) INSERM (award for excellence in research).

Research support

2018-20 Medical sciences research grant, France Alzheimer (PI). Dynamic relationships between lifestyle trajectories, cognition, and biomarkers of the Alzheimer’s pathological cascade (DATALInk).

2016-20 H2020 European Project Joint Programming Initiative « A healthy diet for a healthy life », Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline (D-CogPlast) (WP1 leader). 

2016-18 Alzheimer’s Association Research Grant (PI). Network science tools to identify novel diet patterns in prodromal dementia. In collaboration with Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital (Boston, USA).

2012-15 Junior Researcher Position grant from the French Fondation Plan Alzheimer (PI). Fatty acids, genetics and Alzheimer’s disease: exploring novel gene – environment interactions. 

2010-12 Pilot award LECMA (European League Against Alzheimer’s Disease, France) (PI). Nutrition and neuroimaging markers of Alzheimer’s Disease. 



Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, Debette S, Beiser AS, Seshadri S.APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality. Stroke. 2018 Dec;49(12):2822-2829. doi: 10.1161/STROKEAHA.118.022132.


Samieri C, Empana JP. Cardiovascular Health and Cognitive Decline-Reply. JAMA. 2018 Dec 18;320(23):2483-2484. doi: 10.1001/jama.2018.17566. No abstract available.


Imamura F, Fretts A, Marklund M, Ardisson Korat AV, Yang WS, Lankinen M, Qureshi W, Helmer C, Chen TA, Wong K, Bassett JK, Murphy R, Tintle N, Yu CI, Brouwer IA, Chien KL, Frazier-Wood AC, Del Gobbo LC, Djoussé L, Geleijnse JM, Giles GG, de Goede J, Gudnason V, Harris WS, Hodge A, Hu F; InterAct Consortium, Koulman A, Laakso M, Lind L, Lin HJ, McKnight B, Rajaobelina K, Risérus U, Robinson JG, Samieri C, Siscovick DS, Soedamah-Muthu SS, Sotoodehnia N, Sun Q, Tsai MY, Uusitupa M, Wagenknecht LE, Wareham NJ, Wu JH, Micha R, Forouhi NG, Lemaitre RN, Mozaffarian D; Fatty Acids and Outcomes Research Consortium (FORCE). PLoS Med. 2018 Oct;15(10):e1002670.


Samieri C, Perier MC, Gaye B, Proust-Lima C, Helmer C, Dartigues JF, Berr C, Tzourio C, Empana JP. Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia. JAMA. 2018 Aug 21;320(7):657-664.


Merle BM, Colijn JM, Cougnard-Grégoire A, de Koning-Backus APM, Delyfer MN, Kiefte-de Jong JC, Meester-Smoor M, Féart C, Verzijden T, Samieri C, Franco OH, Korobelnik JF, Klaver CCW, Delcourt C; EYE-RISK consortium. Mediterranean diet and incidence of advanced AMD: The EYE-RISK CONSORTIUM. Ophthalmology. 2018 Aug 13.


Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C, Samieri C. Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia. JAMA Psychiatry. 2018 Oct 1;75(10):1033-1042.


Pilleron S, Pérès K, Jutand MA, Helmer C, Dartigues JF, Samieri C, Féart C. Dietary patterns and risk of self-reported activity limitation in older adults from the Three-City Bordeaux Study. Br J Nutr. 2018 Sep;120(5):549-556.


Lefèvre-Arbogast S, Gaudout D, Bensalem J, Letenneur L, Dartigues JF, Hejblum BP, Féart C, Delcourt C, Samieri C. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology. 2018 May 29;90(22):e1979-e1988.


Proust-Lima C, Philipps V, Dartigues JF, Bennett DA, Glymour MM, Jacqmin-Gadda H, Samieri C. Are latent variable models preferable to composite score approaches when assessing risk factors of change? Evaluation of type-I error and statistical power in longitudinal cognitive studies. Stat Methods Med Res. 2017 Jan 1:962280217739658. [Epub ahead of print]


Samieri C, Morris MC, Bennett DA, Berr C, Amouyel P, Dartigues JF, Tzourio C, Chasman DI, Grodstein F. Fish intake, genetic predisposition to alzheimer’s disease and decline in global cognition and memory in five cohorts of older persons. Am J Epidemiol. 2018;187(5):933-940.


Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson Korat AV, de Goede J, Zhou X, Yang WS, de Oliveira Otto MC, Kröger J, Qureshi W, Virtanen JK, Bassett JK, Frazier-Wood AC, Lankinen M, Murphy RA, Rajaobelina K, Del Gobbo LC, Forouhi NG, Luben R, Khaw KT, Wareham N, Kalsbeek A, Veenstra J, Luo J, Hu FB, Lin HJ, Siscovick DS, Boeing H, Chen TA, Steffen B, Steffen LM, Hodge A, Eriksdottir G, Smith AV, Gudnason V, Harris TB, Brouwer IA, Berr C, Helmer C, Samieri C, Laakso M, Tsai MY, Giles GG, Nurmi T, Wagenknecht L, Schulze MB, Lemaitre RN, Chien KL, Soedamah-Muthu SS, Geleijnse JM, Sun Q, Harris WS, Lind L, Ärnlöv J, Riserus U, Micha R, Mozaffarian D; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE). Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies. Lancet Diabetes Endocrinol. 2017 Dec;5(12):965-974.


Wagner M, Dartigues JF, Samieri C, Proust-Lima C. Modeling Risk Factor Trajectories When Measurement Tools Change Sequentially During Follow-up in Cohort Studies: Application to Dietary Habits in Prodromal Dementia. Am J Epidemiol. 2018;187(4):845-854.


Gaye B, Canonico M, Perier MC, Samieri C, Berr C, Dartigues JF, Tzourio C, Elbaz A, Empana JP. Ideal Cardiovascular Health, Mortality, and Vascular Events in Elderly Subjects: The Three-City Study. J Am Coll Cardiol. 2017 Jun 27;69(25):3015-3026.


Feart C, Helmer C, Merle B, Herrmann FR, Annweiler C, Dartigues JF, Delcourt C, Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017 Nov;13(11):1207-1216.


Schilling S, Tzourio C, Soumaré A, Kaffashian S, Dartigues JF, Ancelin ML, Samieri C, Dufouil C, Debette S. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study. PLoS Med. 2017 Mar 28;14(3):e1002265.


Amadieu C, Lefèvre-Arbogast S, Delcourt C, Dartigues JF, Helmer C, Féart C, Samieri C. Nutrient biomarker patterns and long-term risk of dementia in older adults. Alzheimers Dement. 2017 Oct;13(10):1125-1132.


Dufouil C, Beiser A, McLure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan L, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, D’Agostino RB, Samieri C, Vasan RS, Chêne G, Howard G, Seshadri S. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. 2017 Mar 21;135(12):1145-1159.


Lefèvre-Arbogast S, Féart C, Dartigues JF, Helmer C, Letenneur L, Samieri C. Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons. Nutrients. 2016 Nov 26;8(12). pii: E761.


Pilleron S, Ajana S, Jutand MA, Helmer C, Dartigues JF, Samieri C, Féart C. Dietary Patterns and 12-Year Risk of Frailty: Results From the Three-City Bordeaux Study. J Am Med Dir Assoc. 2017 Feb 1;18(2):169-175.


Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Le Goff M, Samieri C, Dartigues JF, Delcourt C. Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study. PLoS One. 2016 Jul 28;11(7):e0160240.


Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, Wennberg M, Yakoob MY, Chiuve SE, Dela Cruz L, Frazier-Wood AC, Fretts AM, Guallar E, Matsumoto C, Prem K, Tanaka T, Wu JH, Zhou X, Helmer C, Ingelsson E, Yuan JM, Barberger-Gateau P, Campos H, Chaves PH, Djoussé L, Giles GG, Gómez-Aracena J, Hodge AM, Hu FB, Jansson JH, Johansson I, Khaw KT, Koh WP, Lemaitre RN, Lind L, Luben RN, Rimm EB, Risérus U, Samieri C, Franks PW, Siscovick DS, Stampfer M, Steffen LM, Steffen BT, Tsai MY, van Dam RM, Voutilainen S, Willett WC, Woodward M, Mozaffarian D; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe). ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. JAMA Intern Med. 2016 Aug 1;176(8):1155-66.


Allès B, Samieri C, Lorrain S, Jutand MA, Carmichael PH, Shatenstein B, Gaudreau P, Payette H, Laurin D, Barberger-Gateau P. Nutrient Patterns and Their Food Sources in Older Persons from France and Quebec: Dietary and Lifestyle Characteristics. Nutrients. 2016 Apr 19;8(4):225.


Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W, Wang L, Biggs ML, Chen YI, Hernandez DG, Borecki I, Chasman DI, Rich SS, Ferrucci L, Irvin MR, Aslibekyan S, Zhi D, Tiwari HK, Claas SA, Sha J, Kabagambe EK, Lai CQ, Parnell LD, Lee YC, Amouyel P, Lambert JC, Psaty BM, King IB, Mozaffarian D, McKnight B, Bandinelli S, Tsai MY, Ridker PM, Ding J, Mstat KL, Liu Y, Sotoodehnia N, Barberger-Gateau P, Steffen LM, Siscovick DS, Absher D, Arnett DK, Ordovás JM, Lemaitre RN. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr. 2016 Feb;103(2):567-78.


Feart C, Letenneur L, Helmer C, Samieri C, Schalch W, Etheve S, Delcourt C, Dartigues JF, Barberger-Gateau P. Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort. J Gerontol A Biol Sci Med Sci. 2016 May;71(5):683-8.


Pelletier A, Barul C, Féart C, Helmer C, Bernard C, Periot O, Dilharreguy B, Dartigues JF, Allard M, Barberger-Gateau P, Catheline G, Samieri C. Mediterranean diet and preserved brain structural connectivity in older subjects. Alzheimers Dement. 2015 Sep;11(9):1023-31.


Torres MJ, Féart C, Samieri C, Dorigny B, Luiking Y, Berr C, Barberger-Gateau P, Letenneur L. Poor nutritional status is associated with a higher risk of falling and fracture in elderly people living at home in France: the Three-City cohort study. Osteoporos Int. 2015 Aug;26(8):2157-64.


Commenges D, Proust-Lima C, Samieri C, Liquet B. A universal approximate cross-validation criterion for regular risk functions. Int J Biostat. 2015 May 1;11(1):51-67.


Feart C, Samieri C, Barberger-Gateau P. Mediterranean diet and cognitive health: an update of available knowledge. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):51-62.


Samieri C, Sun Q, Townsend MK, Rimm EB, Grodstein F. Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr. 2014 Dec;100(6):1489-1497.


Samieri C, Amariglio RE, Proust-Lima C, Sperling RA, Glymour MM, Rentz DM, Okereke OI, Grodstein F. Subjective cognitive concerns, episodic memory, and the APOE ε4 allele. Alzheimer’s & dementia. 2014 Sep 23; S1552-5260(14)02494-7.


Ancelin ML, Ripoche E, Dupuy AM, Samieri C, Rouaud O, Berr C, Carrière I, Ritchie K. Gender-specific associations between lipids and cognitive decline in the elderly. Eur Neuropsychopharmacol. 2014 Jul;24(7):1056-66.


Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, Stampfer M, Grodstein F. The association between dietary patterns at midlife and health in aging: an observational study. Ann Intern Med. 2013 Nov 5;159(9):584-91.


Samieri C, Lorrain S, Buaud B, Vaysse C, Berr C, Peuchant E, Cunnane SC, Barberger-Gateau P. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. J Lipid Res. 2013 Sep;54(9):2559-67.


Barberger-Gateau P, Samieri C, Féart C, Cunnane S. Acides gras oméga-3 et déclin cognitif : la controverse. Cah Nutr Diét. 2013 Sept ; 48(4) : 170-174.


Feart C, Lorrain S, Ginder Coupez V, Samieri C, Letenneur L, Paineau D, Barberger-Gateau P. Adherence to a Mediterranean diet and risk of fractures in French older persons. Osteoporos Int. Dec;24(12):3031-41.


Samieri C, Grodstein F, Rosner B, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Mediterranean diet and cognitive function in older age. Epidemiology. 2013 Jul;24(4):490-9.


Samieri C, Okereke OI, Devore EE, Grodstein F. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr. 2013 Apr;143(4):493-9.


Féart C, Samieri C, Allès B, Barberger-Gateau P. Potential benefits of adherence to the Mediterranean diet on cognitive health. Proc Nutr Soc. 2013 Feb;72(1):140-52.


Samieri C, Ginder Coupez V, Lorrain S, Letenneur L, Allès B, Féart C, Paineau D, Barberger-Gateau P. Nutrient patterns and risk of fracture in older subjects: results from the Three-City Study. Osteoporos Int. 2013 Apr;24(4):1295-305.


Barberger-Gateau P, Samieri C, Allès B., Féart C. Could nutrition prevent the onset of dementia? Current evidence from epidemiological and intervention studies. Neurodegen Dis Manage. 2012; 2(3):1-10.


Allès B, Samieri C, Féart C, Jutand MA, Laurin D, Barberger-Gateau P. Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals. Nutr Res Rev. 2012 Dec;25(2):207-22.


Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau P. Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology. 2012 Aug 14;79(7):642-50.


Feart C, Alles B, Merle B, Samieri C, Barberger-Gateau P. Adherence to a Mediterranean diet and energy, macro-, and micronutrient intakes in older persons. J Physiol Biochem. 2012 Dec;68(4):691-700.


Féart C, Pérès K, Samieri C, Letenneur L, Dartigues JF, Barberger-Gateau P. Adherence to a Mediterranean diet and onset of disability in older persons. Eur J Epidemiol. 2011 Sep;26(9):747-56.


Samieri C, Féart C, Proust-Lima C, Peuchant E, Tzourio C, Stapf C, Berr C, Barberger-Gateau P. Olive oil consumption, plasma oleic acid and stroke incidence: the Three-City study. Neurology. 2011 Aug 2;77(5):418-25.


Barberger-Gateau P, Samieri C, Féart C, Plourde M. Dietary omega 3 polyunsaturated fatty acids and Alzheimer’s disease: interaction with apolipoprotein E genotype. Curr Alzheimer Res. 2011 Aug;8(5):479-91.


Féart C, Torrès M, Samieri C, Jutand MA, Peuchant E, Simopoulos AP, Barberger-Gateau P. Adherence to a Mediterranean diet and plasma fatty acids: data from the Bordeaux sample of the Three-City study. Br J Nutr. 2011 Jul;106(1):149-58.


Samieri C, Féart C, Proust-Lima C, Peuchant E, Dartigues J-F, Amieva H, Barberger-Gateau P. Omega-3 fatty acids and cognitive decline: modulation by ApoE4 and depressive status. Neurobiol Aging. 2011 Dec;32(12):2317.e13-22.


Feart C, Siewe A, Samieri C, Peuchant E, Helmer C, Alfos S, Pallet V, Barberger-Gateau P. Plasma retinol and association with socio-demographic and dietary characteristics of free-living older persons: the Bordeaux sample of the Three-City study. Int J Vitam Nutr Res. 2010 Jan;80(1):32-44.


Feart C, Samieri C, Barberger-Gateau P. Mediterranean diet and cognitive function in older adults. Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):14-8.


Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger Gateau P. Adherence to a Mediterranean diet, cognitive decline, and risk for dementia. JAMA. 2009 Aug 12;302(6):638-48.


Feart C, Samieri C, Barberger-Gateau P. Mediterranean Diet and Cognitive Decline. [Letter]. JAMA. 2009, 302: 2432.


Feart C, Peuchant E, Letenneur L, Samieri C, Montagnier D, Fourrier-Reglat A, Barberger Gateau P. Plasma eicosapentaenoic acid (EPA) is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City study. Am J Clin Nutr. 2008 May;87(5):1156-62.


Samieri C, Feart C, Letenneur L, Dartigues JF, Peres K, Auriacombe S, Peuchant E, Delcourt C, Barberger-Gateau P. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr. 2008 Sep;88(3):714-21.


Samieri C, Jutand MA, Feart C, Capuron L, Letenneur L, Barberger-Gateau P. Dietary patterns derived by hybrid clustering method in older people: association with cognition, mood, and self-rated health. J Am Diet Assoc. 2008 Sep;108(9):1461-71.


Sirot V, Samieri C, Volatier JL, Leblanc JC. Cadmium dietary intake and biomarker data in French high seafood consumers. J Expo Sci Environ Epidemiol. 2008 Jul;18(4):400-9.

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