Chercheuse INSERM (Senior Researcher, INSERM (French National Institute for Health)

Parcours

EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE COMPLETION DATE FIELD OF STUDY
Université de Bordeaux, Bordeaux, France HDR (Habilitation à diriger des recherches ; accreditation to direct research) 2018
Epidemiology
INSERM U897 and Université de Bordeaux, Bordeaux, France Junior Research Position (French Fondation Plan Alzheimer grant) 2012-2015 Epidemiology – Alzheimer’s disease
Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

Postdoctoral Research fellow

2011-2012 Epidemiology
Université de Bordeaux, Bordeaux, France Postdoctoral Research fellow 2010-2011 Epidemiology (applied Biostatistics and neuro-imaging)
Université de Bordeaux, Bordeaux, France Ph.D (upper honours, Mention Très Honorable) 2007-2009 Epidemiology
Université Paris XI, Paris, France M.Sc (upper honours, Mention Très Bien) 2005-2006 Methodology and Statistics in Biomedical Research
Université Paris XII, Paris, France Doctorate 2004 Veterinary medicine

Lycée Michel Montaigne, Bordeaux, France

Baccalaureate diploma (upper honours, Mention Très Bien) 1997 Mathematics

Fonctions

PERSONAL STATEMENT

My research focuses on the exposome of brain aging and dementia, with an epidemiological approach. My main objective is to understand how environmental factors, including nutrition and cardiometabolic health, influence the etiology of age-related brain diseases, such as dementia and its leading cause, Alzheimer’s disease. I have worked on several large French and US cohorts on dementia and cognitive decline, with the objective of studying with a holistic vision the influence of lifestyle on brain health, from overall lifestyle patterns (eg, dietary patterns) to molecular markers of the exposome.
In 2021, I am setting up a novel cohort on brain aging in early older age, the B cube (Biobank and Brain health in Bordeaux) study. B cube is viewed as a novel epidemiological research platform for the study of the determinants and the natural history of cerebral ageing in the general population, through molecular epidemiology and deep phenotyping. By including 2000 young seniors from 55 years-old, this population-based cohort will allow investigating the premises of dementia before extensive neurodegeneration.

 

POSITIONS AND HONORS

Positions and employment

2012-15 Junior Research Position, INSERM U897 and Université de Bordeaux, France.

2015-      Permanent senior researcher, INSERM (French National Institute for Health).

Honors

2010-12  Pilot Award from the LECMA (European League Against Alzheimer’s Disease, France); Thesis prize from the SFEL (French Society for the Study of Lipids, France).

2011-12  Fulbright Research Scholar Award; Medical research award from the Philippe Foundation (USA & France); travel award from the International Conference on Alzheimer Disease (France).

2012-15  Junior Researcher Position grant from the French Fondation Plan Alzheimer; 1st prize for best free communication at the 2012 Aquitaine Conferences on Neurosciences, Université de Bordeaux (France); travel award, Alzheimer Association International Conference (Canada).

2016      Alzheimer’s Association Research Grant.

2017-20 Prime d’encadrement doctoral et de recherche (PEDR) INSERM (award for excellence in research).

2019 – Joël Ménard 2019 Prize in clinical and translational research, Fondation Alzheimer (France).

Research support

2021-24  Research grant FRM Environnement santé 2020. EGLANTINE: Characterization of the chemical exposome in the general population in relation to brain health (PI). In collaboration with IRSET, Research Institute For Environmental and Occupational Health (Rennes, France).

2020-25 Projet Structurant pour la Compétitivité (PSPC) BPI France. SilverBrainFood: Un projet sur la prévention du déclin cognitif en proposant des solutions digitales, nutritionnelles individualisées innovantes, économiques, avec des modes de distribution alimentaires adaptés et durables destinés tant au grand public qu’aux professionnels  (partner, WP leader).

2018-20 Medical sciences research grant, France Alzheimer. DATALInk: Dynamic relationships between lifestyle trajectories, cognition, and biomarkers of the Alzheimer’s pathological cascade (PI).

2016-20 H2020 European Project Joint Programming Initiative « A healthy diet for a healthy life », Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline (D-CogPlast) (partner, WP leader). 

2016-18 Alzheimer’s Association Research Grant. Network science tools to identify novel diet patterns in prodromal dementia (PI). In collaboration with Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital (Boston, USA).

2012-15 Junior Researcher Position grant from the French Fondation Plan Alzheimer. Fatty acids, genetics and Alzheimer’s disease: exploring novel gene – environment interactions (PI).

2010-12 Pilot award LECMA (European League Against Alzheimer’s Disease, France). Nutrition and neuroimaging markers of Alzheimer’s Disease (PI).

Publications

Selection of publications (past 5 years)

  • Pelletier A, Barul C, Féart C, Helmer C, Bernard C, Periot O, Dilharreguy B, Dartigues JF, Allard M, Barberger-Gateau P, Catheline G, Samieri C. Mediterranean diet and preserved brain structural connectivity in older subjects. Alzheimers Dement. 2015;11:1023-31
  • Del Gobbo LC, […] Samieri C, […], Mozaffarian D; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe). ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. JAMA Intern Med. 2016;176:1155-66
  • Amadieu C, Lefèvre-Arbogast S, Delcourt C, Dartigues JF, Helmer C, Féart C, Samieri C. Nutrient biomarker patterns and long-term risk of dementia in older adults. Alzheimers Dement. 2017;13:1125-1132
  • Feart C, Helmer C, Merle B, Herrmann FR, Annweiler C, Dartigues JF, Delcourt C, Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017;13:1207-1216
  • Samieri C, Perier MC, Gaye B, Proust-Lima C, Helmer C, Dartigues JF, Berr C, Tzourio C, Empana JP. Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia. JAMA. 2018;320:657-664
  • Samieri C, Morris MC, Bennett DA, Berr C, Amouyel P, Dartigues JF, Tzourio C, Chasman DI, Grodstein F. Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons. Am J Epidemiol. 2018;187:933-40.
  • Lefevre-Arbogast S, Gaudout D, Bensalem J, Letenneur L, Dartigues JF, Hejblum BP, Feart C, Delcourt C, Samieri C. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology. 2018;90:e1979-e88.
  • Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C*, Samieri C*. Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia. JAMA Psychiatry. 2018;75:1033-1042
  • Low DY*, Lefevre-Arbogast S*, […], Samieri C, Manach C. Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort. Mol Nutr Food Res. 2019;63:e1900177.
  • Wagner M, Grodstein F, Proust-Lima C, Samieri C. Long-Term Trajectories of Body Weight, Diet, and Physical Activity From Midlife Through Late-Life and Subsequent Cognitive Decline in Women. Am J Epidemiol. 2020;189:305-313
  • Marklund M, […], Samieri C, […], Lemaitre RN, Mozaffarian D, Riserus U. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies. Circulation. 2019;139:2422-36.
  • Proust-Lima C, Philipps V, Dartigues JF, Bennett DA, Glymour MM, Jacqmin-Gadda H, Samieri C. Are latent variable models preferable to composite score approaches when assessing risk factors of change? Evaluation of type-I error and statistical power in longitudinal cognitive studies. Statistical Methods in Medical Research. 2019;28:1942-57.
  • Samieri C*, Sonawane A*, Lefèvre-Arbogast S, Helmer C, Grodstein F, Glass K. Using network science tools to identify novel diet patterns in prodromal dementia: The Three-City Study. Neurology. 2020;94:e2014-e2025.
  • Freitas-Simoes TM, Wagner M, Samieri C, Sala-Vila A, Grodstein F. Consumption of Nuts at Midlife and Healthy Aging in Women. J Aging Res. 2020:5651737
  • Gentreau M, Chuy V, Féart C, Samieri C, Ritchie K, Raymond M, Berticat C, Artero S. Refined carbohydrate-rich diet is associated with long-term risk of dementia and Alzheimer’s disease in apolipoprotein E ε4 allele carriers. Alzheimers Dement. 2020 Jul;16(7):1043-1053.
  • Imamura F, […] , Samieri C, […], Forouhi NG. Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. PLoS Med. 2020 Jun 12;17(6):e1003102.
  • Thomas A, Baillet M, Proust-Lima C, Féart C, Foubert-Samier A, Helmer C, Catheline G, Samieri C. Blood polyunsaturated omega-3 fatty acids, brain atrophy, cognitive decline, and dementia risk. Alzheimers Dement. 2020 Oct 8. Online ahead of print. PMID: 33090665
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