Director of research in Biostatistics


2014 HDR (Habilitation to conduct research), Univ. Bordeaux, France.
2006 PhD in Biostatistics, Univ. Bordeaux Segalen, France.
2003 Master degree in Epidemiology and Public Health, ISPED, Univ. Bordeaux Segalen, France.
2002 Master degree in Biostatistics, National School for Statistics and Information Analysis, ENSAI, Rennes, France.



2019-… Director of Research (DR2), Inserm, Bordeaux, France.
2008-2019 Researcher (CR1), Inserm, Bordeaux, France.
2008 Research Assistant, Biostatistics and Nutrition departments, Inserm, Bordeaux, France.
2008 Assistant Professor, ISPED, Université Bordeaux Segalen, Bordeaux, France.
2007 Postdoctoral fellow, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, USA.
2003-2006 Assistant professor, ISPED, Université Bordeaux Segalen, Bordeaux, France.


Joint models, Latent class mixed models, Latent variable models, (Generalized) linear mixed models, Longitudinal analysis of psychometric scales in Masters, summer schools, short courses

Research interests

Development of dynamic statistical models to describe, explain and predict chronic disease progressions. I specialized in the joint analysis of correlated longitudinal markers and event time history using the so called joint models with applications mainly in neurodegenerative diseases (e.g., Alzheimer’s disease) and cancers. My works often involve latent processes to translate dynamic health phenomena measured by repeated markers, and latent classes to translate the heterogeneity of disease progression. I have also worked on the development of individual dynamic predictions that quantify the risk of experiencing a clinical event based on the dynamic history of an individual. All my works are motivated by epidemiological and clinical questions thanks to strong collaborations with epidemiologists and clinicians, and access to large cohort studies. My developments are made available in R packages with constant maintainance and upgrades.

I serve as Associate Editor for Biometrics (since 2014) and Biostatistics (since 2016).

I belong to the international initiative in Methods in Longitudinal Research in Dementia (MELODEM).


See my github repository and
marqLevAlg: A Parallelized Algorithm for Least-Squares Curve Fitting. R package version 2.0.1.
CInNPL: Causal Inference in a Network of Latent Processes
JLPM: Joint models based on Latent Processes. R package version 1.0
lcmm: Extended Mixed Models Using Latent Classes and Latent Processes. R  package version 1.9.4
NormPsy: Normalisation of  Psychometric Tests. R package version 1.0.3.



Devaux, A., Genuer, R., Pérès, K., & Proust-Lima, C. (2021). Individual dynamic prediction of clinical endpoint from large dimensional longitudinal biomarker history : A landmark approach. arXiv:2102.01466 [cs, stat].
Proust-Lima, C., Philipps, V., Perrot, B., Blanchin, M., & Sébille, V. (2021). Modeling repeated self-reported outcome data : A continuous-time longitudinal Item Response Theory model. arXiv:2109.13064 [stat].
Saulnier, T., Philipps, V., Meissner, W. G., Rascol, O., Pavy-Le-Traon, A., Foubert-Samier, A., & Proust-Lima, C. (2021). Joint models for the longitudinal analysis of measurement scales in the presence of informative dropout. arXiv:2110.02612 [stat].
Valeri, L., Proust-Lima, C., Fan, W., Chen, J. T., & Jacqmin-Gadda, H. (2021). A multistate approach for mediation analysis in the presence of semi-competing risks with application in cancer survival disparities. arXiv:2102.13252 [stat].


Baussard, L., Proust-Lima, C., Philipps, V., Portales, F., Ychou, M., Mazard, T., & Cousson-Gélie, F. (2021). Determinants of Distinct Trajectories of Fatigue in Patients Undergoing Chemotherapy for a Metastatic Colorectal Cancer : 6-Month Follow-up Using Growth Mixture Modeling. Journal of Pain and Symptom Management, S0885-3924(21)00398-5.
Carles, S., Taddé, B. O., Berr, C., Helmer, C., Jacqmin-Gadda, H., Carrière, I., & Proust-Lima, C. (2021). Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study. Alzheimer’s Research & Therapy, 13(1), 148.
Du Preez, A., Lefèvre-Arbogast, S., Houghton, V., de Lucia, C., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust-Lima, C., Pallàs, M., Ruigrok, S. R., Altendorfer, B., González-Domínguez, R., Sánchez-Pla, A., Urpi-Sardà, M., Andres-Lacueva, C., Aigner, L., Lucassen, P. J., Korosi, A., … Thuret, S. (2021). The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Faucon, A.-L., Leffondré, K., Flamant, M., Metzger, M., Boffa, J.-J., Haymann, J.-P., Houillier, P., Thervet, E., Vrtovsnik, F., Proust-Lima, C., Stengel, B., Vidal-Petiot, E., Geri, G., & NephroTest study group. (2021). Trajectory of extracellular fluid volume over time and subsequent risks of end-stage kidney disease and mortality in chronic kidney disease : A prospective cohort study. Journal of Internal Medicine, 289(2), 193‑205.
Frison, E., Proust-Lima, C., Mangin, J.-F., Habert, M.-O., Bombois, S., Ousset, P.-J., Pasquier, F., Hanon, O., Paquet, C., Gabelle, A., Ceccaldi, M., Annweiler, C., Krolak-Salmon, P., Béjot, Y., Belin, C., Wallon, D., Sauvee, M., Beaufils, E., Bourdel-Marchasson, I., … MEMENTO Cohort Study Group. (2021). Diabetes Mellitus and Cognition : Pathway Analysis in the MEMENTO Cohort. Neurology, 97(8), e836‑e848.
Jacqmin-Gadda, H., Proust-Lima, C., & Ferrer, L. (2021). Joint models for longitudinal markers and clinical outcomes. In Handbook of Statistical Methods for Randomized Controlled Trials. CRC Press.
Lefèvre-Arbogast, S., Hejblum, B. P., Helmer, C., Klose, C., Manach, C., Low, D. Y., Urpi-Sarda, M., Andres-Lacueva, C., González-Domínguez, R., Aigner, L., Altendorfer, B., Lucassen, P. J., Ruigrok, S. R., De Lucia, C., Du Preez, A., Proust-Lima, C., Thuret, S., Korosi, A., & Samieri, C. (2021). Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly : A case-control analysis nested within the Three-City cohort study. EBioMedicine, 64, 103216.
Philipps, V., Hejblum, B. P., Prague, M., Commenges, D., & Proust-Lima, C. (2021). Robust and Efficient Optimization Using a Marquardt-Levenberg Algorithm with R Package marqLevAlg. The R journal, accepted.
Raynaud, M., Aubert, O., Reese, P. P., Bouatou, Y., Naesens, M., Kamar, N., Bailly, É., Giral, M., Ladrière, M., Le Quintrec, M., Delahousse, M., Juric, I., Basic-Jukic, N., Gupta, G., Akalin, E., Yoo, D., Chin, C.-S., Proust-Lima, C., Böhmig, G., … Loupy, A. (2021). Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation. Kidney International, 99(1), 186‑197.
Rouanet, A., Avila-Rieger, J., Dugravot, A., Lespinasse, J., Stuckwisch, R., Merrick, R., Anderson, E., Long, L., Helmer, C., Jacqmin-Gadda, H., Dufouil, C., Judd, S., Manly, J., Sabia, S., Gross, A., & Proust-Lima, C. (2021). How Selection Over Time Contributes to the Inconsistency of the Association between Sex/Gender and Cognitive Decline across Cognitive Aging Cohorts. American Journal of Epidemiology, kwab227.
Thomas, A., Proust-Lima, C., Baillet, M., Helmer, C., Delcourt, C., Foubert-Samier, A., Catheline, G., Féart, C., & Samieri, C. (2021). Plasma carotenoids and medial temporal lobe atrophy in older adults. Clinical Nutrition (Edinburgh, Scotland), 40(4), 2460‑2463.
Wagner, M., Grodstein, F., Leffondre, K., Samieri, C., & Proust-Lima, C. (2021). Time-varying associations between an exposure history and a subsequent health outcome : A landmark approach to identify critical windows. BMC Medical Research Methodology, 21(1), 266.


Edjolo, A., Dartigues, J.-F., Pérès, K., & Proust-Lima, C. (2020). Heterogeneous Long-Term Trajectories of Dependency in Older Adults : The PAQUID Cohort, a Population-Based Study over 22 years. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 75(12), 2396‑2403.
Foubert-Samier, A., Helmer, C., Le Goff, M., Guillet, F., Proust-Lima, C., Jacqmin-Gadda, H., Dartigues, J.-F., Amieva, H., & Tison, F. (2020). Cognitive and functional changes in prediagnostic phase of Parkinson disease : A population-based study. Parkinsonism & Related Disorders, 79, 40‑46.
Foubert-Samier, A., Pavy-Le Traon, A., Guillet, F., Le-Goff, M., Helmer, C., Tison, F., Rascol, O., Proust-Lima, C., & Meissner, W. G. (2020). Disease progression and prognostic factors in multiple system atrophy : A prospective cohort study. Neurobiology of Disease, 139, 104813.
Kwint, M., Stam, B., Proust-Lima, C., Philipps, V., Hoekstra, T., Aalbersberg, E., Rossi, M., Sonke, J.-J., Belderbos, J., & Walraven, I. (2020). The prognostic value of volumetric changes of the primary tumor measured on Cone Beam-CT during radiotherapy for concurrent chemoradiation in NSCLC patients. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 146, 44‑51.
Lévêque, E., Lacourt, A., Philipps, V., Luce, D., Guénel, P., Stücker, I., Proust-Lima, C., & Leffondré, K. (2020). A new trajectory approach for investigating the association between an environmental or occupational exposure over lifetime and the risk of chronic disease : Application to smoking, asbestos, and lung cancer. PloS One, 15(8), e0236736.
Taddé, B. O., Jacqmin-Gadda, H., Dartigues, J.-F., Commenges, D., & Proust-Lima, C. (2020). Dynamic modeling of multivariate dimensions and their temporal relationships using latent processes : Application to Alzheimer’s disease. Biometrics, 76(3), 886‑899.
Thomas, A., Baillet, M., Proust-Lima, C., Féart, C., Foubert-Samier, A., Helmer, C., Catheline, G., & Samieri, C. (2020). Blood polyunsaturated omega-3 fatty acids, brain atrophy, cognitive decline, and dementia risk. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Wagner, M., Grodstein, F., Proust-Lima, C., & Samieri, C. (2020). Long-Term Trajectories of Body Weight, Diet, and Physical Activity From Midlife Through Late Life and Subsequent Cognitive Decline in Women. American Journal of Epidemiology, 189(4), 305‑313.


Amieva, H., Meillon, C., Proust-Lima, C., & Dartigues, J. F. (2019). Is Low Psychomotor Speed a Marker of Brain Vulnerability in Late Life? Digit Symbol Substitution Test in the Prediction of Alzheimer, Parkinson, Stroke, Disability, and Depression. Dementia and Geriatric Cognitive Disorders, 47(4‑6), 297‑305.
Ferrer, L., Putter, H., & Proust-Lima, C. (2019). Individual dynamic predictions using landmarking and joint modelling : Validation of estimators and robustness assessment. Statistical Methods in Medical Research, 28(12), 3649‑3666.
Lefèvre-Arbogast, S., Wagner, M., Proust-Lima, C., & Samieri, C. (2019). Nutrition and Metabolic Profiles in the Natural History of Dementia : Recent Insights from Systems Biology and Life Course Epidemiology. Current Nutrition Reports, 8(3), 256‑269.
Low, D. Y., Lefèvre-Arbogast, S., González-Domínguez, R., Urpi-Sarda, M., Micheau, P., Petera, M., Centeno, D., Durand, S., Pujos-Guillot, E., Korosi, A., Lucassen, P. J., Aigner, L., Proust-Lima, C., Hejblum, B. P., Helmer, C., Andres-Lacueva, C., Thuret, S., Samieri, C., & Manach, C. (2019). Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort. Molecular Nutrition & Food Research, 63(18), e1900177.
Proust-Lima, C., Philipps, V., & Dartigues, J.-F. (2019). A joint model for multiple dynamic processes and clinical endpoints : Application to Alzheimer’s disease. Statistics in Medicine, 38(23), 4702‑4717.
Taddé, B. O., Jacqmin-Gadda, H., Dartigues, J.-F., Commenges, D., & Proust-Lima, C. (2019). Dynamic modelling of Multivariate Dimensions and Their Temporal Relationships using Latent Processes : Application to Alzheimer’s Disease. Biometrics.
Wagner, M., Grodstein, F., Proust-Lima, C., & Samieri, C. (2019). Long-Term Trajectories of Body Weight, Diet, and Physical Activity From Midlife Through Late-Life and Subsequent Cognitive Decline in Women. American Journal of Epidemiology.


Asselineau, J., Paye, A., Bessède, E., Perez, P., & Proust-Lima, C. (2018). Different latent class models were used and evaluated for assessing the accuracy of campylobacter diagnostic tests : Overcoming imperfect reference standards? Epidemiology and Infection, 146(12), 1556‑1564.
Bellera, C., Proust-Lima, C., Joseph, L., Richaud, P., Taylor, J., Sandler, H., Hanley, J., & Mathoulin-Pélissier, S. (2018). A two-stage model in a Bayesian framework to estimate a survival endpoint in the presence of confounding by indication. Statistical Methods in Medical Research, 27(4), 1271‑1281.
Grasset, L., Jacqmin-Gadda, H., Proust-Lima, C., Pérès, K., Amieva, H., Dartigues, J.-F., & Helmer, C. (2018). Temporal Trends in the Level and Decline of Cognition and Disability in an Elderly Population : The PAQUID Study. American Journal of Epidemiology, 187(10), 2168‑2176.
Samieri, C., Perier, M.-C., Gaye, B., Proust-Lima, C., Helmer, C., Dartigues, J.-F., Berr, C., Tzourio, C., & Empana, J.-P. (2018). Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia. JAMA, 320(7), 657‑664.
Wagner, M., Dartigues, J.-F., Samieri, C., & Proust-Lima, C. (2018). Modeling Risk-Factor Trajectories When Measurement Tools Change Sequentially During Follow-up in Cohort Studies : Application to Dietary Habits in Prodromal Dementia. American Journal of Epidemiology, 187(4), 845‑854.
Wagner, M., Helmer, C., Tzourio, C., Berr, C., Proust-Lima, C., & Samieri, C. (2018). Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia. JAMA Psychiatry, 75(10), 1033‑1042.


Boucquemont, J., Lawson-Ayayi, S., Rigothier, C., Bonnet, F., Proust-Lima, C., Neau, D., Greib, C., Miremont-Salamé, G., Dabis, F., Dupon, M., Dauchy, F.-A., & for ANRS C03 Aquitaine Cohort Study Group. (2017). Absence of Decline of Kidney Function in Human Immunodeficiency Virus-Infected Patients Under Routine Clinical Management. Nephron, 136(3), 211‑220.
Carrière, I., Farré, A., Proust-Lima, C., Ryan, J., Ancelin, M. L., & Ritchie, K. (2017). Chronic and remitting trajectories of depressive symptoms in the elderly. Characterisation and risk factors. Epidemiology and Psychiatric Sciences, 26(2), 146‑156.
Picat, M.-Q., Pellegrin, I., Bitard, J., Wittkop, L., Proust-Lima, C., Liquet, B., Moreau, J.-F., Bonnet, F., Blanco, P., Thiébaut, R., & ANRS CO3 Aquitaine Cohort. (2017). Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients. PloS One, 12(1), e0169164.
Proust-Lima, C., Philipps, V., Dartigues, J.-F., Bennett, D. A., Glymour, M. M., Jacqmin-Gadda, H., & Samieri, C. (2017). Are latent variable models preferable to composite score approaches when assessing risk factors of change? Evaluation of type-I error and statistical power in longitudinal cognitive studies. Statistical Methods in Medical Research, 962280217739658.
Proust-Lima, C., Philipps, V., & Liquet, B. (2017). Estimation of Extended Mixed Models Using Latent Classes and Latent Processes : The R Package lcmm. Journal of Statistical Software, Articles, 78(2), 1–56.
Tabue-Teguo, M., Grasset, L., Avila-Funes, J. A., Genuer, R., Proust-Lima, C., Péres, K., Féart, C., Amieva, H., Harmand, M. G.-C., Helmer, C., Salles, N., Rainfray, M., & Dartigues, J. F. (2017). Prevalence and Co-Occurrence of Geriatric Syndromes in People Aged 75 Years and Older in France : Results From the Bordeaux Three-city Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 73(1), 109‑116.
Wang, W., Guedj, M., Bertrand, V., Foucquier, J., Jouve, E., Commenges, D., Proust-Lima, C., Murphy, N. P., Blin, O., Magy, L., Cohen, D., & Attarian, S. (2017). A Rasch Analysis of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) in a Cohort of Charcot-Marie-Tooth Type 1A Patients. PloS One, 12(1), e0169878.
More exhaustive list here:


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