|1.||Bachelor of Engineering in Biotechnology||Shivaji University, Kolhapur, India||2004-08|
|2.||Master of Science in Analytical Genomics||University of Birmingham, Birmingham, United Kingdom||2009-10|
|3.||PhD in Statistical Genetics||University of Queensland, Brisbane, Australia||2011-15|
I am a tenured researcher in statistical genetics at the VINTAGE team, within the Bordeaux Population Health Research Center, at the University of Bordeaux, and the visiting scientist at the QIMR Berghofer Medical Research Center, Brisbane, Australia. I consistently achieved distinctions in my academic accomplishments. I am well versed in bioinformatics, statistics and genomics, with skills that help me in achieving my research goals efficiently. I am interested in understanding the genetic basis of complex neurological traits, which can be evidenced from the fact that, within nine years (three years of PhD, a two year postdoc and an ongoing postdoc) of my research career I published twenty papers (ten first authorships) in peer-reviewed genetics and neurology journals (H-index=15), including publications in high impact journals: Nature Genetics (2), Nature Communications (4) and Brain (2, one being awarded “Editor’s choice article of the month”), and developed two widely used software: VEGAS2 (>150 citations) and VEGAS2Pathway.
I completed my PhD from the University of Queensland, Australia (graduation date: 2015, November 9th) under supervision of Assoc. Prof. Stuart Macgregor, and a postdoctoral training at the Neuroscience Campus, VU Amsterdam under supervision of Prof. Danielle Posthuma. I am an active member of International Stroke Genetics Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), International Stroke Genetics consortium (ISGC), and JPND-BRIDGET network.
- I am coordinating several analytical tasks within the BRIDGET-JPND network, including: (i) the cutting-edge whole genome sequencing (WGS) analyses based on a unique resource of WGS data on ~2,500 participants with MRI informations from several cohorts; the data has been centralized and pooled at our lab, analyses are underway; (ii) analyses of large dataset of 1,000 participants with Methyl-C sequencing (a cutting-edge measurement method of DNA methylation) and brain MRI. Overall my expertise in method development and analytical understanding of the cutting age next generation genetic and epigenetic data would help me perform the SENSE project in superior way.
- Leading the largest GWAS on stroke (>100K cases), and leading first well powered GWAS on mortality within 30-days post first incidence of stroke within the CHARGE and ISGC.
Link for VEGAS2 and VEGAS2Pathway software: https://vegas2.qimrberghofer.edu.au/
First authored publications as follows:
- MISHRA A†, Chauhan G, Violleau MH, […], Joutel A, Tzourio C, Debette S†. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain. 2019 Apr 1;142(4):1009-1023.†Corresponding author; (Citations:4)
- Iglesias AI*, MISHRA A*, Vitart V*, et al. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nature Communications; 2018 May 14; 9(1):1864. doi: 10.1038/s41467-018-03646-6. *Authors contributed equally; (Citations:10).
- MISHRA A†, Ferrari R, International FTD-Genomics Consortium, et al. Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia. Brain 2017 Apr 5; 140(5):1437-1446. †Corresponding author; (Citations:24).
- Springelkamp H*, Iglesias AI*, MISHRA A*, Höhn R*, Wojciechowski R*, et al. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Human Molecular Genetics 2017 Jan 15; 26(2):438-453. doi: 10.1093/hmg/ddw399. (Citations:48). *Authors contributed equally; (Citations:50).
- MISHRA A†, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Colorectal Cancer Family Registry (CCFR), Macgregor S†. A novel approach for pathway analysis of GWAS data highlights role of BMP signaling and muscle cell differentiation in colorectal cancer susceptibility. Twin Res Hum Genet. 2017 Feb; 20(1):1-9. †Corresponding author; (Citations:20).
Springelkamp H*, MISHRA A*, Hysi PG*, Gharahkhani P*, Höhn R*, et al. Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology. Genetic Epidemiology. 2015 Jan 28.*Authors contributed equally; (Citations:93).
MISHRA A†, Macgregor S†. VEGAS2: Software for More Flexible Gene-Based Testing. Twin Research and Human Genetics 2015 Feb;18(1):86-91. doi: 10.1017/thg.2014.79. (Citations: 141). †Corresponding author; (Citations:146).
- Springelkamp H*, Höhn R*, MISHRA A*, Hysi PG*, Khor CC*, Loomis SJ*, et al. Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nat Commun. 2014 Sep 22;5:4883. *Authors contributed equally; (Citations:73).
- Yazar S*, MISHRA A*, Ang W, et al. Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. Mol Vis. 2013 Jun 6;19:1238-46. Print 2013. *Authors contributed equally; (Citations:8).
- MISHRA A*, Yazar S*, Hewitt AW, et al. Genetic variants near PDGFRA are associated with corneal curvature in Australians. Invest Ophthalmol Vis Sci. 2012 Oct 11;53(11):7131-6. †Corresponding author; (Citations:34).
For all publications number of citations, H-index and i-10 index refer: https://scholar.google.com/citations?hl=en&user=WTV6IOUAAAAJ&view_op=list_works&sortby=pubdate