{"id":7858,"date":"2024-10-04T16:19:40","date_gmt":"2024-10-04T14:19:40","guid":{"rendered":"https:\/\/www.bordeaux-population-health.center\/?p=7858"},"modified":"2024-10-15T16:46:33","modified_gmt":"2024-10-15T14:46:33","slug":"un-espoir-dans-la-lutte-contre-le-vih-un-candidat-vaccin-preventif-montre-des-resultats-encourageants","status":"publish","type":"post","link":"https:\/\/www.bordeaux-population-health.center\/fr\/un-espoir-dans-la-lutte-contre-le-vih-un-candidat-vaccin-preventif-montre-des-resultats-encourageants\/","title":{"rendered":"Un espoir dans la lutte contre le VIH : un candidat-vaccin pr\u00e9ventif montre des r\u00e9sultats encourageants"},"content":{"rendered":"

Ce candidat vaccin innovant baptis\u00e9 CD40.HIVRI.Env vient de d\u00e9montrer, dans le cadre de l\u2019essai clinique ANRS VRI06 de phase I, sa s\u00fbret\u00e9 et sa capacit\u00e9 \u00e0 induire une r\u00e9ponse immunitaire rapide et durable.<\/strong><\/p>\n

 <\/p>\n

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image : pexels-ron-lach-9893851<\/p>\n

 <\/p>\n

Cette recherche est le fruit d’une collaboration entre le Vaccine Research Institute (VRI),( https:\/\/vaccine-research-institute.fr\/fr<\/a> de l’Inserm, de l’Universit\u00e9 Paris-Est Cr\u00e9teil, le CHUV de Lausanne et les chercheurs bordelais de l\u2019\u00e9quipe BPH-SISTM https:\/\/www.bordeaux-population-health.center\/fr\/les-equipes\/sistm\/<\/a>et de l\u2019UMS MART https:\/\/ums-mart.fr<\/a>.<\/p>\n

Il s\u2019agit de la premi\u00e8re \u00e9tude chez l\u2019Homme avec ce vaccin et l\u2019essai a montr\u00e9 que le vaccin est bien tol\u00e9r\u00e9 et capable de stimuler \u00e0 la fois une r\u00e9ponse immunitaire humorale et cellulaire contre le VIH.<\/p>\n

Ce vaccin se distingue par l\u2019approche novatrice ciblant les cellules dendritiques qui jouent un r\u00f4le cl\u00e9 dans le d\u00e9clenchement d’une r\u00e9ponse immunitaire.<\/p>\n

 <\/p>\n

Sp\u00e9cialis\u00e9es dans la m\u00e9thodologie, la coordination et la science des donn\u00e9es des essais cliniques vaccinaux, les \u00e9quipes bordelaises SISTM et MART ont assur\u00e9 ces \u00e9l\u00e9ments cl\u00e9s de la conduite r\u00e9ussite de cet essai.<\/p>\n

 <\/p>\n

Les r\u00e9sultats d\u00e9taill\u00e9s de cette \u00e9tude ont \u00e9t\u00e9 publi\u00e9s dans la revue eClinical Medicine en octobre 2024.<\/p>\n

Safety and immunogenicity of CD40.HIVRI.Env, a dendritic cell-based HIV vaccine, in healthy HIV-uninfected adults: a first-in-human randomized, placebo-controlled, dose-escalation study (ANRS VRI06)<\/strong><\/a>
\nYves Levy,Christiane Moog,Aur\u00e9lie Wiedemann,Odile Launay,Fabio Candotti,Lucile Hardel,M\u00e9lany Durand,V\u00e9ronique Rieux,Alpha Diallo,Christine Lacabaratz,Sylvain Cardinaud,Sandra Zurawski,Gerard Zurawski,Georgia D. Tomaras,Song Ding,Mireille Centlivre,Rodolphe Thiebaut,Giuseppe Pantaleo,Jean-Daniel Leli\u00e8vre,Laura Richertthe ANRS VRI06 Study Group<\/p>\n

 <\/p>\n

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Lire le\u00a0\u00a0Communiqu\u00e9 de presse\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Ce candidat vaccin innovant baptis\u00e9 CD40.HIVRI.Env vient de d\u00e9montrer, dans le cadre de l\u2019essai clinique ANRS VRI06 de phase I, sa s\u00fbret\u00e9 et sa capacit\u00e9 \u00e0 induire une r\u00e9ponse immunitaire rapide et durable.   image : pexels-ron-lach-9893851   Cette recherche est le fruit d’une collaboration entre le Vaccine Research Institute (VRI),( https:\/\/vaccine-research-institute.fr\/fr de l’Inserm, de […]<\/p>\n","protected":false},"author":851,"featured_media":7862,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-7858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-revue-de-presse"],"acf":[],"yoast_head":"\nUn espoir dans la lutte contre le VIH : un candidat-vaccin pr\u00e9ventif montre des r\u00e9sultats encourageants | Bordeaux population health<\/title>\n<meta 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