{"id":4834,"date":"2023-11-08T12:07:02","date_gmt":"2023-11-08T11:07:02","guid":{"rendered":"https:\/\/www.bordeaux-population-health.center\/?p=4834"},"modified":"2023-11-20T11:01:55","modified_gmt":"2023-11-20T10:01:55","slug":"seminaire-biostatistics-complex-heterogeneity-in-the-utility-of-a-surrogate-marker-rebecca-knowlton13h-salle-nightingale-isped","status":"publish","type":"post","link":"https:\/\/www.bordeaux-population-health.center\/fr\/seminaire-biostatistics-complex-heterogeneity-in-the-utility-of-a-surrogate-marker-rebecca-knowlton13h-salle-nightingale-isped\/","title":{"rendered":"S\u00c9MINAIRE BIOSTATISTICS : Complex Heterogeneity in the Utility of a Surrogate Marker<br \/>&#8211; Rebecca KNOWLTON"},"content":{"rendered":"<div style=\"font-family: arial; font-size: 1.1em;\">\n<p><img decoding=\"async\" class=\"size-medium wp-image-2266 alignright\" style=\"margin-left: 10%; width: 80%;\" src=\"https:\/\/www.bordeaux-population-health.center\/wp-content\/uploads\/2023\/11\/Biostat-Seminar_Rebecca-Knowlton_bandeau.jpg\" alt=\"\" \/><\/p>\n<p><strong style=\"display: block; text-align: center; font-size: 1.2em;\">S\u00c9MINAIRE BIOSTATISTICS<\/strong><br \/>\n<strong style=\"display: block; text-align: center; font-size: 1.4em; margin-bottom: 1em;\">Complex Heterogeneity in the Utility of a Surrogate Marker<\/strong><\/p>\n<div style=\"display: block; text-align: center; margin-bottom: 2em;\">\nCampus Carreire &#8211; Universit\u00e9 de Bordeaux<\/div>\n<div style=\"margin-left: 10%; width: 80%; margin-top: 5em;\">\n<p>Ouvert \u00e0 tous, en pr\u00e9sentiel.<\/p>\n<div style=\"color: #ee9900; font-weight: bold; display: block; margin-top: 2em;\">Speaker:<\/div>\n<p><span style=\"font-size: 1.2em; font-weight: bold;\">Rebecca KNOWLTON<\/span><br \/>\nUniversity of Texas, Austin, USA.<\/p>\n<p><a href=\"https:\/\/stat.utexas.edu\/directory\/rebecca-knowlton\" target=\"_blank\" rel=\"noopener\"><strong>+ d&rsquo;info concernant Rebecca KNOWLTON<\/strong><\/a><\/p>\n<div style=\"color: #ee9900; font-weight: bold; display: block; margin-top: 2em;\">Abstract:<\/div>\n<p>For clinical trials that typically require lengthy or invasive follow-up procedures, the identification and evaluation of surrogate markers offers a promising path towards obtaining quicker and less burdensome results.<br \/>\nMany methods have been proposed to measure the utility of a surrogate marker in predicting the treatment effect of interest.<br \/>\nHowever, the existing literature largely focuses on statistical validation of a surrogate marker overall, and generally fails to identify when a surrogate marker may be useful for certain subpopulations and not for others. Understanding potential heterogeneity is critical when the intent is to replace the true outcome with the surrogate marker in future clinical trials.<br \/>\nTo this end, we propose three methods for evaluating complex heterogeneity with respect to multiple baseline covariates: a fully parametric model, a semiparametric two-step model utilizing two-dimensional kernel smoothing, and a varying coefficient model.<br \/>\nWe demonstrate the performance of our methods on simulated data as well as AIDS clinical trial data, and discuss the tradeoffs of using the different methods depending on the setting.<\/p>\n<div style=\"color: #ee9900;\"><strong style=\"margin-top: 2em; display: block;\">Pr\u00e9c\u00e9dents e-s\u00e9minaires Biostatistics sur la cha\u00eene YouTube<br \/>\n<a href=\"https:\/\/www.youtube.com\/channel\/UCURp-hEQL7k23UzGfqgEurA\/videos\" target=\"_blank\" rel=\"noopener\">https:\/\/www.youtube.com\/channel\/UCURp-hEQL7k23UzGfqgEurA\/videos<\/a><\/strong><\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>S\u00c9MINAIRE BIOSTATISTICS Complex Heterogeneity in the Utility of a Surrogate Marker Campus Carreire &#8211; Universit\u00e9 de Bordeaux Ouvert \u00e0 tous, en pr\u00e9sentiel. Speaker: Rebecca KNOWLTON University of Texas, Austin, USA. + d&rsquo;info concernant Rebecca KNOWLTON Abstract: For clinical trials that typically require lengthy or invasive follow-up procedures, the identification and evaluation of surrogate markers offers [&hellip;]<\/p>\n","protected":false},"author":613,"featured_media":4828,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[],"class_list":["post-4834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-seminaires"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>S\u00c9MINAIRE BIOSTATISTICS : Complex Heterogeneity in the Utility of a Surrogate Marker- Rebecca KNOWLTON | Bordeaux population health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bordeaux-population-health.center\/fr\/seminaire-biostatistics-complex-heterogeneity-in-the-utility-of-a-surrogate-marker-rebecca-knowlton13h-salle-nightingale-isped\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"S\u00c9MINAIRE BIOSTATISTICS : Complex Heterogeneity in the Utility of a Surrogate Marker- Rebecca KNOWLTON | Bordeaux population health\" \/>\n<meta property=\"og:description\" content=\"S\u00c9MINAIRE BIOSTATISTICS Complex Heterogeneity in the Utility of a Surrogate Marker Campus Carreire &#8211; Universit\u00e9 de Bordeaux Ouvert \u00e0 tous, en pr\u00e9sentiel. Speaker: Rebecca KNOWLTON University of Texas, Austin, USA. + d&rsquo;info concernant Rebecca KNOWLTON Abstract: For clinical trials that typically require lengthy or invasive follow-up procedures, the identification and evaluation of surrogate markers offers [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bordeaux-population-health.center\/fr\/seminaire-biostatistics-complex-heterogeneity-in-the-utility-of-a-surrogate-marker-rebecca-knowlton13h-salle-nightingale-isped\/\" \/>\n<meta property=\"og:site_name\" content=\"Bordeaux population health\" \/>\n<meta property=\"article:published_time\" content=\"2023-11-08T11:07:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-20T10:01:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bordeaux-population-health.center\/wp-content\/uploads\/2023\/11\/Biostat-Seminar_Rebecca-Knowlton_Vignette.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"819\" \/>\n\t<meta property=\"og:image:height\" content=\"443\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Nicolas Koskas\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nicolas Koskas\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.bordeaux-population-health.center\\\/fr\\\/seminaire-biostatistics-complex-heterogeneity-in-the-utility-of-a-surrogate-marker-rebecca-knowlton13h-salle-nightingale-isped\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.bordeaux-population-health.center\\\/fr\\\/seminaire-biostatistics-complex-heterogeneity-in-the-utility-of-a-surrogate-marker-rebecca-knowlton13h-salle-nightingale-isped\\\/\"},\"author\":{\"name\":\"Nicolas Koskas\",\"@id\":\"https:\\\/\\\/www.bordeaux-population-health.center\\\/#\\\/schema\\\/person\\\/f2fdc07742e044bb0a3193dc1f103183\"},\"headline\":\"S\u00c9MINAIRE BIOSTATISTICS : Complex Heterogeneity in the Utility of a Surrogate Marker &#8211; 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