Epidémiologie intégrative et génétique du vieillissement cérébral et vasculaire – VINTAGE

A partir de données issues de cohortes hospitalières et en population générale, l’équipe VINTAGE explore les déterminants de maladies vasculaires et neurologiques liées à l’âge, notamment les accidents vasculaires cérébraux (AVC) et la démence. L’équipe s’intéresse tout particulièrement aux marqueurs en imagerie du vieillissement cérébral, à l’analyse de données génomiques de grande dimension en association avec ces phénotypes complexes, à la modélisation statistique du déclin cognitif et du risque de démence, et s’oriente actuellement vers l’intégration de biomarqueurs et de modalités « omics » innovantes.

Objectifs

Du fait de l’allongement de l’espérance de vie, le poids croissant des maladies vasculaires et neurologiques représente un défi majeur de santé publique pour les prochaines décennies. L’amélioration de notre compréhension des mécanismes sous-tendant les AVC et la démence, les deux maladies neurologiques liées à l’âge les plus fréquentes, et l’élaboration de stratégies pour prévenir ou retarder leur apparition, sont des étapes essentielles pour promouvoir le bien vieillir cérébral. L’équipe VINTAGE propose de contribuer à cette recherche avec un intérêt particulier pour l’identification et l’évaluation de nouveaux biomarqueurs (génétiques, en imagerie, etc.) des AVC et de la démence, avec l’objectif d’accélérer l’identification de nouvelles cibles thérapeutiques, de faciliter la détection d’individus à haut risque de développer ces maladies, et d’optimiser les stratégies de prévention.

Axes

  • VINTAGE vise à améliorer la compréhension des déterminants environnementaux et génétiques des AVC et de la démence, avec un intérêt particulier pour les phénotypes intermédiaires cognitifs et en imagerie cérébrale (IRM notamment), en ayant recours à des technologies innovantes (GWAS, séquençage nouvelle génération, biomarqueurs sanguins et du LCR, imagerie de marqueurs pathologiques in-vivo, etc.) et à des cohortes uniques;

  • Celles-ci comportent les études multicentriques suivantes, toutes coordonnées par des membres de l’équipe VINTAGE: des études en population, chez les personnes âgées (cohorte 3C-Dijon) et chez les jeunes étudiants (cohorte i-Share), une cohorte multicentrique de patients présentant des plaintes cognitives ou des déficits cognitifs légers (Memento; études ancillaires Amyging & Vascod); une étude multicentrique sur les dissections des artères cervicales, une des causes les plus fréquentes d’AVC (CADISP) du sujet jeune;

  • Les membres de VINTAGE s’intéressent particulièrement à l’étude en imagerie des marqueurs d’altérations structurelles cérébrales, en particulier des marqueurs de lésions cérébro-vasculaires, en imagerie par résonance magnétique (IRM). Ces marqueurs peuvent être mesurés en population avant l’apparition de symptômes cliniques, et représentent un puissant prédicteur de survenue d’AVC et de démence.

  • VINTAGE vise également à améliorer les modèles étiologiques et de prédiction du déclin cognitif et de la démence, en tenant compte d’obstacles méthodologiques complexes, tels que la sélection, les risques compétitifs et l’attrition, par le biais d’une optimisation de la modélisation statistique (en étroite collaboration avec le consortium MELODEM, coordonné par VINTAGE);

  • L’exploration des déterminants, mécanismes et conséquences de la maladie des petites artères est un objectif important de l’équipe VINTAGE, à travers la coordination d’une fédération hospitalo-universitaire (FHU) récemment créée, dédiée à la recherche ainsi qu’à l’enseignement et au soin clinique autour de la maladie des petites artères, dans le cerveau, le cœur et la rétine

  • Nous visons également à promouvoir le développement de nouvelles approches préventives, par la réalisation d’essais thérapeutiques utilisant comme critère de jugement principal des phénotypes intermédiaires en IRM cérébrale des AVC et de la démence (LEOPOLD [NCT02472028], MAPT-IRM [NCT00672685]), et en appliquant les connaissances acquises dans les projets sus-décrits pour optimiser la conception de futurs essais de prévention du déclin cognitif et de la démence.

  • Compte tenu d’importantes différences liées au sexe en termes de fréquence et caractéristiques des facteurs de risque vasculaires et des maladies neurologiques liées à l’âge, nous nous intéressons aussi à étudier l’impact différentiel des facteurs de risque et des traitements chez les hommes et les femmes.

 

Consortiums internationaux

Les membres de VINTAGE collaborent étroitement avec

  • le consortium CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology), et
  • le consortium international sur la génétique des AVC (International Stroke Genetics Consortium [ISGC], S Debette actuellement vice-chair).

Et ils coordonnent

  • le consortium CADISP (Cervical artery dissection and ischemic stroke patients) et
  • le consortium MELODEM (Methods for longitudinal studies in dementia).



Subventions en cours et soutien à la recherche

  • 2016-2019: JPND-CoFund (Programme européen pour la recherche sur les maladies neurodégénératives), projet BRIDGET – imagerie cérébrale, cognition, démence et séquençage de nouvelle génération (pour analyses génomiques et épigénomiques): une approche transdisciplinaire pour rechercher des facteurs de risque et des facteurs protecteurs des maladies neurodégénératives (PI coordinateur S Debette)

     

  • 2016-2019: Fondation Plan MND : projet MEMENTO, cohorte multicentrique de patients présentant une plainte cognitive ou des troubles cognitifs légers (co-PIs G Chêne, C Dufouil)

     

  • 2015-2020: ERC starting grant, du Conseil Européen de la Recherche: SEGWAY – Etude sur les prédicteurs environnementaux et génomiques d’altérations structurelles cérébrales précoces chez de jeunes étudiants (PI S Debette)

     

  • 2015-2020: H2020: COSTREAM – mécanismes et voies biologiques communes sous-tendant les AVC et la maladie d’Alzheimer (Partenaires S Debette, C Tzourio)

     

  • 2015-2019: ANR (Agence Nationale de la Recherche): VASCOGENE – ce projet utilise des variants génétiques comme un outil pour explorer l’impact de facteurs de risque vasculaires sur le vieillissement cérébral, le déclin cognitif et la démence (PI S Debette)

     

  • 2015-2018: ANR, étude PRESIDIO, e-cohorte sur la dépression (PI C Tzourio)

     

  • 2015-2016: IdEx Université de Bordeaux, Chaire d’Installation (PI S Debette)

     

  • 2014-2019: PHRC (Programme Hospitalier de Recherche Clinique), essai thérapeutique LEOPOLD, un essai prospectif ouvert avec critère de jugement en aveugle (PROBE) testant l’hypothèse d’un ralentissement de la progression des lésions de substance blanche cérébrale par une réduction de la pression artérielle chez des patients présentant une plainte cognitive et des lésions de la substance blanche de grade modéré à sévère en IRM cérébrale (directeur scientifique C Tzourio, investigatrice responsable de la composante IRM S Debette)

     

  • 2013-2019: PHRC: étude VASCOD – Étude ancillaire de la cohorte MEMENTO visant à étudier le rôle de facteurs de risque vasculaires, de l’inflammation et de lésions vasculaires (co-PIs G Chêne, C Dufouil)

     

  • 2012-2017: Fondation Leducq – Transatlantic Network of Excellence: Physiopathologie de la maladie des petits vaisseaux cérébraux (membres S Debette, C Tzourio)

     

  • 2011-2021 : ANR investissement d’avenir, cohorte i- Share, la plus grande étude en cours sur la santé des étudiants (PI C Tzourio)



Principales publications

  1. FOXF2, a novel risk locus for stroke and small artery disease: a genome-wide association study. Chauhan G, Arnold CR, […], Tzourio C, Rexrode KM, Lehmann OJ, Launer LJ, Ikram MA, Carlsson P, Chasman DI, Childs SJ, Longstreth, Jr. WT, Seshadri S, and Debette S, for the CHARGE consortium, the SiGN group and the International Stroke Genetics Consortium. Lancet Neurol, in press
  2. Incidence of dementia over three decades in the framingham heart study. Satizabal CL, Beiser AS, Chouraki V, Chene G, Dufouil C, Seshadri S. N Engl J Med. 2016;374:523-532
  3. MELODEM Initiative. Guidelines for reporting methodological challenges and evaluating potential bias in dementia research. Weuve J, Proust-Lima C, Power MC, Gross AL, Hofer SM, Thiébaut R, Chêne G, Glymour MM, Dufouil C. Alzheimers Dement. 2015;11:1098-109
  4. New insight into the pathogenesis of cervical artery dissection: A genome-wide association study. Debette S, Kamatani Y, […], Lathrop M, Leys D, Amouyel P, and Dallongeville J, for the CADISP group. Nat Genet. 2015; 47(1):78-83.
  5. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Debette S, Compter A, […] Arnold M, Bousser MG. Lancet Neurol 2015;14:640-6
  6. Association of Alzheimer’s disease GWAS loci with MRI markers of brain aging. Chauhan G, Adams HH, […],Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT Jr, Mosley TH, Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. Neurobiol Aging 2015;36:1765.e7-16
  7. Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Debette S, Ibrahim Verbaas CA, Bressler J,[…], Seshadri S, Mosley TH Jr; Biol Psy. 2015;77:749-63
  8. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Chêne G, Beiser A, Au R, Preis SR, Wolf PA, Dufouil C, Seshadri S. Alzheimers Dement 2015;11:310-20.
  9. Common genetic variants influence human subcortical brain structures. Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, […], Chauhan G, Satizabal CL, Becker JT, Yanek L, van der Lee SJ, Ebling M, Fischl B, Longstreth WT Jr, Greve D, Schmidt H, Nyquist P, Vinke LN, van Duijn CM, Xue L, Mazoyer B, Bis JC, Gudnason V, Seshadri S, Ikram MA; Alzheimer’s Disease Neuroimaging Initiative; CHARGE Consortium; EPIGEN; IMAGEN; SYS, Martin NG, Wright MJ, Schumann G, Franke B, Thompson PM, Medland SE. Nature. 2015; 520:224-9.
  10. Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study. Alpérovitch A, Kurth T, Bertrand M, Ancelin ML, Helmer C, Debette S, Tzourio C. BMJ. 2015; 350:h2335.
  11. Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI. Verhaaren BF, Debette S, Bis JC, […], Seshadri SS, Ikram MA, Fornage M. Circ Cardiovasc Genet. 2015; 8:398-409
  12. Is hypertension associated with an accelerated aging of the brain? Tzourio C, Laurent S, Debette S. Hypertension, 2014;63:894-903
  13. Large Vessel Correlates of Cerebral Small Vessel Disease. Brisset M, Boutouyrie P, […], Dufouil C, Mazoyer B, Laurent S, Tzourio C, Debette S. Neurology 2013; 80:662-669.
  14. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Bis JC*, DeCarli C*, Smith AV*, van der Lijn F*, Crivello F*, Fornage M*, Debette S*, Shulman JM, […], Bennett DA, van Duijn CM**, Mosley TH**, Schmidt R**, Tzourio C**, Launer LJ**, Ikram MA**, Seshadri S**. All starred first authors* and last authors** contributed equally to this manuscript. Nat Genet. 2012; 44:545-5
  15. Association of Vascular Risk Factors With Cervical Artery Dissection and Ischemic Stroke in Young Adults. Debette S, Metso T, Pezzini A, […], Arveiler D, Tatlisumak T, Dallongeville J, for the CADISP Group. Circulation, 2011; 123: 1537-1544.
  16. Antihypertensive Treatment and Change in Blood Pressure Are Associated With the Progression of White Matter Lesion Volumes The Three-City (3C)-Dijon Magnetic Resonance Imaging Study. Godin O, Tzourio C, Maillard P, Mazoyer B, Dufouil C. Circulation 2011; 123:266-73.
  17. Dementia risk prediction in the population: are screening models accurate? Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C. Nat Rev Neurol 2010; 6:318-26.
  18. The Clinical Importance of White Matter Hyperintensities on Brain Magnetic Resonance Imaging: Systematic Review and Meta-analysis. Debette S, Markus HS. BMJ 2010; 341:c3666.

Coordonnées

Centre de recherche INSERM U1219
Université de Bordeaux , ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 16 59

Responsable(s)

  • Directrice :
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Co-directrice :
    Research director

    Parcours

    Carole Dufouil, is research director at Inserm Center UMR1219, and co-director of the VINTAGE team (Vascular and Neurological diseases: INTegrative and GEnetic epidemiology).
    She is also adjunct director for international partnerships of Bordeaux School of Public Health (ISPED). She has published over 142 articles in international journals (H-index 53) and is a member of the editorial board of Alzheimer’s and Dementia: translational research & clinical interventions. Her research focuses on the determinants of neurological diseases, particularly Alzheimer’s disease.
    She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on determinants of brain health and has created the international MELODEM initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.
    Dr. Dufouil is co-PI of the 3C-Dijon study and co-PI of the MEMENTO study, a national clinical cohort, which was set up in the context of the Alzheimer Plan 2008-2013 and aims at improving our understanding of the natural course of Alzheimer’s disease.

  • Contact : Christophe Abrantes


Membres


  • Christophe Abrantes
    Responsable Administratif et Financier
  • Marlène Barus
    Bioinformatics engineer
  • Constance Bordes
    PhD student in epidemiology

    Constance Bordes obtained a master’s degree in Public Health/Epidemiology from the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux (2019). Constance joined ELEANOR team during her master’s internship, where she explored the mechanisms of early MRI-markers of cerebral Small Vessel Disease. Between 2019 and 2021, Constance worked in Pr. Debette team as an epidemiologist. Her research interests are focus on exploring the very early mechanisms of structural brain changes leading to cognitive decline or dementia as well as the mechanisms underlying the association between Small Vessel Disease and cognitive decline/dementia. 

    She is currently a PhD student in epidemiology under the supervision of Pr. Debette with the purpose of exploring the lifetime impact of cerebral small vessel disease on cognitive decline and dementia, by using genomics as a tool.

     

  • Vincent Bouteloup
  • Ilana Caro
    PhD student in epidemiolgy

    Ilana Caro obtained a Master’s degree in Genetic, Genomic and System Biology (GGBS) in 2021 in Nantes. She has been awarded a PhD grant from the Digital Public Health graduate program, to work with Prof. Stéphanie Debette in the VINTAGE team on « Deciphering the molecular signature of covert cerebral small vessel disease (cSVD) with a focus on transcriptomic and proteomic biomarkers ».

  • Stephanie Debette
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Coralie Delgado
  • Marie-Gabrielle Duperron
    MD, PhD student

    Marie-Gabrielle is a Public Health resident in Bordeaux. She is following the MD-PhD program “Ecole de l’Inserm Liliane Bettencourt” (Paris), that allowed her early research training. She did her master 1 directed by Pr Bloch, working on the anatomy of dopamine receptors in rats (Unit “Mouvement – Adaptation – Cognition”, Bordeaux). She obtained a master 2 in Neurosciences (“Ecole pratique des hautes études”, Sorbonne, Paris) where she studied anatomical correlation of neuropsychological tests in a cohort of healthy elderly subjects (3C-cohort) with Voxel Based Morphometry, directed by G. Catheline.

    She is currently a master 2 student in Epidemiology at the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux. She is focusing on MRI markers of cerebral small vessel disease and their shared genetic variants, under the supervision of Stéphanie Debette.

  • Blandine Gendre
  • Morgane Lachaize Gaboreau
    Clinical Project Manager

    Education:

    2011-2012: Study coordinator degree (DIU FARC)

    2009 – 2011: MSc degree on Neurosciences et Neuropsychopharmacology 

    2006-2009: Bachelor degree on Biology

    Positions:

    Jul 2011 – Apr 2012: Clinical Research Technicien in Hepatogastroenterlogy department (Bordeaux Hospital)

    May 2012 – Mar 2017: Study Coordinator in Neurology department (Bordeaux Hospital) on parkinsonian syndromes, amyotrophic lateral sclerosis, neuromuscular disease

    Since Jan 2017: Project Manager in the ELEANOR team of the clinical and regulatory part of the Prof Stephanie Debette’s projects (SHIVA University-Hospital Research, PRESTIGE-AF…)

     

  • Quentin Le Grand
    PhD Student in Epidemiology
  • Sophie Lefevre-Arbogast
    Postdoctoral Research Fellow in Epidemiology, Bordeaux Population Health Research Center, team ELEANOR, INSERM U1219, Univ Bordeaux

    RESEARCH EXPERIENCE

     

    • Bordeaux Population Health Research Center (team ELEANOR),  INSERM U1219, Univ Bordeaux, France  & Research Institute for Environmental and Occupational Health (team 9), INSERM U1085, EHESP, Univ Rennes
      • Since Apr 2022 : Postdoctoral Research Fellow
    • François Baclesse Cancer Center, ANTICIPE INSERM U1086, Caen, France
      • Nov 2020 – Mar 2022 : Biostatistian
    • Rush University Medical Center, Rush Institute for Healthy Aging, Chicago, United States
      • Mar 2020 – Oct 2020 : Postdoctoral Research Fellow
    • Bordeaux Population Health Research Center (team LEHA),  INSERM U1219, Univ Bordeaux, France
      • Nov 2019 – Feb 2020 : Postdoctoral Research Fellow
      • Oct 2016 – Oct 2019 : PhD Fellow (Supervision: C. Samieri)
      • Feb 2016 – Sept 2016 : MSc Training Course

    EDUCATION

    • Oct 2019 : Public Health – Epidemiology, PhD, University of Bordeaux, Bordeaux, France
    • Sept 2016 : Agri-Food Sciences, MSc (French Engineering Degree), Agrocampus Ouest, Rennes, France
    • Sept 2016 : Applied Statistics, MSc, University of Rennes 2 – Agrocampus Ouest, Rennes, Franc

     

  • Caroline Meguerditchian
  • Aniket Mishra
    Tenured Researcher in Statistical Genetics
    Serial Number  Degree University Year
    1. Bachelor of Engineering in Biotechnology Shivaji University, Kolhapur, India 2004-08
    2. Master of Science in Analytical Genomics University of Birmingham, Birmingham, United Kingdom 2009-10 
    3. PhD in Statistical Genetics University of Queensland, Brisbane, Australia  2011-15 
  • Gaelle Munsch
  • Carole Proust
    Assistant Ingénieur

    Carole Proust is Engineer inserm since 2004. Carole is a biologist working with David-Alexandre Trégouët to characterize the role of rare DNA variants in thrombotic disorders using various experimental functional analyses. Carole was recruited at INSERM in 2004 to reorganize, perpetuate and establish new cardiovascular DNA biobanks (up to ~50 000 samples) as part of the previous INSERM U525/U937 department directed by Dr François Cambien in Paris. She was then in charge of several high-throughput genotyping and transcriptomics projects to search for new susceptibility genes for cardiovascular diseases. By 2014, as part of the Team Genomics of Cardiovascular Diseases headed by David Trégouët at INSERM U1166 in Paris, she gained experience in more experimental biology to functionally characterize the role of genetic variations on thrombotic processes. In 2018, she followed David Trégouët and move to Bordeaux, INSERM U1219 , to pursue their joint research program on venous thrombosis. On a daily basis, Carole is working in the INSERM U1034 lab directed by Thierry Couffinahl which offers the necessary environment to follow her experimental work.

  • Cecilia Samieri
    Chercheuse INSERM (Senior Researcher, INSERM (French National Institute for Health)

    Parcours

    EDUCATION/TRAINING

    INSTITUTION AND LOCATION DEGREE COMPLETION DATE FIELD OF STUDY
    Université de Bordeaux, Bordeaux, France HDR (Habilitation à diriger des recherches ; accreditation to direct research) 2018
    Epidemiology
    INSERM U897 and Université de Bordeaux, Bordeaux, France Junior Research Position (French Fondation Plan Alzheimer grant) 2012-2015 Epidemiology – Alzheimer’s disease
    Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

    Postdoctoral Research fellow

    2011-2012 Epidemiology
    Université de Bordeaux, Bordeaux, France Postdoctoral Research fellow 2010-2011 Epidemiology (applied Biostatistics and neuro-imaging)
    Université de Bordeaux, Bordeaux, France Ph.D (upper honours, Mention Très Honorable) 2007-2009 Epidemiology
    Université Paris XI, Paris, France M.Sc (upper honours, Mention Très Bien) 2005-2006 Methodology and Statistics in Biomedical Research
    Université Paris XII, Paris, France Doctorate 2004 Veterinary medicine

    Lycée Michel Montaigne, Bordeaux, France

    Baccalaureate diploma (upper honours, Mention Très Bien) 1997 Mathematics
  • Aïcha Soumaré
    Epidemiologist

    Aïcha Soumaré, earned a PhD in Public Health-Epidemiology with upper honors from the Paris-Sud 11 University in 2009, and is a recipient of the Halimi/Aguirre-Basualdo Ph.D award specialized in medicine*.

    Her research focuses on the environmental and genetic determinants of stroke, dementia, and MRI markers of brain aging.

    Prior to joining the Bordeaux team of Pr. Debette in 2015 as an epidemiologist, she worked in the same capacity at the Parisian INSERM unit U708-“neuroepidemiology” for five years. There, she contributed, among other things, to the identification of risk factors of dilated perivascular spaces in the general population, as well as to the first study and paper reporting the increased risk of dementia associated with this particular emerging MRI marker of cerebral small vessel disease (cSVD) in the context of a large population-based sample of elderly individuals. 

    Since then, her Bordeaux adventure has led to various other contributions to the scientific literature including –but not limited to– the investigation of the influence of environmental factors (e.g., orthostatic hypotension, lipids, blood biomarkers or individual protein levels) on dementia and MRI-cSVD markers, the exploration of causal pathways between cerebrovascular disease and dementia using genetic instruments/polygenic risk scores, or the assessment of the prevalence and severity of brain incidental findings on healthy young adults MRIs.

    Recently, she has developed an interest in the “the retina is a window to the brain” concept which proposes that the retinal microvasculature might be used as a proxy for its brain counterpart based on their similarities. Leveraging this concept could theoretically facilitate early detection of patients at high risk for cSVD and improve characterization of cSVD into subtypes based on retinal vascular characteristics. Hence, one of her objectives is to test this “retina-brain”model as reflected by some of her current orientations that involve for example (i) conducting a systematic review of the literature summarizing current data on the relation between brain MRI and retinal cSVD biomarkers, (ii) examining, as proof of concept, whether traditional fundus-based retinal microvascular geometric features are associated with common visible MRI-cSVD markers including a newly generated extreme cSVD phenotype, (iii) extending those investigations to novel high-resolution AO and OCT-A retinal microvascular biomarkers and cSVD biomarkers (common and emerging) quantified by cutting-edge methods developed by her group (RHU SHIVA), (iv) exploring associations of genetic (polygenic) risk scores of those cSVD biomarkers with incident dementia…

    Dr. Soumaré also collaborates with the Steering committee of the 3C study by handling the proposals of ancillary studies and data access to the cohort in the context of its coordinating center.

     

    * from the Chancellerie des Universités de Paris
  • Judith Thomas Crusells
    PhD
    International Project Manager

    Judith Thomas Crusells est titulaire d’un doctorat en neurosciences de l’université d’Helsinki (Finlande), d’un master en biotechnologie de l’université de Kuopio (Finlande) et d’un diplôme en commerce, marketing et relations publiques de l’université ouverte de Catalogne (Espagne). Sa carrière scientifique dans les domaines des facteurs de croissance neuronale et de la survie neuronale après une lésion a été développée dans des institutions internationales renommées telles que l’Institut de biotechnologie (Helsinki, Finlande), l’hôpital universitaire de la Sarre (Homburg, Allemagne), l’hôpital universitaire de Zurich et l’École polytechnique fédérale de Zurich (ETH, Zürich, Suisse).

    Judith a également été engagée comme consultante technique à l’Organisation mondiale de la santé (OMS, Genève, Suisse) dans les départements de la santé publique et environnementale, des vaccins et de la santé mentale, où elle était responsable de la coordination de projets et d’initiatives internationaux, de l’organisation de conférences internationales et de l’élaboration de documents techniques sur l’évaluation de la charge mondiale de morbidité.

    Depuis janvier 2016, Judith travaille en tant que chef de projet dans l’équipe ELEANOR en collaborant à la gestion de projets nationaux et internationaux dirigés par le Prof. Stéphanie Debette

     

     

  • David-Alexandre Trégouët
  • Violaine Verrecchia
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