Psychoepidemiology of aging and chronic diseases

The research programs conducted within the team “Psychoepidemiology of Aging and Chronic diseases” associate methods from Epidemiology and Psycho-Neuropsychology to study the influence of psycho-social factors on clinical trajectories and use of care in aging and chronic diseases.


Part of the team is highly involved in the study of the contribution of cognitive, psychological and social psychosocial factors to frailty syndrome recently labelled as an “International Associated Laboratory” titled “Frailty, Cognition and Aging” INSERM and the Mexican National Institute of Geriatrics (INGER).
The team relies on 8 permanent researchers, 4 post-doc researchers, 4 medical doctors, 2 statistician engineers, 8 technical and methodological support staff and 5 PhD students.

Such approach considers the vulnerability of persons suffering from chronic diseases within an integrative and global approach including physical, psychological, familial and social factors, their impact on disease expression and the use of care.
In this context, the team “Psycho-epidemiology of aging and chronic diseases” aims at providing a comprehensive approach of the changes in functional autonomy, cognitive, psychological and familial functioning occurring in aging and chronic diseases. Beyond this observational approach, the research program includes several clinical studies aiming at assessing the impact of psycho-social interventions in aging and chronic diseases.

Research area


Changes in functional ability, cognitive, psychological, familial functioning in aging and chronic diseases (Coordinator: Karine Pérès)

The first axis of our research is oriented towards a comprehensive approach of the changes in functional autonomy, cognitive, psychological and familial functioning associated with aging and chronic diseases. In particular several research projects address the questions of whether and how psycho-social and cultural factors modulate incidence and expression of Alzheimer’s disease and related disorders, the impact of professional retirement on cognitive and psychological functioning, the relationship between psychiatric and cognitive features of aging, and the contribution of psychosocial, familial and professional environment on disease management. Most of studies are conducted within the ongoing prospective population-based studies: PAQUID, Three-Cities and AMI studies coordinated by our team.


Psychosocial interventions and care strategies (Coordinator: Hélène Amieva)

The second axis of our research is oriented towards psycho-social interventions conducted in patients (and/or family caregivers) with neurodegenerative diseases and cardiovascular diseases. Several researches aim at assessing the impact of non-pharmacological treatments in several neurodegenerative conditions as well as the impact of therapeutic patient/caregiver education interventions in cardiovascular diseases.

Main publications

  1. Amieva H, Robert PH, Grandoulier AS, Meillon C, De Rotrou J, Andrieu S, Berr C, Desgranges B, Dubois B, Girtanner C, Joël ME, Lavallart B, Nourhashemi F, Pasquier F, Rainfray M, Touchon J, Chêne G, Dartigues JF. Group and individual cognitive therapies in Alzheimer’s disease: the ETNA3 randomized trial. Int Psychogeriatr. 2015:1-11.
  2. Amieva H, Ouvrard C, Giulioli C, Meillon C, Rullier L, Dartigues JF. Self-Reported Hearing Loss, Hearing Aids, and Cognitive Decline in Elderly Adults: A 25-Year Study. J Am Geriatr Soc. 2015;63(10):2099-104.
  3. Amieva H, Mokri H, Le Goff M, Jacqmin-Gadda H, Foubert-Samier A, Orgogozo JM, Stern Y, Dartigues JF. Compensatory mechanisms in higher-educated subjects with Alzheimer’s disease: a study of 20 years of cognitive decline. Brain 2014;137:1167-75.
  4. González-Colaço Harmand M, Meillon C, Rullier L, Avila-Funes JA, Bergua V, Dartigues JF, Amieva H. Cognitive decline after entering a nursing home: a 22-year follow-up study of institutionalized and noninstitutionalized elderly people. J Am Med Dir Assoc 2014;15(7):504-8.
  5. Pérès K, Helmer C, Amieva H, Matharan F, Carcaillon L, Jacqmin-Gadda H, Auriacombe S, Orgogozo JM, Barberger-Gateau P, Dartigues JF.  Gender differences in the prodromal signs of dementia: memory complaint and IADL-restriction. a prospective population-based cohort. J Alzheimers Dis. 2011;27(1):39-47.


Centre de recherche INSERM U1219
Université de Bordeaux – ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex

Tél : +33 (0)5 57 57 15 96
Tél : +33 (0)5 57 57 15 98
Fax : +33 (0)5 57 57 14 86

  • Director : Hélène Amieva
  • Contact : Marie-Hélène Sage


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