The team is devoted to Pharmacoepidemiology, which studies medical drugs and devices at the level of populations. The researches conducted aim to characterize drug patterns of use and potential misuses, assess potential health hazards associated with this use in real-life, and ensure that the beneficial effect proven in clinical trials is confirmed in everyday use. The final aim is to quantify the actual public health impact of marketed medicines.
Objectives
The challenge is to identify patterns of use of medical drugs that compromise their beneficial effects on public health. The prerequisite for a medical drug to be marketed is that the information obtained from clinical trials, i.e. in experimental conditions of use, allows considering that the benefit it will provide to public health outweighs the burden of its unavoidable adverse effects. Once a medical drug gets marketed, it is no longer used in this experimental, controlled, setting but in real-life “natural” conditions, in which some specific patterns of uses or some uses in specific populations can convey increased risks for public health. These uses and associated risks can alter drastically the benefit-risk balance of the drug and its impact on population health. The objective of the team is to identify such situations; the key aspects of the researches conducted in this purpose are the following:
- the more a drug is used, the most important its impact on public health (positive or negative) can be
- this impact, in terms of risk, can be increased when the populations using the drug present with specific frailties, as in the case of cancer for instance
- in situations of massive use, even mild to moderate effects on health induced by drugs can convey a tremendous impact on public health
- such mild to moderate changes (beneficial or detrimental) are the most difficult to identify and quantify in an real-life setting.
Conducting such researches consequently implies, aside to the performing of studies applied to specific fields of health, to continuously develop and assess new methods for the study of drugs in real-life setting.
Research areas
- Pharmacoepidemiology of psychotropic drugs
- Pharmacoepidemiology of cancer drugs
- Research, development and assessment of new methods applied to pharmacoepidemiology
Main publications
- Blin P, Fauchier L, Dureau-Pournin C, Sacher F, Dallongeville J, Bernard MA, Lassalle R, Droz-Perroteau C, Moore N. Effectiveness and Safety of Rivaroxaban 15 or 20 mg Versus Vitamin K Antagonists in Nonvalvular Atrial Fibrillation. Stroke. 2019;50:2469-76.
- Verdoux H, Quiles C, de Leon J. Clinical determinants of fever in clozapine users and implications for treatment management: A narrative review. Schizophr Res. 2019;211:1-9
- Prevel R, Boyer A, M’Zali F, Lasheras A, Zahar JR, Rogues AM, Gruson D. Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review. Crit Care. 2019;23:170
- Verdoux H, Pambrun E, Tournier M, Cortaredona S, Verger P. Multi-trajectories of antidepressant and antipsychotic use: a 11-year naturalistic study in a community-based sample. Acta Psychiatr Scand. 2019;139:536-47
- Gouverneur A, Bezin J, Jové J, Bosco-Lévy P, Fourrier-Réglat A, Noize P. Treatment Modalities and Survival in Older Adults with Metastatic Colorectal Cancer in Real Life. J Am Geriatr Soc. 2019;67:913-19
- Bezin J, Moore N, Mansiaux Y, Steg PG, Pariente A. Real-Life Benefits of Statins for Cardiovascular Prevention in Elderly Subjects: A Population-Based Cohort Study. Am J Med. 2019;132:740-48
- Devillier P, Molimard M, Ansolabehere X, Bardoulat I, Coulombel N, Maurel F, Le Jeunne P, Demoly P. Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France. Allergy. 2019;74:1317-26
- Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N. Comparative Effectiveness and Safety of Standard or Reduced Dose Dabigatran vs. Rivaroxaban in Nonvalvular Atrial Fibrillation. Clin Pharmacol Ther. 2019;105:1439-1455
- Verdoux H, Pambrun E, Tournier M, Cortaredona S, Verger P. Trajectories of Antipsychotic Drug Use Over 10 Years in a French Community-Based Sample of Persons Aged 50 and Older. Am J Geriatr Psychiatry. 2019;27:73-83
- Bezin J, Mansiaux Y, Noize P, Salvo F, Bégaud B, Pariente A. Use of Lipid-Lowering Drugs and the Risk of Cataract: A Population-Based Nested Case-Control Study. Clin Pharmacol Ther. 2019;105:458-65
Complete list of the publications (2015-2020)
Details
Centre de recherche INSERM U1219
Université de Bordeaux – ISPED case 11
146 rue Léo-Saignat
33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 95 12
Informations
News
- 2 Jan 2020
Creation of the DRUGS-SAFER Centre
After five years of collaboration within the framework of the National Platform of Pharmacoepidemiology DRUGS-SAFE, the research partnership…
- 27 Dec 2019
PROSIT project: The Medicines and ERIAS teams laureates of the Research Call PREPS 2019
The PROSIT project coordinated by the BPH Pharmacoepi team was selected as part of the 2019 DGOS-PREPS Research…
- 15 Nov 2019
Launch of the IRAZU Project (PHRC-K 2018)
The IRAZU project focuses on the impact of cardiovascular co-morbidities on the efficacy of bevacizumab, in real care…
