The team studies populations of different ages (elderly, middle-aged, young), in prospective designs allowing for the study of long-term, slow processes, and using subclinical biomarkers allowing for the detection of early health-related effects of exposures.
Objectives
Age-related diseases are long-term processes, developing over several decades. Exposures that may favour or, on the contrary, prevent their development also probably have long-term, cumulative effects. The study of such lifelong effects of exposures represents a major challenge for the epidemiologist, but raises the hope of opening new avenues for the prevention of age-related diseases, in particular by identifying specific time windows for intervention.
We will study populations of different ages (elderly, middle-aged, young), in prospective designs allowing for the study of long-term, slow processes, and using subclinical biomarkers allowing for the detection of early health-related effects of exposures. Models of aging will be mainly neurological and eye diseases, but will extend to other health endpoints, such as physical performance, diabetes or renal insufficiency.
Research area
- The first axis “aging, health and disability” will provide a public health perspective of aging (including secular trends in health status and disability, as well as the study of recourse to care in the elderly). We will also provide some insights into major pathophysiological mechanisms of age-related diseases (mainly of the brain, eye and kidney), in particular by using ocular biomarkers of microvascular and neurological status, as well as biomarkers of infections and inflammation.
- In the second axis “nutrition, health and aging”, we will study the role of nutrition in brain and eye aging, but also in physical performance decline and sarcopenia. Metabolic disorders and obesity will also be addressed. This axis will combine observational and interventional studies, at different key ages.
- Finally, the third axis “toxic exposures, health and aging” will be dedicated to the study of the associations of age-related diseases (mainly of the brain and eye) with voluntary (smoking, alcohol, other drugs) and professional and environmental exposures (in particular pesticides).
Main publications
- Cosh S, Carriere I, Nael V, Tzourio C, Delcourt C, Helmer C; Sense-Cog Consortium. The association of vision loss and dimensions of depression over 12 years in older adults: Findings from the Three City study. J Affect Disord. 2019 Jan 15;243:477-484. doi: 10.1016/j.jad.2018.09.071.
- Butcher L, Pérès K, André P, Morris RH, Walter S, Dartigues JF, Rodriguez-Mañas L, Feart C, Erusalimsky JD; FRAILOMIC consortium. Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers. Exp Gerontol. 2018 Nov;113:173-179. doi: 10.1016/j.exger.2018.10.004. Epub 2018 Oct 9.
- Grasset L, Jacqmin-Gadda H, Proust-Lima C, Pérès K, Amieva H, Dartigues JF, Helmer C. Temporal Trends in the Level and Decline of Cognition and Disability in an Elderly Population: The PAQUID Study. Am J Epidemiol. 2018 Oct 1;187(10):2168-2176. doi: 10.1093/aje/kwy118.
- Pilleron S, Pérès K, Jutand MA, Helmer C, Dartigues JF, Samieri C, Féart C. Dietary patterns and risk of self-reported activity limitation in older adults from the Three-City Bordeaux Study. Br J Nutr. 2018 Sep;120(5):549-556. doi: 10.1017/S0007114518001654.
- Naël V, Moreau G, Monfermé S, Cougnard-Grégoire A, Scherlen AC, Arleo A, Korobelnik JF, Delcourt C, Helmer C. Prevalence and Associated Factors of Uncorrected Refractive Error in Older Adults in a Population-Based Study in France. JAMA Ophthalmol. 2018 Sep 20. doi: 10.1001/jamaophthalmol.2018.4229.
- Colijn JM, Hollander AID, Demirkan A, Cougnard-Grégoire A, Verzijden T, Kersten E, Meester MA, Merle BMJ, Papageorgiou G, Ahmad S, Mulder MT, Costa MA, Benlian P, Bertelsen G, Bron A, Claes B, Creuzot-Garcher C, Erke MG, Fauser S, Foster PJ, Hammond CJ, Hense HW, Hoyng CB, Khawaja AP, Korobelnik J, Piermarocchi S, Segato T, Silva R, Souied EH, Williams KM, van Duijn CM, Delcourt C, Klaver CCW; E3 Consortium and EYE-RISK Consortium. Increased High Density Lipoprotein-levels associated with Age-related Macular degeneration. Evidence from the EYE-RISK and E3 Consortia. Ophthalmology. 2018 Oct 10. pii: S0161-6420(18)31091-1. doi: 10.1016/j.ophtha.2018.09.045. [Epub ahead of print]
- Samieri C, Perier MC, Gaye B, Proust-Lima C, Helmer C, Dartigues JF, Berr C, Tzourio C, Empana JP. Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia. JAMA. 2018 Aug 21;320(7):657-664. doi: 10.1001/jama.2018.11499.
- Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C*, Samieri C*. Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia. JAMA Psychiatry. 2018 Oct 1;75(10):1033-1042. doi: 10.1001/jamapsychiatry.2018.2004.
- Merle BMJ, Colijn JM, Cougnard-Grégoire A, de Koning-Backus APM, Delyfer MN, Kiefte-de Jong JC, Meester-Smoor M, Féart C, Verzijden T, Samieri C, Franco OH, Korobelnik JF, Klaver CCW, Delcourt C; EYE-RISK Consortium. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium. Ophthalmology. 2018 Aug 13. pii: S0161-6420(18)30721-8. doi: 10.1016/j.ophtha.2018.08.006. [Epub ahead of print]
- Aldebert G, Faillie JL, Hillaire-Buys D, Mura T, Carrière I, Delcourt C, Creuzot-Garcher C, Villain M, Daien V. Association of Anticholinergic Drug Use With Risk for Late Age-Related Macular Degeneration. JAMA Ophthalmol. 2018 Jul 1;136(7):770-778. doi: 10.1001/jamaophthalmol.2018.1719.
- Blanc-Bisson C, Velayoudom-Cephise FL, Cougnard-Gregoire A, Helmer C, Rajaobelina K, Delcourt C, Alexandre L, Blanco L, Mohammedi K, Monlun M, Rigalleau V. Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study. Cardiovasc Diabetol. 2018 Jun 8;17(1):82. doi: 10.1186/s12933-018-0718-8.
- Lefèvre-Arbogast S, Gaudout D, Bensalem J, Letenneur L, Dartigues JF, Hejblum BP, Féart C, Delcourt C, Samieri C. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology. 2018 May 29;90(22):e1979-e1988. doi: 10.1212/WNL.0000000000005607. Epub 2018 Apr 27.
- Samieri C, Morris MC, Bennett DA, Berr C, Amouyel P, Dartigues JF, Tzourio C, Chasman DI, Grodstein F. Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons. Am J Epidemiol. 2018 May 1;187(5):933-940. doi: 10.1093/aje/kwx330.
- Ajana S, Weber D, Helmer C, Merle BM, Stuetz W, Dartigues JF, Rougier MB, Korobelnik JF, Grune T, Delcourt C, Féart C. Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1828-1835. doi: 10.1167/iovs.17-22656
- Wagner M, Dartigues JF, Samieri C*, Proust-Lima C*. Modeling Risk-Factor Trajectories When Measurement Tools Change Sequentially During Follow-up in Cohort Studies: Application to Dietary Habits in Prodromal Dementia. Am J Epidemiol. 2018 Apr 1;187(4):845-854. doi: 10.1093/aje/kwx293.
- Harambat J, Kunzmann K, Azukaitis K, Bayazit AK, Canpolat N, Doyon A, Duzova A, Niemirska A, Sözeri B, Thurn-Valsassina D, Anarat A, Bessenay L, Candan C, Peco-Antic A, Yilmaz A, Tschumi S, Testa S, Jankauskiene A, Erdogan H, Rosales A, Alpay H, Lugani F, Arbeiter K, Mencarelli F, Kiyak A, Dönmez O, Drozdz D, Melk A, Querfeld U, Schaefer F; 4C Study Consortium. Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease. Kidney Int. 2017 Dec;92(6):1507-1514. doi: 10.1016/j.kint.2017.05.006
- Feart C, Helmer C, Merle B, Herrmann FR, Annweiler C, Dartigues JF, Delcourt C, Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017 Nov;13(11):1207-1216.
- Korobelnik JF, Rougier MB, Delyfer MN, Bron A, Merle BMJ, Savel H, Chêne G, Delcourt C, Creuzot-Garcher C. Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial. JAMA Ophthalmol. 2017 Nov 1;135(11):1259-1266.
- Amadieu C, Lefèvre-Arbogast S, Delcourt C, Dartigues JF, Helmer C, Féart C, Samieri C. Nutrient biomarker patterns and long-term risk of dementia in older adults. Alzheimers Dement. 2017 Oct;13(10):1125-1132.
- Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4569-4578.
- Kaboré R, Couchoud C, Macher MA, Salomon R, Ranchin B, Lahoche A, Roussey-Kesler G, Garaix F, Decramer S, Pietrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K, Harambat J. Age-Dependent Risk of Graft Failure in Young Kidney Transplant Recipients. Transplantation. 2017 Jun;101(6):1327-1335.
- Chesnaye NC, Schaefer F, Bonthuis M, Holman R, Baiko S, Baskın E, Bjerre A, Cloarec S, Cornelissen EAM, Espinosa L, Heaf J, Stone R, Shtiza D, Zagozdzon I, Harambat J, Jager KJ, Groothoff JW, van Stralen KJ; ESPN/ERA-EDTA Registry Committee. Mortality risk disparities in children receiving chronic renal replacement therapy for the treatment of end-stage renal disease across Europe: an ESPN-ERA/EDTA registry analysis. Lancet. 2017 May 27;389(10084):2128-2137
- Rahi B, Ajana S, Tabue-Teguo M, Dartigues JF, Peres K, Feart C. High adherence to a Mediterranean diet and lower risk of frailty among French older adults community-dwellers: Results from the Three-City-Bordeaux Study. Clin Nutr. 2017 May 31.
Details
Centre de recherche INSERM U1219
Université de Bordeaux, ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 95 38
Tél : +33 (0)5 57 57 15 96
Fax : +33 (0)5 57 57 14 86
Informations
Members
- Soufiane Ajana
- Audrey Cougnard-Gregoire
- Cecile Delcourt
- MarieNoelle Delyfer
- Bénédicte Driollet
- Catherine Feart
- Leslie Grasset
- Jérôme Harambat
- Emilie Hucteau
- Jean-Francois Korobelnik
- Corinne Lacour
- Melanie Le Goff
- Sophie Lefevre-Arbogast
- Morgane Linard
- Benedicte Merle
- Sylvie Mivielle
- Hermine Pellay
- Kalina Rajaobelina
- Vincent Rigalleau
- Cedric Schweitzer
- Maude Wagner
