Lifelong exposures health and aging – LEHA

The team studies populations of different ages (elderly, middle-aged, young), in prospective designs allowing for the study of long-term, slow processes, and using subclinical biomarkers allowing for the detection of early health-related effects of exposures.

Objectives

Age-related diseases are long-term processes, developing over several decades. Exposures that may favour or, on the contrary, prevent their development also probably have long-term, cumulative effects. The study of such lifelong effects of exposures represents a major challenge for the epidemiologist, but raises the hope of opening new avenues for the prevention of age-related diseases, in particular by identifying specific time windows for intervention.

We will study populations of different ages (elderly, middle-aged, young), in prospective designs allowing for the study of long-term, slow processes, and using subclinical biomarkers allowing for the detection of early health-related effects of exposures. Models of aging will be mainly neurological and eye diseases, but will extend to other health endpoints, such as physical performance, diabetes or renal insufficiency.

 

2016-10-13_Equipe-LEHA_U1219

Research area

  • The first axis “aging, health and disability” will provide a public health perspective of aging (including secular trends in health status and disability, as well as the study of recourse to care in the elderly). We will also provide some insights into major pathophysiological mechanisms of age-related diseases (mainly of the brain, eye and kidney), in particular by using ocular biomarkers of microvascular and neurological status, as well as biomarkers of infections and inflammation.
  • In the second axis “nutrition, health and aging”, we will study the role of nutrition in brain and eye aging, but also in physical performance decline and sarcopenia. Metabolic disorders and obesity will also be addressed. This axis will combine observational and interventional studies, at different key ages.
  • Finally, the third axis “toxic exposures, health and aging” will be dedicated to the study of the associations of age-related diseases (mainly of the brain and eye) with voluntary (smoking, alcohol, other drugs) and professional and environmental exposures (in particular pesticides).

 



Main publications

  1. Delcourt C, Souied E, Sanchez A, Bandello F; STARS Survey Group. Development and Validation of a Risk Score for Age-Related Macular Degeneration: The STARS Questionnaire. Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6399-6407.
  2. Feart C, Helmer C, Merle B, Herrmann FR, Annweiler C, Dartigues JF, Delcourt C, Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017 Nov;13(11):1207-1216.
  3. Korobelnik JF, Rougier MB, Delyfer MN, Bron A, Merle BMJ, Savel H, Chêne G, Delcourt C, Creuzot-Garcher C. Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial. JAMA Ophthalmol. 2017 Nov 1;135(11):1259-1266.
  4. Amadieu C, Lefèvre-Arbogast S, Delcourt C, Dartigues JF, Helmer C, Féart C, Samieri C. Nutrient biomarker patterns and long-term risk of dementia in older adults. Alzheimers Dement. 2017 Oct;13(10):1125-1132.
  5. Samieri C, Morris MC, Bennett DA, Berr C, Amouyel P, Dartigues JF, Tzourio C, Chasman DI, Grodstein F. Fish intake, genetic predisposition to alzheimer’s disease and decline in global cognition and memory in five cohorts of older persons. Am J Epidemiol. 2017 Oct 19. [Epub ahead of print]
  6. Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4569-4578.
  7. Wagner M, Dartigues JF, Samieri C, Proust-Lima C. Modeling Risk Factor Trajectories When Measurement Tools Change Sequentially During Follow-up in Cohort Studies: Application to Dietary Habits in Prodromal Dementia. Am J Epidemiol. 2017 Aug 23. doi: 10.1093/aje/kwx293. [Epub ahead of print]
  8. Kaboré R, Couchoud C, Macher MA, Salomon R, Ranchin B, Lahoche A, Roussey-Kesler G, Garaix F, Decramer S, Pietrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K, Harambat J. Age-Dependent Risk of Graft Failure in Young Kidney Transplant Recipients. Transplantation. 2017 Jun;101(6):1327-1335.
  9. Chesnaye NC, Schaefer F, Bonthuis M, Holman R, Baiko S, Baskın E, Bjerre A, Cloarec S, Cornelissen EAM, Espinosa L, Heaf J, Stone R, Shtiza D, Zagozdzon I, Harambat J, Jager KJ, Groothoff JW, van Stralen KJ; ESPN/ERA-EDTA Registry Committee. Mortality risk disparities in children receiving chronic renal replacement therapy for the treatment of end-stage renal disease across Europe: an ESPN-ERA/EDTA registry analysis. Lancet. 2017 May 27;389(10084):2128-2137
  10. Rahi B, Ajana S, Tabue-Teguo M, Dartigues JF, Peres K, Feart C. High adherence to a Mediterranean diet and lower risk of frailty among French older adults community-dwellers: Results from the Three-City-Bordeaux Study. Clin Nutr. 2017 May 31.
  11. Naël V, Pérès K, Carrière I, Daien V, Scherlen AC, Arleo A, Korobelnik JF, Delcourt C, Helmer C. Visual Impairment, Undercorrected Refractive Errors, and Activity Limitations in Older Adults: Findings From the Three-City Alienor Study. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2359-2365.
  12. Lefèvre-Arbogast S, Féart C, Dartigues JF, Helmer C, Letenneur L, Samieri C. Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons. Nutrients. 2016 Nov 26;8(12).
  13. Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, Cougnard-Gregoire A, Merle BMJ, Korb C, Erke MG, Bron A, Anastasopoulos E, Meester-Smoor MA, Segato T, Piermarocchi S, de Jong PTVM, Vingerling JR, Topouzis F, Creuzot-Garcher C, Bertelsen G, Pfeiffer N, Fletcher AE, Foster PJ, Silva R, Korobelnik JF, Delcourt C, Klaver CCW; EYE-RISK consortium; European Eye Epidemiology (E3) consortium. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. 2017 Dec;124(12):1753-1763.
  14. Rajaobelina K, Helmer C, Vélayoudom-Céphise FL, Nov S, Farges B, Pupier E, Blanco L, Hugo M, Gin H, Rigalleau V. Progression of skin autofluorescence of AGEs over 4 years in patients with type 1 diabetes. Diabetes Metab Res Rev. 2017 Oct;33(7).
  15. Tellouck L, Durieux M, Coupé P, Cougnard-Grégoire A, Tellouck J, Tourdias T, Munsch F, Garrigues A, Helmer C, Malet F, Dartigues JF, Dousset V, Delcourt C, Schweitzer C. Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging.Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6539-6547
  16. Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Le Goff M, Samieri C, Dartigues JF, Delcourt C. Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study. PLoS One. 2016 Jul 28;11(7):e0160240.
  17. Merle BM, Silver RE, Rosner B, Seddon JM. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr;103(4):1135-44.
  18. Grasset L, Brayne C, Joly P, Jacqmin-Gadda H, Peres K, Foubert-Samier A, Dartigues JF, Helmer C. Trends in dementia incidence: Evolution over a 10-year period in France. Alzheimers Dement. 2016 Mar;12(3):272-80.

Details

Centre de recherche INSERM U1219
Université de Bordeaux, ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex

Tél : +33 (0)5 57 57 95 38
Tél : +33 (0)5 57 57 15 96
Fax : +33 (0)5 57 57 14 86



Informations

Members


  • Soufiane Ajana
  • Audrey Cougnard-Gregoire
    Ingénieur d’étude, PhD

    Education 

    2006  Short Fellowship in the Department of Psychiatry and Psychology, Maastricht University Medical Centre

    2005  Short Fellowship in McGill University, Department of Schizophrenia and Neurodevelopmental Disorders Research 

     2004   PhD in Public Health and Epidemiology, Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

    2000 Master of Public Health and Epidemiology, Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

  • Cecile Delcourt
    Directrice de Recherche Inserm
    Directrice de l’équipe
  • MarieNoelle Delyfer
    Professeur des Universités – Praticien Hospitalier
  • Bénédicte Driollet
    PhD student Epidemiology, Bordeaux Population Health Research Center, LEHA team, INSERM U1219

    EXPERIENCE

    • Sep 2017 – Today : PhD Student, Public Health, Epidemiology surpervised by J. Harambat and K. Leffondré (LEHA team) – Bordeaux Population Health Research Center – INSERM U1219
    • Feb – Aug 2017 : Final year trainee in Epidemiology and Biostatistics (LEHA team) – Bordeaux Population Health Research Center – INSERM U1219
    • Apr – Jun 2016 : Trainee in Epidemiology (Infection Group) – School of Medecine, University of St Andrews, Scotland

    EDUCATION

    • 2015 – 2017 : Master’s degree in Public Health and Epidemiology, Institute of Public Health Epidemiology and Development (ISPED) – University of Bordeaux 
    • 2013 – 2015 : Bachelor’s degree in Applied mathematics in social sciences, major in cognitive sciences- University of Bordeaux
    • 2011-2013 : First year of medical studies – University of Bordeaux
    • 2011 : Baccalauréat in science with honors – Saint Louis Villa Pia High School, Bayonne
  • Catherine Feart
    Chargée de recherche INSERM

    Parcours

    Researcher in Nutritional Epidemiology

     

    Contact details:

    Epidemiology of Nutrition and Food Behaviors

    National Institute of Health and Medical Research (INSERM) U1219

    University of Bordeaux

    146 Rue Léo Saignat

    CS61292

    33076 Bordeaux cedex

    Tel + 33 5 47 30 42 04

    Fax + 33 5 57 57 14 86

    catherine.feart@isped.u-bordeaux2.fr

     

    Education :

    Post-Doctoral fellowship in the Team Epidemiology of Nutrition, INSERM U897 (2006-2011)

    Post-Doctoral fellowship in the Unit of Nutrition and Cellular Signalling, Bordeaux University (2004-2005)

    PhD in Food Sciences and Nutrition, Bordeaux University, France (2004)

    Master in Food Sciences and Nutrition, Bordeaux University, France (2000)

     

    Domains of research:

    Epidemiology of nutrition and age-related disorders, including dementia.

    The original feature of my research is to associate methods from epidemiology and biology to study the mechanisms underlying the association between nutrition and age-related disorders, among aged participants of long follow-up cohort studies.

     

     

     

     

     

     

     

     

     

     

  • Leslie Grasset
    Doctorante en épidémiologie
  • Jérôme Harambat
    MD PhD

    Parcours

    2015    Habilitation à Diriger des Recherches (Université de Bordeaux)

    2013    Thèse d’Université en Epidémiologie (Université de Bordeaux)

    2010-11  Mobilité Recherche Université d’Amsterdam

    2011    Concours national de Praticien Hospitalier

    2006-7  Mobilité clinique CHU de Lyon

    2006    Thèse de Doctorat en Médecine (Bordeaux 2)

    2006    DES de Pédiatrie (Bordeaux 2)

    2006    DIU de Néphrologie Pédiatrique (Lyon 1)

    2005    Master Recherche en Epidémiologie et Biostatistiques (Bordeaux 2)

  • Emilie Hucteau
  • Jean-Francois Korobelnik
    Professeur des Universités Praticien Hospitalier
  • Corinne Lacour
    Adjoint Administratif

     

  • Melanie Le Goff
  • Sophie Lefevre-Arbogast
    PhD student Epidemiology, Bordeaux Population Health Research Center, team LEHA, INSERM U1219

    Experience


    Nov 2016 – Today

     

    PhD Student, Public Health, Epidemiology, supervised by C. Samieri

    Bordeaux Population Health Research Center – INSERM U1219

    Metabolic signature of dietary exposure in relation to Alzheimer’s Disease- Nutritional systems epidemiology to identify new targets for prevention (bioactives and populations).

    Funded by the French National Research Agency as part of the European project D-CogPlast (identification of Dietary modulators of Cognitive ageing and brain Plasticity and proof of concept of efficacy for preventing cognitive decline – European Union’s H2020 Research and Innovation Programme – Joint Programming Initiative “healthy diet for a heathy life”)

    Sept – Oct 2016

     

    Statistician in the lifelong exposure health and aging (LEHA) team

    Bordeaux Population Health Research Center – INSERM U1219

    Feb – Aug 2016

    Final year trainee in Epidemiology and Biostatistics (LEHA team)

    Bordeaux Population Health Research Center – INSERM U1219

    Aug – Dec 2014

     

    Trainee in Plant Science and Biostatistics

    The Hermitage Research Center, the Univeristy of Queensland (Australia)


    Education


    2011 – 2016

     

     

    Food Science and Engineering MSc from Agrocampus Ouest, french Grande Ecole

    Major in data science, Statistics for the life and agri-food sciences

    Agrocampus Ouest, Rennes

    2011

    Baccalauréat in science with honors

    Lycée Victor et Hélène Basch, Rennes


  • Morgane Linard
  • Benedicte Merle
  • Sylvie Mivielle
    Assistante de gestion
  • Hermine Pellay
  • Kalina Rajaobelina
    PhD Student

    2013-2015

    PhD student in epidemilogy

    Thesis topic : Advanced glycation end products (AGEs) and metabolic memory in 3 populations at key ages

    (Thesis supervised by Pr Vincent Rigalleau, PHD, MD in nutrition at Bordeaux Hopistal University Center)

    2011-2013

    Master of Public Health , speciality Epidemiology,

    Institute of public Health Epidemiology and development (ISPED), University of Bordeaux, France

    2009-2011

    Bachelor of Science degree, speciality Cellular biology and physiology

    University of Bordeaux, France

  • Vincent Rigalleau

    N° d’inscription à l’ordre des médecins : 33/09825, N° ADELI : 331098251
    Thèmes de recherche :

    Composition corporelle, Dépense énergétique, activité physique, Diabète et Insuffisance rénale

    Parcours

    Formation et postes

    1988 Concours de l’internat C
    1991 DEA “Nutrition, métabolisme, régulations hormonales, développement” (Lyon)
    1993 Service national, Médecin aspirant à l’Hôpital d’Instruction des Armées LAVERAN (Marseille)
    1994 Thèse de médecine et DES de  Médecine Interne (Bordeaux)
    1995-2002 CCA puis PHU en Nutrition-Diabétologie (Bordeaux)
    1998 Thèse de doctorat en biologie humaine “Interactions lipides-glucides et hyperglycémie” (directeur: Michel Beylot, université Claude Bernard Lyon I)
    2000 Stage post-doctoral à l’Institut de Physiologie de Lausanne (directeur: Luc Tappy)
    2001 Habilitation à diriger des recherches
    2002 PU-PH en Nutrition-Diabétologie (Service Pr Gin, CHU de Bordeaux)
    2011 Responsable de la filière « Diabète » adulte du CHU de bordeaux
    2012 Rattachement à l’INSERM U897- Epidémiologie et biostatistique, équipe LEHA (dir : C Delcourt)

     

    Education

    -1982: Baccalaureat
    -1982-1988: Medical studies (Poitiers, France)
    -1988: Concours de l’internat (Bordeaux, France)
    -1991: DEA: (postgraduate degree, Lyon, France) Nutrition, Metabolism, Hormonal Regulation. Director: Dr Laville. Dissertation topic: Study of Insulin Action on Free Fatty Acid Metabolism in Normal Human Subjects. Ranked first, with distinction.
    -29/4/94: MD: Director: Prof. H. Gin. Title: Lipid-Carbohydrate Interactions and Non-Insulin Dependent Diabetes: Effect of a Lipid Infusion on Postabsorptive Glucose Metabolism in Non-Insulin Dependent Diabetic Subjects
    -6/10/94: Medical specialization: Internal medicine.
    -27/10/98: PhD: Director: Dr Beylot. Title: Lipid-Carbohydrate Interactions and Hyperglycemia. Awarded the Jacques Mirouze Prize from the French National Academy of Medecine (14/12/99).
    -9/99-9/2000: Post-doctoral fellow at the Institut de Physiologie (Prof. Luc Tappy), Lausanne Medical School, Switzerland.
    -21/12/2001:Habilitation for the direction of Research.

    Soutiens financiers et prix obtenus

    1992 soutien de l’institut Servier du Diabète (20000 FF)
    1995 bourse de l’institut Servier du Diabète (80000 FF)
    1996 prix de recherche en nutrition CIDEF (50000 FF)
    1999 prix de recherche en nutrition de l’Institut Appert (50000 FF), bourse de séjour à l’étranger de l’ALFEDIAM (60 000 FF), prix du Rank Prize Funds (500 £), prix Jacques Mirouze-Institut Servier du Diabète (30000 FF), de l’académie nationale de médecine
    2001 bourse ALFEDIAM-ROCHE (200 000 FF)
    2003 prix ALFEDIAM-MERCK LIPHA SANTE (12 000 €)

    GRANTS

    -1995: Grant from Institut Servier du Diabète (80000 FF) for the project “Role of Lipid-Glucid Interactions in the Perturbation of the Oral Glucose Tolerance Test in Type 2 Diabetes”
    -1996: Grant for research in nutrition CIDEF (50000 FF) for the project “Role of Lipid-Carbohydrate Interactions in the Perturbation of the Oral Glucose Tolerance Test in Type 2 Diabetes”
    -1999: Grant for research in nutrition  from the Institut Appert (50,000 FF) and grant from the ALFEDIAM (60,000 FF) for the project “Effect of Free Fatty Acids on Splanchnic Glucose Utilization and Hepatic Glycogen Synthesis”
    -1999: Jacques Mirouze-Institut Servier du Diabète prize (30,000 FF), from the French Nationale Academy of Medecine for thesis entitled: “Lipid-Carbohydrate Interactions and Hyperglycemia”
    -1999: Grant from the Conseil Régional d’Aquitaine (40,000 FF) for the project: “Mechanism of Impaired Glucose Tolerance in Patients with Chronic Renal Failure”
    -2001: Grant ALFEDIAM-ROCHE (200,000 FF) for the project:  “Effects of Experimental Hyperglycaemia, and Type 2 Diabetes, on Hepatic Glucose Metabolism”
    -2003: Grant ALFEDIAM-MERCK LIPHA SANTE (12 000 €) for the project: “Effect of Metformin on hepatic glucose metabolism in Non Alcoholic Fatty Liver Disease”

     

    Participation à des études multicentriques

    1994  étude HOPE (investigateur)
    2000 étude GENESIS France-Belgique (membre du comité de validation)
    2001 étude DYNAMIT (investigateur)
    2007 PHRC sur le bilan énergétique du patient parkinsonien électrostimulé (investigateur)
    2010 PHRC Activité Physique et diabète de Type 2 (APDT2) (investigateur)
    2011 PHRC Etude d’une Cohorte nationale de patients adultes atteints de Phénylcétonurie (ECOPHEN) (investigateur)

    Participation in multicentric studies

    – HOPE (investigator)
    – GENESIS France-Belgium (member of the scientific committee)
    – DYNAMIT, ECOPHEN, ORTHODIAB (investigator)

     

    Participation à des comités, conseils

    2001-2002 conseil d’université (UFR III, UER Bordeaux 2)
    2002-2005 Délégation à la Recherche Clinique du CHU de Bordeaux.
    2005-2008  membre du bureau éditorial du British Journal of Nutrition
    2006-2009 membre du Conseil Scientifique de l’ALFEDIAM
    2007-2011 Coordinateur interrégional (Sud-Ouest) du DESC de Nutrition
    2011 Président du comité de titration de l’essai GALAPAGOS (sanofi-aventis)
    2012 Président du Comité Local d’Organisation des JFN Bordeaux 2013
    2013-2015 Membre du conseil scientifique de la Société Française de Nutrition
    2016  Membre du conseil scientifique de la Fondation Francophone pour la Recherche sur le Diabète

     

    Sociétés savantes

    Société Francophone du Diabète, European Association for the Study of Diabetes, American Diabetes Association, Société Française de Nutrition, Société Francophone de Nutrition Entérale et Parentérale, Société Française des Erreurs Innées du Métabolisme

  • Cedric Schweitzer
    MD
    FEBO

    Parcours

    • PROFESSIONAL EXPERIENCE:

     

    November 2010-..

    Attending physician

    Department of ophthalmology Pr Korobelnik

    University hospital,

    Bordeaux

    France

    Novembre 2008-Octobre 2010

    Fellowship

    Department of ophthalmology Pr Colin

     

    University hospital,

    Bordeaux

    France

    Novembre 2003-Octobre 2008

    Residency

    University hospital,

    Bordeaux

    France

    1995- 2003

    Medical student

     

    University Montpellier 2

    Montpellier

    France

    2000

    Medical student

     

    University of southern California

    Los Angeles, CA, USA.

    1995

    French high school certificate

     

    High school A. Daudet

    Nimes,

    France

     

     

     

     

     

     

    • CERTIFICATES:

     

    1998

    Master of Biology and medicine :

    Embryology & anatomy

     

    University Montpellier 2

    Montpellier

    France

    1999

    Master of Biology and medicine :

    Biology of human reproduction and development

     

    University Montpellier 2

    Montpellier

    France

    2006

    Certificate of

    Glaucoma

     

    Angers University

    Angers

    France

    2007

    Certificate of inflammatory and infectious eye diseases

     

    Paris 7 University

    Paris

    France

    2008

    Certificate of

    Vitreo-retinal diseases 

    Paris 7 University

    Paris

    France

    2008

    European Board of Ophthalmology (EBO)

     

    Paris

    2008

    Certificate of medical doctor (thesis)

    Bordeaux 2 University,

    Bordeaux

    France

    2008

    Certificate of medical doctor in Ophthalmology

     

    Bordeaux 2 University,

    Bordeaux

    France

    Juin 2009

    Certificate of vitreo-retinal surgery

    Bordeaux 2 University,

    Bordeaux

    France

    Juin 2010

    Certificate of cataract and refractive surgery

    Bordeaux 2 University,

    Bordeaux

    France

    Avril 2012

    Certificate of english language for medicine

    University Toulouse 3

    Toulouse

    France

    Novembre 2013-…

    PhD program :

    Epidemiology and biostatistics (INSERM Unit U897) :

     

    Bordeaux 2 University,

    Bordeaux

    France

     

    • MOST SIGNIFICANT STUDIES

    2012

    FEMCAT study

    (Impact médico-économique de la chirurgie de la cataracte au laser femtoseconde) CHU de Bordeaux, Granted by the french ministry of health (3.2 millions euros) (PSTIC 2012)

    (Femtocataract study, cost-effectiveness study)

    Principal investigator and coordinator

    2012

    BIOLENS study

    Biomécanique de la cornée et monitorage continu des fluctuations de la pression IntraOculaire avec des LENtilles Souples chez des patients glaucomateux  (Biomechanical properties of the cornea and 24-hour continuous monitoring using a contact lens sensor)

    Principal investigator and coordinator

    2011

    Screening of glaucoma in a population sample

    Principal investigator

    2011

    ENVOL

    Etude du nerf optique et des voies visuelles chez des patients glaucomateux

    (Study evaluating visual pathways using 3-teslas MRI in a glaucoma population)

    Principal investigator

    2011

    ALIENOR

    Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes

    (Population-based study evaluating incidence of age-related eye diseases and their risk factors)

    Co-investigator

    2010

    IFIS

    Intraoperative floppy iris syndrome : tamsulosine versus alfuzosine

    Principal investigator and coordinator

    2010

    AGORA

    Epidemiological study of glaucoma

    Principal investigator

  • Maude Wagner
    PhD Student

    Education

    2016-19 PhD Student in Biostatistics, University of Bordeaux, France

    Thesis title: Modeling of lifestyle trajectories and dynamic relationships with biomarkers of the pathological cascade of Alzheimer’s disease

    SupervisorsCécile Proust-Lima – Biostatistics team, Inserm U1219, Bordeaux

                         Cécilia Samieri – Lifelong Exposures, Health and Aging (LEHA) team, Inserm U1219, Bordeaux

     2014-16 Master’s degree in Biostatistics and Public Health, ISPED, University of Bordeaux, France

    › 2011-14 License of Mathematics Applied to Social Sciences, University of Bordeaux, France

     

     

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