The team studies populations of different ages (elderly, middle-aged, young), in prospective designs allowing for the study of long-term, slow processes, and using subclinical biomarkers allowing for the detection of early health-related effects of exposures.
Objectives
Age-related diseases are long-term processes, developing over several decades. Exposures that may favour or, on the contrary, prevent their development also probably have long-term, cumulative effects. The study of such lifelong effects of exposures represents a major challenge for the epidemiologist, but raises the hope of opening new avenues for the prevention of age-related diseases, in particular by identifying specific time windows for intervention.
We will study populations of different ages (elderly, middle-aged, young), in prospective designs allowing for the study of long-term, slow processes, and using subclinical biomarkers allowing for the detection of early health-related effects of exposures. Models of aging will be mainly neurological and eye diseases, but will extend to other health endpoints, such as physical performance, diabetes or renal insufficiency.
Research area
- The first axis “aging, health and disability” will provide a public health perspective of aging (including secular trends in health status and disability, as well as the study of recourse to care in the elderly). We will also provide some insights into major pathophysiological mechanisms of age-related diseases (mainly of the brain, eye and kidney), in particular by using ocular biomarkers of microvascular and neurological status, as well as biomarkers of infections and inflammation.
- In the second axis “nutrition, health and aging”, we will study the role of nutrition in brain and eye aging, but also in physical performance decline and sarcopenia. Metabolic disorders and obesity will also be addressed. This axis will combine observational and interventional studies, at different key ages.
- Finally, the third axis “toxic exposures, health and aging” will be dedicated to the study of the associations of age-related diseases (mainly of the brain and eye) with voluntary (smoking, alcohol, other drugs) and professional and environmental exposures (in particular pesticides).
Main publications
- Delcourt C, Souied E, Sanchez A, Bandello F; STARS Survey Group. Development and Validation of a Risk Score for Age-Related Macular Degeneration: The STARS Questionnaire. Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6399-6407.
- Feart C, Helmer C, Merle B, Herrmann FR, Annweiler C, Dartigues JF, Delcourt C, Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017 Nov;13(11):1207-1216.
- Korobelnik JF, Rougier MB, Delyfer MN, Bron A, Merle BMJ, Savel H, Chêne G, Delcourt C, Creuzot-Garcher C. Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial. JAMA Ophthalmol. 2017 Nov 1;135(11):1259-1266.
- Amadieu C, Lefèvre-Arbogast S, Delcourt C, Dartigues JF, Helmer C, Féart C, Samieri C. Nutrient biomarker patterns and long-term risk of dementia in older adults. Alzheimers Dement. 2017 Oct;13(10):1125-1132.
- Samieri C, Morris MC, Bennett DA, Berr C, Amouyel P, Dartigues JF, Tzourio C, Chasman DI, Grodstein F. Fish intake, genetic predisposition to alzheimer’s disease and decline in global cognition and memory in five cohorts of older persons. Am J Epidemiol. 2017 Oct 19. [Epub ahead of print]
- Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4569-4578.
- Wagner M, Dartigues JF, Samieri C, Proust-Lima C. Modeling Risk Factor Trajectories When Measurement Tools Change Sequentially During Follow-up in Cohort Studies: Application to Dietary Habits in Prodromal Dementia. Am J Epidemiol. 2017 Aug 23. doi: 10.1093/aje/kwx293. [Epub ahead of print]
- Kaboré R, Couchoud C, Macher MA, Salomon R, Ranchin B, Lahoche A, Roussey-Kesler G, Garaix F, Decramer S, Pietrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K, Harambat J. Age-Dependent Risk of Graft Failure in Young Kidney Transplant Recipients. Transplantation. 2017 Jun;101(6):1327-1335.
- Chesnaye NC, Schaefer F, Bonthuis M, Holman R, Baiko S, Baskın E, Bjerre A, Cloarec S, Cornelissen EAM, Espinosa L, Heaf J, Stone R, Shtiza D, Zagozdzon I, Harambat J, Jager KJ, Groothoff JW, van Stralen KJ; ESPN/ERA-EDTA Registry Committee. Mortality risk disparities in children receiving chronic renal replacement therapy for the treatment of end-stage renal disease across Europe: an ESPN-ERA/EDTA registry analysis. Lancet. 2017 May 27;389(10084):2128-2137
- Rahi B, Ajana S, Tabue-Teguo M, Dartigues JF, Peres K, Feart C. High adherence to a Mediterranean diet and lower risk of frailty among French older adults community-dwellers: Results from the Three-City-Bordeaux Study. Clin Nutr. 2017 May 31.
- Naël V, Pérès K, Carrière I, Daien V, Scherlen AC, Arleo A, Korobelnik JF, Delcourt C, Helmer C. Visual Impairment, Undercorrected Refractive Errors, and Activity Limitations in Older Adults: Findings From the Three-City Alienor Study. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2359-2365.
- Lefèvre-Arbogast S, Féart C, Dartigues JF, Helmer C, Letenneur L, Samieri C. Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons. Nutrients. 2016 Nov 26;8(12).
- Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, Cougnard-Gregoire A, Merle BMJ, Korb C, Erke MG, Bron A, Anastasopoulos E, Meester-Smoor MA, Segato T, Piermarocchi S, de Jong PTVM, Vingerling JR, Topouzis F, Creuzot-Garcher C, Bertelsen G, Pfeiffer N, Fletcher AE, Foster PJ, Silva R, Korobelnik JF, Delcourt C, Klaver CCW; EYE-RISK consortium; European Eye Epidemiology (E3) consortium. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. 2017 Dec;124(12):1753-1763.
- Rajaobelina K, Helmer C, Vélayoudom-Céphise FL, Nov S, Farges B, Pupier E, Blanco L, Hugo M, Gin H, Rigalleau V. Progression of skin autofluorescence of AGEs over 4 years in patients with type 1 diabetes. Diabetes Metab Res Rev. 2017 Oct;33(7).
- Tellouck L, Durieux M, Coupé P, Cougnard-Grégoire A, Tellouck J, Tourdias T, Munsch F, Garrigues A, Helmer C, Malet F, Dartigues JF, Dousset V, Delcourt C, Schweitzer C. Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging.Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6539-6547
- Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Le Goff M, Samieri C, Dartigues JF, Delcourt C. Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study. PLoS One. 2016 Jul 28;11(7):e0160240.
- Merle BM, Silver RE, Rosner B, Seddon JM. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr;103(4):1135-44.
- Grasset L, Brayne C, Joly P, Jacqmin-Gadda H, Peres K, Foubert-Samier A, Dartigues JF, Helmer C. Trends in dementia incidence: Evolution over a 10-year period in France. Alzheimers Dement. 2016 Mar;12(3):272-80.
Details
Centre de recherche INSERM U1219
Université de Bordeaux, ISPED
146 rue Léo-Saignat
33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 95 38
Tél : +33 (0)5 57 57 15 96
Fax : +33 (0)5 57 57 14 86
Informations
Members
- Soufiane Ajana
- Audrey Cougnard-Gregoire
- Cecile Delcourt
- MarieNoelle Delyfer
- Bénédicte Driollet
- Catherine Feart
- Leslie Grasset
- Jérôme Harambat
- Emilie Hucteau
- Jean-Francois Korobelnik
- Corinne Lacour
- Melanie Le Goff
- Sophie Lefevre-Arbogast
- Morgane Linard
- Benedicte Merle
- Sylvie Mivielle
- Hermine Pellay
- Kalina Rajaobelina
- Vincent Rigalleau
- Cedric Schweitzer
- Maude Wagner
