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Chargé de Recherche INSERM
Responsable pédagogique du Master Santé Internationale

Parcours

2014       

“Habilitation à diriger des recherches” in Public Health and Epidemiology 

Institute of Public Health & Epidemiology, Bordeaux University , Bordeaux, France

2002 – 2005           

PhD in Public Health and Epidemiology

Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

Fellow of the French Ministry of Education, Research and Technology

2001 – 2002

Master of Public Health, Biostatistics and Epidemiology 

Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

2000 – 2001

Post-graduate diploma in Public Health 

Institute of Public Health & Epidemiology, University Victor Segalen, Bordeaux, France

Fonctions

Professional experience as a researcher

 Since 2014. Principal Investigator of the WETIV-R Cohort. A multi-country prospective intervention cohort (Côte d’Ivoire, Burkina Faso, Togo) aimed at aimed evaluating the integration of sexual and reproductive health services into HIV care.

 Since 2013. Principal Investigator of the IeDEA West Africa “Women & Mothers” program. A multi-country research program aimed at describing and better addressing health outcomes of HIV-infected women in west-Africa, with a focus on sexual and reproductive health outcomes, such as pregnancy intention, incidence and complications after ART initiation and its association with maternal disease progression.

Since 2013. Associated investigator of the LJM cluster randomized trial. A study aimed at increasing retention in care of HIV-positive women in PMTCT services through continuous quality improvement-breakthrough series in primary and secondary health care facilities in Nigeria.

 2010 – 2013. Principal Investigator (PI) or Investigator (I) of a series of epidemiological studies on: Quality of Life among HIV-infected women (Abidjan, Côte d’Ivoire, 2010) (PI); Life events and intimate partner violence among women (Lomé, Togo, 2011) (PI); Visual impairment among HIV-infected patients (Abidjan, Côte d’Ivoire, 2012) (PI); HIV prevention and care among Men who have sex with men (Ho Chi Minh City, Vietnam, 2012) (I); Menstrual hygiene among schoolgirls in rural and urban settings (Lomé & Kpalimé, Togo, 2013) (I); Nationwide prevalence study of intimate partner violence among women (Dominican Republic, 2013) (I).

 2008 – 2011. Project leader of the ANRS 12200 UMA trial (Côte d’Ivoire, Zambia). Safety and efficacy of the Efavirenz-Tenofovir-Emtricitabine and Zidovudine-Lamivudine-Lopinavir/ritonavir combinations in pregnant and breastfeeding women to prevent mother-to-child transmission of HIV-1 in resource-limited settings. A multicentre randomized phase III clinical trial.

 2007 – 2008. Principal investigator of the ARVAM-CI AntiRétroViraux et Allaitement Maternel en Côte d’Ivoire (Abidjan, Côte d’Ivoire). Evaluation among breastfeeding women treated by HAART of the diffusion of antiretrovirals through breastmilk and assessment of the effect of antiretrovirals on breast-milk HIV-1 RNA and DNA loads.

 2006 – 2007. Invited researcher at the Africa Centre for Health and Population Studies (University of KwaZulu Natal, Mtubatuba, South Africa – director: Prof. Marie-Louise Newell).

 2003 – 2006. Expert technical advisor in epidemiology and data analysis, MTCT Plus initiative (Abidjan, Côte d’Ivoire).

 2001 – 2006. Co-investigator of the Ditrame Plus ANRS 1201/1202 study (Abidjan, Côte d’Ivoire). Interventions aimed at the prevention of HIV transmission through breastmilk were evaluated within this study.

 

International collaborations with United Nations agencies

Co-chair of the WHO/UNICEF/UNAIDS working group on the estimation of survival of HIV-exposed, uninfected children (since 2014, UN focal point: Nigel Rollins).

Technical advisor in epidemiology and co-investigator of the two Nigerian studies part of the WHO INtegration and Scaling Up PMTCT through Implementation REsearch (INSPIRE) initiative (since 2013, UN focal points: Nigel Rollins and Nathan Shaffer).

Core group member of the consolidated WHO guidelines development group on HIV & maternal and child health (2012-2013, UN focal point: Nathan Shaffer ; 2014-2015, UN focal point: Shaffiq Essajee).

Writer of the WHO guidelines entitled “Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: recommendations for a public health approach – 2010 version” (2010-2011, UN focal points: TinTin Sint and Nathan Shaffer).

Co-chair of the UNAIDS working group on the estimation of net survival of children HIV-infected perinatally and through breastfeeding (2009-2010, UN focal point: Peter Ghys).

Publications

Rollins NC, Becquet R, Orne-Gliemann J, Phiri S, Hayashi C, Baller A, Shaffer N. Defining and analyzing Retention-in-Care among pregnant and breastfeeding HIV-infected women: Unpacking the data to interpret and improve PMTCT outcomes. J Acquir Immune Defic Syndr 2014;67(2):S150-6.

Oyeledun B, Oronsaye F, Oyelade T, Becquet R, Odoh D, Anyaike C, Ogirima F, Ameh B, Ajibola A, Osibo B, Imarhiagbe C, Abutu I. Increasing retention in care of HIV-positive women in PMTCT services through continuous quality improvement-breakthrough (CQI-BTS) series in primary and secondary health care facilities in Nigeria: a cluster randomized controlled trial. The Lafiyan Jikin Mata Study. J Acquir Immune Defic Syndr 2014;67(2):S125-31.

Burgos-Soto J, Balestre E, Minga A, Ajayi S, Sawadogo A, Zanou MD, Leroy V, Ekouevi DK, Dabis F, Becquet R. Incidence of pregnancy following antiretroviral therapy initiation and associated factors in eight West African countries. J Acquir Immune Defic Syndr 2014;67(2):e45-54.

Burgos-Soto J, Orne-Gliemann J, Encrenaz G, Patassi A, Woronowski A, Kariyiare B, Lawson-Evi A, Leroy V, Dabis F, Ekouevi DK, Becquet R. Intimate partner sexual and physical violence among women in Togo, West-Africa: Prevalence, associated factors and the specific role of HIV infection. Global Health Action 2014;26(7):23456.

Shaffer N, Abrams EJ, Becquet R. Option B+ for prevention of mother-to-child transmission of HIV in resource-constrained settings: great promise but some early caution. AIDS. 2014;28(4):599-601.

Justumus P, Colby D, Mai Doan Anh T, Balestre E, Becquet R *, Orne-Gliemann J. Willingness to Use the Internet to Seek Information on HIV Prevention and Care among Men Who Have Sex with Men in Ho Chi Minh City, Vietnam. PLoS ONE. 2013;8(8): e71471.

Ekouevi DK, Coffie PA, Salou M, Kariyiare BG, Dagnra AC, Tchounga B, Prince-Davi M, Becquet R, Pitche VP. [HIV seroprevalence among drug users in Togo]. Santé Publique. 2013;25(4):491-8.

Ekouevi DK, D’almeida S, Salou M, Kariyiare BG, Coffie PA, Dagnra AC, Tchounga B, Becquet R, Prince-David M, Pitche VP. HIV seroprevalence among inmates in Togo. Med Mal Infect. 2013;43(2013):279–285

Becquet R, Dabis F. Turning the tide on HIV in women and children: Preventing breast-milk HIV transmission while increasing maternal life expectancy. Clinical Infectious Diseases. 2013;56(1):140-2.

Rollins NC, Mahy M, Becquet R, Kuhn L, Creek T, Mofenson L. Estimates of peripartum and postnatal mother-to-child transmission probabilities of HIV for use in Spectrum and other population-based models. Sex Transm Infect 2012;88 Suppl 2:i44-i51.

Becquet R, Marston M, Dabis F, Moulton LH, Gray G, Coovadia H, Essex M, Ekouevi DK, Jackson D, Coutsoudis A, Kilewo C, Leroy V, Wiktor S, Nduati R, Msellati P, Zaba B, Ghys PD, Newell ML. Children who acquire HIV infection perinatally are at higher risk of early death than those acquiring infection through breastmilk: a meta-analysis. PLoS One. 2012;7(2):e28510.

Ekouevi DK, Kariyiare BG, Coffie PA, Jutand MA, Akpadza K, Lawson-Evi A, Tatagan A, Dabis F, Sibe M, Pitche VP, Becquet R, David M. Feasibility and acceptability of rapid HIV screening in a labour ward in Togo. J Int AIDS Soc. 2012;15(2):17380.

Becquet R, Ekouevi DK. Breastfeeding, triple ARV prophylaxis and MTCT Prevention. The Lancet Infectious Diseases. 2011;11(3):154-5.

Marston M, Becquet R, Zaba B, Moulton LH, Gray G, Coovadia H, Essex M, Ekouevi DK, Jackson D, Coutsoudis A, Kilewo C, Leroy V, Wiktor S, Nduati R, Msellati P, Dabis F, Newell ML, Ghys PD. Net survival of perinatally and postnatally HIV-infected children: a pooled analysis of individual data from sub-Saharan Africa. International Journal of Epidemiology. 2011;40(2):385-396.

Stover J, Johnson P, Hallett T, Marston M, Becquet R, Timaeus IM. The Spectrum projection package: improvements in estimating incidence by age and sex, mother-to-child transmission, HIV progression in children and double orphans. Sex Transm Infect. 2010;86 Suppl 2:ii16-21.

Becquet R, Burgos-Soto J, Carrieri MP, Spire B. Quality of life assessment in HIV clinical research in resource-limited setting: better late than never. Trop Med Int Health. 2010;15(9):1008-1010.

Becquet R, Bland RM, Ekouevi DK, Dabis F, Newell ML. Universal ART among pregnant and post-partum HIV-infected women would improve maternal health and decrease postnatal HIV transmission. AIDS 2010;24(8):1239-41.

Becquet R, Ekouevi DK, Arrivé E, Stringer JS, Méda N, Chaix ML, Treluyer JM, Leroy V, Rouzioux C, Blanche S, Dabis F. Universal antiretroviral therapy for pregnant and breastfeeding HIV-infected women: Towards the elimination of mother-to-child transmission of HIV-1 in resource-limited settings. Clinical Infectious Diseases 2009;49(12):1936-45.

Becquet R, Bland RM, Leroy V, Rollins NC, Ekouevi DK, Coutsoudis A, Dabis F, Coovadia HM, Salamon R, Newell ML. Duration, pattern of breastfeeding and postnatal transmission of HIV: pooled analysis of individual data from a West and South African cohort study. PLoS One 2009;4(10):e7397.

Desgrees-du-Lou A, Brou H, Traore AT, Djohan G, Becquet R, Leroy V. From prenatal HIV testing of the mother to prevention of sexual HIV transmission within the couple. Soc Sci Med 2009;69(6):892-9.

Rollins NC, Becquet R, Bland RM, Coutsoudis A, Coovadia HM, Newell ML. Preventing postnatal mother-to-child transmission of HIV: Context matters. AIDS 2009;23(6):740.

Tonwe-Gold B, Ekouevi DK, Bosse CA, Toure S, Kone M, Becquet R, Leroy V, Toro P, Dabis F, El Sadr WM and Abrams EJ. Implementing family-focused HIV care and treatment: the first 2 years’ experience of the mother-to-child transmission-plus program in Abidjan, Cote d’Ivoire. Trop Med Int Health 2009;14(2): 204-12.

Rollins NC, Becquet R, Bland RM, Coutsoudis A, Coovadia HM, Newell ML. Infant feeding, HIV transmission and mortality at 18 months: the need for appropriate choices by mothers and prioritisation within programs. AIDS 2008;22(17):2349-57.

Ekouevi DK, Coffie PA, Becquet R, Tonwe-Gold B, Horo A, Thiebaut R, Leroy V, Blanche S, Dabis F, Abrams EJ. Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Côte d’Ivoire. AIDS 2008;22(14):1815-20.

Becquet R, Mofenson LM. Early antiretroviral therapy of HIV-infected infants in resource-limited countries: possible, feasible, effective – and challenging. AIDS 2008;22(11):1365-8.

Becquet R, Ekouevi DK, Menan H, Amani-Bosse C, Viho I, Dabis F, Timite-Konan M, Leroy V. Early mixed feeding and breastfeeding beyond six months increase the risk of postnatal HIV transmission: ANRS 1201/1202 Ditrame Plus, Abidjan, Côte d’Ivoire. Preventive Medicine 2008;47(1):27-33.

Brou H, Djohan G, Becquet R, Allou G, Ekouevi DK, Zanou B, Leroy V, Desgrées du Loû A. Sexual prevention of HIV within the couple after prenatal HIV-testing in West Africa. AIDS Care 2008;20(4):413-18.

Harambat J, Fassinou P, Becquet R, Toure P, Rouet F, Dabis F, Msellati P, Blanche S, Timite-Konan M, Salamon R, Leroy V. 18-month occurrence of severe events among early diagnosed HIV-infected children before antiretroviral therapy in Abidjan, Cote d’Ivoire: a cohort study. BMC Public Health 2008;8:169.

Orne-Gliemann J, Becquet R, Ekouevi DK, Leroy V, Perez F, Dabis F. Children and HIV/AIDS. From research to policy and action in resource-limited settings. AIDS 2008;22(7):797-805.

Leroy V, Ekouevi DK, Becquet R, Viho I, Dequae-Merchadou L, Tonwe-Gold B, Rouet F, Sakarovitch C, Horo A, Timite-Konan M, Rouzioux C, Dabis F. 18-month effectiveness of short-course antiretroviral regimens combined with alternatives to breastfeeding to prevent HIV mother-to-child transmission. PLoS ONE 2008;3(2):e1645.

Coffie PA, Ekouevi DK, Chaix ML, Tonwe-Gold B, Amani-Bosse C, Becquet R, Viho I, N’Dri-Yoman T, Leroy V, Abrams EJ, Rouzioux C, Dabis F. Maternal 12-month response to antiretroviral therapy following prevention of mother-to-child transmission of HIV-1, Côte d’Ivoire, 2003-2006. Clinical Infectious Diseases 2008;46(4):611-21.

Ekouevi DK, Inwoley A, Tonwe-Gold B, Danel C, Becquet R, Viho I, Rouet F, Dabis F, Anglaret X, Leroy V. Variation of CD4 count and percentage among women receiving antiretroviral prophylaxis for the prevention of mother-to-child transmission of HIV: Implication for HAART initiation in resource-limited settings. AIDS Research and Human Retroviruses 2007;23(12):1469-74.

Brou H, Djohan G, Becquet R, Allou G, Ekouevi DK, Viho I, Leroy V, Desgrées du Loû A. When do HIV-infected women disclose their serostatus to their male partners and why? Experience from a prevention of mother-to-child-transmission programme in Abidjan, Côte d’Ivoire. PLoS Medicine 2007;4(12):e342.

Desgrées du Loû A, Brou H, Djohan G, Becquet R, Ekouevi DK, Zanou B, Viho I, Dabis F, Leroy V. Beneficial effects of offering prenatal HIV counselling and testing on developing a HIV preventive attitude among couples. Abidjan, 2002-2005. AIDS and Behaviour (electronic publication on the 6th of November 2007).

Becquet R, Leroy V. [The challenges of preventing mother-to-child transmission of HIV in Africa – a literature review]. La Presse Médicale 2007;36(12):1947-57.

Bland RM, Becquet R, Rollins NC, Coutsoudis A, Coovadia HM, Newell ML. Breast health problems are rare in both HIV-infected and uninfected women who received counselling and support for breast-feeding in South Africa. Clinical Infectious Diseases 2007;45(11):1502-10.

Becquet R, Newell ML. Prevention of postnatal HIV infection: infant feeding and antiretroviral interventions. Current Opinion in HIV and AIDS 2007;2(5):361–366.

Tonwe-Gold B, Ekouevi DK, Viho I, Amani-Bosse C, Toure S, Coffie S, Rouet F, Becquet R, Leroy V, El-Sadr W, Abrams EJ, Dabis F. Highly active antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa. PLoS Medicine 2007;4(8):e257.

Martinson NA, Ekouevi DK, Dabis F, Morris L, Lupodwana P, Tonwe-Gold B, Dhlamini P, Becquet R, Steyn JG, Leroy V, Gray G, McIntyre J. Transmission Rates in Consecutive Pregnancies Exposed to Single-Dose Nevirapine in Soweto, South Africa and Abidjan, Cote d’Ivoire. J Acquir Immune Defic Syndr 2007;45(2): 206-209.

Becquet R. Antiretroviral therapy among HIV-infected breastfeeding mothers: a promising strategy to prevent HIV transmission through breastmilk in Africa. Future HIV therapy 2007;1(1):17-21.

Becquet R, Bequet L, Ekouevi DK, Viho I, Sakarovitch C, Fassinou P, Bedikou G, Timite-Konan M, Dabis F, Leroy V. Two-year morbidity-mortality and alternatives to prolonged breast-feeding among children born to HIV-infected mothers in Côte d’Ivoire. PLoS Medicine 2007;4(1): e17.

Leroy V, Sakarovitch C, Viho I, Becquet R, Ekouevi DK, Bequet L, Rouet F, Dabis F, Timite-Konan M. Acceptability of formula-feeding to prevent postnatal transmission of HIV-1 infection in Abidjan, Côte d’Ivoire, Ditrame Plus ANRS 1201/1202. J Acquir Immune Defic Syndr 2007;44(1): 77-86.

Ekouevi DK, Toure R, Becquet R, Viho I, Sakarovitch C, Rouet F, Tonwe-Gold B, Bequet L, Fassinou P, Leroy V, Blanche S, Dabis F. Serum lactate levels in infants exposed peripartum to antiretrovirals to prevent mother-to-child transmission of HIV: ANRS 1209 study, Abidjan, Côte d’Ivoire. Pediatrics 2006; 118(4)e1071-e1077.

Rouet F, Inwoley A, Ekouevi DK, Viho I, Becquet R, Sakarovitch C, Bequet L, Tonwe-Gold B, Chaix ML, Leroy V, Rouzioux C, Dabis F. CD4 percentages and total lymphocyte counts as early surrogate markers for pediatric HIV-1 infection in resource-limited settings. Journal of Tropical Pediatrics 2006;52(5):346-354.

Becquet R, Leroy V, Ekouevi DK, Viho I, Castetbon K, Fassinou P, Dabis F, Timite-Konan M. Complementary feeding adequacy in relation to nutritional status among early weaned breastfed children who are born to HIV-infected mothers: ANRS 1201/1202 Ditrame Plus, Abidjan, Côte d’Ivoire. Pediatrics 2006;117(4):e701-e710.

Becquet R, Castetbon K, Viho I, Ekouevi DK, Bequet L, Ehouo B, Dabis F, Leroy V. Infant feeding practices before implementing alternatives to prolonged breastfeeding to reduce HIV transmission through breastmilk in Abidjan, Côte d’Ivoire. Journal of Tropical Pediatrics 2005;51(6):351-5.

Becquet R, Ekouevi DK, Viho I, Sakarovitch C, Toure H, Castetbon K, Coulibaly N, Timite-Konan M, Bequet L, Dabis F, Leroy V. Acceptability of exclusive breastfeeding with early cessation to prevent HIV transmission through breastmilk, ANRS 1201/1202 Ditrame Plus, Abidjan, Côte d’Ivoire. J Acquir Immune Defic Syndr 2005;40(5):600-8.

Becquet R, Leroy V. HIV and infant feeding: a complex issue in ressource-limited settings. AIDS 2005;19(15): 1717-8.

Becquet R, Ekouevi DK, Sakarovitch C, Bequet L, Viho I, Tonwe-Gold B, Dabis F, Leroy V. Knowledge, attitudes and beliefs of health care workers regarding alternatives to prolonged breastfeeding, ANRS 1201/1202 Ditrame Plus, Abidjan, Côte d’Ivoire. J Acquir Immune Defic Syndr 2005;40(1):102-5.

Dabis F, Bequet L, Ekouevi DK, Viho I, Rouet F, Horo A, Sakarovitch C, Becquet R, Fassinou P, Dequae L, Welffens-Ekra C, Rouzioux C, Leroy V. Field efficacy of Zidovudine, Lamivudine and single-dose Nevirapine to prevent peripartum transmission of HIV. The ANRS 1201/1202 Ditrame Plus study, Abidjan, Cote d’Ivoire. AIDS 2005;19(3): 309-18.

Ekouevi DK, Becquet R, Bequet L, Viho I, Towne-Gold B, Dabis F, Leroy V. Obtaining informed consent in HIV infected pregnant women participating in a PMTCT study in Abidjan, Côte d’Ivoire. AIDS 2004;18(10): 1486-8.

Ekouevi DK, Rouet F, Becquet R, Inwoley A, Viho I, Towne-Gold B, Bequet L, Dabis F, Leroy V. Immune status and uptake of antiretroviral interventions to prevent mother-to-child transmission of HIV in Africa. J Acquir Immune Defic Syndr 2004;36(2):755-7.

Rollins N, Meda N, Becquet R, Coutsoudis A, Humphrey J, Jeffrey B, Kanshana S, Kuhn L, Leroy V, Mbori-Ngacha D, McIntyre J, Newell ML. Preventing post-natal transmission of HIV-1 through breastfeeding: modifying infant feeding practices. J Acquir Immune Defic Syndr 2004;35(2):188-95.

Becquet R, Leroy V, Salmi LR. Breastfeeding, atopy, and asthma. The Lancet 2003;361(9352):174.

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