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Chargée de recherche INSERM (Senior Researcher, INSERM (French National Institute for Health)

Parcours

EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE COMPLETION DATE FIELD OF STUDY
INSERM U897 and Université de Bordeaux, Bordeaux, France Junior Research Position (French Fondation Plan Alzheimer grant) 2012-2015 Epidemiology – Alzheimer’s disease
Channing Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

Postdoctoral Research fellow

2011-2012 Epidemiology
Université de Bordeaux, Bordeaux, France Postdoctoral Research fellow 2010-2011 Epidemiology (applied Biostatistics and neuro-imaging)
Université de Bordeaux, Bordeaux, France Ph.D (upper honours, Mention Très Honorable) 2007-2009 Epidemiology
Université Paris XI, Paris, France M.Sc (upper honours, Mention Très Bien) 2005-2006 Methodology and Statistics in Biomedical Research
Université Paris XII, Paris, France Doctorate 2004 Veterinary medicine

Lycée Michel Montaigne, Bordeaux, France

Baccalaureate diploma (upper honours, Mention Très Bien) 1997 Mathematics

Fonctions

PERSONAL STATEMENT

 My research has mainly focused on the epidemiology of aging, with the aim of understanding how environmental factors, in particular diet, influences the aetiology of brain diseases and conditions in aging, such as dementia, cognitive decline or stroke. Since environmental factors have a pleiotropic role in health, a broader perspective of my research has recently focused on environmental strategies to maintain overall health in aging. Specifically, I have contributed to demonstrate the impact of a healthier diet in midlife (eg., a Mediterranean diet) for healthy aging. There is indeed increasing evidence that a number of age-related diseases originate in midlife and even in earlier periods of life. For example, it is now recognized that lesions associated with age-related brain diseases accumulate silently over decades before brain diseases in the late-life. At the same time, brain plasticity, which provides more numerous neurons and connections – globally referred to as “brain reserve” – to cope with lesions and maintain optimal cognitive performances with aging, start developing in the first decades of life. While it has become more and more evident that future brain aging research should move on early prevention, the optimal strategy, including the most critical window of opportunity for prevention, remains to be elucidated. To inform early mechanisms underlying the relation of the environment and brain health, I am currently working on extending my research interests to the investigation of environmental factors and brain structure of young adults in a large ongoing cohort of French students. A better understanding on how the environment shapes brain structural plasticity in early adult life will eventually help designing future prevention strategies.

POSITIONS AND HONORS

Positions and employment

2012-15 Junior Research Position, INSERM U897 and Université de Bordeaux, France.

2015-      Permanent senior researcher, INSERM (French National Institute for Health).

Honors

2010-12  Pilot Award from the LECMA (European League Against Alzheimer’s Disease, France); Thesis prize from the SFEL (French Society for the Study of Lipids, France).

2011-12  Fulbright Research Scholar Award; Medical research award from the Philippe Foundation (USA & France); travel award from the International Conference on Alzheimer Disease (France).

2012-15  Junior Researcher Position grant from the French Fondation Plan Alzheimer; 1st prize for best free communication at the 2012 Aquitaine Conferences on Neurosciences, Université de Bordeaux (France); travel award, Alzheimer Association International Conference (Canada).

Publications

Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W, Wang L, Biggs ML, Chen YI, Hernandez DG, Borecki I, Chasman DI, Rich SS, Ferrucci L, Irvin MR, Aslibekyan S, Zhi D, Tiwari HK, Claas SA, Sha J, Kabagambe EK, Lai CQ, Parnell LD, Lee YC, Amouyel P, Lambert JC, Psaty BM, King IB, Mozaffarian D, McKnight B, Bandinelli S, Tsai MY, Ridker PM, Ding J, Mstat KL, Liu Y, Sotoodehnia N, Barberger-Gateau P, Steffen LM, Siscovick DS, Absher D, Arnett DK, Ordovás JM, Lemaitre RN. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr. 2016 Jan 20. [Epub ahead of print]
Feart C, Letenneur L, Helmer C, Samieri C, Schalch W, Etheve S, Delcourt C, Dartigues JF, Barberger-Gateau P. Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort. J Gerontol A Biol Sci Med Sci. 2015 Aug 18.
Pelletier A, Barul C, Féart C, Helmer C, Bernard C, Periot O, Dilharreguy B, Dartigues JF, Allard M, Barberger-Gateau P, Catheline G, Samieri C. Mediterranean diet and preserved brain structural connectivity in older subjects. Alzheimers Dement. 2015 Sep;11(9):1023-31.
Torres MJ, Féart C, Samieri C, Dorigny B, Luiking Y, Berr C, Barberger-Gateau P, Letenneur L. Poor nutritional status is associated with a higher risk of falling and fracture in elderly people living at home in France: the Three-City cohort study. Osteoporos Int. 2015 Apr 11. [Epub ahead of print]
Commenges D, Proust-Lima C, Samieri C, Liquet B. A universal approximate cross-validation criterion for regular risk functions. Int J Biostat. 2015 May 1;11(1):51-67.
Samieri C, Sun Q, Townsend MK, Rimm EB, Grodstein F. Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr. 2014 Dec;100(6):1489-1497.
Feart C, Samieri C, Barberger-Gateau P. Mediterranean diet and cognitive health: an update of available knowledge. Curr Opin Clin Nutr Metab Care. 2014 Nov 15.
Samieri C, Amariglio RE, Proust-Lima C, Sperling RA, Glymour MM, Rentz DM, Okereke OI, Grodstein F. Subjective cognitive concerns, episodic memory, and the APOE ε4 allele. Alzheimer’s & dementia. 2014 Sep 23; S1552-5260(14)02494-7.
Ancelin ML, Ripoche E, Dupuy AM, Samieri C, Rouaud O, Berr C, Carrière I, Ritchie K. Gender-specific associations between lipids and cognitive decline in the elderly. Eur Neuropsychopharmacol. 2014 Jul;24(7):1056-66.
Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, Stampfer M, Grodstein F. The association between dietary patterns at midlife and health in aging: an observational study. Ann Intern Med. 2013 Nov 5;159(9):584-91.
Samieri C, Lorrain S, Buaud B, Vaysse C, Berr C, Peuchant E, Cunnane SC, Barberger-Gateau P. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. J Lipid Res. 2013 Sep;54(9):2559-67.
Barberger-Gateau P, Samieri C, Féart C, Cunnane S. Acides gras oméga-3 et déclin cognitif : la controverse. Cah Nutr Diét. 2013 Sept ; 48(4) : 170-174.
Feart C, Lorrain S, Ginder Coupez V, Samieri C, Letenneur L, Paineau D, Barberger-Gateau P. Adherence to a Mediterranean diet and risk of fractures in French older persons. Osteoporos Int. Dec;24(12):3031-41.
Samieri C, Grodstein F, Rosner B, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Mediterranean diet and cognitive function in older age. Epidemiology. 2013 Jul;24(4):490-9.
Samieri C, Okereke OI, Devore EE, Grodstein F. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr. 2013 Apr;143(4):493-9.
Féart C, Samieri C, Allès B, Barberger-Gateau P. Potential benefits of adherence to the Mediterranean diet on cognitive health. Proc Nutr Soc. 2013 Feb;72(1):140-52.
Samieri C, Ginder Coupez V, Lorrain S, Letenneur L, Allès B, Féart C, Paineau D, Barberger-Gateau P. Nutrient patterns and risk of fracture in older subjects: results from the Three-City Study. Osteoporos Int. 2013 Apr;24(4):1295-305.
Barberger-Gateau P, Samieri C, Allès B., Féart C. Could nutrition prevent the onset of dementia? Current evidence from epidemiological and intervention studies. Neurodegen Dis Manage. 2012; 2(3):1-10.
Allès B, Samieri C, Féart C, Jutand MA, Laurin D, Barberger-Gateau P. Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals. Nutr Res Rev. 2012 Dec;25(2):207-22.
Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau P. Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology. 2012 Aug 14;79(7):642-50.
Feart C, Alles B, Merle B, Samieri C, Barberger-Gateau P. Adherence to a Mediterranean diet and energy, macro-, and micronutrient intakes in older persons. J Physiol Biochem. 2012 Dec;68(4):691-700.
Féart C, Pérès K, Samieri C, Letenneur L, Dartigues JF, Barberger-Gateau P. Adherence to a Mediterranean diet and onset of disability in older persons. Eur J Epidemiol. 2011 Sep;26(9):747-56.
Samieri C, Féart C, Proust-Lima C, Peuchant E, Tzourio C, Stapf C, Berr C, Barberger-Gateau P.

Neurology. 2011 Aug 2;77(5):418-25.

Barberger-Gateau P, Samieri C, Féart C, Plourde M. Dietary omega 3 polyunsaturated fatty acids and Alzheimer’s disease: interaction with apolipoprotein E genotype. Curr Alzheimer Res. 2011 Aug;8(5):479-91.
Féart C, Torrès M, Samieri C, Jutand MA, Peuchant E, Simopoulos AP, Barberger-Gateau P. Adherence to a Mediterranean diet and plasma fatty acids: data from the Bordeaux sample of the Three-City study. Br J Nutr. 2011 Jul;106(1):149-58.
Samieri C, Féart C, Proust-Lima C, Peuchant E, Dartigues J-F, Amieva H, Barberger-Gateau P. ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression. Neurobiol Aging. 2011 Dec;32(12):2317.e13-22.
Feart C, Siewe A, Samieri C, Peuchant E, Helmer C, Alfos S, Pallet V, Barberger-Gateau P. Plasma retinol and association with socio-demographic and dietary characteristics of free-living older persons: the Bordeaux sample of the three-city study. Int J Vitam Nutr Res. 2010 Jan;80(1):32-44.
Feart C, Samieri C, Barberger-Gateau P. Mediterranean diet and cognitive function in older adults. Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):14-8.
Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger Gateau P. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. Jama. 2009 Aug 12;302(6):638-48.
Feart C, Samieri C, Barberger-Gateau P. Mediterranean Diet and Cognitive Decline. [Letter]. Jama, 2009, 302: 2432.
Feart C, Peuchant E, Letenneur L, Samieri C, Montagnier D, Fourrier-Reglat A, Barberger Gateau P. Plasma eicosapentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City Study. Am J Clin Nutr. 2008 May;87(5):1156-62.
Samieri C, Feart C, Letenneur L, Dartigues JF, Peres K, Auriacombe S, Peuchant E, Delcourt C, Barberger-Gateau P. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr. 2008 Sep;88(3):714-21.
Samieri C, Jutand MA, Feart C, Capuron L, Letenneur L, Barberger-Gateau P. Dietary patterns derived by hybrid clustering method in older people: association with cognition, mood, and self-rated health. J Am Diet Assoc. 2008 Sep;108(9):1461-71.
Sirot V, Samieri C, Volatier JL, Leblanc JC. Cadmium dietary intake and biomarker data in French high seafood consumers. J Expo Sci Environ Epidemiol. 2008 Jul;18(4):400-9.
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