Research Associate in Biostatistics


2014 Habilitation à diriger des Recherches, Université Bordeaux, France.
2006 PhD in Biostatistics, Université Bordeaux Segalen, France.
2003 Master in Epidemiology and Public Health, ISPED, Université Bordeaux Segalen, France.
2002 Master degree in Biostatistics, National School for Statistics and Information Analysis, ENSAI, Rennes, France.



2008-… Research Associate (CR1), Inserm, Bordeaux, France.
2008 Research Assistant, Biostatistics and Nutrition departments, Inserm, Bordeaux, France.
2008 Assistant Professor, ISPED, Université Bordeaux Segalen, Bordeaux, France.
2007 Postdoctoral fellow, Department of Biostatistics, School of Public Health, University of Michigan,
Ann Arbor, USA.
2003-2006 Assistant professor, ISPED, Université Bordeaux Segalen, Bordeaux, France.



lcmm: Extended Mixed Models Using Latent Classes and Latent Processes. R  package version 1.7.2.
NormPsy: Normalisation of  Psychometric Tests. R package version 1.0.3.
HETMIXSURV, Fortran 90 program for multivariate heterogeneous longitudinal data analysis. HETMIXSURV


Commenges, D., Proust-Lima, C., Samieri, C., & Liquet, B. (2015). A universal approximate cross-validation criterion for regular risk functions. International journal of biostatistics, accepted.
Proust-Lima, C., Philipps, V., & Liquet, B. (2015). Estimation of extended mixed models using latent classes and latent processes: the R package lcmm. arXiv:1503.00890 [stat].
Proust-Lima, C., Dartigues, J.-F., & Jacqmin-Gadda, H. (2015). Joint modelling of repeated multivariate cognitive measures and competing risks of dementia and death: a latent process and latent class approach.
Blanche, P., Proust-Lima, C., Loubère, L., Berr, C., Dartigues, J.-F., & Jacqmin-Gadda, H. (2014). Quantifying and comparing dynamic predictive accuracy of joint models for longitudinal marker and time-to-event in presence of censoring and competing risks. Biometrics.
Marioni, R. E., Proust-Lima, C., Amieva, H., Brayne, C., Matthews, F. E., Dartigues, J.-F., & Jacqmin-Gadda, H. (2014). Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk. European Journal of Epidemiology, 29(3), 211‑219.
Mura, T., Proust-Lima, C., Jacqmin-Gadda, H., Akbaraly, T. N., Touchon, J., Dubois, B., & Berr, C. (2014). Measuring cognitive change in subjects with prodromal Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 85(4), 363‑370.
Philipps, V., Amieva, H., Andrieu, S., Dufouil, C., Berr, C., Dartigues, J.-F., … Proust-Lima, C. (2014). Normalized Mini-Mental State Examination for assessing cognitive change in population-based brain aging studies. Neuroepidemiology, 43(1), 15‑25.
Proust-Lima, C., Séne, M., Taylor, J. M., & Jacqmin-Gadda, H. (2014). Joint latent class models for longitudinal and time-to-event data: A review. Statistical Methods in Medical Research, 23(1), 74‑90.
Samieri, C., Proust-Lima, C., M Glymour, M., Okereke, O. I., Amariglio, R. E., Sperling, R. A., … Grodstein, F. (2014). Subjective cognitive concerns, episodic memory, and the APOE ε4 allele. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 10(6), 752‑759.e1.
Sène, M., Bellera, C. A., & Proust-Lima, C. (2014). Shared random-effect models for the joint analysis of longitudinal and time-to-event data: application to the prediction of prostate cancer recurrence. Journal de la Société Française de Statistique, 155(1), 134‑155.
Sène, M., Taylor, J. M., Dignam, J. J., Jacqmin-Gadda, H., & Proust-Lima, C. (2014). Individualized dynamic prediction of prostate cancer recurrence with and without the initiation of a second treatment: Development and validation. Statistical Methods in Medical Research.
Mura, T., Proust-Lima, C., Akbaraly, T., Amieva, H., Tzourio, C., Chevassus, H., … Berr, C. (2013). Chronic use of benzodiazepines and latent cognitive decline in the elderly: results from the Three-city study. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 23(3), 212‑223.
Proust-Lima, C., Amieva, H., & Jacqmin-Gadda, H. (2013). Analysis of multivariate mixed longitudinal data: a flexible latent process approach. The British Journal of Mathematical and Statistical Psychology, 66(3), 470‑487.
Taylor, J. M. G., Park, Y., Ankerst, D. P., Proust-Lima, C., Williams, S., Kestin, L., … Sandler, H. (2013). Real-time individual predictions of prostate cancer recurrence using joint models. Biometrics, 69(1), 206‑213.
 Commenges, D., Liquet, B., & Proust-Lima, C. (2012). Choice of prognostic estimators in joint models by estimating differences of expected conditional Kullback-Leibler risks. Biometrics, 68(2), 380‑387.
Samieri, C., Maillard, P., Crivello, F., Proust-Lima, C., Peuchant, E., Helmer, C., … Barberger-Gateau, P. (2012). Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology, 79(7), 642‑650.
Proust-Lima, C., Dartigues, J.-F., & Jacqmin-Gadda, H. (2011). Misuse of the linear mixed model when evaluating risk factors of cognitive decline. American Journal of Epidemiology, 174(9), 1077‑1088.
Proust-Lima, C., Taylor, J. M. G., Sécher, S., Sandler, H., Kestin, L., Pickles, T., … Williams, S. (2011). Confirmation of a low α/β ratio for prostate cancer treated by external beam radiation therapy alone using a post-treatment repeated-measures model for PSA dynamics. International Journal of Radiation Oncology, Biology, Physics, 79(1), 195‑201.
Samieri, C., Féart, C., Proust-Lima, C., Peuchant, E., Dartigues, J.-F., Amieva, H., & Barberger-Gateau, P. (2011). Omega-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression. Neurobiology of Aging, 32(12), 2317.e13‑2317.e22.
Samieri, C., Féart, C., Proust-Lima, C., Peuchant, E., Tzourio, C., Stapf, C., … Barberger-Gateau, P. (2011). Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology, 77(5), 418‑425.
Jacqmin-Gadda, H., Proust-Lima, C., & Amiéva, H. (2010). Semi-parametric latent process model for longitudinal ordinal data: Application to cognitive decline. Statistics in Medicine, 29(26), 2723‑2731.
Jacqmin-Gadda, H., Proust-Lima, C., Taylor, J. M. G., & Commenges, D. (2010). Score test for conditional independence between longitudinal outcome and time to event given the classes in the joint latent class model. Biometrics, 66(1), 11‑19.
Proust-Lima, C., Joly, P., Dartigues, J.-F., & Jacqmin-Gadda, H. (2009). Joint modelling of multivariate longitudinal outcomes and a time-to-event: A nonlinear latent class approach. Computational Statistics & Data Analysis, 53(4), 1142‑1154.
Proust-Lima, C., & Taylor, J. M. G. (2009). Development and validation of a dynamic prognostic tool for prostate cancer recurrence using repeated measures of posttreatment PSA: a joint modeling approach. Biostatistics (Oxford, England), 10(3), 535‑549.
Dantan, E., Proust-Lima, C., Letenneur, L., & Jacqmin-Gadda, H. (2008). Pattern mixture models and latent class models for the analysis of multivariate longitudinal data with informative dropouts. The International Journal of Biostatistics, 4(1), Article 14.
Proust-Lima, C., Amieva, H., Letenneur, L., Orgogozo, J.-M., Jacqmin-Gadda, H., & Dartigues, J.-F. (2008). Gender and education impact on brain aging: a general cognitive factor approach. Psychology and Aging, 23(3), 608‑620.
Proust-Lima, C., Taylor, J. M. G., Williams, S. G., Ankerst, D. P., Liu, N., Kestin, L. L., … Sandler, H. M. (2008). Determinants of change in prostate-specific antigen over time and its association with recurrence after external beam radiation therapy for prostate cancer in five large cohorts. International Journal of Radiation Oncology, Biology, Physics, 72(3), 782‑791.
Jacqmin-Gadda, H., Sibillot, S., Proust, C., Molina, J.-M., & Thiébaut, R. (2007). Robustness of the linear mixed model to misspecified error distribution. Computational Statistics & Data Analysis, 51(10), 5142‑5154.
Letenneur, L., Proust-Lima, C., Le Gouge, A., Dartigues, J. F., & Barberger-Gateau, P. (2007). Flavonoid intake and cognitive decline over a 10-year period. American Journal of Epidemiology, 165(12), 1364‑1371.
Proust-Lima, C., Amieva, H., Dartigues, J.-F., & Jacqmin-Gadda, H. (2007). Sensitivity of four psychometric tests to measure cognitive changes in brain aging-population-based studies. American Journal of Epidemiology, 165(3), 344‑350.
Proust-Lima, C., Letenneur, L., & Jacqmin-Gadda, H. (2007). A nonlinear latent class model for joint analysis of multivariate longitudinal data and a binary outcome. Statistics in Medicine, 26(10), 2229‑2245.
Proust, C., Jacqmin-Gadda, H., Taylor, J. M. G., Ganiayre, J., & Commenges, D. (2006). A nonlinear model with latent process for cognitive evolution using multivariate longitudinal data. Biometrics, 62(4), 1014‑1024.
Proust, C., & Jacqmin-Gadda, H. (2005). Estimation of linear mixed models with a mixture of distribution for the random effects. Computer Methods and Programs in Biomedicine, 78(2), 165‑173.


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