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Enseignant-chercheur (Maître de Conférences)

Parcours

2016 – en cours Maître de conférences section 26 en Biostatistique à l’ISPED

2015 – 2016 post-doctorant à la Harvard T.H. Chan School of Public Health avec Tianxi Cai

2015 Docteur en Santé Publique – option Biostatistique de l’université de Bordeaux
Thèse « Analyse intégrative de données de grande dimension appliquée à la recherche vaccinale » effectuée sous la direction de Rodolphe Thiébaut et de François Caron à l’ISPED (Institut de Santé Publique, d’Epidémiologie et de Developpement) ; Inserm U897, au sein l’équipe Biostatistiques

2011 Ingénieur en statistique de l’ENSAI (École Nationale de la Statistique et de l’Analyse de l’Information) –  spécialité Biostatistique

Logiciels

kernscr an R package to perform kernel machine score test for pathway analysis in the presence of semi-competing risks. Available on CRAN, development version available on github.

NPflow an R package to perform Dirichlet process mixture of multivariate normal, skew-normal or skew t-distributions modeling oriented towards flow-cytometry data preprocessing applications, using C++ code to speed up computations. Available on CRAN, development version on github.

TcGSA an R package to analyze longitudinal gene-expression data at the gene set level. Available on CRAN, development version on github.

tcgsaseq an R package to perform gene set analysis of longitudinal RNA-seq data with variance component score test, accounting for data heteroscedasticity through precision weights. Available on CRAN, development version on github.

Publications

Hejblum BP, Cui J, Lahey LJ, Cagan A, Sparks JA, Sokolove J, Cai T, Liao KP, Association between anti-citrullinated fibrinogen antibodies and coronary artery disease in rheumatoid arthritis, Arthritis Care & Research, in press, 2017.

Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum BP, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S, VEBCON Consortium, Thiébaut R, Altfeld M, and Addo M, Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV, Cell Reports 20(9):2251-2261, 2017. DOI: 10.1016/j.celrep.2017.08.023

Agniel D, Hejblum BP, Variance component score test for time-course gene set analysis of longitudinal RNA-seq data, Biostatistics, in press, 2017. DOI: 10.1093/biostatistics/kxx005

Neykov M, Hejblum BP, Sinnott JA, Kernel Machine Score Test for Pathway Analysis in the Presence of Semi-Competing Risks, Stat Methods in Med Res, in press, 2016. DOI:

Liquet B, Lafaye de Micheaux P, Hejblum BP, Thiébaut R, Group and Sparse Group Partial Least Square Approaches Applied in Genomics Context, Bioinformatics 32(1): 35-42, 2016. DOI:10.1093/bioinformatics/btv535

Hejblum BP, Skinner J, Thiébaut R, Time-Course Gene Set Analysis for Longitudinal Gene Expression Data, PLoS Comput Biol 11(6): e1004310, 2015. DOI: 10.1371/journal.pcbi.1004310.

Furman D*, Hejblum BP*, Simon N, Jojic V, Dekker CL, Thiébaut R, Tibshirani RJ, Davis MM, A systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination, PNAS, 111(2):869–874, 2014. DOI: 10.1073/pnas.1321060111.

Thiébaut R, Hejblum B, Richert L, L’analyse des «Big Data» en recherche clinique, Revue d’Épidémiologie et de Santé Publique, 62(1):1–4, 2014. DOI: 10.1016/j.respe.2013.12.021

Commenges D and Hejblum BP,  Evidence synthesis through a degradation model applied to myocardial infarction, Lifetime Data Analysis 19(1): 1–18, 2013. DOI: 10.1007/s10985-012-9227-3.

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