Epidémiologie intégrative et génétique du vieillissement cérébral et vasculaire – VINTAGE

A partir de données issues de cohortes hospitalières et en population générale, l’équipe VINTAGE explore les déterminants de maladies vasculaires et neurologiques liées à l’âge, notamment les accidents vasculaires cérébraux (AVC) et la démence. L’équipe s’intéresse tout particulièrement aux marqueurs en imagerie du vieillissement cérébral, à l’analyse de données génomiques de grande dimension en association avec ces phénotypes complexes, à la modélisation statistique du déclin cognitif et du risque de démence, et s’oriente actuellement vers l’intégration de biomarqueurs et de modalités « omics » innovantes.

Objectifs

Du fait de l’allongement de l’espérance de vie, le poids croissant des maladies vasculaires et neurologiques représente un défi majeur de santé publique pour les prochaines décennies. L’amélioration de notre compréhension des mécanismes sous-tendant les AVC et la démence, les deux maladies neurologiques liées à l’âge les plus fréquentes, et l’élaboration de stratégies pour prévenir ou retarder leur apparition, sont des étapes essentielles pour promouvoir le bien vieillir cérébral. L’équipe VINTAGE propose de contribuer à cette recherche avec un intérêt particulier pour l’identification et l’évaluation de nouveaux biomarqueurs (génétiques, en imagerie, etc.) des AVC et de la démence, avec l’objectif d’accélérer l’identification de nouvelles cibles thérapeutiques, de faciliter la détection d’individus à haut risque de développer ces maladies, et d’optimiser les stratégies de prévention.

2016-04_VINTAGE-TEAM

Coordonnées

Centre de recherche INSERM U1219
Université de Bordeaux , ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 16 59

Responsable(s)

  • Directrice :
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Co-directrice :
    Research director

    Parcours

    Carole Dufouil, is research director at Inserm Center UMR1219, and co-director of the VINTAGE team (Vascular and Neurological diseases: INTegrative and GEnetic epidemiology).
    She is also adjunct director for international partnerships of Bordeaux School of Public Health (ISPED). She has published over 142 articles in international journals (H-index 53) and is a member of the editorial board of Alzheimer’s and Dementia: translational research & clinical interventions. Her research focuses on the determinants of neurological diseases, particularly Alzheimer’s disease.
    She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on determinants of brain health and has created the international MELODEM initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.
    Dr. Dufouil is co-PI of the 3C-Dijon study and co-PI of the MEMENTO study, a national clinical cohort, which was set up in the context of the Alzheimer Plan 2008-2013 and aims at improving our understanding of the natural course of Alzheimer’s disease.

  • Contact : Nathalie Wattrelos


Axes

  • VINTAGE vise à améliorer la compréhension des déterminants environnementaux et génétiques des AVC et de la démence, avec un intérêt particulier pour les phénotypes intermédiaires cognitifs et en imagerie cérébrale (IRM notamment), en ayant recours à des technologies innovantes (GWAS, séquençage nouvelle génération, biomarqueurs sanguins et du LCR, imagerie de marqueurs pathologiques in-vivo, etc.) et à des cohortes uniques;

  • Celles-ci comportent les études multicentriques suivantes, toutes coordonnées par des membres de l’équipe VINTAGE: des études en population, chez les personnes âgées (cohorte 3C-Dijon) et chez les jeunes étudiants (cohorte i-Share), une cohorte multicentrique de patients présentant des plaintes cognitives ou des déficits cognitifs légers (Memento; études ancillaires Amyging & Vascod); une étude multicentrique sur les dissections des artères cervicales, une des causes les plus fréquentes d’AVC (CADISP) du sujet jeune;

  • Les membres de VINTAGE s’intéressent particulièrement à l’étude en imagerie des marqueurs d’altérations structurelles cérébrales, en particulier des marqueurs de lésions cérébro-vasculaires, en imagerie par résonance magnétique (IRM). Ces marqueurs peuvent être mesurés en population avant l’apparition de symptômes cliniques, et représentent un puissant prédicteur de survenue d’AVC et de démence.

  • VINTAGE vise également à améliorer les modèles étiologiques et de prédiction du déclin cognitif et de la démence, en tenant compte d’obstacles méthodologiques complexes, tels que la sélection, les risques compétitifs et l’attrition, par le biais d’une optimisation de la modélisation statistique (en étroite collaboration avec le consortium MELODEM, coordonné par VINTAGE);

  • L’exploration des déterminants, mécanismes et conséquences de la maladie des petites artères est un objectif important de l’équipe VINTAGE, à travers la coordination d’une fédération hospitalo-universitaire (FHU) récemment créée, dédiée à la recherche ainsi qu’à l’enseignement et au soin clinique autour de la maladie des petites artères, dans le cerveau, le cœur et la rétine

  • Nous visons également à promouvoir le développement de nouvelles approches préventives, par la réalisation d’essais thérapeutiques utilisant comme critère de jugement principal des phénotypes intermédiaires en IRM cérébrale des AVC et de la démence (LEOPOLD [NCT02472028], MAPT-IRM [NCT00672685]), et en appliquant les connaissances acquises dans les projets sus-décrits pour optimiser la conception de futurs essais de prévention du déclin cognitif et de la démence.

  • Compte tenu d’importantes différences liées au sexe en termes de fréquence et caractéristiques des facteurs de risque vasculaires et des maladies neurologiques liées à l’âge, nous nous intéressons aussi à étudier l’impact différentiel des facteurs de risque et des traitements chez les hommes et les femmes.

 



Consortiums internationaux

Les membres de VINTAGE collaborent étroitement avec

  • le consortium CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology), et
  • le consortium international sur la génétique des AVC (International Stroke Genetics Consortium [ISGC], S Debette actuellement vice-chair).

Et ils coordonnent

  • le consortium CADISP (Cervical artery dissection and ischemic stroke patients) et
  • le consortium MELODEM (Methods for longitudinal studies in dementia).



Subventions en cours et soutien à la recherche

  • 2016-2019: JPND-CoFund (Programme européen pour la recherche sur les maladies neurodégénératives), projet BRIDGET – imagerie cérébrale, cognition, démence et séquençage de nouvelle génération (pour analyses génomiques et épigénomiques): une approche transdisciplinaire pour rechercher des facteurs de risque et des facteurs protecteurs des maladies neurodégénératives (PI coordinateur S Debette)

  • 2016-2019: Fondation Plan MND : projet MEMENTO, cohorte multicentrique de patients présentant une plainte cognitive ou des troubles cognitifs légers (co-PIs G Chêne, C Dufouil)

  • 2015-2020: ERC starting grant, du Conseil Européen de la Recherche: SEGWAY – Etude sur les prédicteurs environnementaux et génomiques d’altérations structurelles cérébrales précoces chez de jeunes étudiants (PI S Debette)

  • 2015-2020: H2020: COSTREAM – mécanismes et voies biologiques communes sous-tendant les AVC et la maladie d’Alzheimer (Partenaires S Debette, C Tzourio)

  • 2015-2019: ANR (Agence Nationale de la Recherche): VASCOGENE – ce projet utilise des variants génétiques comme un outil pour explorer l’impact de facteurs de risque vasculaires sur le vieillissement cérébral, le déclin cognitif et la démence (PI S Debette)

  • 2015-2018: ANR, étude PRESIDIO, e-cohorte sur la dépression (PI C Tzourio)

  • 2015-2016: IdEx Université de Bordeaux, Chaire d’Installation (PI S Debette)

  • 2014-2019: PHRC (Programme Hospitalier de Recherche Clinique), essai thérapeutique LEOPOLD, un essai prospectif ouvert avec critère de jugement en aveugle (PROBE) testant l’hypothèse d’un ralentissement de la progression des lésions de substance blanche cérébrale par une réduction de la pression artérielle chez des patients présentant une plainte cognitive et des lésions de la substance blanche de grade modéré à sévère en IRM cérébrale (directeur scientifique C Tzourio, investigatrice responsable de la composante IRM S Debette)

  • 2013-2019: PHRC: étude VASCOD – Étude ancillaire de la cohorte MEMENTO visant à étudier le rôle de facteurs de risque vasculaires, de l’inflammation et de lésions vasculaires (co-PIs G Chêne, C Dufouil)

  • 2012-2017: Fondation Leducq – Transatlantic Network of Excellence: Physiopathologie de la maladie des petits vaisseaux cérébraux (membres S Debette, C Tzourio)

  • 2011-2021 : ANR investissement d’avenir, cohorte i- Share, la plus grande étude en cours sur la santé des étudiants (PI C Tzourio)



Principales publications

  1. FOXF2, a novel risk locus for stroke and small artery disease: a genome-wide association study. Chauhan G, Arnold CR, […], Tzourio C, Rexrode KM, Lehmann OJ, Launer LJ, Ikram MA, Carlsson P, Chasman DI, Childs SJ, Longstreth, Jr. WT, Seshadri S, and Debette S, for the CHARGE consortium, the SiGN group and the International Stroke Genetics Consortium. Lancet Neurol, in press
  2. Incidence of dementia over three decades in the framingham heart study. Satizabal CL, Beiser AS, Chouraki V, Chene G, Dufouil C, Seshadri S. N Engl J Med. 2016;374:523-532
  3. MELODEM Initiative. Guidelines for reporting methodological challenges and evaluating potential bias in dementia research. Weuve J, Proust-Lima C, Power MC, Gross AL, Hofer SM, Thiébaut R, Chêne G, Glymour MM, Dufouil C. Alzheimers Dement. 2015;11:1098-109
  4. New insight into the pathogenesis of cervical artery dissection: A genome-wide association study. Debette S, Kamatani Y, […], Lathrop M, Leys D, Amouyel P, and Dallongeville J, for the CADISP group. Nat Genet. 2015; 47(1):78-83.
  5. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Debette S, Compter A, […] Arnold M, Bousser MG. Lancet Neurol 2015;14:640-6
  6. Association of Alzheimer’s disease GWAS loci with MRI markers of brain aging. Chauhan G, Adams HH, […],Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT Jr, Mosley TH, Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. Neurobiol Aging 2015;36:1765.e7-16
  7. Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Debette S, Ibrahim Verbaas CA, Bressler J,[…], Seshadri S, Mosley TH Jr; Biol Psy. 2015;77:749-63
  8. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Chêne G, Beiser A, Au R, Preis SR, Wolf PA, Dufouil C, Seshadri S. Alzheimers Dement 2015;11:310-20.
  9. Common genetic variants influence human subcortical brain structures. Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, […], Chauhan G, Satizabal CL, Becker JT, Yanek L, van der Lee SJ, Ebling M, Fischl B, Longstreth WT Jr, Greve D, Schmidt H, Nyquist P, Vinke LN, van Duijn CM, Xue L, Mazoyer B, Bis JC, Gudnason V, Seshadri S, Ikram MA; Alzheimer’s Disease Neuroimaging Initiative; CHARGE Consortium; EPIGEN; IMAGEN; SYS, Martin NG, Wright MJ, Schumann G, Franke B, Thompson PM, Medland SE. Nature. 2015; 520:224-9.
  10. Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study. Alpérovitch A, Kurth T, Bertrand M, Ancelin ML, Helmer C, Debette S, Tzourio C. BMJ. 2015; 350:h2335.
  11. Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI. Verhaaren BF, Debette S, Bis JC, […], Seshadri SS, Ikram MA, Fornage M. Circ Cardiovasc Genet. 2015; 8:398-409
  12. Is hypertension associated with an accelerated aging of the brain? Tzourio C, Laurent S, Debette S. Hypertension, 2014;63:894-903
  13. Large Vessel Correlates of Cerebral Small Vessel Disease. Brisset M, Boutouyrie P, […], Dufouil C, Mazoyer B, Laurent S, Tzourio C, Debette S. Neurology 2013; 80:662-669.
  14. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Bis JC*, DeCarli C*, Smith AV*, van der Lijn F*, Crivello F*, Fornage M*, Debette S*, Shulman JM, […], Bennett DA, van Duijn CM**, Mosley TH**, Schmidt R**, Tzourio C**, Launer LJ**, Ikram MA**, Seshadri S**. All starred first authors* and last authors** contributed equally to this manuscript. Nat Genet. 2012; 44:545-5
  15. Association of Vascular Risk Factors With Cervical Artery Dissection and Ischemic Stroke in Young Adults. Debette S, Metso T, Pezzini A, […], Arveiler D, Tatlisumak T, Dallongeville J, for the CADISP Group. Circulation, 2011; 123: 1537-1544.
  16. Antihypertensive Treatment and Change in Blood Pressure Are Associated With the Progression of White Matter Lesion Volumes The Three-City (3C)-Dijon Magnetic Resonance Imaging Study. Godin O, Tzourio C, Maillard P, Mazoyer B, Dufouil C. Circulation 2011; 123:266-73.
  17. Dementia risk prediction in the population: are screening models accurate? Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C. Nat Rev Neurol 2010; 6:318-26.
  18. The Clinical Importance of White Matter Hyperintensities on Brain Magnetic Resonance Imaging: Systematic Review and Meta-analysis. Debette S, Markus HS. BMJ 2010; 341:c3666.

Membres


  • Vincent Bouteloup
  • Aurore Capelli
    Attachée de Recherche Clinique

    2015- Attachée de Recherche Clinique à l’Université de Bordeaux
     ANR i-Share, Université de Bordeaux, sous la direction de Stéphanie Debette et de Christophe Tzourio

    Octobre – Décembre 2014 : Attachée de Recherche Clinique au CHU de Bordeaux
    Plateforme Cassiopée, SFR Santé Publique, Société, ISPED, sous la direction de Viviane Ramel et de Roger Salamon

    2014 – DIU FARC-TEC Formation des Attachés de Recherche Clinique et des Techniques d’Etudes Cliniques, Université Bordeaux Segalen.

    2010-2013 : Chargée d’études contractuelle à l’Université Bordeaux Segalen / bio-informaticienne au CHU de Bordeaux
    USR 3413, SANPSY Sommeil, Attention et Neuropsychiatrie, CNRS-Université Bordeaux Segalen, sous la direction du Pr. Pierre PHILIP.

    2007-2009 : Post-doctorante au CNRS

    UMR 7152, LPPA Laboratoire de Physiologie de la Perception et de l’Action, CNRS-Collège de France, sous la direction du Pr. Alain BERTHOZ.

    2007- Doctorat – spécialité Sciences Cognitives

    2008- Master 2 Recherche de Psychologie des Processus Cognitifs

     

  • Ganesh Chauhan
    Post-doc

    The primary aim of my research is to understand the genetic basis of complex neurological disorders, with a special emphasis on stroke, dementia and cerebral small vessel disease. I am a statistical geneticist and use approaches starting from candidate genes, genome wide association studies to whole exome sequencing to identify rare and common genetic variants in genes responsible for complex genetic disorders. I have been performing large scale genome wide association studies and trans-ethnic meta-analysis of genome wide association studies as part of collaboration with CHARGE consortium and other large consortia in Prof. Debette’s lab since 2012. I have performed whole genome imputation using the 1000G reference panel and I am currently analyzing whole exome sequencing data for the French population based cohort of 3C-Dijon. 

  • Genevieve Chene
    MD, PhD
    Professor

    Parcours

    Geneviève Chêne, MD PhD, born in 1962, is professor in biostatistics and public health at Bordeaux University since 1999. As a researcher, since 2006, Geneviève has established an Inserm research team on “HIV infections and associated morbidity” and a Clinical Trials Unit as a platform of excellence for national and international studies in HIV/AIDS sponsored by the National Agency for Research on AIDS and viral hepatitis (ANRS). Most cited works showed how the efficacy and safety of antiretroviral therapy can be durable over the long term or contributed to the development of epidemiological and statistical innovations needed to conceive clinical trials or large cohorts or analyse their data. This research is now led by Dr Linda Wittkop within the MORPH3Eus (MultimORbidity and Public Health in patients with HIV or Hepatitis). Since 2010, as co- principal investigator of Memento, a national cohort of 2,300 participants recruited in memory clinics, she is actively transferring know-how in other areas than HIV and has joined the team VINTAGE (Vascular and Neurological Diseases: Integrative and Genetic Epidemiology). Since 2014, as head of an international platform for international clinical trials (“EUCLID”), funded by the investments for the future through F-CRIN infrastructure, she is involved in the support and coordination of trials in new vaccines (HIV, viral hepatitis, Ebola virus), neuro-degenerative diseases, obesity/metabolism or medical devices. This platform is one component of the Clinical Epidemiology Center (CIC-EC7, Inserm, CHU de Bordeaux) that she is leading since 2008.

    As a professor of public health, Geneviève Chêne teaches clinical epidemiology at the Bordeaux School of Public Health (Univ Bordeaux) where she initiated an international distant-learning program in epidemiology and clinical research (more than 4500 students since 2001).

    In 2013, she was nominated in the “Comité des Sages” by the Prime Minister for the preparation of the National Strategy for Health. Geneviève Chêne is currently the Director of the Public Health Multi-Organization Thematic Institute of the French National Alliance for Life Sciences and Health (Aviesan and Inserm, Paris) and, since 2013, serves as vice-chair of the scientific evaluation committee of the National Program for Clinical Research (PHRC).

    Her main areas of interest are: Translational epidemiology and public health, clinical epidemiology, e-learning, infectious diseases, Alzheimer and neuro-degenerative diseases

  • Antoine Cremer
    MD

     

    Epreuve de titres et travaux :

    Titres :

    2009 : Docteur en médecine après soutenance de la thèse de médecine : Mesure non invasive de la pression artérielle centrale par le QKD, validation par mesures invasives, Pr Gosse, CHU de Bordeaux.

    2009 : DES de maladies cardiovasculaires, CHU de Bordeaux.

    2010 : Praticien hospitalier, service de cardiologie, centre hospitalier Gabriel Martin, St Paul.

    2011: Fellow ship sous la direction du Pr A. Avolio, Australian School of Advanced Medicine, Macquarie University Hospital, Sydney, Australie.

    2011-2015 : Chef de clinique assistant des hôpitaux de Bordeaux.

    2015-… : : Praticien hospitalier du CHU de Bordeaux, unité de cardiologie et d’hypertension artérielle.

    Prix et bourses :

    2010-2011:

     -Lauréat de la bourse de séjour à l’étranger de la société française de cardiologie de 35.000 euros

    -Lauréat de la bourse de voyage franco-australienne des sociétés française et australienne d’HTA de 5000 euros

    2014 :

    – Lauréat d’une bourse de recherche de 15.000 euros de la société française d’HTA                                          pour le projet GLOBAL-HTN

     – Lauréat de l’appel d’offre interne du CHU de 30.000 euros pour le projet GLOBAL-HTN

     

  • Stephanie Debette
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Carole Dufouil
    Research director

    Parcours

    Carole Dufouil, is research director at Inserm Center UMR1219, and co-director of the VINTAGE team (Vascular and Neurological diseases: INTegrative and GEnetic epidemiology).
    She is also adjunct director for international partnerships of Bordeaux School of Public Health (ISPED). She has published over 142 articles in international journals (H-index 53) and is a member of the editorial board of Alzheimer’s and Dementia: translational research & clinical interventions. Her research focuses on the determinants of neurological diseases, particularly Alzheimer’s disease.
    She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on determinants of brain health and has created the international MELODEM initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.
    Dr. Dufouil is co-PI of the 3C-Dijon study and co-PI of the MEMENTO study, a national clinical cohort, which was set up in the context of the Alzheimer Plan 2008-2013 and aims at improving our understanding of the natural course of Alzheimer’s disease.

  • Marie-Gabrielle Duperron
    MD, PhD student

    Marie-Gabrielle is a Public Health resident in Bordeaux. She is following the MD-PhD program “Ecole de l’Inserm Liliane Bettencourt” (Paris), that allowed her early research training. She did her master 1 directed by Pr Bloch, working on the anatomy of dopamine receptors in rats (Unit “Mouvement – Adaptation – Cognition”, Bordeaux). She obtained a master 2 in Neurosciences (“Ecole pratique des hautes études”, Sorbonne, Paris) where she studied anatomical correlation of neuropsychological tests in a cohort of healthy elderly subjects (3C-cohort) with Voxel Based Morphometry, directed by G. Catheline.

    She is currently a master 2 student in Epidemiology at the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux. She is focusing on MRI markers of cerebral small vessel disease and their shared genetic variants, under the supervision of Stéphanie Debette.

  • Clelia Favary
  • Eric Frison
    MD, PhD student

    Eric Frison is a Medical Doctor with a specialization in Public Health and a MSc in Epidemiology. His residency in public health allowed him to acquire a broad vision of the geriatric network, including clinical practice, epidemiology, and health programming.

    He is assistant professor in clinical epidemiology, working in the clinical trial unit of Univ. Hospital Bordeaux (methodological consulting and supervision) and teaching clinical epidemiology at Univ. Bordeaux (medical school and Bordeaux school of Public Health).

    He is currently a PhD student in epidemiology, directed by Prof. Geneviève Chêne in Inserm unit 1219, VINTAGE team. His PhD thesis is on the comprehensive study of metabolic risk factors for cognitive decline and dementia.

  • Aniket Mishra
    Postdoctoral researcher in genetic epidemiology
    Serial Number  Degree University Year
    1. Bachelor of Engineering in Biotechnology Shivaji University, Kolhapur, India 2004-08
    2. Master of Science in Analytical Genomics University of Birmingham, Birmingham, United Kingdom 2009-10 
    3. PhD in Statistical Genetics University of Queensland, Brisbane, Australia  2011-15 
  • Maria Pothier
    pre-doctoral student

    Maria is a Master 2 student in Epidemiology, at the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux. She is doing a 5 month internship in the VINTAGE team under the supervision of Stéphanie Debette, focusing on mendelian randomization to explore the relation between cerebrovascular disease and dementia.

    Before her Master 2,  she followed the “Frontières du Vivant” bachelor program in Paris, which is an  interdisciplinary bachelor program in life sciences, promoting learning through research, and then a Master 1 in Public Health at ISPED.

  • Muralidharan Sargurupremraj
    Post-doc

    Following my Bachelor’s on a broad Biotechnology background from India, I did Masters on a much narrowed down and an interesting topic “Molecular Genetics” from the University of Leicester, UK. I am primarily interested in the genetics of complex diseases and the effect of environmental interactions. My Ph.D. was on “How intermediate quantitative traits – like cytokines can function as genetic markers for the diagnosis of early onset Asthma”.  At present, I am working on the applications of genome-wide (GW) analysis tools in associating genetic background with phenotypes of cerebral small vessel disease and neurological endophenotypes such as cognitive (memory) functions. In addition, I am interested in following up significant findings from GW association studies with respect to its functional impact, by exploring publicly available functional datasets on gene expression, protein function, epigenetic modifications, etc. My future interests will be along this line with additional component like studying the effect of epigenetic modifications.

  • Sabrina Schilling
    PhD candidate

    Sabrina Schilling was initially trained as an Agrohealth engineer and joined the clinical research field in 2007, first as a clinical research associated and then as a study engineer. After a university diploma in statistical methods in epidemiology, she applied for a PhD in Public Health-Epidemiology at the Doctoral Network of the Ecole des Hautes Etudes en Santé Publique (EHESP). During her PhD she explored the association between lipid metabolism (apolipoprotein E ε genotype and plasma lipid levels) and MRI-markers of cerebrovascular disease (white matter hyperintensities, subclinical brain infarcts and microbleeds). She is also involved in organizational missions within the unit (international meetings and workshops, Neurepiomics summer school, etc.).

  • Aicha Soumare
    Senior Researcher

    Aïcha Soumaré, completed a PhD in Public Health-Epidemiology from the Paris-Sud 11 University in 2009, and is a recipient of the Halimi/Aguirre-Basualdo Ph.D award specialized in medicine*. Soon after she held a research associate position at the INSERM U708-“neuroepidemiology” in Paris. Since 2014, Aïcha joined the group of Pr. Debette as a senior researcher.

    Her research interests are centered on understanding the determinants of age-related neurological disorders such as dementia or stroke. Particularly, she focuses on exploring how modifiable vascular risk factors –including MRI markers of brain lesions– can influence the risk of developing those diseases. In order to bypass some of the limits of observational studies (confounding, reverse causation), her current work includes the use of Mendelian Randomization approaches to investigate the causal impact of those vascular factors by inferring causality from the effect of their genetic variants.

    Dr. Soumaré also collaborates with the Steering committee of the 3C study by handling the proposals of ancillary studies and data access to the cohort in the context of its coordinating center.

     

    * from the Chancellerie des Universités de Paris
  • Judith Thomas Crusells
    PhD
    International Project Manager

    Judith Thomas Crusells holds a PhD in neuroscience from the University of Helsinki (Finland) and a Diploma in business, marketing and public relations from the Open University of Catalonia (Spain). Her scientific career in the fields of neuronal growth factors and neuronal survival after damage was accomplished at highly renowned international institutions such as the Institute of Biotechnology (Helsinki, Finland), the University Hospital of Saarland (Homburg, Germany), the University Hospital of Zürich and the Swiss Federal Institute of Technology in Zürich (ETH, Zürich, Switzerland).

    Judith has also been engaged as technical consultant at the World Health Organization (WHO, Geneva, Switzerland) in the departments of Public and Environmental Health, Vaccines, and Mental Health, where she has been accountable for the coordination of projects and international initiatives, organization of international conferences, and the development of technical documents on global assessment of the burden of diseases.

    Since January 2016, Judith is the international project manager of Pr. Stephanie Debette’s group.

  • Christophe Tzourio
    Directeur

    Parcours

    Christophe Tzourio est neurologue et épidémiologiste. Il a été Interne des Hôpitaux de Paris et Chef de Clinique en neurologie à l’Hôpital Lariboisière. Il a rejoint l’INSERM en 1994 comme Chargé de Recherche et a été promu Directeur de Recherche en 2000. En 2005, il est devenu directeur d’une nouvelle unité de recherche INSERM U708, à l’hôpital de la Pitié-Salpêtrière à Paris. En 2001, il a été nommé professeur d’épidémiologie à l’Université de Bordeaux et praticien hospitalier au CHU de Bordeaux. En Septembre 2013, il est devenu directeur du Bordeaux Population Health (BPH), Inserm U1219, à l’Université de Bordeaux.

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