Vascular and neurological diseases: integrative and genetic epidemiology – VINTAGE

Leveraging extensive data from several complementary population- and clinic-based cohort studies, the VINTAGE team explores the determinants of common, age-related vascular and neurological diseases, especially stroke and dementia. The team focuses particularly on imaging markers of brain aging, large-scale genomic studies, statistical modeling of cognitive decline and dementia risk, with a current development towards integrating additional biomarker and “omics” modalities.

Objectives

With expanding longevity, the increasing prevalence of vascular and neurological diseases represents a major public health challenge for the next decades. Improving our understanding of the mechanisms underlying stroke and dementia, the two most common age-related neurological diseases, and developing strategies to prevent or delay their occurrence, is an essential step in promoting healthy brain aging. The VINTAGE team proposes to contribute to this research with a special focus on identifying and assessing novel biomarkers (genetic, imaging, etc.) for stroke and dementia, to identify novel biotargets and to facilitate the detection of persons at high risk of developing these conditions, for optimized prevention.

2016-04_VINTAGE-TEAM

 

Details

Centre de recherche INSERM U1219
Université de Bordeaux, ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 16 59

  • Director :
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Co-director  :
    Research director

    Parcours

    Carole Dufouil, is research director at Inserm Center UMR1219, and co-director of the VINTAGE team (Vascular and Neurological diseases: INTegrative and GEnetic epidemiology).
    She is also adjunct director for international partnerships of Bordeaux School of Public Health (ISPED). She has published over 142 articles in international journals (H-index 53) and is a member of the editorial board of Alzheimer’s and Dementia: translational research & clinical interventions. Her research focuses on the determinants of neurological diseases, particularly Alzheimer’s disease.
    She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on determinants of brain health and has created the international MELODEM initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.
    Dr. Dufouil is co-PI of the 3C-Dijon study and co-PI of the MEMENTO study, a national clinical cohort, which was set up in the context of the Alzheimer Plan 2008-2013 and aims at improving our understanding of the natural course of Alzheimer’s disease.

  • Contact : Nathalie Wattrelos 


Research areas

  • VINTAGE aims at improving the understanding of environmental and genetic determinants of stroke and dementia, with a strong focus on cognitive and especially MRI endophenotypes, implementing innovative technologies (GWAS, next generation sequencing, blood and CSF biomarkers, etc.) and unique datasets;

  • These comprise the following multicenter studies, all coordinated by VINTAGE members: ongoing community-based studies in older adults (3C-Dijon Cohort) and young students (i-Share Cohort), a multicenter cohort of patients with cognitive complaints or mild cognitive deficits (Memento; Amyging & Vascod ancillary studies); a multicenter study on cervical artery dissection, one of the most common causes of stroke (CADISP) in young adults;

  • VINTAGE members have a special interest in studying markers of structural brain alterations, especially markers of vascular brain injury, using magnetic resonance imaging (MRI). These can be detected in advance of clinical symptoms, powerfully predict the occurrence of stroke and dementia and can be implemented as intermediate markers.

  • VINTAGE members also works on improving etiological and prediction models of vascular cognitive impairment and dementia, by accounting for intricate methodological challenges, such as selection, competing risks and attrition, through elaborate statistical modeling (in close collaboration with the MELODEM consortium, coordinated by VINTAGE)

  • Exploring the determinants, mechanisms, and consequences of small artery disease is another important focus of the VINTAGE team, with the coordination of a recently created hospital-university federation (FHU) dedicated to research, teaching and clinical care of small artery disease in brain, heart and eye.

  • We also aim at promoting the development of new preventive approaches, by conducting therapeutic trials using MRI endophenotypes of stroke and dementia as outcomes (LEOPOLD, MAPT-MRI), and by applying the knowledge gained from the aforementioned projects to optimize the design of future preventive trials of cognitive decline and dementia.

  • Given important sex-related differences in vascular risk factors and age-related neurological diseases, a special emphasis is placed on studying the differential impact of risk factors and treatments in men and women.


International consortia

VINTAGE members collaborate closely with

  • the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and
  • the International Stroke Genetics Consortium (ISGC, S Debette currently vice-chair).

And they coordinate

  • the CADISP (Cervical artery dissection and ischemic stroke patients) and
  • the MELODEM consortium (Methods for longitudinal studies in dementia). 



Ongoing grants and research support

  • 2016-2019: EU JPND (Joint Program on Neurodegenerative Disease Research) grant, BRIDGET brain imaging, cognition, dementia & next generation genomics: a transdisciplinary approach to search for risk & protective factors of neurodegenerative disease, focusing on genetic and epigenetic determinants (Coordinating PI S Debette)

  • 2016-2019: French Plan maladies neurodégénératives (PMND): MEMENTO project – multicenter cohort of patients with cognitive complaints or mild cognitive deficits,(co-PIs G Chêne, C Dufouil)

  • 2015-2020: ERC starting grant, European Research Council: SEWGAY – Study on Environmental and GenomeWide predictors of early structural brain Alterations in Young students (PI S Debette)

  • 2015-2020: H2020 grant, partner: COSTREAM – Common mechanisms and pathways in Stroke and Alzheimer’s disease (Partners S Debette, C Tzourio)

  • 2015-2019: ANR (French National Research Agency): VASCOGENE – using genetic variants as a tool to explore the impact of vascular risk factors on brain aging, cognitive decline and dementia (PI S Debette)

  • 2015-2018: ANR, PRESIDIO study, e-cohort on depression (PI C Tzourio)

  • 2015-2016: IdEx Chair of Excellence: Bordeaux University (PI S Debette)

  • 2014-2019: PHRC, LEOPOLD trial, a prospective randomized open blinded end-point trial testing the hypothesis of slowing down the progression of cerebral white matter lesions by lowering blood pressure in patients with cognitive complaints and a moderate to high grade of white matter lesions on brain MRI. (study director C Tzourio, lead investigator for MRI component S Debette)

  • 2013-2019: PHRC (National Program for Clinical research): VASCOD study – Ancillary Study of MEMENTO cohort aiming at investigating the role of vascular risk factors, inflammation and vascular damage on cognitive decline and progression of neurodegeneration (co-PIs G Chêne, C Dufouil)

  • 2012-2017: Fondation Leducq Transatlantic Network of Excellence, member: Pathophysiology of cerebral small vessel disease (Members S Debette, C Tzourio)

  • 2011-2021: ANR Investment for the future grant, i-Share cohort, the largest ongoing cohort on student health (PI C Tzourio)



Selected publications

 

  1. FOXF2, a novel risk locus for stroke and small artery disease: a genome-wide association study. Chauhan G, Arnold CR, […], Tzourio C, Rexrode KM, Lehmann OJ, Launer LJ, Ikram MA, Carlsson P, Chasman DI, Childs SJ, Longstreth, Jr. WT, Seshadri S, and Debette S, for the CHARGE consortium, the SiGN group and the International Stroke Genetics Consortium. Lancet Neurol, in press
  2. Incidence of dementia over three decades in the framingham heart study. Satizabal CL, Beiser AS, Chouraki V, Chene G, Dufouil C, Seshadri S. N Engl J Med. 2016;374:523-532
  3. MELODEM Initiative. Guidelines for reporting methodological challenges and evaluating potential bias in dementia research. Weuve J, Proust-Lima C, Power MC, Gross AL, Hofer SM, Thiébaut R, Chêne G, Glymour MM, Dufouil C. Alzheimers Dement. 2015;11:1098-109
  4. New insight into the pathogenesis of cervical artery dissection: A genome-wide association study. Debette S, Kamatani Y, […], Lathrop M, Leys D, Amouyel P, and Dallongeville J, for the CADISP group. Nat Genet. 2015; 47(1):78-83
  5. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Debette S, Compter A, […] Arnold M, Bousser MG. Lancet Neurol 2015;14:640-6
  6. Association of Alzheimer’s disease GWAS loci with MRI markers of brain aging. Chauhan G, Adams HH, […],Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT Jr, Mosley TH, Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. Neurobiol Aging 2015;36:1765.e7-16
  7. Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Debette S, Ibrahim Verbaas CA, Bressler J,[…], Seshadri S, Mosley TH Jr; Biol Psy. 2015;77:749-63
  8. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Chêne G, Beiser A, Au R, Preis SR, Wolf PA, Dufouil C, Seshadri S. Alzheimers Dement 2015;11:310-20
  9. Common genetic variants influence human subcortical brain structures. Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, […], Chauhan G, Satizabal CL, Becker JT, Yanek L, van der Lee SJ, Ebling M, Fischl B, Longstreth WT Jr, Greve D, Schmidt H, Nyquist P, Vinke LN, van Duijn CM, Xue L, Mazoyer B, Bis JC, Gudnason V, Seshadri S, Ikram MA; Alzheimer’s Disease Neuroimaging Initiative; CHARGE Consortium; EPIGEN; IMAGEN; SYS, Martin NG, Wright MJ, Schumann G, Franke B, Thompson PM, Medland SE. Nature. 2015; 520:224-9
  10. Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study. Alpérovitch A, Kurth T, Bertrand M, Ancelin ML, Helmer C, Debette S, Tzourio C. BMJ. 2015; 350:h2335
  11. Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI. Verhaaren BF, Debette S, Bis JC, […], Seshadri SS, Ikram MA, Fornage M. Circ Cardiovasc Genet. 2015; 8:398-409
  12. Is hypertension associated with an accelerated aging of the brain? Tzourio C, Laurent S, Debette S. Hypertension, 2014;63:894-903
  13. Large Vessel Correlates of Cerebral Small Vessel Disease. Brisset M, Boutouyrie P, […], Dufouil C, Mazoyer B, Laurent S, Tzourio C, Debette S. Neurology 2013; 80:662-669.
  14. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Bis JC*, DeCarli C*, Smith AV*, van der Lijn F*, Crivello F*, Fornage M*, Debette S*, Shulman JM, […], Bennett DA, van Duijn CM**, Mosley TH**, Schmidt R**, Tzourio C**, Launer LJ**, Ikram MA**, Seshadri S**. All starred first authors* and last authors** contributed equally to this manuscript. Nat Genet. 2012; 44:545-5
  15. Association of Vascular Risk Factors With Cervical Artery Dissection and Ischemic Stroke in Young Adults. Debette S, Metso T, Pezzini A, […], Arveiler D, Tatlisumak T, Dallongeville J, for the CADISP Group. Circulation, 2011; 123: 1537-1544
  16. Antihypertensive Treatment and Change in Blood Pressure Are Associated With the Progression of White Matter Lesion Volumes The Three-City (3C)-Dijon Magnetic Resonance Imaging Study. Godin O, Tzourio C, Maillard P, Mazoyer B, Dufouil C. Circulation 2011; 123:266-73
  17. Dementia risk prediction in the population: are screening models accurate? Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C. Nat Rev Neurol 2010; 6:318-26.
  18. The Clinical Importance of White Matter Hyperintensities on Brain Magnetic Resonance Imaging: Systematic Review and Meta-analysis. Debette S, Markus HS. BMJ 2010; 341:c3666

Members


  • Vincent Bouteloup
  • Aurore Capelli
    Attachée de Recherche Clinique

    2015- Attachée de Recherche Clinique à l’Université de Bordeaux
     ANR i-Share, Université de Bordeaux, sous la direction de Stéphanie Debette et de Christophe Tzourio

    Octobre – Décembre 2014 : Attachée de Recherche Clinique au CHU de Bordeaux
    Plateforme Cassiopée, SFR Santé Publique, Société, ISPED, sous la direction de Viviane Ramel et de Roger Salamon

    2014 – DIU FARC-TEC Formation des Attachés de Recherche Clinique et des Techniques d’Etudes Cliniques, Université Bordeaux Segalen.

    2010-2013 : Chargée d’études contractuelle à l’Université Bordeaux Segalen / bio-informaticienne au CHU de Bordeaux
    USR 3413, SANPSY Sommeil, Attention et Neuropsychiatrie, CNRS-Université Bordeaux Segalen, sous la direction du Pr. Pierre PHILIP.

    2007-2009 : Post-doctorante au CNRS

    UMR 7152, LPPA Laboratoire de Physiologie de la Perception et de l’Action, CNRS-Collège de France, sous la direction du Pr. Alain BERTHOZ.

    2007- Doctorat – spécialité Sciences Cognitives

    2008- Master 2 Recherche de Psychologie des Processus Cognitifs

     

  • Ganesh Chauhan
    Post-doc

    The primary aim of my research is to understand the genetic basis of complex neurological disorders, with a special emphasis on stroke, dementia and cerebral small vessel disease. I am a statistical geneticist and use approaches starting from candidate genes, genome wide association studies to whole exome sequencing to identify rare and common genetic variants in genes responsible for complex genetic disorders. I have been performing large scale genome wide association studies and trans-ethnic meta-analysis of genome wide association studies as part of collaboration with CHARGE consortium and other large consortia in Prof. Debette’s lab since 2012. I have performed whole genome imputation using the 1000G reference panel and I am currently analyzing whole exome sequencing data for the French population based cohort of 3C-Dijon. 

  • Genevieve Chene
    MD, PhD
    Professor

    Parcours

    Geneviève Chêne, MD PhD, born in 1962, is professor in biostatistics and public health at Bordeaux University since 1999. As a researcher, since 2006, Geneviève has established an Inserm research team on “HIV infections and associated morbidity” and a Clinical Trials Unit as a platform of excellence for national and international studies in HIV/AIDS sponsored by the National Agency for Research on AIDS and viral hepatitis (ANRS). Most cited works showed how the efficacy and safety of antiretroviral therapy can be durable over the long term or contributed to the development of epidemiological and statistical innovations needed to conceive clinical trials or large cohorts or analyse their data. This research is now led by Dr Linda Wittkop within the MORPH3Eus (MultimORbidity and Public Health in patients with HIV or Hepatitis). Since 2010, as co- principal investigator of Memento, a national cohort of 2,300 participants recruited in memory clinics, she is actively transferring know-how in other areas than HIV and has joined the team VINTAGE (Vascular and Neurological Diseases: Integrative and Genetic Epidemiology). Since 2014, as head of an international platform for international clinical trials (“EUCLID”), funded by the investments for the future through F-CRIN infrastructure, she is involved in the support and coordination of trials in new vaccines (HIV, viral hepatitis, Ebola virus), neuro-degenerative diseases, obesity/metabolism or medical devices. This platform is one component of the Clinical Epidemiology Center (CIC-EC7, Inserm, CHU de Bordeaux) that she is leading since 2008.

    As a professor of public health, Geneviève Chêne teaches clinical epidemiology at the Bordeaux School of Public Health (Univ Bordeaux) where she initiated an international distant-learning program in epidemiology and clinical research (more than 4500 students since 2001).

    In 2013, she was nominated in the “Comité des Sages” by the Prime Minister for the preparation of the National Strategy for Health. Geneviève Chêne is currently the Director of the Public Health Multi-Organization Thematic Institute of the French National Alliance for Life Sciences and Health (Aviesan and Inserm, Paris) and, since 2013, serves as vice-chair of the scientific evaluation committee of the National Program for Clinical Research (PHRC).

    Her main areas of interest are: Translational epidemiology and public health, clinical epidemiology, e-learning, infectious diseases, Alzheimer and neuro-degenerative diseases

  • Antoine Cremer
    MD

     

    Epreuve de titres et travaux :

    Titres :

    2009 : Docteur en médecine après soutenance de la thèse de médecine : Mesure non invasive de la pression artérielle centrale par le QKD, validation par mesures invasives, Pr Gosse, CHU de Bordeaux.

    2009 : DES de maladies cardiovasculaires, CHU de Bordeaux.

    2010 : Praticien hospitalier, service de cardiologie, centre hospitalier Gabriel Martin, St Paul.

    2011: Fellow ship sous la direction du Pr A. Avolio, Australian School of Advanced Medicine, Macquarie University Hospital, Sydney, Australie.

    2011-2015 : Chef de clinique assistant des hôpitaux de Bordeaux.

    2015-… : : Praticien hospitalier du CHU de Bordeaux, unité de cardiologie et d’hypertension artérielle.

    Prix et bourses :

    2010-2011:

     -Lauréat de la bourse de séjour à l’étranger de la société française de cardiologie de 35.000 euros

    -Lauréat de la bourse de voyage franco-australienne des sociétés française et australienne d’HTA de 5000 euros

    2014 :

    – Lauréat d’une bourse de recherche de 15.000 euros de la société française d’HTA                                          pour le projet GLOBAL-HTN

     – Lauréat de l’appel d’offre interne du CHU de 30.000 euros pour le projet GLOBAL-HTN

     

  • Stephanie Debette
    MD, PhD
    Professor
    Team director

    Functions

    Stéphanie Debette is Professor of epidemiology at Bordeaux University and INSERM Center U1219, where she directs the VINTAGE team.
    She is also practicing neurologist at Bordeaux University Hospital and adjunct associate professor in the department of neurology at Boston University School of Medicine, USA. S Debette holds a master degree in statistical genetics and a PhD in Epidemiology (2008).

    She co-authored 100+ papers (including first or last author papers in Nat Genet, Lancet Neurol, BMJ, Ann Neurol, Circulation, Neurology). She obtained a Fulbright fellowship, a Chair of Excellence from the French National Research Agency (ANR), a Chair of Excellence from Bordeaux University, and is member of a Leducq Transatlantic Network of Excellence on cerebral small vessel disease. Recently she obtained and ERC starting grant to study genetic determinants of early structural brain alterations in young students, and she coordinates a European JPND grant on “next generation” genomic approaches to detect risk and protective factors for brain imaging markers of cognitive decline and dementia.

    S Debette is a longstanding collaborator of the CHARGE consortium, where she co-leads projects on the genomics of stroke, MRI-markers of vascular brain injury and memory. She is currently vice-chair of the International Stroke Genetics Consortium (ISGC), of which she hosted a workshop in 2014. She initiated and coordinates the international CADISP consortium on genetic and environmental risk factors of cervical artery dissections and young stroke (>15 publications).

    S Debette coordinates the Bordeaux Hospital-University Federation SMART on small artery disease in brain, heart and retina.
    She recently launched the neurepiomics summer school, an international course on “neuroepidemiology in the omics era” and co-edited a book on the risk factors of stroke and cerebrovascular disease. S Debette is a member of the editorial boards of Stroke and the European Journal of Stroke, the scientific committee of the French Foundation for Stroke Research, and founder of the Music for the Brain philanthropic initiative.

  • Carole Dufouil
    Research director

    Parcours

    Carole Dufouil, is research director at Inserm Center UMR1219, and co-director of the VINTAGE team (Vascular and Neurological diseases: INTegrative and GEnetic epidemiology).
    She is also adjunct director for international partnerships of Bordeaux School of Public Health (ISPED). She has published over 142 articles in international journals (H-index 53) and is a member of the editorial board of Alzheimer’s and Dementia: translational research & clinical interventions. Her research focuses on the determinants of neurological diseases, particularly Alzheimer’s disease.
    She is particularly interested in the role of vascular risk factor exposure and cognitively stimulating activities, and in imaging markers (PET, MRI) of brain aging and disease. She is also interested in the methodological challenges related to the analysis of studies on determinants of brain health and has created the international MELODEM initiative, which aims at harmonizing analytical approaches in longitudinal studies on dementia.
    Dr. Dufouil is co-PI of the 3C-Dijon study and co-PI of the MEMENTO study, a national clinical cohort, which was set up in the context of the Alzheimer Plan 2008-2013 and aims at improving our understanding of the natural course of Alzheimer’s disease.

  • Marie-Gabrielle Duperron
    MD, PhD student

    Marie-Gabrielle is a Public Health resident in Bordeaux. She is following the MD-PhD program “Ecole de l’Inserm Liliane Bettencourt” (Paris), that allowed her early research training. She did her master 1 directed by Pr Bloch, working on the anatomy of dopamine receptors in rats (Unit “Mouvement – Adaptation – Cognition”, Bordeaux). She obtained a master 2 in Neurosciences (“Ecole pratique des hautes études”, Sorbonne, Paris) where she studied anatomical correlation of neuropsychological tests in a cohort of healthy elderly subjects (3C-cohort) with Voxel Based Morphometry, directed by G. Catheline.

    She is currently a master 2 student in Epidemiology at the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux. She is focusing on MRI markers of cerebral small vessel disease and their shared genetic variants, under the supervision of Stéphanie Debette.

  • Clelia Favary
  • Eric Frison
    MD, PhD student

    Eric Frison is a Medical Doctor with a specialization in Public Health and a MSc in Epidemiology. His residency in public health allowed him to acquire a broad vision of the geriatric network, including clinical practice, epidemiology, and health programming.

    He is assistant professor in clinical epidemiology, working in the clinical trial unit of Univ. Hospital Bordeaux (methodological consulting and supervision) and teaching clinical epidemiology at Univ. Bordeaux (medical school and Bordeaux school of Public Health).

    He is currently a PhD student in epidemiology, directed by Prof. Geneviève Chêne in Inserm unit 1219, VINTAGE team. His PhD thesis is on the comprehensive study of metabolic risk factors for cognitive decline and dementia.

  • Aniket Mishra
    Postdoctoral researcher in genetic epidemiology
    Serial Number  Degree University Year
    1. Bachelor of Engineering in Biotechnology Shivaji University, Kolhapur, India 2004-08
    2. Master of Science in Analytical Genomics University of Birmingham, Birmingham, United Kingdom 2009-10 
    3. PhD in Statistical Genetics University of Queensland, Brisbane, Australia  2011-15 
  • Maria Pothier
    pre-doctoral student

    Maria is a Master 2 student in Epidemiology, at the Institute of Public Health, Epidemiology and Development (ISPED) in Bordeaux. She is doing a 5 month internship in the VINTAGE team under the supervision of Stéphanie Debette, focusing on mendelian randomization to explore the relation between cerebrovascular disease and dementia.

    Before her Master 2,  she followed the “Frontières du Vivant” bachelor program in Paris, which is an  interdisciplinary bachelor program in life sciences, promoting learning through research, and then a Master 1 in Public Health at ISPED.

  • Muralidharan Sargurupremraj
    Post-doc

    Following my Bachelor’s on a broad Biotechnology background from India, I did Masters on a much narrowed down and an interesting topic “Molecular Genetics” from the University of Leicester, UK. I am primarily interested in the genetics of complex diseases and the effect of environmental interactions. My Ph.D. was on “How intermediate quantitative traits – like cytokines can function as genetic markers for the diagnosis of early onset Asthma”.  At present, I am working on the applications of genome-wide (GW) analysis tools in associating genetic background with phenotypes of cerebral small vessel disease and neurological endophenotypes such as cognitive (memory) functions. In addition, I am interested in following up significant findings from GW association studies with respect to its functional impact, by exploring publicly available functional datasets on gene expression, protein function, epigenetic modifications, etc. My future interests will be along this line with additional component like studying the effect of epigenetic modifications.

  • Sabrina Schilling
    PhD candidate

    Sabrina Schilling was initially trained as an Agrohealth engineer and joined the clinical research field in 2007, first as a clinical research associated and then as a study engineer. After a university diploma in statistical methods in epidemiology, she applied for a PhD in Public Health-Epidemiology at the Doctoral Network of the Ecole des Hautes Etudes en Santé Publique (EHESP). During her PhD she explored the association between lipid metabolism (apolipoprotein E ε genotype and plasma lipid levels) and MRI-markers of cerebrovascular disease (white matter hyperintensities, subclinical brain infarcts and microbleeds). She is also involved in organizational missions within the unit (international meetings and workshops, Neurepiomics summer school, etc.).

  • Aicha Soumare
    Senior Researcher

    Aïcha Soumaré, completed a PhD in Public Health-Epidemiology from the Paris-Sud 11 University in 2009, and is a recipient of the Halimi/Aguirre-Basualdo Ph.D award specialized in medicine*. Soon after she held a research associate position at the INSERM U708-“neuroepidemiology” in Paris. Since 2014, Aïcha joined the group of Pr. Debette as a senior researcher.

    Her research interests are centered on understanding the determinants of age-related neurological disorders such as dementia or stroke. Particularly, she focuses on exploring how modifiable vascular risk factors –including MRI markers of brain lesions– can influence the risk of developing those diseases. In order to bypass some of the limits of observational studies (confounding, reverse causation), her current work includes the use of Mendelian Randomization approaches to investigate the causal impact of those vascular factors by inferring causality from the effect of their genetic variants.

    Dr. Soumaré also collaborates with the Steering committee of the 3C study by handling the proposals of ancillary studies and data access to the cohort in the context of its coordinating center.

     

    * from the Chancellerie des Universités de Paris
  • Judith Thomas Crusells
    PhD
    International Project Manager

    Judith Thomas Crusells holds a PhD in neuroscience from the University of Helsinki (Finland) and a Diploma in business, marketing and public relations from the Open University of Catalonia (Spain). Her scientific career in the fields of neuronal growth factors and neuronal survival after damage was accomplished at highly renowned international institutions such as the Institute of Biotechnology (Helsinki, Finland), the University Hospital of Saarland (Homburg, Germany), the University Hospital of Zürich and the Swiss Federal Institute of Technology in Zürich (ETH, Zürich, Switzerland).

    Judith has also been engaged as technical consultant at the World Health Organization (WHO, Geneva, Switzerland) in the departments of Public and Environmental Health, Vaccines, and Mental Health, where she has been accountable for the coordination of projects and international initiatives, organization of international conferences, and the development of technical documents on global assessment of the burden of diseases.

    Since January 2016, Judith is the international project manager of Pr. Stephanie Debette’s group.

  • Christophe Tzourio
    Directeur

    Parcours

    Christophe Tzourio est neurologue et épidémiologiste. Il a été Interne des Hôpitaux de Paris et Chef de Clinique en neurologie à l’Hôpital Lariboisière. Il a rejoint l’INSERM en 1994 comme Chargé de Recherche et a été promu Directeur de Recherche en 2000. En 2005, il est devenu directeur d’une nouvelle unité de recherche INSERM U708, à l’hôpital de la Pitié-Salpêtrière à Paris. En 2001, il a été nommé professeur d’épidémiologie à l’Université de Bordeaux et praticien hospitalier au CHU de Bordeaux. En Septembre 2013, il est devenu directeur du Bordeaux Population Health (BPH), Inserm U1219, à l’Université de Bordeaux.

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