Epidemiology of cancer and environmental exposures – EPICENE

The team is the junction of two entities preexisting in the U 897: the Occupational and Environmental Health Team and the Cancer Axis.

 

Objectives

Research in the field of the epidemiology of cancers and environmental health is impacted by two major issues: i) the necessity to take into account main factors explaining disparities in cancer diagnosis and survival such as screening, stage at diagnosis, socio-economic status, geographical location… ii) the importance of accurately defining environmental exposures to better quantify the risks. We will address these two crucial methodological issues in order to apply them for dedicated studies on environmental epidemiology of cancers.

Details

Centre de recherche INSERM U1219
Université de Bordeaux – ISPED case 11
146 rue Léo-Saignat 33076 BORDEAUX cedex
Tél : +33 (0)5 57 57 95 31
Tél : +33 (0)5 57 57 12 34
Fax : +33 (0)5 57 57 47 33

  • Director : 
    Directrice

    Parcours

    Brief Biography

    Medical doctor specialized in biology (1993). After an MSc (Institut Pasteur, Paris) and a post-doctoral fellowship in transfusion (National Blood center, LR Salmi, in the environmental team at the University of Bordeaux), I gained her PhD in Epidemiology (2002). I obtained the French authorization to supervise research (HDR, University of Bordeaux) in 2006 and became a professor in Epidemiology in 2010. I head the cancer axis in the Inserm U897 unit since 2010 and the epidemiological axis in SIRIC Brio since 2012. I have published more than 100 articles and authored 9 book chapters.

    Research Interests

    Focus on assessing disparities in cancer outcomes (recurrence, survival) and predicting events in cancer through epidemiological studies (population-based studies, prognostic models, diagnostic tools). I’m responsible for the design and analysis of several clinical trials (drug, medical devices and public health interventions) and cohort studies (breast, colorectal cancer and sarcoma). I collaborate with geriatricians and oncologists on a number of projects focusing on elderly patients with cancer.

     

  • Co-director  : Isabelle Baldi

Contacts :

  • Sabrina Constant
  • Christel Dantas


Informations

Research areas 

Cancer events and Outcomes assessments.

The topic aims at understanding and measuring therapeutic progress and survival improvement. We will take into account the key elements: i) the several factors that explain the variations in care access and practices; ii) the use of standardized definition of clinical events and use of the appropriate statistical models for these events; iii) the focus on elderly people. Our objective is to provide reliable tools to measure cancer survival and to propose interventions.

Methods in environmental and occupational exposures assessment

The hallmark of our research is our ability to develop methods to measure individuals’ exposures over the lifetime. We have more specifically investigated exposures to pesticides and fibers/nanoparticles and we started to investigate exposure to electromagnetic fields. Our efforts will be directed towards improving the knowledge of environmental and occupational exposures combining i) field approach: ii) development of tools for indirect exposure assessment and iii) determination of the best exposure metrics to include in the statistical analysis

Environmental Etiology of Cancer

We will analyse the role of certain pollutants in the occurrence of some rare cancers for which the incidence trends, spatial and temporal variations or risks in some occupational groups suggest the role of environmental factors. But, since for very frequent cancers the role of environmental determinants frequently remains unclear, we will also direct our efforts to better understanding – for various types of cancer- who the vulnerable populations are and which characteristics of exposure may explain increases in cancer risk.



Main publications

  1. Bellera CA, Rainfray M, Mathoulin-Pélissier S et al. Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol 2013;23: 2166-72.
  2. Baldi I, Lebailly P, Bouvier G, Rondeau V, Bouchart V, Canal-Raffin M, Garrigou A. Levels and determinants of pesticide exposure in re-entry workers in vineyards: results of the PESTEXPO study. Environ Res 2014; 132:360-9
  3. Lacourt A, Gramond C, Rolland P, Ducamp S, Audignon S, Astoul P, Chamming’s S, Gilg Soit Ilg A, Rinaldo M, Raherison C, Galateau-Salle F, Imbernon E, Pairon JC, Goldberg M, Brochard P. Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma. Thorax 2014;69(6):532-9.
  4. Coureau G, Bouvier G, Lebailly P, Fabbro-Peray P, Gruber A, Leffondre K, Loiseau H, Mathoulin-Pélissier S, Salamon R, Baldi I. Mobile phone use and brain tumors in the CERENAT study. Occup Environ Med 2014;71(7):514-22
  5. De Angelis R, Minicozzi P, Sant M, Dal Maso L, Brewster DH, Osca-Gelis G, Visser O, Maynadié M, Marcos-Gragera R, Troussard X, Agius D, Roazzi P, Meneghini E, Monnereau A; EUROCARE-5 Working Group. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000-2007: Results of EUROCARE-5 population-based study. Eur J Cancer 2015: 51(15) : 2254–2268

Members


  • Carine Bellera
    Biostatisticienne

    2014                HDR (Ability to conduct scientific research), INSERM U897, Bordeaux University, France.
    2010                Post-doctoral Fellow, INSERM U897, Bordeaux
    2006               PhD, McGill University, Canada.
    2001                MSc, McGill University, Canada.

  • Ghislaine Bouvier
    Maître de Conférences
    Assistant Professor
  • Mireille Canal Raffin
  • Fleur Delva
  • Stephane ducamp
    Hygieniste industriel ; animateur de réseaux
  • Angéline Galvin
    Doctorante en épidémiologie
  • Alain Garrigou
    Professeur des universités en ergonomie
    Président du collège des enseignants chercheurs en ergonomie

    2015-  à aujourd’hui : Professeur des université en ergonomie, département HSE de l’IUT de Bordeaux & Equipe Epicene, U1219 Inserm, université de Bordeaux 

    1998-2015

    Maître de conférences en ergonomie (Deuxième Classe) Université de Bordeaux et chercheur au Laboratoire Santé Travail Environnement (LSTE (EA 3672), ISPED), université de Bordeaux

    1997-1998

    Maître de conférences invité (Première Classe)

    Université Pierre Mendès-France/ Chaire municipale de la ville de Grenoble et Laboratoire CRISTO (Centre de Recherche sur l’Innovation Socio-Technique et Organisations industrielles),  à mi-temps et Chercheur sur contrat au Laboratoire d’Ergonomie des Systèmes Complexes (Université de Bordeaux 2) à quart-temps

    1997

    Chercheur contractuel (à mi-temps)

    Laboratoire d’Ergonomie des Systèmes Complexes à l’Université de Bordeaux 2 

    Consultant (à mi-temps)

    Ergonomie & Conception à Pessac (Gironde)

    1993/1996

    Chercheur (mi-temps)

    Institut de Recherche en Santé et Sécurité au Travail (IRSST) 

    505 Ouest Boulevard de Maisonneuve

    Montréal (Québec) H3A 3C2, Canada

    Professeur Substitut (mi-temps)

    Université du Québec à Montréal

    Département des Sciences Biologiques

    Case postale 8888, succursale A

    Montréal (Québec) H3C 3P8, Canada 

    1991/1992/1993

    Attaché Temporaire d’Enseignement et de Recherche (ATER)

    Laboratoire d’Ergonomie et de Neurophysiologie du Travail 

    Conservatoire National des Arts et Métiers

    41 rue Gay-Lussac

    75005 Paris

    1990/1991

    Moniteur de Recherche, 

    Laboratoire d’Ergonomie et de Neurophysiologie du Travail 

    Conservatoire National des Arts et Métiers

    41 rue Gay-Lussac

    75005 Paris

    1988/1990

    Allocataire de recherche,

    Laboratoire d’Ergonomie et de Neurophysiologie du Travail 

    Conservatoire National des Arts et Métiers

    41 rue Gay-Lussac

    75005 Paris

    1983/1984

    Contrôleur du Travail

    Inspection du Travail de Haute-Savoie

    74 000 Annecy

  • Aude Lacourt
    Chargée de recherche INSERM
  • Lucile Migault
    Doctorante en épidémiologie
  • Alain Monnereau
  • Clément Piel
    Doctorant en épidémiologie
    PhD student — “Tumeurs du système nerveux central et expositions agricoles aux pesticides”, Équipe EPICENE, Université de Bordeaux, depuis 2015.
     
    MPH, Master de Santé Publique, spécialité Épidémiologie — ISPED, Université de Bordeaux, 2015.
     
    PharmD, Docteur de Pharmacie — Université Paris Sud, 2015.
  • Chantal Raherison
  • Marion Savina

partners

logo_ISPED logo_SFR-santepublique-societe logo_CHU-Bordeaux logo_Institut-Bergonie logo_INRIA logo_ANRS logo_HONcode